LOCUS       NZ_CP021062.1          15142 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP021062.1 Bacillus thuringiensis strain ATCC 10792 plasmid poh1,
            complete sequence.
ACCESSION   NZ_CP021062
VERSION     NZ_CP021062.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 14:52:01
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 569481
            Orig. end    :: 584623
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15142
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:14394]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14394
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..15142
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15142
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             674..1093
                     /locus_tag="ctg1_488"
                     /transl_table=11
                     /translation="MKKLVLAGALGIAVFSGMNLPGAEASKASAATTNLEIQEVTKYYS
                     MSSYEVSQKESFNLKKGEELTVFVQNSGFPISYTVFDADNQVIGTFNANSPYGRVFKAQ
                     KDGNISVQFQAGVNSTYMKKMNFTAKFAVSKLSQQ"
     CDS             complement(1163..1378)
                     /locus_tag="ctg1_489"
                     /transl_table=11
                     /translation="MQIRENNNSNEILIAAAASAIEQMKYEIALEFGVTLGPDSTARAN
                     GSVGGEITKRLVRMAQEQLSGQYKIH"
     CDS             complement(1540..3282)
                     /gene_functions="other (smcogs) SMCOG1061:methyl-accepting
                     chemotaxis protein (Score: 299.9; E-value: 6.5e-91)"
                     /gene_kind="other"
                     /locus_tag="ctg1_490"
                     /transl_table=11
                     /translation="MKKYWHKLSLLQKNVLLTVLVILTLVGSMGALSFNMFQNSMMSIF
                     ERQSFETGDAVLNQLDLEIVRDVAKDPTAQRVKKEKLTGQLDKSIKDMKSVGQTYVTGA
                     KLNDKAELQIVALDTQLANTVSVKPGEYYEQPTYWMKTYDKVIQTKQAQMTEVYEDELG
                     FWVTILEPVTDENKNIIAIVAADLEASIIPLTKKNFMIQGLLFIIISLTIAITIQIFIS
                     RNSLSPVKDLQEGLRKVGEGDLSIKLNERSDDIGITNIYFNNTIKKFNRIIDKVRQTAE
                     QVSTSSQELSVSTKENSIAFKEIASAITGLNLGAHSHEYVVQKCFGIVQEMESKMKEIK
                     GAAKQVGNAVEDMEQHSVEGKDLIKQIVNQMKRIQDTVQDVPSSIYAFEARSKEIHEIL
                     TVITTISNQTNSLALNASTESSCAGEMGEEFSGVADEVSILAERTEASARDIAKLIGET
                     QAEAERAVRSIQKSSKEVELGISLVQSSGAFFEKISESAQSVTNQIKATSNHSSDILKD
                     NQTIVHFINELSHIANTYVNSSSNVETSMKEQELYVQEIAELANSLNWLSQELQGLIGE
                     FKSK"
     CDS             4264..4743
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_491"
                     /sec_met_domain="Abi (E-value: 8.9e-14, bitscore: 46.7,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKKINRFMFALPTISFVFLILLGSFLFVLPLDLFLPEIQKNPIT
                     EAPLILQVLLGVLAAPIYETVVFQVFLFWLLSLIPYIKNRDYLIILIASIIFGLNHRYG
                     ITYIVGTTIIGLLYNYAYWVYKKKNEKYQVTMPAFGVVFLIHLLHNSIAFIASNL"
     CDS             complement(5463..5873)
                     /locus_tag="ctg1_492"
                     /transl_table=11
                     /translation="MIKKLIISSIALGTTIGVSKPTFAATIHSPSQFKETRNVHVQSLY
                     SPWQYLGQTSRELQIKSKDPKVLAFELAKEAPFYEEELVDICSVILDANVDVVYWTSKE
                     WVRFEEGNYEFKHEIKIFRDKERQQLITKLES"
     CDS             complement(6290..6703)
                     /locus_tag="ctg1_493"
                     /transl_table=11
                     /translation="MKNEVILNKISTIERCIKRIQDVYGNDPENLEDFTKQDSIILNIQ
                     RACEASIDLAMHIVAGKKLGLPQSSREAFDLLVTAGLLSADLANKLKAMVGFRNIAVHD
                     YQSVNLDIVRQIIEKHLTDFKLFTKEVMGILEF"
     CDS             complement(6693..7100)
                     /locus_tag="ctg1_494"
                     /transl_table=11
                     /translation="MIFQSMITAIIEKLQETVNPYWIIVFGSTAENREREDSDIDIAYV
                     SDTTLGNYERFLLAQELANIVHRDVDLVDLSEASTVFQAQIIHTGKTIFCSDEKRKVIF
                     EMKTLKMYSKLNEERQVVFDDIKKRGSIYEE"
     CDS             complement(7718..9424)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 319.5; E-value:
                     7.2e-97)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_495"
                     /transl_table=11
                     /translation="MKNNSLIKTLKIVNWPIAKVIIAIFISIVSVFVSLLVPIYIKEII
                     DKIDFTNLPIKIILLVISFFIIASFLQGLSQYLLSYIGELTIRDLRKNMWEYIINLPVK
                     YYDNKETGQIMSRLIEDSSIVNNFVSMKLPIMLSQLILFFGALGLMIYMDWKITLFMLI
                     TVVVTTVIIIPLGNKIYVISTNHQQTIAEFSGILSRVLSDIRLVKIANAENLEIKRGND
                     KLERLFGLGIKQSKLYSFINPLITLIIMFTIIGILSYSGYRLSVGTLSTGTLVALLFYL
                     LQIIEPLTGLSSFFTDYKKTLGATDRIQEIYKNQLENKAGYAPSYEQDISFQNVSFSYG
                     EKEILKNVNFLAERNKVTAFVGPSGAGKSTIFSLLVKLYECQDGNIKYGDQSINNIDLT
                     LWRSKIGYAMQNAPVMNGTVLDNITYGLTRSYSMEEIHTVAQIANAHEFIMNLENQFDT
                     LVGERGILLSGGQKQRLALCRVFLHNPEILLLDEATSSLDSESEKHIERAINYVKSNKT
                     TLIIAHRLSTIMAADHIIFLDDGKITGQGTHEELLNTHERYRDFVTYQTIK"
     CDS             complement(9414..9965)
                     /locus_tag="ctg1_496"
                     /transl_table=11
                     /translation="MIEILRTLVNFLIALFSGELPGIYYIWIIALLIVQIIQSTLNYNL
                     FNKKEKFSKYTMEGLLAFLIILIGSMLLSKLLAFIIEDSVINKTELTHYFVSLIVLTIF
                     VAIGCIKELIRHTIKNSNMSLVTFIIVSLIASILSFKLLLPLTGGSFTLSKSFIYTLII
                     VVTGIIVLLVSMEEKYVDEE"
     CDS             complement(10001..11311)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     337; E-value: 2.5e-102)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_497"
                     /sec_met_domain="LANC_like (E-value: 1.3e-60, bitscore:
                     200.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIKLNENELKTLNEINQKLIKLYSDFEKVESYINDSASPGLEAI
                     ELASLAGGYAGIALALGVSDDVSSNQSTDEISYEYIKRCIAIIQSNPTYSFSLFSGLTG
                     ILISLKFNSKNGQRYKNIIEQLLQVITHNYKESLSISQANLINNTVTTDDFDVILGWSG
                     ILRTLLEFDNDLYDTELNKIIEDISLYLIKLGAFTNDSKPCWFIEYAQLSDIEKETFVG
                     GFYNNGMSHGISGVLASLSILYIKGYRFNGLESSINNIRTWLLQNILEHRGVEYIPNVT
                     VDNTNTFNHRDAWCYGTPGVSTALFISAMTDENLYIKEKSIELFKTFLKRASEEHKLIS
                     PTICHGFAGILMLCIRLIEYGVSDPEILEIANNVFQKLMSFYKENELILFPDYEIIENK
                     RVEIHKIGLLEGVTGIFLIIQSLLHDKNEWDQIFLIS"
     CDS             complement(11323..14394)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     879.9; E-value: 3.5e-266)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_498"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.1e-115,
                     bitscore: 379.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.7e-17,
                     bitscore: 58.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.5e-25, bitscore:
                     85.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLLNTYMYRKPILTLKEYQELFDSKISTLEYENKIKEIFSDD
                     KLKLAIYISSPTMYEALNRLDSLDAKKKRNFLHGITKFLIRMSTRPTPFGLFAGMGIES
                     INNNGKGSFNIDSYFRLDFSTIYKIVEVLENQDEILKKANIRFNNLLYKHGNRLKLPYQ
                     SNVHNKDNIDEHMKIMTVKNSPVLDYIRKITRNDINFEQLVDKINKEFNTEDTTSKGYL
                     KKLIDNDILFSDLRPALSSNDPFKYLITILEEKNINHELLDNLKQINFSLDKFNLTKEE
                     ISVKELSNFKSLLKTFKLCGEKDIRVDAKLTNSSELALGDEDITNLEELSRIMSYLGCI
                     NPLQVLNSYRDSFIEKYGPYQEVPILELLDEDLGLGKPNDYVTNGNSQPQISENLRAVR
                     NLIQNWQTEALINNENIILDEDKIKEIKKHISRNDIEKENIDLELYFNYFQCKGANKFY
                     LVPNTGSTQIGNTYGRFKYMFNKNEINQLKDFNEFIEDQDSNIKFADLRINPDNSSLAN
                     IMNSPSVYKSEINLCTNPSESCSNNIDIENLVVGINNNKFYIRDSSSNNIIIPKISNMF
                     NYENANLIYRFLADVGALYSGIWGNIHHHFYDSHVYPKIVYKNIVVSPKRWIFHHTFTQ
                     KMSEEEFISVFLDWCTRNNITNYIYLAEYDNKLLLNIKNKLHLSIIFQEFSKLKMNDRL
                     SLFECEEDIFVSSNKRFEECVFSFRQTDRKKITFTNSLNRNYQYINDMNRVKLLGSDWI
                     SLRVNYVDSRVEEFLSCGYKEFYKHNKDINKIEKGFFVRYADPTPHLRIRFKLSKNEKY
                     NTFLGNITEWLTNEREKGLVNDFHFVSYNPEIERYGNFLIDKAEDIFSIDSLIVADSFE
                     GDVPLNRELFCCLNIMSILKGFNLNFASQLEILNMAIDPKMYKEAYRENKANLDPIITN
                     IYDYIEIPMSEKLIIPTTFNDRDNVIRKYAELIDANEDVLTNVKSDIIASILHMHCNRL
                     NGINRDLENKILGMCYHTIKKYMNLIKYKYNVLV"
     CDS             complement(14407..15141)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 119.7; E-value: 3.1e-36)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_499"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.4e-24, bitscore:
                     81.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVISSIIGKKNVKGIAPAVSILSYKIVDKNGYGELRWTINAIK
                     LAIQENVHIINISYTSNKIDDIDMIYEYKEVVEEAINKGIYVICAAGNECKEIKQGSEN
                     LPIYLAEGIVIASTDYKGELSSFSNYGVGIDFSMPSGGFSQGFPSQYGLVIVAKPRSMA
                     RLHLEDQYQVPKDYTLTMGTSISSALFSGTIALLLSRYYRLYKKLPKRNEILSLVKLSG
                     KQINRHYSMVEVNTYRALNEIK"
ORIGIN
        1 ttctcactaa tttcaaaagt ggatttatta aatgtacacg tattttaaac aacactgatt
       61 atatttttgg atgagtataa taacacttca aattcttttc ctaattaatc tagagataca
      121 tttccttcat tgatttttta aatcactcct ctaaataaga atttaagata aatgtccttt
      181 cccaaaggcc ctttcctaat tttggtatta cgaattaagt ataattcgaa aataaaatta
      241 tacaattgag aaaaataata atgttaaaaa tttacatacg cgtaaagttt ttaacattta
      301 ctgaaaaata atgtgttata tgaggattaa tttaatatat ttggtgttaa aaaatatttt
      361 taatagagga ttgttcattt ccattcagaa aaactccacc ttggtgtttt caaattatga
      421 agtccccact ttctagtctt tctacaaaag atataaattt caatctcatt catgattttt
      481 ttaattaccc ttcccttctg ttaagaagac ttcaaaactt gaatagatta ccttatatcg
      541 ctactttgtg tatgcaaaat tacataccaa tccccattga aaataattct cattgtaact
      601 ataatggttt cagggattgg aattttcact ttcgtttcaa atctcacaat aaattaaagg
      661 aggaaatact attatgaaaa aattggtttt agcaggtgca ctaggaattg cagtattttc
      721 aggtatgaac ttaccagggg ctgaggcatc aaaagcgagt gcagctacta cgaatttaga
      781 aattcaagaa gtcacaaaat actactctat gagttcttat gaagtgtctc aaaaagaatc
      841 atttaatctt aaaaaagggg aagaacttac agtctttgtg caaaattcag ggttcccaat
      901 ttcttatacg gtctttgatg cggataatca agtaattggc acattcaatg ctaattcccc
      961 atatggtcgc gtattcaagg cacaaaaaga cggtaatatt tctgtacaat ttcaagcagg
     1021 tgtaaattct acgtacatga agaagatgaa ttttacagct aaatttgctg tttctaaact
     1081 tagccaacaa taaaaaatgt aacgatcccc tttaaaaaca aattaaaaag gtatatccct
     1141 tcaatgggat atacctttag ttttagtgaa ttttatattg accagatagc tgctcttgcg
     1201 ccatacgaac taaacgcttt gtaatttctc cacctactga accatttgct cgtgcagttg
     1261 aatccggtcc aagtgtaaca ccaaactcca gagcaatttc atatttcatt tgttcaattg
     1321 cacttgctgc agctgctatt aagatttcgt ttgaattatt attttcgcga atttgcattt
     1381 tttaaacacc tccgttgaat ttggtaatat catgctctat ttccaacaaa atatgcaaaa
     1441 aattattcgt ttagctatta tatataccta agctttcatc tcttatatag aaataaataa
     1501 aggtataggt catactctat acctacacct tctactatcc tacttacttt tgaattcccc
     1561 tattaatccc tgtaactctt gcgagagcca atttaaagaa tttgctaact ctgcaatctc
     1621 ttgtacatat agttcttgct ctttcatact tgtctccaca ttactactgc tattcacata
     1681 tgtatttgca atgtgtgata attcatttat aaaatgaaca atagtttgat tatcttttag
     1741 aatgtcactt gaatgattcg aagtcgcttt aatttgattt gtaacagatt gtgcagattc
     1801 tgaaatcttt tcaaagaaag caccactact ttgaacaagt gatattccta attctacttc
     1861 ctttgaactc ttctgtatgg atcttacagc tctctctgct tcagcctggg tttcaccaat
     1921 taatttagct atatcccttg cagatgcctc ggttctttcc gctaatatac ttacctcgtc
     1981 cgcaacacct gaaaattctt cccccatctc tccagcacat gaggattcag tagaagcatt
     2041 taaagctaat gaatttgttt gatttgaaat ggttgtaatt acagtaagaa tttcatgaat
     2101 ttccttagat cgtgcttcga atgcataaat actagaaggt acatcctgaa ctgtatcttg
     2161 gattcttttc atttgattca cgatttgctt aatcaaatct tttccctcta cagaatgctg
     2221 ttccatgtct tccacagcat tgccaacttg ttttgcagct cctttaattt ctttcatctt
     2281 actttccatt tcttgaacaa tcccaaaaca tttttgcact acatattcat gagaatgtgc
     2341 tcctaaattt aatcctgtaa tagcacttgc aatttcttta aaggctatgc tattctcttt
     2401 tgtacttacc gacaattcct gtgaagatgt cgaaacctgt tcagcagtct gccttacttt
     2461 atctataatc ctattaaact ttttaatagt gttattaaaa tagatattag ttatccctat
     2521 atcatcagat ctttcattca attttatact taaatcccct tcaccaactt tacgtaaccc
     2581 ttcttgtaaa tcctttacag gcgatagaga gtttcgtgag ataaatattt gaattgtaat
     2641 tgcgatagtt aatgaaatta taataaatag taaaccttgt atcataaagt ttttctttgt
     2701 aagaggaata atagaagctt ccaaatccgc tgcaacaatt gcaattatat ttttattttc
     2761 atctgtaact ggctctaaaa ttgttaccca gaaccctaat tcatcttcat acacttctgt
     2821 catttgtgcc tgttttgttt gtattacttt atcatatgtt ttcatccaat aagtaggctg
     2881 ctcatagtat tcacctggtt ttacagaaac agtatttgct aattgtgtat ccaaagctac
     2941 tatttgtaat tcagctttat catttagctt ggctcctgta acatatgttt gcccaacact
     3001 tttcatatct tttatagatt tatctaattg ccctgtcaat ttttctttct tcactctttg
     3061 agctgtagga tcttttgcta catctcttac tatttctaaa tctaattgat ttaatactgc
     3121 atcacctgtt tcaaaagact gcctctcaaa tatagacatc atactatttt gaaacatatt
     3181 aaaacttaac gctcccatac ttccaacaag ggtcagaatt actaataccg ttagtaatac
     3241 atttttttga agcaacgata gcttatgcca atattttttc attgatttct cctttcttat
     3301 tttcaacaat acaaaaacaa agtagtaaca tattaagagg ttttctttct gctattaatt
     3361 taaactttaa aatagcatac taatctttca accaaacgtt ccaatttttt tcatttgcga
     3421 tcgcatcttt tatatgtcca gctactcctg gaaatctatt taaaggaaga cgcaatactt
     3481 ctactacttc accttttcta tttgtactga tttcttctaa atcgatgata ttaaagggtt
     3541 tgcctataat aattgctata atgtttaata gacgactaag aatatttaaa attccatatt
     3601 tatctcctaa agattttcaa attagatttg ttgcagtacc ttcagcgagg attttttata
     3661 atatcgttag ttttaaataa agataagaat ttttaagagc ctcatcttta gttattttta
     3721 tcttgcagaa caataaaatc tgaaagttta attcaatctc ctattttata acttttttcc
     3781 ttatttttct ataacattat aatatttacc tgtacaatct aaacttagac tcttttggcc
     3841 tttactcttc aattgtctta aattcatatg aggtagcgca gaaagtaaat ttttaacaaa
     3901 aaacttttgt attaaaaaat gcaaaaatac atactcctct aaaactatat gcacttaaat
     3961 attcatatag taaaataatc agtacaagct tgtcctatac agcatatttc cttaacgggc
     4021 ttgatattat attcatcata aaattggtgt gaccttaata tctcacttag ctctttaata
     4081 ttttgatatt aacaatatag tgttaatata tccctacttt atcgctacac ctacatataa
     4141 gccaaggatt caattacaga acggttttca tcaatagtag acgaaaacat gtcaaacaaa
     4201 aagagactca attatttatt acttttcgta tagatataat aaaagattat aggagaaata
     4261 tatatgctca aaaaaataaa tagatttatg tttgctttgc ctacaatttc ttttgttttt
     4321 cttattttat taggatcatt tttattcgta ctaccattag atctattctt acctgaaata
     4381 caaaaaaacc caataacaga agcacctctt attcttcaag ttttattagg ggtattagcg
     4441 gcacctatat atgaaacagt agtttttcaa gtatttttat tttggctatt aagtttgatt
     4501 ccttacatta aaaatcgcga ttaccttatc attttaatag cttcaattat atttggatta
     4561 aatcatcgat atggaatcac ttatatagtt ggtacaacga taattggtct tttatataac
     4621 tatgcttatt gggtatataa aaaaaagaat gaaaaatatc aggttacaat gcctgctttt
     4681 ggggttgttt ttttgattca cttattacat aattctattg cttttatagc atcaaattta
     4741 taaatgtttt aaaggtaata tagattaatg aattatgttt gtacttgtta aagctaagag
     4801 acacgaaata aaaattaaaa agaggctaat tcactaatac ttctaaatag tcttgtttca
     4861 gtttgtttat ttgaagaata aaaagagagg gacctgtcag atagacagta ttttcaaaac
     4921 acagctaagc cacctgagtc tatatttgta tggactcagg ttatttaatt tctcttgaaa
     4981 tctttgatga ttataacatt gtatatattt gcggacttaa gatagatgaa gaagtctttt
     5041 ttatgtgcat tatcctaaaa gttttacttt cgcaacatac tttccttcat ttttctaaca
     5101 tcccatcctc ttcttgcaat cgtttagtct tagtacccga acctttaggt tccattctac
     5161 ctaaacataa ctcttttgct ttcccacgtt ctgcttctag ttttttagta cctaaatttt
     5221 cgaatcattt catttaacgt cttacaattg gataatacat gtctatttct ttcttaacag
     5281 ttttatatct tcttttaagt ataaacccac ttccttttcc tttcattttg tatagcaagt
     5341 aattctaatt taccccatag aaaaatcccc tccataataa ataggttaat gtgttttctt
     5401 tttcctatct actatgaggg gagaatagca tactaaagat agcttctttt tttgtaaaag
     5461 aactaagatt ctagtttcgt aattaattgc tgacgttctt tatccctaaa aattttaatt
     5521 tcatgtttaa attcataatt tccttcttca aatctaaccc attccttact tgtccaatat
     5581 acaacatcta catttgcatc taaaattaca gaacatatgt caactaattc ttcttcgtag
     5641 aatggcgctt cttttgctag ttcaaaagct agtacttttg gatccttact tttaatttga
     5701 agttcccttg aagtttgccc taaatactgc catggagaat atagggattg cacatgaaca
     5761 tttcgagttt ctttaaactg tgatggagaa tgtattgtag cagcaaatgt aggtttgctc
     5821 actcctattg ttgtacctaa agcaatagaa ctaataataa gttttttaat cattttttca
     5881 gcccctttaa ttattttgga tatgcttcat ttttatacta cgttcatgtt cgtgtaaatg
     5941 aagatgattt gacatgattc atcatttttt tcaaaaactg aatattaatt aatcgttata
     6001 aatttaccca aaacaaaaaa gtttccttac ggaaactttt ttgttttggg tatacattat
     6061 atgtataaaa attagttttg aaaatattta cttatttgtt gataaaattg tatatggata
     6121 ttttccctac tatttatcta cacacatctc atgcaaagcc tcactacaac ataaacaaat
     6181 tcatcttatg accacgtttc ttcttacgaa attaagtgat tgtttcaata gctggtttgg
     6241 gaatcataga attactttct ttcttagcct tattattctg ttcttttgcc taaaattcca
     6301 atatccccat tacttctttt gtaaatagtt taaaatccgt taaatgtttt tcaataattt
     6361 gacgaacaat atctaaattt acactttgat aatcatgaac agcaatatta cgaaatccaa
     6421 ccatcgcctt taacttattt gctagatcag cgctaagtaa tcctgctgta accaataaat
     6481 caaaggcctc tcgactagat tggggtagtc ctaatttttt ccctgcaaca atatgcattg
     6541 ctaaatcaat actcgcttca caagctcttt gtatattcaa tattattgaa tcttgttttg
     6601 taaagtcctc taaattttca gggtcatttc catacacatc ttggattctt tttatacaac
     6661 gctctattgt agaaatttta tttaaaataa cctcattctt catatataga acctcttttc
     6721 tttatatcat caaatactac ctgtcgttct tcattcaatt ttgaatacat ttttaaggtt
     6781 ttcatttcaa aaataacctt acgcttttca tccgaacaaa atattgtctt tcctgtatgt
     6841 ataatctgag cttgaaaaac tgtagaagct tcggataaat caactaaatc aacatctcta
     6901 tgaacaatgt tagctaactc ctgtgctaat aaaaaacgtt catagttccc taatgttgtg
     6961 tcacttacat aagctatatc aatatcacta tcttctcgtt ctctgttctc agccgttgat
     7021 ccaaacacaa ttatccaata gggattcacc gtctcttgta atttttctat aatagctgtt
     7081 atcatgcttt gaaaaatcat ttaattaatc ccccttattg tacttgaatt ttattatatc
     7141 ataatcattc ccaaaccttc cggataacaa aaaaatgata ataaagagcg aaatcttctt
     7201 aaaactaaat attaacgcaa ttctttcctt ttgatgctct tcagattatc tttgtttttc
     7261 tgcatataaa aaatagataa attacaagac ggggctaaag tgaaaattct tactttttat
     7321 ttataagacc cctaagtact ctcaattttt tataaggggt accacaaacg cactgacata
     7381 taacccacgc taaggattga ttgcatcata acaaaaatat ggaacaactt taatttatat
     7441 taaagagctt tgacaacctt tttatttcaa aaaaaattga aagtacttat taattttatt
     7501 acatctaggt ttttagatag ctgacatata tagaaaagct tattaaaatt agaaataata
     7561 atgaaatcta ataaatatat accatattct tgttctttta caattaaaat gatgctaaca
     7621 ttaaaattta cttctcatac aaaaaacaag taataattta ttcattaaaa gagcttccat
     7681 tctcaaagta tggaagccgg caaattctat caatatacta tttaattgtt tgataagtca
     7741 caaaatccct ataacgttca tgagtattca atagttcctc atgagtacct tgacctgtta
     7801 ttttgccatc atcaaggaaa ataatatgat cagcagccat gatggtagat aaacgatgcg
     7861 caatgatgag tgttgtttta ttagatttca cataatttat agctctctca atatgttttt
     7921 cactttcact atctaaacta gacgtagcct catcaagcaa taggatttct ggattatgta
     7981 aaaatactct acataaagct aatctctgtt tttgtccccc agataataga attcctcttt
     8041 ctccaactaa agtatcaaac tgattttcca aattcataat aaattcatgt gcgtttgcaa
     8101 tttgggcgac tgtgtgaatt tcttccatag aataagatct tgttagtcca taagtaatgt
     8161 tatcgagaac agttccattc ataactggag cattttgcat tgcgtatcct attttacttc
     8221 tccataaagt taaatcgata ttattaatag actgatcgcc atattttata tttccatctt
     8281 ggcactcata caatttcact aatagagaga aaattgtact ttttccagct cctgaagggc
     8341 ctacaaatgc agttacctta tttctttcag ctaaaaaatt tacgtttttt aatatttcct
     8401 tctcaccata agaaaatgat acattttgaa aacttatatc ttgctcatac gatggagcat
     8461 aaccagcttt attctctaat tgatttttat aaatttcttg tatcctgtca gtagccccta
     8521 aagtcttttt ataatctgta aaaaaactac tcaaaccagt taaaggttct attatttgta
     8581 atagataaaa caataaagct actaatgttc ctgtagaaag agtaccaaca gataatctat
     8641 aaccactgta acttagtata ccaataatag tgaacattat aattaaagta attaaagggt
     8701 taataaagga atacaatttt gattgtttta tgcctaatcc aaaaagtctt tctaatttat
     8761 catttccacg tttaatttct aaattttctg cattcgctat cttaaccagt cttatatctg
     8821 ataatactct acttaagatg ccactaaatt cggcaatagt ttgttgatgg ttagtagata
     8881 taacataaat cttattgcct aatggaataa taataacagt agtgacaact actgttatta
     8941 acataaaaag tgttattttc caatccatgt aaatcattag gcccaaagct ccaaaaaata
     9001 aaattaattg cgataacata ataggcagtt tcatagaaac aaaattatta actatagaac
     9061 tatcctcaat taatctactc attatttggc ctgtttcctt attatcataa tatttaacag
     9121 gcaaattaat tatatattcc cacatgtttt tacgtaaatc ccttatagta agctctccaa
     9181 tatagctcag gaggtactgt gataaccctt gtaaaaaaga tgcgataata aaaaacgaga
     9241 tgactaataa aattatttta atagggagat ttgtaaaatc aattttatct attatttctt
     9301 ttatatatat aggaacaagt agactcacaa aaacagagac aatagatata aaaattgcta
     9361 ttataacctt tgcgattggc caattgacaa tctttaaggt cttaattaat gaattattct
     9421 tcatctacat atttctcctc catactaact agtagaacaa ttatcccagt aactacaata
     9481 attaaagtat aaataaaaga cttagagagc gtaaaagaac cgcctgttaa aggtaataat
     9541 aatttaaatg aaagtatact agctattaag gaaacgatta taaatgttac aagagacata
     9601 ttactatttt ttatggtatg ccgtattaac tctttaatac agcctatagc cacaaatata
     9661 gttaatacta taagagagac aaaataatgt gttaactctg tcttattaat aactgagtct
     9721 tctattatga aagcaagtaa cttagataat aacatgcttc caatcaatat aattagaaaa
     9781 gccaataacc cttccattgt atacttagaa aatttttctt ttttattgaa gagattataa
     9841 tttagcgtag actggattat ttgaactatt aatagagcaa taatccaaat ataatatatc
     9901 ccaggtaatt ctcctgaaaa tagagcaatt aaaaaattaa ctagtgtcct taaaatttca
     9961 atcatcacga atccctcctg ttgctttaat ttgttaaacg ttacgagatt agaaatattt
    10021 gatcccattc attcttgtca tgaagcaaag attgaatgat aagaaatata cccgttaccc
    10081 cctctaataa tccaatttta tgaatttcaa ctcgtttatt ttcaattatt tcataatcag
    10141 gaaataatat caattcattt tctttgtaga aactcattaa tttttgaaaa acattatttg
    10201 ctatttctaa tatctctggg tcacttacac catattctat caatcttatg cataacatta
    10261 gaatacccgc aaaaccgtga cagatagtag gggatataag tttgtgttcc tcactagctc
    10321 tctttaaaaa ggttttaaaa agttctatgg atttttcttt aatatacaga ttctcatctg
    10381 tcatagcaga aataaaaaga gcagtggata caccaggagt tccgtaacac caagcatctc
    10441 ggtgattaaa cgtattagta ttatctaccg taacattagg aatatattct acgcctctat
    10501 gttctaaaat attttgtaac aaccacgttc tgatattatt aatactgctc tctaacccat
    10561 taaatctata accttttata tataagatag aaaggcttgc taatactcct gatatgccat
    10621 gtgacatccc attattgtag aaccccccta caaaagtttc tttttcaata tcacttaatt
    10681 gtgcatattc aataaaccaa cacggtttag aatcatttgt aaatgcccct aatttgatga
    10741 gatatagcga tatatcttca ataatcttat ttaattctgt atcatataga tcattatcaa
    10801 attccagaag ggtccttaat atacctgacc accctaatat aacatcgaaa tcatcagtag
    10861 ttactgtatt gttaataaga ttagcctggc ttatacttaa tgattcctta taattatgtg
    10921 taattacttg tagaagttgt tcaattatat ttttatatct ttgtccattt tttgagttaa
    10981 actttaatga aattaaaatt cctgttaacc cagaaaataa agaaaatgag tatgtagggt
    11041 tgctttgaat aattgctatg catctcttta tatactcata tgaaatttca tccgtacttt
    11101 gattggatga tacatcatca gaaactccta aggctaaagc tattccagca tatcctccag
    11161 caagagaagc tagttctata gcctcaagcc caggagaagc agaatcgtta atatagcttt
    11221 caaccttctc aaagtcacta tacaatttaa ttaacttttg attaatctca tttaatgtct
    11281 ttaattcatt ttcatttagt ttaatagtca tttgataacc cctcatacta atacattgta
    11341 tttatattta atcagattca tatatttttt tatggtatga taacacatac ctaaaatttt
    11401 attctctaaa tctctgttta ttccatttaa gcggttacaa tgcatgtgaa ggatactcgc
    11461 aataatatca gatttcacat tagtaagaac atcttcattt gcatctataa gttccgcata
    11521 ttttcttata acattgtctc tatcattaaa tgtagtagga ataataagct tttcactcat
    11581 cggaatctca atataatcat atatgtttgt aataatagga tctaggtttg ctttattttc
    11641 tcgataggct tctttataca ttttagggtc tatagccata tttaaaattt ccaattgact
    11701 tgcaaaattt aaattaaatc cttttaggat actcataatg tttaagcaac aaaacagttc
    11761 cctgtttaat ggtacatctc cttcaaagct atctgctaca attaatgagt ctatactaaa
    11821 aatatcttca gctttatcaa ttaaaaaatt cccgtatctt tctatttcag ggttatatga
    11881 tacaaaatga aagtcattga ctaacccctt ttctctctca tttgttaacc attcagtaat
    11941 attacctaaa aatgtattat acttttcatt tttcgaaagc ttaaaacgta ttcttaggtg
    12001 cggagtagga tctgcatagc gaacgaaaaa tcctttttca atcttgttga tatctttatt
    12061 gtgtttataa aattctttat atccacaaga taaaaactct tcaactctgg aatccacata
    12121 gtttacacgc aaagaaatcc aatcgcttcc taataacttt acacggttca tatcattaat
    12181 gtattgataa tttctattta aagaattagt aaatgtaatt ttttttcgat cggtttgcct
    12241 aaaactaaag acacattctt caaagcgttt atttgaagaa acaaatatat cttcttcaca
    12301 ttcaaaaagg cttaatctat cattcatctt taactttgag aattcttgaa aaattatact
    12361 taaatgtaat ttatttttta tatttagcaa taatttatta tcatactcgg cgaggtaaat
    12421 ataatttgtg atgttatttc tagtacacca atctaagaaa actgagatga attcttcttc
    12481 agacatcttt tgagtaaatg tatgatggaa aatccatcgc tttggagaaa caacaatatt
    12541 tttatagact atcttaggat atacgtgact atcataaaaa tgatgatgta tatttcccca
    12601 tattccactg tatagagcac caacatcagc taaaaatcga tatataagat ttgcattttc
    12661 ataattaaac atattactta ttttaggtat aataatatta ttagaagagg aatctcttat
    12721 gtaaaattta ttgttattaa taccaacaac taaattttct atatcaatat tattagagca
    12781 actttcacta ggattagtac aaagatttat ttcactctta tatacactag gtgaattcat
    12841 aatgttagct aaactgctat tgtctggatt tatccttaag tctgcaaatt ttatattact
    12901 atcttgatct tctatgaatt cattaaaatc ttttaattga tttatttcat ttttgttaaa
    12961 catatattta aatcttccat aggtgttacc tatttgagta gaacctgtat taggaactaa
    13021 ataaaatttg tttgcacctt tgcattgaaa atagttaaaa tagagttcta aatcaatatt
    13081 ttctttttca atatcatttc tactgatatg ttttttaatt tctttaattt tgtcttcatc
    13141 aagaataata ttttcattat taataagagc ttcggtctgc cagttttgaa ttaagttcct
    13201 aactgctcta aggttttcac ttatttgtgg ttgagagttt ccattcgtta cgtaatcatt
    13261 aggctttcct aaacctaaat cttcgtctaa aagttccaat atcggtactt cttgataagg
    13321 gccatatttc tcaataaaag aatccctata cgaattaaga acttgaagtg gatttataca
    13381 tcctagatag ctcattattc tacttaattc ctctaagtta gttatatctt catctcctaa
    13441 agctaactcc gagctattag ttaacttagc atctactctt atgtcttttt ctccacataa
    13501 tttaaaggtt tttaaaagtg atttaaaatt acttaattcc ttaacagaaa tttcttcttt
    13561 agttaaatta aacttatcta atgaaaaatt aatttgtttt aaattatcta acaattcatg
    13621 attaatattc ttttcttcta agatagtaat gagatactta aagggatcat tagaagataa
    13681 tgctggtctt aaatcagaaa acaaaatatc attatctatt aattttttca aataaccttt
    13741 agatgtagta tcttcagtat taaactcttt attaatttta tctacaagtt gttcaaaatt
    13801 gatatcattc cttgtaattt tacgtatata atctaaaact ggactatttt taacagtcat
    13861 aattttcata tgctcatcta tattgtcctt attatgtaca ttactttgat atggtaattt
    13921 caacctatta ccatgtttgt aaagaagatt attaaatcta atatttgctt ttttcaaaat
    13981 ctcatcctga ttttctagca cttcgacgat tttatatatt gtggaaaaat ctaacctaaa
    14041 atacgaatct atattgaatg atccttttcc attattattg atagattcaa ttcccatacc
    14101 agcgaagaga ccgaaaggag ttggccttgt agacattctt attagaaatt tggtaatacc
    14161 atgtaaaaag tttctctttt ttttagcatc taaactgtct aacctattta aagcttcata
    14221 catagtagga cttgatatat atatagctaa ttttaattta tcatctgaaa atatctcttt
    14281 tatcttattt tcgtattcta aagttgatat ttttgaatca aaaagctctt gatactcttt
    14341 taaagttaaa atgggtttac ggtacatata tgtatttagt aattgatgct tcacattaat
    14401 tcctccttac ttaatctcat ttagagctct atacgtattc acttcaacca ttgaataatg
    14461 cctgtttatt tgtttaccac ttaacttaac taaacttaaa atttcatttc tctttggtaa
    14521 ctttttatat aatctatagt atctacttaa taacaaagcg atggttccac taaacaacgc
    14581 agacgatatg cttgtaccca tagtaagagt atagtctttc ggaacttgat attgatcttc
    14641 caaatgtaac cgtgccattg aacgcggctt tgccacaatc accaatccat actgagaagg
    14701 gaaaccttgt gaaaatccac ctgatggcat ggagaaatct atccctactc cataattact
    14761 aaaagaggac agttctcctt tatagtctgt agatgctata actatcccct ccgctaaata
    14821 tatcgggagg ttttctgaac cctgcttgat ttctttgcat tcatttccag cagcgcatat
    14881 tacataaatc cccttattaa ttgcctcctc aacaacttct ttatattcat aaatcatatc
    14941 gatatcatct attttattag atgtataact aatatttatg atgtgaacat tttcttgaat
    15001 agctagttta atagcattaa tagtccatct taattctcca tatccattct tatctacaat
    15061 tttataacta aggatgctta ctgcaggagc aattccctta acatttttct tacctataat
    15121 agaactaatt actgctgtcc ca
//
