NZ_CP007616.1 - 3 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP007616.1

Region	Type	From	To
Region 1	NRPS	150,890	198,488
Region 2	sactipeptide	254,173	275,552
Region 3	NRPS,lanthipeptide-class-ii,T1PKS	280,692	372,120

NZ_CP007616.1 - Region 1 - NRPS

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Location: 150,890 - 198,488 nt. (total: 47,599 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

NRPS/PKS domains

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 150889 - 198488:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_166

Search NORINE for peptide: strict or relaxed

AMP-binding (479..877): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMVFGAVCK
Nearest Stachelhaus code(s):: Leu DAMLVGAVCK (71% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1540..1944): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DSSDIGEVSK
Nearest Stachelhaus code(s):: Lys DAEDIGTVSK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

NZ_CP007616.1 - Region 2 - sactipeptide

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Location: 254,173 - 275,552 nt. (total: 21,380 nt) Show pHMM detection rules used

sactipeptide: (subtilosin or thuricin or TIGR04404 or Subtilosin_A or skfc)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

Sactipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Sactipeptide predictions

Sactipeptide(s) for allorf_266491_266616

allorf_266491_266616

Leader:

MKSYLIAVYL

Core:

VKLLFIIYNVNCVWCVWCALHNITLIDREVV

antiSMASH-DB 4.0 matches for allorf_266491_266616

51.6% NZ_JYPH01000039.1: Sactipeptides: allorf_12067_12156_sactipeptide

VNCVWCVWCALHNITLIDREVV

+NCVWCV C ITLIDREVV

INCVWCVCCVCRTITLIDREVV

15.4% NZ_CP102267.1: Lanthipeptides: allorf_0904640_0904792_lanthipeptide

VKLLFIIYNVNCVWCV

+ +FI+ V C +CV

TEYVFILGEVRCTYCV

12.5% NZ_SDJV01000024.1: Lanthipeptides: ES032_RS12705_lanthipeptide

LFIIYNVNCVWCVWCALHNI

+++ NV+ VWC + +

VYVTANVSSVWCAGATVGAV

MIBiG 3.1 matches for allorf_266491_266616

12.9% BGC0000517 (BAB04173.1): Lanthipeptide: haloduracin β or haloduracin α

CALHNIT

CA +NI+

CAWYNIS

Sactipeptide(s) for ctg1_249

ctg1_249

Leader:

METPVVQPRD

Core:

WTCWSCLVCAACSVELLNLVTAATGASTAS

antiSMASH-DB 4.0 matches for ctg1_249

100.0% NZ_CM000752.1and 15 others:

NZ_CM000752.1 Sactipeptides: BTHUR0007_RS37430_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15955_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15950_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33370_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33365_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29070_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29065_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29060_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31360_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31355_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31350_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30820_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30815_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30810_sactipeptideNZ_NUXK01000018.1 Sactipeptides: COJ27_RS31850_sactipeptide

Sactipeptides: BTHUR0007_RS37435_sactipeptide

WTCWSCLVCAACSVELLNLVTAATGASTAS

26.7% NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide

Lanthipeptides: BAMF_RS41655_lanthipeptide

LLNLVTAATGASTAS

LL L+T G+ST S

LLTLITTIVGSSTIS

26.7% NC_018089.1and 13 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08730_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptide

Lanthipeptides: SMUGS5_RS08730_lanthipeptide

ACSVELLNLVTAATGASTA

AC++ ++ + A TG STA

ACAIGVVGITVAVTGISTA

with 1 more sequence matches

23.3% NZ_QKUF01000004.1: Lanthipeptides: EI42_RS08635_lanthipeptide

TCWSCLVCAACS

TCWSC C C

TCWSCSRCTDCK

Sactipeptide(s) for ctg1_250

ctg1_250

Leader:

METPVVQPRD

Core:

WTCWSCLVCAACSVELLNLVTAATGASTAS

antiSMASH-DB 4.0 matches for ctg1_250

100.0% NZ_CM000752.1and 15 others:

Sactipeptides: BTHUR0007_RS37435_sactipeptide

WTCWSCLVCAACSVELLNLVTAATGASTAS

26.7% NC_014551.1and 5 others:

Lanthipeptides: BAMF_RS41655_lanthipeptide

LLNLVTAATGASTAS

LL L+T G+ST S

LLTLITTIVGSSTIS

26.7% NC_018089.1and 13 others:

Lanthipeptides: SMUGS5_RS08730_lanthipeptide

ACSVELLNLVTAATGASTA

AC++ ++ + A TG STA

ACAIGVVGITVAVTGISTA

with 1 more sequence matches

23.3% NZ_QKUF01000004.1: Lanthipeptides: EI42_RS08635_lanthipeptide

TCWSCLVCAACS

TCWSC C C

TCWSCSRCTDCK

Sactipeptides

Core peptide predictions

ctg1_249: Putative sactipeptide; RODEO score: 28.0; Core sequence, approximate: WTCWSCLVCAACSVELLNLVTAATGASTAS
ctg1_250: Putative sactipeptide; RODEO score: 28.0; Core sequence, approximate: WTCWSCLVCAACSVELLNLVTAATGASTAS
allorf_266491_266616: Putative sactipeptide; RODEO score: 28.0; Core sequence, approximate: VKLLFIIYNVNCVWCVWCALHNITLIDREVV

NZ_CP007616.1 - Region 3 - NRPS,T1PKS,lanthipeptide-class-ii

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Location: 280,692 - 372,120 nt. (total: 91,429 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

NRPS/PKS domains

Lanthipeptides

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_276

ctg1_268

Leader:

MEKTRSKLNNATIEGG

Core:

IETLKDENECLRMEIDYLKKLKALLQNEKKLQNKTKWKF

Core with dehydrations:

IEDhbLKDENECysLRMEIDYLKKLKALLQNEKKLQNKDhbKWKF

antiSMASH-DB 4.0 matches for ctg1_268

97.4% NZ_CM000758.1: Lanthipeptides: BTHUR0013_RS36715_lanthipeptide

IETLKDENECLRMEIDYLKKLKALLQNEKKLQNKTKWKF

IETLKDENECLRMEIDYLKKLKALLQ EKKLQNKTKWKF

IETLKDENECLRMEIDYLKKLKALLQKEKKLQNKTKWKF

94.9% NZ_KB976165.1: Lanthipeptides: ICC_RS35950_lanthipeptide

IETLKDENECLRMEIDYLKKLKALLQNEKKLQNKTKWKF

IETLKDENECLRMEI+YLKKLKALLQ EKKLQNKTKWKF

IETLKDENECLRMEINYLKKLKALLQKEKKLQNKTKWKF

87.2% NZ_CM000748.1: Lanthipeptides: BTHUR0003_RS35340_lanthipeptide

IETLKDENECLRMEIDYLKKLKALLQNEKKLQNKTK

IETLKDENECLRMEI+YLKKLKALLQ EKKLQNKTK

IETLKDENECLRMEINYLKKLKALLQKEKKLQNKTK

with 1 more sequence matches

69.2% NZ_MOOT01000057.1: Lanthipeptides: BK765_RS32535_lanthipeptide

LKDENECLRMEIDYLKKLKALLQNEKKLQN

LKDENECLRMEIDYLKKLKAL+Q EKKLQ+

LKDENECLRMEIDYLKKLKALVQKEKKLQS

ctg1_277

Leader:

METEKYLQVVEDEEIEQLVGG

Core:

AGPGWVETLTKDCPWNVPVACVTIMGQRICKKCY

Core with dehydrations:

AGPGWVEDhbLDhbKDCysPWNVPVACysVDhbIMGQRICysKKCysY

antiSMASH-DB 4.0 matches for ctg1_277

100.0% NZ_JH792312.1and 1 other:

NZ_QNRN01000010.1 Lanthipeptides: DET63_RS17570_lanthipeptide

Lanthipeptides: IIG_RS24665_lanthipeptide

AGPGWVETLTKDCPWNVPVACVTIMGQRICKKCY

97.1% NZ_CP036100.1and 1 other:

NZ_CP072062.1 Lanthipeptides: J5V93_RS29280_lanthipeptide

Lanthipeptides: EXW47_RS29185_lanthipeptide

AGPGWVETLTKDCPWNVPVACVTIMGQRICKKCY

AGPGWVET+TKDCPWNVPVACVTIMGQRICKKCY

AGPGWVETVTKDCPWNVPVACVTIMGQRICKKCY

91.2% NZ_CM000748.1and 1 other:

NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS26815_lanthipeptide

Lanthipeptides: BTHUR0003_RS30910_lanthipeptide

GPGWVETLTKDCPWNVPVACVTIMGQRICKKC

GPGWVETLTKDCPWN+PVACVTIMGQRICKKC

GPGWVETLTKDCPWNMPVACVTIMGQRICKKC

with 42 more sequence matches

88.2% NZ_KB976276.1: Lanthipeptides: IIC_RS09105_lanthipeptide

AGPGWVETLTKDCPWNVPVACVTIMGQRICKKCY

AGPGWVETLTKDCPW PVACV IMGQ+ICKKCY

AGPGWVETLTKDCPWKQPVACVIIMGQKICKKCY

85.3% NZ_CM000731.1and 2 others:

NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptideNZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide

Lanthipeptides: BCERE0020_RS28875_lanthipeptide

AGPGWVETLTKDCPWNVPVACVTIMGQRICKKCY

AGPGWVETLTKDCPW P ACV IMGQ+ICKKCY

AGPGWVETLTKDCPWKQPAACVIIMGQKICKKCY

85.3% NZ_CP036053.1and 7 others:

NZ_JAOPRA010000024.1 Lanthipeptides: OCE16_RS27090_lanthipeptideNZ_KB976667.1 Lanthipeptides: IG5_RS06165_lanthipeptideNZ_LDKD02000003.1 Lanthipeptides: ABH17_RS27060_lanthipeptideNZ_NUAO01000019.1 Lanthipeptides: CN544_RS19345_lanthipeptideNZ_NVFH01000027.1 Lanthipeptides: COL40_RS24675_lanthipeptideNZ_NVHY01000021.1 Lanthipeptides: COM05_RS26660_lanthipeptideNZ_NVOV01000033.1 Lanthipeptides: CON78_RS26470_lanthipeptide

Lanthipeptides: EXW64_RS27135_lanthipeptide

AGPGWVETLTKDCPWNVPVACVTIMGQRICKKCY

AGPGWVETLTKDCPW P ACV IMGQ+ICKKCY

AGPGWVETLTKDCPWKQPGACVIIMGQKICKKCY

73.5% NZ_KB976165.1: Lanthipeptides: ICC_RS24850_lanthipeptide

GPGWVETLTKDCPWNVPVACVTIMGQRICKKC

GPGWVETLTKDCP P AC+TI GQ ICKKC

GPGWVETLTKDCPGYKPYACITIAGQTICKKC

70.6% NZ_CM000758.1and 1 other:

NZ_MOOT01000057.1 Lanthipeptides: BK765_RS20265_lanthipeptide

Lanthipeptides: BTHUR0013_RS15850_lanthipeptide

GPGWVETLTKDCPWNVPVACVTIMGQRICKKC

GPGW+ TLTKDCP N P AC+TI GQ ICKKC

GPGWIATLTKDCPANKPYACITIAGQTICKKC

58.8% NZ_FNYB01000007.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS28100_lanthipeptide

Lanthipeptides: BMZ34_RS15340_lanthipeptide

GPGWVETLTKDCPWNVPVACVTIMGQRICKKCY

GPG++ETLTKDCP P CV I G CK+CY

GPGYIETLTKDCPRVTPQICVPINGIWTCKRCY

50.0% NC_017621.1and 16 others:

NZ_CP039462.1 Lanthipeptides: E8M06_RS05390_lanthipeptideNZ_JABTZM010000032.1 Lanthipeptides: HRQ47_RS09675_lanthipeptideNZ_JAEVFQ010000010.1 Lanthipeptides: JNO64_RS06375_lanthipeptideNZ_JAFFHD010000003.1 Lanthipeptides: JN532_RS02075_lanthipeptideNZ_JAGFVG010000007.1 Lanthipeptides: J5581_RS04225_lanthipeptideNZ_JAIJZO010000001.1 Lanthipeptides: K5Q34_RS00965_lanthipeptideNZ_JAIMDS010000024.1 Lanthipeptides: K6V32_RS10650_lanthipeptideNZ_JAJUWV010000001.1 Lanthipeptides: LZF89_RS05505_lanthipeptideNZ_JAMDIS010000017.1 Lanthipeptides: M5P45_RS08180_lanthipeptideNZ_JAMYIU010000001.1 Lanthipeptides: NKE44_RS01780_lanthipeptideNZ_JAMYIX010000001.1 Lanthipeptides: NKE54_RS02675_lanthipeptideNZ_JAMYIY010000001.1 Lanthipeptides: NKE64_RS02785_lanthipeptideNZ_JAMYJP010000014.1 Lanthipeptides: NKE68_RS07350_lanthipeptideNZ_LR738722.1 Lanthipeptides: STREPSUIS_RS03955_lanthipeptideNZ_VZMP01000023.1 Lanthipeptides: F6P50_RS09295_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05700_lanthipeptide

Lanthipeptides: SSUD12_RS06540_lanthipeptide

AGPGWVETLTKDCPWNVPVACVTIMGQRICKKC

AG G+V+TLTKDCP + CV I CK C

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

50.0% NZ_AQQB01000068.1and 6 others:

NZ_BCEY01000024.1 Lanthipeptides: GOZ53_RS05100_lanthipeptideNZ_BCEZ01000067.1 Lanthipeptides: GOZ55_RS11230_lanthipeptideNZ_BCFC01000053.1 Lanthipeptides: GOZ35_RS07920_lanthipeptideNZ_BCFG01000017.1 Lanthipeptides: GOZ50_RS03220_lanthipeptideNZ_BCFI01000009.1 Lanthipeptides: GOZ54_RS02495_lanthipeptideNZ_CP019557.1 Lanthipeptides: BZG42_RS05725_lanthipeptide

Lanthipeptides: K738_RS01000000110290_lanthipeptide

AGPGWVETLTKDCPWNVPVACVTIMGQRICKKC

AG G V+TLTKDCP + CV I CK C

AGSGLVKTLTKDCPGFLSNICVNIGFISGCKNC

50.0% NZ_CP040409.1and 4 others:

NZ_CP040414.1 Lanthipeptides: FE331_RS04020_lanthipeptideNZ_CP040415.1 Lanthipeptides: allorf_0721024_0721203_lanthipeptideNZ_CP040417.1 Lanthipeptides: FE328_RS00745_lanthipeptideNZ_CP040424.1 Lanthipeptides: FE321_RS03445_lanthipeptide

Lanthipeptides: FE336_RS03450_lanthipeptide

GPGWVETLTKDCPWNVPVACVTIMGQRICKKC

GPG ++TLTKDCP V CV + CKKC

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKC

41.2% NZ_CP040409.1and 4 others:

NZ_CP040414.1 Lanthipeptides: FE331_RS04030_lanthipeptideNZ_CP040415.1 Lanthipeptides: FE330_RS03440_lanthipeptideNZ_CP040417.1 Lanthipeptides: FE328_RS00755_lanthipeptideNZ_CP040424.1 Lanthipeptides: FE321_RS03455_lanthipeptide

Lanthipeptides: FE336_RS03460_lanthipeptide

AGPGWVETLTKDCPWNVPVAC

GPG V TLTKDCP VP C

VGPGLVRTLTKDCPNVVPKVC

41.2% NZ_CP058255.1: Lanthipeptides: HW369_RS18920_lanthipeptide

VETLTKDCPWNVPVACVTIMGQRICKKC

V T+TKDCP V CVT CK C

VPTITKDCPNTVSSVCVTFPFISACKNC

38.2% NZ_CP063989.1: Lanthipeptides: ID810_RS00795_lanthipeptide

AGPGWVETLTKDCPWNVP-----VACVTIMGQRICK

AG GWV T C W +P C I Q C+

AGSGWVYTF--GCCWCLPWYSSLTKCGAICSQGTCQ

35.3% NZ_CP036073.1and 11 others:

NZ_CP036073.1 Lanthipeptides: EXW45_RS04930_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04925_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04920_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04915_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04910_lanthipeptideNZ_NUEG01000031.1 Lanthipeptides: CN905_RS18915_lanthipeptideNZ_NUEG01000031.1 Lanthipeptides: CN905_RS18910_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05275_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05270_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05265_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05260_lanthipeptide

Lanthipeptides: EXW45_RS04935_lanthipeptide

AGPGWVETLTKDCPWNVPVAC

AG GW+ T+T DCP +V V C

AGCGWLCTVTDDCPNSVFVCC

35.3% NZ_CP048273.1and 3 others:

NZ_CP048273.1 Lanthipeptides: M654_RS18555_lanthipeptideNZ_LT745776.1 Lanthipeptides: B2C81_RS11280_lanthipeptideNZ_LT745776.1 Lanthipeptides: B2C81_RS11275_lanthipeptide

Lanthipeptides: M654_RS18560_lanthipeptide

AGPGWVETLTKDCPWNVPVAC

AG GW T+T DCP +V V C

AGCGWACTITDDCPNSVFVCC

35.3% NZ_CP048890.1and 3 others:

NZ_CP071478.1 Lanthipeptides: J0P05_RS32905_lanthipeptideNZ_LUCO01000008.1 Lanthipeptides: BMBG_RS24280_lanthipeptideNZ_NVLN01000014.1 Lanthipeptides: CON11_RS24965_lanthipeptide

Lanthipeptides: BMG_RS30865_lanthipeptide

AGPGWVETLTKDCPWNVPVAC

AG GW T+T DCP +V V C

AGCGWSCTITDDCPNSVFVCC

35.3% NZ_PKIA01000004.1: Lanthipeptides: CYK22_RS03780_lanthipeptide

GPGWVETLTKDCPWNVPVAC

GPGW+ T+T DCP +V V C

GPGWIATITDDCPNSVFVCC

32.4% NC_004070.1and 26 others:

NC_008024.1 Lanthipeptides: MGAS10750_RS08460_lanthipeptideNZ_CAAHHZ010000002.1 Lanthipeptides: E9518_RS02835_lanthipeptideNZ_CAAHIH010000002.1 Lanthipeptides: E9602_RS03585_lanthipeptideNZ_CAAHIO010000002.1 Lanthipeptides: E9584_RS04360_lanthipeptideNZ_CAAHJE010000002.1 Lanthipeptides: E9605_RS03435_lanthipeptideNZ_CAAHJS010000002.1 Lanthipeptides: E9628_RS02300_lanthipeptideNZ_CAAHKC010000012.1 Lanthipeptides: E9636_RS08085_lanthipeptideNZ_CAAHMR010000003.1 Lanthipeptides: E9727_RS05510_lanthipeptideNZ_CAAHQE010000003.1 Lanthipeptides: E9931_RS04945_lanthipeptideNZ_CAAHQG010000004.1 Lanthipeptides: E9903_RS05690_lanthipeptideNZ_CAAIFD010000008.1 Lanthipeptides: FAG63_RS07845_lanthipeptideNZ_CAAJDK010000010.1 Lanthipeptides: FAO79_RS08000_lanthipeptideNZ_CAAJFI010000003.1 Lanthipeptides: FAP60_RS03740_lanthipeptideNZ_CP008926.1 Lanthipeptides: DP15_RS03855_lanthipeptideNZ_CP035434.1 Lanthipeptides: ETT65_RS08240_lanthipeptideNZ_CP035435.1 Lanthipeptides: ETT64_RS07905_lanthipeptideNZ_CP035447.1 Lanthipeptides: ETT52_RS07920_lanthipeptideNZ_CP035449.1 Lanthipeptides: ETT50_RS08255_lanthipeptideNZ_CP035453.1 Lanthipeptides: ETT46_RS08220_lanthipeptideNZ_CP060646.1 Lanthipeptides: H7789_RS07920_lanthipeptideNZ_CP065054.1 Lanthipeptides: I2432_RS09105_lanthipeptideNZ_LRGW01000003.1 Lanthipeptides: AWU01_RS03260_lanthipeptideNZ_LS483298.1 Lanthipeptides: DQM39_RS08650_lanthipeptideNZ_LS483407.1 Lanthipeptides: DQM86_RS08100_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS07865_lanthipeptideNZ_LS483430.1 Lanthipeptides: DQN28_RS07600_lanthipeptide

Lanthipeptides: SPYM3_RS08605_lanthipeptide

GPGWVETLTKDCPWNVPVAC

G GW T+T DCP +V V C

GSGWFATITDDCPNSVFVCC

32.4% NZ_BMMB01000007.1and 1 other:

NZ_BMMB01000007.1 Lanthipeptides: IEX62_RS15675_lanthipeptide

Lanthipeptides: IEX62_RS15680_lanthipeptide

GPGWVETLTKDCPWNVPVAC

G GW+ TLT DCP ++ V C

GDGWITTLTDDCPNSIIVCC

32.4% NZ_CAJHJN010000010.1and 4 others:

NZ_CP066093.1 Lanthipeptides: I6I02_RS06995_lanthipeptideNZ_JACLQK010000029.1 Lanthipeptides: H7U04_RS10750_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02855_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05170_lanthipeptide

Lanthipeptides: JMZ68_RS08975_lanthipeptide

GPGWVETLTKDCPWNVPVAC

G GW T+T DCP +V V C

GTGWFATITDDCPNSVFVCC

32.4% NZ_CP018188.1and 5 others:

NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09335_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09335_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06620_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06620_lanthipeptideNZ_VDNV01000006.1 Lanthipeptides: FSV44_RS08680_lanthipeptide

Lanthipeptides: BSR19_RS10820_lanthipeptide

GPGWVETLTKDCPWNVPVAC

GPGW+ T+T DCP ++ V C

GPGWIATITDDCPNSIFVCC

32.4% NZ_JANHJQ010000013.1: Lanthipeptides: NON16_RS14160_lanthipeptide

GPGWVETLTKDCPWNVPVAC

G GW T+T DCP +V V C

GCGWSCTVTDDCPNSVFVCC

29.4% NZ_CAAIJM010000014.1: Lanthipeptides: FAI23_RS09465_lanthipeptide

GWVETLTKDCPWNVPVAC

GW T+T DCP +V V C

GWFATITDDCPNSVFVCC

29.4% NZ_MJEH01000022.1and 2 others:

NZ_MJEH01000022.1 Lanthipeptides: BFG57_RS18360_lanthipeptideNZ_MJEH01000022.1 Lanthipeptides: BFG57_RS09480_lanthipeptide

Lanthipeptides: BFG57_RS18365_lanthipeptide

GPGWVETLTKDCPWNVPVAC

G GW+ T+T DCP ++ V C

GDGWISTITDDCPNSIIVCC

29.4% NZ_NIHT01000008.1and 1 other:

NZ_NIHT01000008.1 Lanthipeptides: CDL23_RS06740_lanthipeptide

Lanthipeptides: CDL23_RS06745_lanthipeptide

GPGWVETLTKDCPWNVPVAC

G GW+ T+T DCP ++ V C

GSGWLPTITDDCPNSIFVCC

26.5% NZ_AULU01000012.1: Lanthipeptides: H580_RS25790_lanthipeptide

GPGWVETLTKDCP

G GWV T T DCP

GCGWVCTYTLDCP

26.5% NZ_BMSZ01000006.1: Lanthipeptides: allorf_250966_251172_lanthipeptide

GPGWVETLTKDCPWNVPVACVTI

G G V T PW+ P +C T+

GSGKVWNSTFRFPWSAPRSCRTL

26.5% NZ_CP037940.1: Lanthipeptides: EQG49_RS07315_lanthipeptide

GPGWVETLTKDCPWNVPVACVT

G G ++TLT +C N A +T

GSGVIKTLTHECKMNTYQAILT

26.5% NZ_MOWR01000001.1: Lanthipeptides: BMI76_RS01705_lanthipeptide

GWVETLTKDCPWNVPVAC

GW T+T +CP +V V C

GWSFTITDECPNSVFVCC

26.2% NZ_FMXP01000004.1: Lanthipeptides: BLQ04_RS01515_lanthipeptide

AGPGWVETLTKDCPWNVPVAC

A GW++TLTKDCP + C

ADRGWIKTLTKDCPNVISSIC

23.5% NZ_VATK01000028.1: Lanthipeptides: FDO66_RS19480_lanthipeptide

GWVETLTKDCPWNVPVACVTI

GW+ + T DC W +P C +

GWICSYTLDCAW-LPFGCSCL

20.6% NZ_AUBN01000022.1: Lanthipeptides: G448_RS16025_lanthipeptide

AGPGWVETLTKDC

A GW TLT +C

ASSGWFCTLTIEC

20.6% NZ_CP036455.1and 4 others:

NZ_JAGPXN010000019.1 Lanthipeptides: KBX06_RS22045_lanthipeptideNZ_JAODUN010000003.1 Lanthipeptides: BXY51_RS10560_lanthipeptideNZ_KB895893.1 Lanthipeptides: C569_RS0129325_lanthipeptideNZ_KB900614.1 Lanthipeptides: SALPAC6_RS0114155_lanthipeptide

Lanthipeptides: EKD16_RS25235_lanthipeptide

PGWVETLTKDC

GWV TLT +C

SGWVCTLTIEC

20.6% NZ_CP046629.1and 3 others:

NZ_FNJX01000002.1 Lanthipeptides: BLR40_RS05025_lanthipeptideNZ_FNZS01000001.1 Lanthipeptides: BMX70_RS03125_lanthipeptideNZ_FOLK01000002.1 Lanthipeptides: BM262_RS05670_lanthipeptide

Lanthipeptides: GPA00_RS05740_lanthipeptide

GPGWVETLTKDCPWN

G G V T++ DC N

GSGVVPTVSHDCHMN

20.6% NZ_CP061274.1and 1 other:

NZ_JADKRR010000001.1 Lanthipeptides: ITJ40_RS10085_lanthipeptide

Lanthipeptides: H9X71_RS09850_lanthipeptide

AGPGWVETLTKDC

A GW+ TLT +C

ASSGWLCTLTIEC

20.6% NZ_CP083176.1and 4 others:

NZ_JABUHD010000002.1 Lanthipeptides: HRR08_RS05415_lanthipeptideNZ_LSLF01000001.1 Lanthipeptides: AXE72_RS04025_lanthipeptideNZ_PNHB01000001.1 Lanthipeptides: CJ210_RS02800_lanthipeptideNZ_QJVA01000001.1 Lanthipeptides: D0T19_RS02755_lanthipeptide

Lanthipeptides: K9E37_RS06280_lanthipeptide

GPGWVETLTKDCPWNV

G G + TLT +C N

GDGVMHTLTHECHMNT

20.6% NZ_JAGFVL010000062.1: Lanthipeptides: J5J03_RS19425_lanthipeptide

GPGWVETLTKDC

GPGW+ + T DC

GPGWIPSFTGDC

20.6% NZ_QSNA01000006.1and 1 other:

NZ_VEAP01000011.1 Lanthipeptides: allorf_058964_059119_lanthipeptide

Lanthipeptides: allorf_108759_108914_lanthipeptide

CPWNVPVACVTIMG

CP N + V+IMG

CPNNTVASTVSIMG

20.0% NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17980_lanthipeptide

Lanthipeptides: C794_RS17980_lanthipeptide

AGPGWVETLTKDCPWNVPVA

GW T+TK+C N V

GNQGWFCTITKECQVNCNVG

17.6% NZ_BNBJ01000003.1and 1 other:

NZ_JAMFLF010000021.1 Lanthipeptides: allorf_030895_031062_lanthipeptide

Lanthipeptides: allorf_023401_023568_lanthipeptide

PWNVPVACVTI

PWN P +C T+

PWNPPRSCRTL

14.7% NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01890_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01095_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01750_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07560_lanthipeptide

Lanthipeptides: SMUNN2025_RS09965_lanthipeptide

ETLTKDCPWN

T++ DC WN

NTISSDCRWN

13.6% NZ_CP078093.1: Lanthipeptides: KVH43_RS13025_lanthipeptide

WNVPVACVTIMGQRICKK

W V C T + +R C +

WTANVFCYTYISERHCSE

13.3% NZ_CP061033.1: Lanthipeptides: allorf_2072629_2072850_lanthipeptide

GPGWVETLTKDCPWNVPV

GPG LT+ W

GPGLSHLLTRSKTWEASA

MIBiG 3.1 matches for ctg1_277

20.6% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

GWVETLTKDC

GW TLTK+C

GWC-TLTKEC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Module view

Legend

Lanthipeptides

NRPS/PKS products

NRPS/PKS substrates

Core peptide predictions

ctg1_268 - Class II

Cleavage pHMM score: -1.60

RODEO score: 0

Monoisotopic mass: 4785.6 Da

Molecular weight: 4788.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4806.6 Da N = 1

ctg1_277 - Class II

Cleavage pHMM score: -0.80

RODEO score: 0

Monoisotopic mass: 3711.8 Da

Molecular weight: 3714.4 Da

Number of bridges: 3

Predicted core structure(s)

For candidate cluster 3, location 280691 - 372120:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal) + (bOH-Tyr - Pro) + (X - ohmal) + (D-Asn) + (X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_285

AMP-binding (280..682): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFYFGLVCK
Nearest Stachelhaus code(s):: Met DVFYLGGVFK (59% 8Å match); Ala DVFFVGLVAK (50% 8Å match); Pro DLFYLALVCK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1323..1722): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFYLGGVCK
Nearest Stachelhaus code(s):: Met DVFYLGGVFK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

ctg1_287

Search NORINE for peptide: strict or relaxed

AMP-binding (461..856): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_291

AMP-binding (448..845): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DMWNTGMVHK
Nearest Stachelhaus code(s):: Ser DMWNTGLVHK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

PKS_AT (1551..1847): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 133.6
inactive: 95.1
Methoxymalonyl-CoA: 43.2
Methylmalonyl-CoA: 24.0
Propionyl-CoA: 15.4
Isobutyryl-CoA: 9.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg1_292

Search NORINE for peptide: strict or relaxed

AMP-binding (8..410): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLIDK
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_296

PKS_AT (5..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 51.2
inactive: 31.2
Methoxymalonyl-CoA: 30.8
Methylmalonyl-CoA: 13.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg1_301

Search NORINE for peptide: strict or relaxed

AMP-binding (274..685): bOH-Tyr

nrpys: bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAQDIAAVDK
Nearest Stachelhaus code(s):: bOH-Tyr DASTIAAVDK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1329..1728): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVLNLAMVIK
Nearest Stachelhaus code(s):: Ala DVHNLAIVYK (76% 8Å match); Ser DVWNVAMVHK (62% 8Å match)
Stachelhaus code match:: 70% (weak)

ctg1_302

PKS_AT (1899..2194): mal

ATSignature: 2-Rhyd-Malonyl-CoA

Top 3 matches:: 2-Rhyd-Malonyl-CoA: 100.0%; Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 111.1
inactive: 77.2
Methoxymalonyl-CoA: 50.9
Methylmalonyl-CoA: 42.0
Propionyl-CoA: 29.8
Ethylmalonyl-CoA: 14.3
2-Methylbutyryl-CoA: 13.3
CHC-CoA: 13.0
Isobutyryl-CoA: 10.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0