LOCUS       NZ_CP026930.2          11536 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP026930.2 Escherichia coli strain CFS3246 plasmid pCFS3246-1,
            complete sequence.
ACCESSION   NZ_CP026930
VERSION     NZ_CP026930.2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-08 00:03:04
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 102504
            Orig. end    :: 114040
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11536
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6536]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6536
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..11536
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11536
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(712..1146)
                     /locus_tag="ctg1_126"
                     /transl_table=11
                     /translation="MYGTCETLCRELAAKYPGDAPLMLVIWSPEEIQALADGMEISLTD
                     HEIRTVLARMEDIPEDQRTESGISSAAVMEIISNVSENRQVTVPAELLASLIQTAEQAL
                     WKREWAARDNGLAVPECVTRRQAVVNQARTLLKNNTHENN"
     CDS             complement(1160..1381)
                     /locus_tag="ctg1_127"
                     /transl_table=11
                     /translation="MNYAGHEKLRADVAEVANTMCDLRARLNDMEHRCRFDSDVLVERL
                     TRQTLYRANRLFMEAYTEILELDSCFKD"
     CDS             complement(1382..2065)
                     /locus_tag="ctg1_128"
                     /transl_table=11
                     /translation="MSRFILGDCVRVMATIPDNAIDFILTDPPYLVGFRDRSGRTIAGD
                     VNDDWLQPASNEMYRVLKKDALMVSFYGWNRIDRFMAAWKRAGFSVVGHLVFTKSYTSK
                     SAYVAYRHECAYILAKGRPALPPKPLPDVLGWKYSGNRHHPTEKPVTSLQPLIESFTHP
                     NAIVLDPFAGSGSTCVAALQSGRRYIGIELLEQYHRAGQQRLAAVQRAMQQGAANDNWF
                     EPEAA"
     CDS             complement(2142..2567)
                     /locus_tag="ctg1_129"
                     /transl_table=11
                     /translation="MVFFWCVFGCILGFKWVCLSSLPHFNHQSMIICLVLVFYWVECGL
                     FLGFVWRVTKDVAGLLFLLHWLTRRGRNAACGQCPASGRARDGRFYRSWLASVTVYASL
                     SPFSDECPSSRFRGISSPSERRRLRYSTVGLTRYRTR"
     CDS             2582..3544
                     /locus_tag="ctg1_130"
                     /transl_table=11
                     /translation="MLVFIDDGSTNIKLQWQESDGTIKQHISPNSFKREWAVSFGDKKV
                     FNYTLNGEQYSFDPISPDAVVTTNIAWQYSDVNVVAVHHALLTSGLPVSEVDIVCTLPL
                     TEYYDRNNQPNTENIERKKANFRKKITLNGGDTFTIKDVKVMPESIPAGYEVLQELDEL
                     DSLLIIDLGGTTLDISQVMGKLSGISKIYGDSSLGVSLVTSAVKDALSLARTKGSSYLA
                     DDIIIHRKDNNYLKQRINDENKISIVTEAMNEALRKLEQRVLNTLNEFSGYTHVMVIGG
                     GAELICDAVKKHTQIRDERFFKTNNSQYDLVNGMYLIGN"
     CDS             3547..3897
                     /locus_tag="ctg1_131"
                     /transl_table=11
                     /translation="MDKRRTIAFKLNPDVNQTDKIVCDTLDSIPQGERSRLNRAALTAG
                     LALYRQDPRAPFLLCELLTKETTFSDIVNILRSLFPKEMADFNSSTITQPSSQQEQRSD
                     EETKKNAMKLIN"
     CDS             complement(4048..4560)
                     /locus_tag="ctg1_132"
                     /transl_table=11
                     /translation="MNISVEDLFPESFQRIKEEEEANRPDPNWFAHLPPEKINAYMSKY
                     PFKSFDDIPLDNSGLQYPSLQELEFYFPPAALAANCHQLPERMRQKPVVTMINGLTLLR
                     SLGVQAFNIDPRRWHKIKTYLSQGTIEYPQMSEDGKVIIDGRHRILLIMQIYKVTDVPV
                     FFLKGIS"
     CDS             5001..6536
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Cloacin"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_133"
                     /sec_met_domain="Cloacin (E-value: 3.4e-94, bitscore:
                     307.6, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDNEGSVPTEGIDYGDTMVVWPSTGRIPGGDVKPGGSSGLAPSM
                     PPGWGDYSPQGIALVQSVLFPGIIRRIILDKELEEGDWSGWSVSVHSPWGNEKVSAART
                     VLENGLRGGLPEPSRPAAVSFARLEPASGNEQKIIRLMVTQQLEQVTDIPASQLPAAGN
                     NVPVKYRLTDLMQNGTQYMAIIGGIPMTVPVVDAVPVPDRSRPGTNIKDVYSAPVSPNL
                     PDLVLSVGQMNTPVRSNPEIQEDGVISETGNYVEAGYTMSSNNHDVIVRFPEGSGVSPL
                     YISAVEILDSNSLSQRQEAENNAKDDFRVKKEQENDEKTVLTKTSEVIISVGDKVGEYL
                     GDKYKALSREIAENINNFQGKTIRSYDDAMSSINKLMANPSLKINATDKEAIVNAWKAF
                     NAEDMGNKFAALGKTFKAADYAIKANNIREKSIEGYQTGNWGPLMLEVESWVISGMASA
                     VALSLFSLTLGSALIAFGLSATVVGFVGVVIAGAIGAFIDDKFVDELNHKIIK"
     CDS             complement(6554..7081)
                     /locus_tag="ctg1_134"
                     /transl_table=11
                     /translation="MTSNKDKNKKANEILYAFSIIGIIPLMAILILRINDPYSQVLYYL
                     YNKVAFLPSITSLHDPVMTTLMSNYNKTAPVMGILVFLCTYKTREIIKPVTRKLVVQSC
                     FWGPVFYAILIYITLFYNLELTTAGGFFKLLSHNVITLFILYCSIYFTVLTMTYAILLM
                     PLLVIKYFKGRQ"
     CDS             7324..8139
                     /locus_tag="ctg1_135"
                     /transl_table=11
                     /translation="METLTVHAPSPSTNLPSYGNGAFSLSAPHVPGAGPLLVQVVYSFF
                     QSPNMCLQALTQLEDYIKKHGASNPLTLQIISTNIGYFCNADRNLVLHPGISVYDAYHF
                     AKPAPSQYDYRSMNMKQMSGNVTTPIVALAHYLWGNGAERSVNIANIGLKISPMKINQI
                     KDIIKSGVVGTFPVSTKFTHATGDYNVITGAYLGNITLKTEGTLTISANGSWTYNGVVR
                     SYDDKYDFNASTHRGIIGESLTRLGAMFSGKEYQILLPGEIHIKESGKR"
     CDS             complement(8189..8542)
                     /locus_tag="ctg1_136"
                     /transl_table=11
                     /translation="MKVISMKFIFILTIIALAAVFFWSEDKGPACYQVSDEQARTFVKN
                     DYLQRMKRWDNDVQLLGTEIPKITWEKIERSLTDVEDEKTLLVPFKAEGPEGKRMYYGM
                     YHCEEGYVEYAND"
     CDS             complement(8715..9497)
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 96.2; E-value: 5.2e-29)"
                     /gene_kind="other"
                     /locus_tag="ctg1_137"
                     /transl_table=11
                     /translation="MQHLPAPIHHARDAAQLPVAIDYPAALALRQMSMVHDELPKYLLA
                     PEVSALLHYVPDLRRKMLLATLWNTGARINEALALTRGDFSLTPPYPFVQLATLKQRTE
                     KAARTAGRMPAGQQTHRLVPLSDSWYVSQLQTMVATLKIPMERRNKRTGRTEKARIWEV
                     TDRTVRTWIGEAVAAAAADGVTFSVPVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSI
                     SSTEVYTKVFALDVAARHRVQFSMPESDAVTMLKNRHA"
     CDS             complement(9499..9912)
                     /locus_tag="ctg1_138"
                     /transl_table=11
                     /translation="MFFIENEGQAVARTDYWQSVQAQAGYVYLSWNAGVARLLVPDAAK
                     HLLREMRGAEYVIISKGTLHGRDALELVFEDGSDAPFVIHMLSEQCDRLLPENNQGGGF
                     VVTVWTRGGNQLRYPGKYRVVENLPDVSPWSEH"
     CDS             10882..11529
                     /locus_tag="ctg1_139"
                     /transl_table=11
                     /translation="MKHRTWITEALRLHFEEHLPRVVAGRRLSVPKSTVCSMFVRFRRA
                     GLSWPLPAGMSEQELDACLYGQFSTVPVVRPESTVISEAPVVKKRPRRPNFPYEFKIAL
                     VEQSLQPGACVAQIARENGINDNLLFNWRHQYRKGGLLPSGKNMPALLPVTLTPEPDNK
                     IPAPAQEPEQINTPSDSLCCELVLPAGTLRLKGKLTPALLQTLIREIKGSSH"
ORIGIN
        1 tacgcagcac atcgcaggcc agcccactgg acaggatatg ctcaatacac tcactgacca
       61 gatacatttc caccgacgaa aaacgtgctc cccggttcac gatggcatcg agcaccacgg
      121 gcaggttttc gtcatcttca tcgagccagc aggggtgatc gctttccttc acgaccaggc
      181 gaaagcggcg cgtctggcgg gtcagcaacg tctgaccggt ggtggtcagc gccgcacgga
      241 tacgccgcgc atcttctgcc acctggtaac agatgcttcg taccgcatcg tgcaccgcat
      301 caagaacagc cctgatttcg tcttcggtca gccattctcc ggcatacggg aaagacacct
      361 gcgttccgtc tgccggaagt accggcagcg actgccactg actgccggac agtaccagtt
      421 ccgccccggt tccggtcagt ctctgaatgg cggaggccag gagcggcggc agtacgccgc
      481 cgtgacggtt gataagtaac gtcgccagcc ggggcgcatc cagccgcacg taaatgctga
      541 tccagcccgg atagttcgga tttcgctggt caacatccgt ctcttccggc cagccctgcg
      601 ccagcagcag gttacgggcg tgacgacaaa tcagtgcgtt cagcgtgctg ttttcgttca
      661 tgattaagcg ttctccctgt atcgccgccc gcagggcagg cggcgataac atcagttgtt
      721 ttcgtgtgtg ttgtttttca gcagggtgcg ggcctgatta accaccgcct gacggcgggt
      781 aacgcattcc gggacggcga ggccgttatc acgggcggcc cactcacgtt tccacagtgc
      841 ctgttcagcg gtctgaatca gggacgccag cagttcagca gggacggtca cctggcggtt
      901 ttcgctcacg ttgctgataa tctccatcac cgcggcggaa gaaataccgg attcagtccg
      961 ctggtcttcc gggatgtcct ccatgcgcgc caggacggtc ctgatttcat gatcggtcag
     1021 agaaatttcc ataccgtcag ccagtgcctg aatctcttcc ggggaccaga taaccagcat
     1081 cagcggcgcg tctcccggat actttgctgc cagctcccgg catagcgttt cgcatgttcc
     1141 gtacattctc gtctccttct caatctttga agcaggaatc cagttccaga atttcggtat
     1201 acgcctccat aaacaggcga ttggcgcgat acagcgtctg gcgtgtcagg cgttcaacaa
     1261 gcacatcgga atcaaagcga cagcgatgct ccatatcgtt cagcctagcc cgaaggtcac
     1321 acatggtgtt ggccacctcc gccacgtcgg cgcgaagttt ttcgtgtccg gcatagttca
     1381 tttacgcagc ctccggttca aaccagttat cattcgcggc cccctgctgc atggcccgtt
     1441 gcacggcggc cagtcgttgc tgtccggcac ggtgatactg ttcaagcagc tcgataccga
     1501 tataccggcg tccggactgg agggcggcca cgcaggttga gccgctgcct gcaaacgggt
     1561 ccagcacaat cgcgttcgga tgtgtgaagc tctcaatcag tggttgcagg ctggtaacgg
     1621 gcttttccgt cgggtgatgg cggttgcccg aatatttcca gcccagcacg tcgggtaatg
     1681 gcttcggagg cagcgccgga cggccttttg ccaggatata ggcgcattcg tgacggtacg
     1741 cgacatacgc agatttggat gtgtagcttt tggtgaacac aaggtgccct acaacgctga
     1801 atccggcgcg tttccaggct gccataaagc ggtcaatacg gttccagcca tagaaactca
     1861 ccatcagcgc atcttttttt agtacgcggt acatctcatt actggcaggt tgcagccagt
     1921 catcgttaac gtcaccggca atggtgcgcc cggaacggtc acgaaaacca acgagatatg
     1981 gtgggtcggt taagatgaaa tcaatggcgt tatcaggaat cgtggccata acacgcacgc
     2041 agtcacccag gataaaacgg gacataacag cactcctcct cttacagagg gcaccgggag
     2101 ggcgcccctg tggcgcccgt tctccgctgc ctgtgggctg ttcaccgcgt ccggtaacgg
     2161 gtcaggccga ccgtggaata ccgcagccgt cgtctttctg acggcgagga tatgccgcga
     2221 aagcggcttg aagggcattc atcagaaaag ggcgacaggc tggcgtacac tgtcaccgac
     2281 gccagccagg agcggtaaaa gcgcccgtcc cgtgcccggc cggacgcggg acactgacca
     2341 caggcagcgt tcctgccgcg ccgcgtcagc cagtgcagta aaaagaggag cccggcgaca
     2401 tcttttgtta cccgccaaac aaaacccaaa aacaacccac actcaaccca ataaaacacc
     2461 aaaacaagac aaataatcat tgattgatgg ttaaaatggg gtaaacttga caaacaaacc
     2521 cacttaaaac ccaaaataca cccaaataca caccaaaaaa acaccataag gagttttata
     2581 aatgttggta ttcattgatg acggttcaac aaacatcaaa ctacagtggc aggaaagcga
     2641 cggaacaatt aaacagcaca ttagcccgaa cagcttcaaa cgcgagtggg cagtctcttt
     2701 tggtgataaa aaggtcttta actacacact gaacggcgaa cagtattcat ttgatccaat
     2761 cagcccggat gctgtagtca caaccaatat cgcatggcaa tacagcgacg ttaatgtcgt
     2821 tgcggtgcat cacgccttac tgaccagtgg tctgccggta agcgaagtgg atattgtttg
     2881 cacacttcct ctgacagagt attacgacag gaataaccaa cccaatacgg aaaatattga
     2941 gcgtaagaaa gcaaacttcc ggaaaaaaat tacattaaat ggtggggata cattcacaat
     3001 aaaagatgta aaagtcatgc ctgaatctat accagcaggt tatgaagttc tacaagaact
     3061 ggatgagtta gattctttat taattataga cctcgggggc accacattag atatttctca
     3121 ggtaatgggg aaattatcag ggatcagtaa aatatacgga gactcatctc ttggtgtatc
     3181 tctggtcaca tctgcagtaa aagatgcact ttctcttgcg agaacaaaag gaagtagcta
     3241 tcttgctgac gatataatta ttcacagaaa agacaacaac tatctgaagc aacgaattaa
     3301 tgatgagaac aaaatatcaa tagtcaccga agcaatgaat gaagcacttc gtaaacttga
     3361 gcaacgtgta ttaaatacgc tcaatgaatt ttctggttat acgcatgtta tggttatagg
     3421 cggtggcgca gaattaatat gcgatgcagt aaaaaaacac acacagattc gtgatgaacg
     3481 ttttttcaaa accaataact ctcaatatga tttagttaac ggtatgtatc tcataggtaa
     3541 ttaataatgg acaagcgcag aaccattgcc ttcaaactaa atccagatgt aaatcaaaca
     3601 gataaaattg tttgtgatac actggacagt atcccgcaag gggaacgcag ccgccttaac
     3661 cgggccgcac tgacggcagg tctggcctta tacagacaag atcccagggc ccctttcctt
     3721 ttatgtgaac tgctgacgaa agaaaccaca ttttcagata tcgtgaatat attgagatcg
     3781 ctatttccaa aagagatggc tgattttaat tcttcaacaa tcactcaacc ctcttcacaa
     3841 caggagcaaa gaagtgatga agagacaaaa aaaaacgcga tgaagttaat aaactgatta
     3901 aatttttatt gatatcttta cccccataaa cggggtaaag gtatcaacaa acctattttt
     3961 tagctatgta cagattacat ctgacaagtt atttctacgt aacaaatcac agtctaaaaa
     4021 tcagtatagc tttacccttt gcactgttca gcttattcct ttcagaaaaa aaacgggaac
     4081 atcagttact ttataaatct gcataataag tagtattcta tgcctgccat ctataattac
     4141 tttcccgtct tcggacattt gtggatattc aatcgttcct tgacttaaat aggttttaat
     4201 tttgtgccat cggcgtggat cgatattgaa agcctgaacg ccaagcgacc ttaacagggt
     4261 taacccatta atcatcgtga ccacaggctt ttgtctcatt ctctcaggaa gttgatggca
     4321 attagcagcc agggccgccg ggggaaaata aaactccagt tcctgtagtg aagggtattg
     4381 caaaccactg ttgtccagag gaatatcatc aaaggatttg aaaggatact tggacatata
     4441 cgcattgatt ttttcaggcg gtaaatgtgc aaaccagtta ggatcaggcc tgttcgcttc
     4501 ttcttcttct ttaattcgtt gaaatgactc cggaaacaaa tcttccacac ttatgttcat
     4561 cacaatatcc tcccttgaga gcattgctca tcgccaccga taaggatttc attataaaac
     4621 acgccagtac agaacaactc actggtttca aactcccgtc gtccgtcctg accggtacgg
     4681 taactaacaa gacctgtaca catatcacga tgtgtaccat gccataaagt gacagtatcc
     4741 ccccaggtgt ctcatatcat agtttcatta aaacatgctg aggccagaga acagttatgc
     4801 ctgtgccgtt ttttgtggta tcaggcgaga atagaacgtg gtgtgaatgc ctgttttttg
     4861 atcgttttca caaaaattga aatccacagt cttgacagag aaaacacagc ggcgtaattt
     4921 ttgatctgta cataaaacca gtggttatat gtacagtatt taattttaat tgattgtttt
     4981 taaagtcaaa gaggttttct atgagtgata atgaaggtag tgtaccgaca gaaggtattg
     5041 attacgggga cacaatggtt gtgtggccgt caacaggacg aattccgggc ggtgatgtga
     5101 aacccggagg ctcatcaggt ctcgctccat ccatgcctcc gggatggggg gattacagcc
     5161 cacaaggtat cgcacttgta caaagtgttc tttttcctgg aattattcgc cggattattc
     5221 ttgataaaga acttgaagag ggagactggt cgggatggtc tgtcagtgtg catagcccct
     5281 ggggaaacga gaaagtttcc gctgcacgaa cagttcttga aaatggttta cgtggtggtt
     5341 tgccagaacc gtctcgcccg gctgctgttt cttttgcccg tctggagcct gcttccggaa
     5401 atgagcaaaa aattattcgt cttatggtta cacagcaact ggagcaggta acggatatcc
     5461 ctgccagcca gttaccagca gcgggtaata atgtaccggt aaaatatcgt ctgacggacc
     5521 ttatgcagaa tggtacacaa tatatggcta ttatcggagg tattccgatg acagtgccag
     5581 tagtggatgc cgttccagtt ccggaccgga gtcgtccggg aaccaatatt aaagatgttt
     5641 acagtgcccc tgtatcacca aatctaccgg acctggtatt aagtgtgggt cagatgaata
     5701 ctccagttcg gtctaatccc gaaatccagg aagatggcgt tatttctgag acagggaatt
     5761 atgttgaggc tggttatacg atgtccagta ataatcatga tgtcattgtc cgttttcctg
     5821 aaggcagtgg agtttctccg ctatatattt cagccgtgga gattctggac agtaatagtt
     5881 taagccagcg ccaggaagcc gaaaataacg caaaggatga cttcagagtc aagaaagaac
     5941 aagaaaatga cgagaagacg gtcctgacaa aaaccagcga ggtcatcatt agtgtcggtg
     6001 acaaagtcgg ggaatatctt ggagataaat acaaggcgct ttcccgtgaa attgcagaga
     6061 atataaataa ttttcaggga aaaacgattc gtagttatga tgatgcaatg tcttccatta
     6121 ataagttaat ggctaacccc agccttaaaa taaatgcaac ggacaaagaa gccattgtga
     6181 atgcgtggaa agcatttaat gctgaggata tggggaataa atttgctgcg ttgggtaaaa
     6241 cgttcaaagc agcagattat gcaataaagg caaacaacat cagggagaag agtattgagg
     6301 gttaccagac tggtaactgg gggccattaa tgctggaagt cgagtcctgg gttatcagtg
     6361 ggatggcatc tgctgtagct cttagtttgt tttctttgac attaggctcg gcccttatag
     6421 cctttggtct ttcggccaca gttgttggtt ttgttggcgt agttattgca ggtgctattg
     6481 gtgcatttat cgatgataaa tttgttgatg agttgaatca caagatcata aaataattaa
     6541 aaggaaggca gtgttactgc ctccctttaa aatatttaat gacaagtaat ggcatcagta
     6601 aaatcgcata tgtcatggtt aaaacagtaa agtaaatgga gcaatataaa ataaacagag
     6661 tgatgacatt atgagataat aatttaaaaa aaccacctgc tgttgttagt tccagattat
     6721 agaacagtgt gatataaatc agaatggcat aaaaaacggg cccccagaaa caggattgca
     6781 caacaagttt tcttgttact ggctttatga tttctcttgt cttatatgtg caaagaaaaa
     6841 cgagaatacc cataactggc gctgtcttgt tgtagtttga cataagtgtt gtcatgacgg
     6901 gatcatgcaa tgatgtaata gaagggagaa atgccacctt attatataag tagtacagca
     6961 cttgagaata tggatcattt attcgaagta ttaatatagc cattaatgga ataatcccga
     7021 ttatggaaaa tgcatataat atttcgtttg ctttcttgtt cttatcttta ttgctggtca
     7081 tatatatacc tttttgtatt ttatatatag attatatatc agagttctca atatatttcc
     7141 agtatttaat ggagtgtaca gatatatatc ttatatatgg tagttcagga gctgccctac
     7201 catttttaac ggcatatcag gcaaacaatg ttatggggag cctctctcat ggggtttgtt
     7261 cgccggcgga ggcgttagcc agcggcgaac tctgttatct tgttaactta taaggagtta
     7321 tgtatggaaa ccttaactgt tcatgcacca tcaccatcaa ctaacttacc aagttatggc
     7381 aatggtgcat tttctctttc agcaccacat gtgcctggtg ctggccctct tttagtccag
     7441 gttgtttata gttttttcca gagtccaaac atgtgtcttc aggctttaac tcaacttgag
     7501 gattacatca aaaaacatgg ggccagcaac cctctcacat tgcagatcat atcgacaaat
     7561 attggttact tctgtaacgc cgaccgaaat ctggttcttc accctggaat aagcgtttat
     7621 gacgcttacc acttcgcaaa accagcgcca agtcaatatg actatcgctc aatgaatatg
     7681 aaacaaatga gcggtaatgt cactacacca attgtggcgc ttgctcacta tttatggggt
     7741 aatggcgctg aaaggagcgt taatatcgcc aacattggtc ttaaaatttc ccctatgaaa
     7801 attaatcaga taaaagacat tataaaatct ggtgtagtag gcacattccc tgtttctaca
     7861 aagttcacac atgccactgg tgattataat gttattaccg gtgcatatct tggtaatatc
     7921 acactgaaaa cagaaggtac tttaactatc tctgccaatg gctcctggac ttacaatggc
     7981 gttgttcgtt catatgatga taaatacgat tttaacgcca gcactcaccg tggcattatc
     8041 ggagagtcgc tcacaaggct cggggcgatg ttttctggta aagagtacca gatactgctt
     8101 cctggtgaaa ttcacattaa agaaagtggt aagcgataat ataagggccg gggttccggc
     8161 ctttttatgc agcctttata acagtgtatt agtcattcgc atattcaaca tatccctcct
     8221 cacaatggta catgccataa tacattctct taccctccgg gccttcagct ttaaatggga
     8281 caagaagtgt tttttcatct tcaacatctg ttaaacttct ctcaatcttt tcccatgtaa
     8341 ttttcgggat ttctgtacca agaagttgta catcgttgtc ccagcgtttc attctttgca
     8401 ggtaatcatt ttttacaaac gttctggcct gttcatcgct gacctgatag catgccggac
     8461 ctttatcttc agaccagaaa aaaacagcag caagagcaat aatcgttaaa ataaaaataa
     8521 atttcatgct aattactttc ataaaatctc cacaacttct gtcgttcatt cgatataaaa
     8581 aaacattacg aatatatccg tacaatgtga gcatactgtg aagtggcttt aacaattatg
     8641 aaataataca agagatcaca tattgcagtg gtctcttttt tatagaagaa atcacaattc
     8701 ataattgtga cttattatgc atgtctgttt ttcagcattg tgaccgcatc ggactcaggc
     8761 atcgaaaact gcacccggtg ccgtgcagcc acatccagtg caaacacctt cgtgtagacc
     8821 tccgttgagc tgatggactt atgccccatc aggctctgca ggaccttcag cggtataccg
     8881 gcatacagca tgtgcatcgc ataggaatgg cggaacgtat gtggcgtgac cgggacagag
     8941 aacgtcacac catcagcggc agcggcggca accgcctccc caatccaggt cctgaccgtt
     9001 ctgtccgtca cttcccagat ccgcgctttc tctgtcctgc ctgttcgttt attacgccgt
     9061 tccatgggga ttttcagtgt ggctaccatc gtctgcagct ggctgacgta ccaggagtcg
     9121 gagagcggaa ccagccggtg agtctgctga ccggcgggca ttcttcctgc cgtcctggcg
     9181 gctttttctg tccgctgctt cagagtggcc agctgcacaa acggatacgg gggcgtgagc
     9241 gaaaaatccc cccgcgtcag cgccagtgct tcattaatgc gcgcaccggt gttccacagt
     9301 gtggccagca gcattttgcg gcgcagatcc ggcacgtaat ggagcagggc gctcacttca
     9361 ggggccagca ggtattttgg cagttcatca tgaaccatcg acatctggcg gagtgccagc
     9421 gctgccggat aatcgatggc aacaggaagc tgagcggcat cccgggcatg gtggatcggt
     9481 gccggcaggt gctgcatatc agtgttcact ccacggggaa acgtcgggca ggttttccac
     9541 aacacggtac tttcccggat aacggagctg gttaccgcca cgcgtccaga cggtgacaac
     9601 aaaaccccct ccctggttgt tttcggggag caggcgatcg cactgctcac tcagcatgtg
     9661 gatcacaaac ggcgcatcgc tgccgtcttc aaataccagt tccagcgcat cgcggccatg
     9721 cagcgttccc ttactgatga tgacgtactc agccccccgc atctccctga gtaaatgttt
     9781 tgccgcatcc gggacaagca gcctggctac gccggcattc cagctgaggt agacatatcc
     9841 ggcctgcgcc tgtacagact gccagtaatc cgttctggcg acagcctgac cttcattctc
     9901 aataaaaaac atgggtgact ccttttttct tttccgggca gggacggtca tgcgataacg
     9961 tcatccatca tcactgccct taccgtcacg ccgtctgata acatcatgcc gttatcatca
    10021 ttaccatgat aacaagcatc catataacca cgccgttaaa ttactggaga gccgtttccg
    10081 tcagatccga ctttccggaa tatcacaact ttccggaagt gtaccacgct gagaaaatca
    10141 tcatatcgct gttttccgcc cctgcgcggc gcatcacagg tcagggagat gacacaacat
    10201 atagtgtcat tagcagctga attcagcact acatgttgtg cttacagggt gtggcgctgt
    10261 gcggaggggg aggaagatcc gtaaccaggg gttttcggat ctctggagca gaaaagaaaa
    10321 ttattgccag ataatcacaa aaaatggtgg attattgtga tgaagtgatt attgcaatca
    10381 gaacaataac tggaattgta aaggtcatat tcatcaataa atagcagagt cacagatctg
    10441 ctgaaagcca aaccatgaag atactacccg agtccgcttc tggaagatcc atttcaaata
    10501 tccggataca caggcaactg tggcgacgat tgtaatgaca ttaaccatat cggcttccct
    10561 gaagcattgg ttatggcaac cacgttatca atatctttcc atcattttca gtaaatatca
    10621 ctaacagacc gatattaccg gacctgtaag ttatttgtga ctgatatcac caatttgtaa
    10681 atcaaatgtg aaaatatggt ttatctgtgc tttatttttc cccgacataa aatggaggtc
    10741 tttatgaaag atgtcagtat tttgaatgaa atgatcttca gcgcatcaac agaaaatggt
    10801 aaccggctca tttaaaccgt ctggtctgtt tcctccggct ctacaaaaat aatgtccatc
    10861 atttttaatg gacactatcg tatgaaacac cggacctgga tcactgaagc tttacgtctt
    10921 cactttgaag aacatttacc ccgggttgtg gccgggcgtc gcctgagtgt accaaaatca
    10981 acagtttgta gtatgttcgt gcgctttcgg agagctggcc tttcgtggcc tttgcccgca
    11041 ggcatgtcgg agcaggaact tgatgcctgc ctttacggac aattttccac ggtaccagtc
    11101 gtacgtcctg aaagcaccgt tatatccgaa gcccccgtgg taaaaaaacg tccccggcgg
    11161 cccaacttcc cttatgagtt taaaatcgcc ttagtggagc agtcactgca gcccggagcc
    11221 tgtgtggcgc agatcgcccg ggaaaacgga atcaacgata acctgctctt caactggcgc
    11281 catcaatacc ggaaaggtgg cctgctgcct tccggaaaaa atatgccggc actgcttccc
    11341 gtgacgttaa cgccggagcc ggataataaa atcccggccc ccgcacagga accagagcag
    11401 ataaatacac cgtccgacag tctgtgttgt gagctggttc tgccggccgg aactctcagg
    11461 cttaaaggta aactgacgcc ggcgttatta cagacactta tccgcgaaat aaaagggagc
    11521 agccactgat gatatc
//
