LOCUS       NZ_CP012434.1           7438 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP012434.1 Enterococcus faecium strain ISMMS_VRE_1 plasmid
            ISMMS_VRE_p4, complete sequence.
ACCESSION   NZ_CP012434
VERSION     NZ_CP012434.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-08 00:10:43
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7438
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..2010)
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MLKKINAVLSLFVCITILFFSTNVINGIKTSEALYKNTAEIHMQY
                     KDDMDFNSYINALYEISTQENINISQYSFTAVNQLTILATNPNANKHWKFSKKNILARN
                     DSKVHYTNNKNSKYQLKLPNNFLNINIYPFSHVENIGLSEILYVQGNSNKLIPVLKKYG
                     TPTISNINQSDTFQINTNIVLVICYLSIFIVITTIIFAFSKMKEITLKKMLGYNSFDTI
                     KDSIKELNLLFCSLIITFILSIFLSIYYSNENFFLSFLLCSIFHFIISFLFIIVTLSIY
                     HLSSIKNYLKNSRPLKLNLCILNICLFLSMILLLIASTKVINTHNEAENNSLKYWERTT
                     NLYKTNITNQLNRNNTVEENNYLKKASKFVYKIQKNYKTFIIAPYNYATIQENNKEFFI
                     GQKVYPNFEDYVSQPAGAGICVDLNYLKYYNPISFEESTDLNLINSDPLTTYILVPKKY
                     KEYAKMIEKNYLEDIQFRLEDSPPQAPYKNPNLKNLKIKLIFVNNNQKYFSFNTLYGKA
                     KDNYTITDPIVRVINPEITESLFWGNILTSDGGLFFDQKHTSNQNFFNQINPYIKEFNL
                     ENIINFSYSVFQETGELLSQKKVNKLNAYLQYLLILGLFIIINFQMIFVSFTINSKKIA
                     LKKIFGYSPISQVLDLCLLPFTIELFATMCFQLIF"
     protocluster    1..7438
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2063:2438]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2064..2438
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..7438
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7438
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(2064..2438)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.9e-09,
                     bitscore: 28.1, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFLCLSALMGVLLTSGGIASATEALNLDVPEDHTAIYGGGMEA
                     TEEGFSSSKLRYAAGGGDFNCGVNGFKVYANYYHARAKHSATAKNGRGGQVRSVQKAGV
                     RAYATCNATLTGNTGWWNVY"
     CDS             2571..3035
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 61.9; E-value: 1.6e-18)"
                     /gene_kind="other"
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MEDLGSKLRELRVKKGYTQEYVARKFNVTRQTISKWENNKTTPDI
                     ETLKKICEFYSTNINSILNEDNSKNKKNNLLVLTAIIFNIFVTILGLFELIQMNFFSFT
                     HGIFTWFALSGLIVIDILNYFYIYYSYLKNEKFFIQCFSPSYFDYFIKLI"
     CDS             3567..3971
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MELDTNNHSVFLLYYHLVLVTKYRRQVIDDEISDYAKTTFERISE
                     SYHITLVEWNHDKDHVHIMFKAQPKTELTKFINAYKSASSRLIKRDFPRVKQFLWKEMF
                     WSKSFCLLTTGGAPIDVIKKYIQNQGNNHK"
     CDS             3988..5136
                     /gene_functions="other (smcogs) SMCOG1192:transposase
                     (Score: 399.5; E-value: 2.4e-121)"
                     /gene_kind="other"
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MEQLKAYKFRIYPTEEQEIFFAKSFGCVRKVYNLMLDDRKKAYEE
                     VKNDSSKKMTFPTPAKYKKEFPFLKEIDSLALANAQLNLDKAYKNFFRDKSVGFPRFKS
                     KKNPVQSYTTNNQNGTVALIDSKFIKVPKLKSLVRIKLHRQPKGIIKSATISRHSSGKY
                     YISLLCKEEIIELPKTNSTIGIDLGIMDFAILSDGQKIDNNKFTSKMEKKLKREQRKLS
                     RRALLAKNKGTNLFEAKNYQKQKRKVARLHEKVMNQRTDFLNKLSTEMIKNHDIICIED
                     LNTKGMLRNHKLAKSISDVSWSKFVTKLQYKADWYGRKIIKVDKWFPSSQICSECGHKD
                     GKKSLEIREWTCPVCHTHHDRDINASINILTEGLRLHSMGLA"
     CDS             complement(5365..6546)
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MKNNRIYKNQLNYGLLLPVFLLCIIGLLSLYVALYHDSYTNSKIT
                     KELIKQVLWYSIGFTSAITIYFFNPKILWKLTPIFYGLCIIMLLLLLKFYNPQLAVLTG
                     AKNWFYIAGFSFQPTELVKIGYTLMLAKITVNYQQKSITSNTKDDWIYLLKTFIATLPI
                     GILLFFQNDLGTMLVFIVIYIFILFTSNINIKIIAPIIAIGVVLSLIFLYLVISDTGRD
                     FLLKIGFHDYQFKRIDSWLNPFLDPNGSSYQLANSLIAIGSGGLLGTGFNVSNIHVPVR
                     ESDMIFSVIGENFGFIGSCLVIFLYFYLIYQMYKTCFKSNNLFFTYIGIGIVAMIFFHV
                     FENIGASIGLLPLTGIPLPYISQGGSAILSNFLGLGFMLCCSRYTNEKKGTQK"
     CDS             complement(6836..7153)
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MTISKVIKQKRIEKQLTQEDLAEMLLVSKKTISNWENGRTIPDTE
                     NLIQFAKLFDLSLDNILLGEEKIMVKNYGKKSYKNTNTIISFCNFFKFSFHLNSVRILL
                     F"
ORIGIN
        1 aaatatcaat tgaaaacaca tagtagcaaa taactctatt gtaaaaggga gtaaacataa
       61 atctaaaact tgacttattg gtgaatatcc aaatattttt tttaaagcta ttttttttga
      121 atttatagta aaactaacaa aaatcatttg aaaattaatt attataaata atcctaatat
      181 taaaagatat tgtagatatg catttaattt atttactttt ttttgagata ataattcacc
      241 agtttcttga aaaacagaat aagaaaaatt tatgatattt tctaggttaa attcttttat
      301 atacggatta atttgattaa aaaagttttg gtttgaagta tgtttctgat caaaaaataa
      361 tccaccatca ctagtcaata tatttcccca aaataatgat tctgttattt ctggattaat
      421 aactctaact atgggatcag ttattgtata gttatctttt gcctttccat ataaggtatt
      481 aaaactaaaa tacttttggt tattattaac aaatattagt tttattttta aatttttcaa
      541 attaggattt ttataaggag cttgaggagg agagtcctca agtctaaact gtatgtcttc
      601 taaataattt ttttcaatca tttttgcata ttctttatat tttttaggta ctagaatgta
      661 agtagttagt ggatcagagt ttattaaatt taagtcagta gattcttcaa aagaaatagg
      721 attgtaatat tttagatagt ttaaatcaac acatattcct gcaccagcag gttgactaac
      781 atagtcttca aaatttggat aaactttttg tccaataaaa aattctttat tattctcttg
      841 gatagttgcg taattgtatg gcgcgataat aaaagtttta taattcttct gtattttata
      901 aacaaattta ctagcttttt tcaagtagtt attttcttct acggtgttgt ttctatttaa
      961 ttgattagta atatttgttt tgtataaatt agtagttctt tcccaatatt taagagaatt
     1021 attttcggct tcattatggg tatttattac ttttgtagaa gctattaaca gaaggatcat
     1081 gcttaagaat agacagatat ttaatataca aagatttaac ttaagtggtc gtgaattttt
     1141 tagataattt tttatactag ataaatgata gatacttaga gtaactatga taaataaaaa
     1201 actaattata aaatgaaaaa tactacatag aagaaatgat aggaaaaaat tttcgttact
     1261 gtaatatatg ctcaaaaaaa tagataaaat gaaagttata atcaaagaac aaaataagag
     1321 gtttaactct ttaatagaat cttttatagt atcaaaagag ttatagccta acattttttt
     1381 tagagtgatt tctttcattt ttgaaaaagc aaatataatt gtagtaatta caataaatat
     1441 actaagatag cagataacaa gaacaatatt agtattaatt tgaaaagtat ctgattgatt
     1501 gatattggaa atagtaggtg ttccatattt tttcagtaca ggaattaatt tgtttgagtt
     1561 tccttgtaca tataatattt cacttaatcc aatattttcc acatgagaaa aaggataaat
     1621 atttatattt aaaaaattat ttggaagttt taattggtac ttagaatttt tgttattagt
     1681 ataatggact ttagaatcgt ttcttgctaa tatatttttt ttagaaaatt tccagtgttt
     1741 gttagcgtta gggtttgtag caagaatagt tagttggtta acagcagtaa aactatattg
     1801 agaaatatta atattttctt gtgtagatat ttcatacaaa gcgtttatat aactgttaaa
     1861 gtccatatca tctttatatt gcatatgaat ttcagcggta tttttatata gcgcttcaga
     1921 agtctttata ccatttataa cattagtaga aaaaaatagt attgtaatgc agacaaaaag
     1981 tgataaaaca gcgtttattt tttttaacat attttgaatt tcctttcaaa tgtaaataaa
     2041 aaagagagtt taaactctct tttttaataa acattccacc aaccagtatt tccagtaagt
     2101 gtggcattgc atgttgcata agctcttact ccagctttct gaactgatcg tacttgaccg
     2161 cctcgtccat ttttagctgt tgcactatgt ttagctctag catggtagta atttgcataa
     2221 actttaaatc cattaacccc acagttgaaa tccccgccgc cagcagcata tctcaattta
     2281 ctagaagaaa atccttcttc tgtagcttcc attcctcctc cgtaaatggc ggtatggtct
     2341 tcgggtacat ctagatttaa agcttctgtg gcactagcta ttcctccact agttaataag
     2401 acacccatta aagcagaaag acataaaaat tttttcataa cttatttctc ctatcttttt
     2461 tactagaatt attttatttt agtgtgtttt ataaaataaa gaactttttt ggcgcgttag
     2521 tatttttatg ataaaatttt atgtaaataa tcgtttacat aggagaaaaa atggaggatt
     2581 taggatctaa gctaagagaa ttaagagtga aaaaagggta tactcaagaa tatgtggcaa
     2641 gaaaatttaa cgttacacgt caaactattt caaagtggga aaataacaaa acaacaccag
     2701 atatagagac actaaaaaaa atttgtgaat tttatagtac taacataaat tctattttaa
     2761 atgaagataa ttcaaaaaat aaaaaaaata atttactggt attgacagct attattttta
     2821 atatatttgt tactatatta ggtttatttg aattgattca aatgaatttt tttagcttta
     2881 cacatggaat atttacttgg tttgctctat ctggattaat agtaatagat atcttaaatt
     2941 atttttatat ttactattct tatttaaaaa atgaaaaatt ttttatacaa tgtttttccc
     3001 ctagttattt tgattatttt attaagctaa tatgaagtag ttagttattt aattgcatag
     3061 ttgacataat gtcgactatg ccaagtagcc tctctaccaa gggatacagg ggctcacttt
     3121 gtgatttttc attggtctag gtcaaaagct ctttttaagg cttgattttc tgcagttgct
     3181 tctttccgtt tctttgtgaa tttttaccag tcatttttta ctggggtgtt atttttcata
     3241 aaatatgata aatttttggt agcgcttcat aagcgcgttg ctttttcaag aataaacact
     3301 cattattttt taactggctg ctcgaaagag cagtcttttt tattatttat ccgtttgttt
     3361 tacaaacaat tcttcgttag gactgttgta ataatttgaa tttaacagaa ttaggcagaa
     3421 gtcgcccatc ctctataggt gggtgatgaa tgccgttcgg tatgagggtt accgttggta
     3481 actcgaagac cgacaactaa ggcgtattgc ctttttattt tgttccatgt tacaatcagt
     3541 ctatacaaga aatgagttga tataacatgg aattagatac aaataatcat tcagtatttc
     3601 ttctttatta ccaccttgtt ttagtaacga aatatcgtag acaagtgatt gatgatgaaa
     3661 tatctgatta tgccaaaact acttttgaaa gaatttcaga atcgtatcac attactttag
     3721 tggagtggaa tcatgataaa gaccacgttc atattatgtt caaagctcaa cctaaaacag
     3781 aattgacaaa attcatcaat gcctataaaa gtgccagctc aagattgata aaacgtgact
     3841 ttccaagagt caaacaattt ctttggaaag aaatgttctg gtctaaaagt ttttgtcttc
     3901 tgacaactgg tggcgcacca attgatgtga ttaagaagta tatccaaaat caaggaaaca
     3961 atcataaata gaaagtaggt gaactttatg gaacaactaa aagcatacaa attcagaatc
     4021 tatccaacag aggaacaaga aatcttcttt gccaaatctt ttggttgtgt ccgtaaggtc
     4081 tacaatctaa tgcttgatga ccgaaaaaag gcgtatgaag aagttaaaaa tgattcttct
     4141 aaaaaaatga cttttccgac accagctaaa tacaagaaag aatttccgtt tttgaaagaa
     4201 attgatagcc ttgctttagc caatgcccaa cttaatttag ataaagcata caagaatttt
     4261 tttcgggata aatccgttgg atttccacgt ttcaaaagta agaaaaatcc tgttcagagt
     4321 tatacaacga ataatcaaaa tggtacagtt gctttgattg atagtaaatt catcaaagtt
     4381 cctaaattga agtcattagt aagaattaag cttcatagac aaccaaaagg gattatcaaa
     4441 tccgctacaa tatcacgtca ttctagcggt aaatactata tttctttgtt gtgtaaagaa
     4501 gaaattatcg aattacctaa aactaattcc acaattggta ttgacttagg tattatggac
     4561 tttgcgattc tttctgatgg acaaaaaatt gataataata aattcacgtc caaaatggaa
     4621 aagaaactaa agcgtgaaca acgcaaattg tctaggcgtg ctttattggc taaaaataaa
     4681 ggtaccaatc tatttgaagc taaaaattat caaaaacaaa aacgcaaagt agctagattg
     4741 catgaaaaag taatgaatca acgtactgat tttctgaata agttgagtac agaaatgatc
     4801 aaaaatcacg atattatctg tattgaagac ttaaacacaa aaggtatgtt gcgaaatcat
     4861 aaattagcta aaagtatttc tgatgtttct tggtcaaagt ttgtgactaa attacaatac
     4921 aaggctgact ggtatggacg aaaaatcatc aaagtagata aatggtttcc gtctagtcag
     4981 atttgttcag agtgcggaca taaagatggc aagaaatctc ttgaaattcg agaatggact
     5041 tgtcctgttt gtcatactca tcatgatcgt gatatcaatg ctagtatcaa tattctgacc
     5101 gaaggtctaa gactacattc tatgggattg gcttagatcc aatcatcaag aaccgtagga
     5161 actacgggga tagcttggta aataagagac accgctgtta gtaaagaaat acgctatcaa
     5221 gtatgctcta ttcccaagaa gctcccactt caagcgttaa gaaccgtcag gtttagctaa
     5281 gtggtgagta gttcactgat taactttaag gtatcataat ttttattgaa atagacattc
     5341 tattcataaa gtgttatttt gaattcattt ttgtgttcct tttttttcgt tagtatatct
     5401 actacaacac aacataaatc ccaaccccaa aaaattacta agaatggcag aaccaccttg
     5461 actaatatag gggagtggaa taccagttag aggtagtaat ccgatacttg cacctatatt
     5521 ttcaaaaaca tgaaaaaaaa tcattgcaac aatgcctata ccgatatagg tgaaaaataa
     5581 gttattgctt ttaaaacatg ttttatacat ttgataaatt aaataaaagt ataggaatat
     5641 tacaagacaa cttcctataa agccaaaatt ttctccaatt acagaaaata tcatatcgga
     5701 ttctctaaca ggaacgtgaa tgtttgatac attaaaacca gtacctaaaa gtccgccaga
     5761 gccaatagca attaaactat ttgctaactg atagctagat ccatttggat ctaaaaatgg
     5821 attcaaccat gagtctattc ttttaaactg atagtcgtga aatcctattt ttaataagaa
     5881 atctcttcct gtatctgata taaccaaata taaaaatatt aaggataaaa caacaccaat
     5941 ggcgattatt ggggcaatta tttttatatt tatgttagac gtaaacaaaa taaaaatata
     6001 aataacaatg aagactaaca ttgttcctag atcgttctga aaaaataata atattcctat
     6061 tggaagagta gcaataaaag ttttaagtaa ataaatccaa tcatctttcg tattactagt
     6121 aatagatttt tgctgataat tgacggttat tttagctagc ataagggtgt atcctatttt
     6181 gactaactca gtaggttgaa acgaaaaacc agcaatataa aaccaatttt ttgctccagt
     6241 taagactgct aattgtggat tatagaattt caagagaagt aataacatta tgatgcataa
     6301 tccgtaaaat ataggagtta atttccacaa aattttagga ttaaaaaaat aaatagttat
     6361 tgctgaagtg aacccaatac tataccacaa tacttgttta attaattctt ttgtgatttt
     6421 tgaattagtg taagagtcgt gatataaagc aacatataaa gaaagtaatc caatgataca
     6481 tagcagaaaa actggcaata aaagcccata attcaactga tttttgtaga ttctattatt
     6541 tttcatttcg aaaggtcctt tttcataatt tataaataaa aataacacaa taaagttatt
     6601 tttactagtt ttgagtttta gacgaaaatt acaattagct acttttttat cttactaaat
     6661 agttctatct ttttatataa agtatagaaa aattaataaa acaattggaa atatgctgtg
     6721 aagaaataag tttctatgtt tattaaagat aataattaaa gtattaatta ttaatgtatt
     6781 aattattaat agtaaactta gaaaaaatat taataaccaa gtggcaattg aatggctaaa
     6841 ataaaagaat ccggactgaa ttaaggtgaa aactaaactt aaaaaaatta caaaatgaaa
     6901 taatagtatt agtgtttttg tatgattttt taccataatt ttttaccata attttttctt
     6961 ctcctaacaa aatattgtct agtgataaat caaataactt agcaaactga attaaatttt
     7021 ctgtatctgg tattgttcga ccattttccc aattagaaat ggttttttta gatactaaaa
     7081 gcatttcagc taaatcttct tgagttagtt gtttttctat tcttttttgt ttgattactt
     7141 tacttatagt catttgatca cctaaacata ttttttattc ttagaaagat agagtctata
     7201 gaaattgatt tcttctttat ggaaagttgg taattgttac caaaatttcc accacttttt
     7261 ttctgttgtt attgcattgt tgttttcttt attgacagaa gttaattcct cttcttcagg
     7321 ttcttccgta taagctaatt gtaactgttc ttgcagtttt tcgatctgtt gatttgcctg
     7381 caaggtgagt tgttgttgct ggtcgagtaa cttttgcatt tgttttattt gagtatct
//
