LOCUS       NZ_CP004877.1          21380 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP004877.1 Bacillus thuringiensis serovar kurstaki str. HD-1
            plasmid pBMB431, complete sequence.
ACCESSION   NZ_CP004877
VERSION     NZ_CP004877.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 14:56:58
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 83109
            Orig. end    :: 104489
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21380
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11380]"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11380
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     cand_cluster    1..21380
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21380
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /region_number="2"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     CDS             567..1199
                     /locus_tag="ctg1_48"
                     /transl_table=11
                     /translation="MIIDHISNNVVKKLEQTVRYEKKQVQVLRVSKSSSNMHAYMIFPE
                     FSEVKISNTELDEYIENLSTSLKYVIDRKLSLQEIEKQNHSFIMTCAVEEDGVIDDETI
                     HFNTTYVKPPTLASKVFKLVCGLGNRLNSLKELHITVLNNNINRIEIEFYNENETYVAV
                     EKEEIANAIMGAYTKANIYYSADLRYVAEGNEIKLKSIKPKLAGDVL"
     CDS             1196..1831
                     /locus_tag="ctg1_49"
                     /transl_table=11
                     /translation="MKREKGMIGVLCTYVFMILVLIPLHTAHASVKMDFNELKGNDVSS
                     SFNEGLNNRTKTTEKDDSFGSSIIQKVEGMYAPAFKVGVNIFSISFILGVIVMVMGLIT
                     KNGQWMKWATGSMIFSFVSMMAMRLSVYFLFSSDVFSFMNIFTDFLDLFKATALIFTPF
                     MLIAGIRLRRIHESTKQPEYYRWSNRVITGSCLLCMLAVLAPWLFANM"
     CDS             2128..2511
                     /locus_tag="ctg1_50"
                     /transl_table=11
                     /translation="MKRNPEYTALRNSILIGWLLTIIVMGLSIYFSSIIYLLIGCFILS
                     LKYGLMGTIKNVEKRLPTWANFGVIEKTVNRRVTRPFQFRGGLIVSLALGFIEMVIKGL
                     CISYYILGLETHVYRLMRRNTRM"
     CDS             2528..3166
                     /locus_tag="ctg1_51"
                     /transl_table=11
                     /translation="MKVLIFELILIVLLIPINIMVKKHAPKWKGRAGEKMVKRIVRKLD
                     HERYWVLHDVAVHTEYGDTTQIDHIVIAETGIFVIETKNYEGWIYGSEKAARWTQGIFR
                     KKHSFQNPFRQNYKHMKTIEWVMEQQLPCISIAAFHPKCSLKRVNVHSKDKHVLYYNDL
                     KKCIESYIDVKLTKDEVEHIYQTILQANITDKDTENKHVKYLQNKFAKQ"
     CDS             3185..3298
                     /locus_tag="ctg1_52"
                     /transl_table=11
                     /translation="MLYIIGFLVIIVVVIRLNVKYYQLKGNPKDFVMKKKD"
     CDS             3458..4201
                     /locus_tag="ctg1_53"
                     /transl_table=11
                     /translation="MKEVLDVETYLKKMKNQKINYDKVLRKMINDWEARNERPKVLLHS
                     CCAPCSTASLEFLAEHADITVFFSNSNIHPKSEYMRRSNEQKIFVEKFNDRTGHTVGFL
                     EDDYRSNVFFKMVKEEGLAEEPEGGLRCSACFDMRLDRSAEVAQEKGFDYFGSAITLSK
                     NKNSQLINELGIGVQKNYDSRYLPSDFKKSNGYQRSIEMCNEYDVFRQCYCGCSFAAEK
                     QGIDLRSVNKDAIHYLKENNLSLKK"
     CDS             complement(4359..4517)
                     /locus_tag="ctg1_54"
                     /transl_table=11
                     /translation="MQDRKKSIKSPGSVMKPDFAETDAQKVKQEIQNDVRAGQGAMTSR
                     EAGAMRD"
     CDS             complement(4977..6374)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 268.8; E-value: 1.9e-81)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_55"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.8e-43, bitscore:
                     141.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIIKFLLLINLISGTFIPITTVHAENKSQYYTIMLKNYENNQK
                     LASKFQKYDMQVVYSVPEIGVIQVKATEKAMNIVHSDPNIDSYNKSLQSFNSREVATNV
                     SSPLPLNEIWENQWDMQQVTHNGDSYRLYPGTKNVTVGIIDSGIDINHPDLKDNISPGS
                     KNLVPKGGFREQESQETGELNRLIDLRGHGTFTAGQVAANGFMKGVAPGIGIKMYRVFG
                     NGAGEAIWVIKAIVEAAKDNVDVINLSLGEYLINGIVSSSDGESSEELSEIKAYRKAIK
                     YAKSKGSIIVAAAGNDALDVTNKQEMNDFFRKKNENTGITFTGEVLDVPAELPNIVTVS
                     SVGPSKLLSLFSNYGESFIDIAAPGGDNRLFQQYGLEQWVKNKLMLKELILTTAPGGGY
                     ALSIGVSLAAPKVSGALALIIDKNNFKKNPDKAVRYLYKNGVSNDTPTNKSFFGNGLLD
                     VYKAISQ"
     CDS             complement(6595..7242)
                     /locus_tag="ctg1_56"
                     /transl_table=11
                     /translation="MLINLVMKDFLLVKKYFLILLVFAAIAPIYLSSQLQLNDGGLVSF
                     LLTVILMEYILFGTVSKFEDQYKGAALLCATPYTRSAFVKAKYLFLFVIFICAAIIRII
                     ISVVAPSGIESLSASALGITFLTLSILFGVLLPVQFKFGYDKTKIISLLTAFLIPFVAP
                     TLIRGLQSSDIDFKSIFPFSPTVLTWMPCFISIIIGFISMIISLKVYAKKDL"
     CDS             complement(7232..8098)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 148.9; E-value:
                     3.1e-45)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_57"
                     /transl_table=11
                     /translation="MNVVLEVNNLNKSYGNFSLKDVTFSLNTDCITGFIGTNGSGKTTT
                     IKAILGLILKDSGKINFLGKDMDKHERKSKNKIGIVLDEGYFYDELTVKEMKNVIAPSY
                     TEWDETVFQNYIKKFNLNLEQKISTLSKGMRMKFAVALALSHHADLLIMDEPTSGLDPL
                     VRSELMDILLDFMKEPGKSVFFSTHITSDLDKIADMIILIDDGKVLVNDEKDVLIDTHA
                     LVKGDNRLINKQTRPLFLNLHQTHYGFEGITNKKDDVRRLMPDVLIERPTIEEIMLSYI
                     GGNIHVN"
     CDS             complement(8095..8478)
                     /gene_functions="regulatory (smcogs) SMCOG1136:GntR family
                     transcriptional regulator (Score: 71.9; E-value: 1e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_58"
                     /transl_table=11
                     /translation="MKIVLSNVSSLPLYQQIKEQIKESIFNNELKEGEQLPSIRSLAND
                     LHVSVLTTKRVYAELETEGFIITKVGKGTYVAPTNLELLMESKRRMVEVKLTEVCQMAR
                     SIGIHADDLHSILDLILEEENEK"
     CDS             complement(8478..8603)
                     /gene="allorf_091587_091712"
                     /gene_functions="biosynthetic-additional (sactipeptides)
                     predicted sactipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_091587_091712"
                     /protein_id="allorf_091587_091712"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKSYLIAVYLVKLLFIIYNVNCVWCVWCALHNITLIDREVV"
     CDS_motif       complement(8574..8603)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKSYLIAVYL"
                     /locus_tag="allorf_091587_091712_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       complement(8478..8573)
                     /prepeptide="core"
                     /locus_tag="allorf_091587_091712_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="28.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="VKLLFIIYNVNCVWCVWCALHNITLIDREVV"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MKSYLIAVYL"
                     /leader_location="[8573:8603](-)"
     CDS             9257..9379
                     /gene_functions="biosynthetic-additional (sactipeptides)
                     predicted sactipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_59"
                     /transl_table=11
                     /translation="METPVVQPRDWTCWSCLVCAACSVELLNLVTAATGASTAS"
     CDS_motif       9257..9286
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: METPVVQPRD"
                     /locus_tag="ctg1_59_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       9287..9379
                     /prepeptide="core"
                     /locus_tag="ctg1_59_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="27.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="WTCWSCLVCAACSVELLNLVTAATGASTAS"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="METPVVQPRD"
                     /leader_location="[9256:9286](+)"
     CDS             9486..9608
                     /gene_functions="biosynthetic-additional (sactipeptides)
                     predicted sactipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_60"
                     /transl_table=11
                     /translation="METPVVQPRDWTCWSCLVCAACSVELLNLVTAATGASTAS"
     CDS_motif       9486..9515
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: METPVVQPRD"
                     /locus_tag="ctg1_60_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       9516..9608
                     /prepeptide="core"
                     /locus_tag="ctg1_60_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="28.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="WTCWSCLVCAACSVELLNLVTAATGASTAS"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="METPVVQPRD"
                     /leader_location="[9485:9515](+)"
     CDS             9714..9836
                     /gene_functions="biosynthetic-additional (sactipeptides)
                     predicted sactipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_61"
                     /transl_table=11
                     /translation="METPVVQPRDWTCWSCLVCAACSVELLNLVTAATGASTAS"
     CDS_motif       9714..9743
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: METPVVQPRD"
                     /locus_tag="ctg1_61_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       9744..9836
                     /prepeptide="core"
                     /locus_tag="ctg1_61_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="28.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="WTCWSCLVCAACSVELLNLVTAATGASTAS"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="METPVVQPRD"
                     /leader_location="[9713:9743](+)"
     CDS             9889..9999
                     /locus_tag="ctg1_62"
                     /transl_table=11
                     /translation="MTNSYVKNKSYIFIENEYGIFVIHKLKTNLNFIGDD"
     CDS             10001..11380
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thurincin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_63"
                     /sec_met_domain="Thurincin_rSAM_RRE (E-value: 1.3e-34,
                     bitscore: 112.7, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.6e-08, bitscore: 29.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-07, bitscore:
                     26.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="subtilosin (E-value: 2.9e-46, bitscore:
                     152.2, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.2e-21, bitscore: 70.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.3e-09, bitscore:
                     32.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.8e-08, bitscore: 28.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGYLFWKEKLEIRKFTSNYESMLVVHKNPNESAPTLKNENTFTI
                     NKTATEIIELIDGTKTYGQVVSFLSLKYSEDPISIEKKLNAFLNNVSKVYNMNIGTQEE
                     PINVPVNLIEEQTIYPKVASIEITNRCNVRCRHCYGDFGAVKPKVMSLDQIKSLLDDLN
                     NIGVKLIELTGGDITVHPNLKEILLYALNLDFSQITLLTNGIALSEKVMDIIIKNKSKT
                     FVQIDMHSLDDNYLTWFFKVPNTLHKIKNNIMKLAENDVRLRIATIVTHLNVHEVEDIA
                     EWVHNLGIDSIGVSPVIPMGRALGCSDLYLNEEDVKTYGEALLKINKKYPKFVSLYEGA
                     RAEIRNCGAITSHIVIAPDGEIKMCTMHSLDDLKNSIGNVFEQNIKDIYDEKFKYINAF
                     FNLQAPQMDSEECKECENKRFCSTCFLRSFIKAQEIGDKCKWFKNHVPEIIKEPLMVGQ
                     N"
     CDS             11545..13254
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 174.8; E-value:
                     4.8e-53)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_64"
                     /transl_table=11
                     /translation="MNKKINKQDEIQISYKELLFLYPYLKNTKTLLALGLIGMVIASLI
                     IAPIPYIIGYIIDKVILLNKSYDQLLKTTLILLLIYCINYLISIGYEYLFTRVQQNVVN
                     EIRLSMISNIIDAPLSYINQKEKGYILSRIAESGNVSALFSPNLLRVFSGIFDFFFALF
                     IMFNLSVKLTGIIVIIIPIYFIISKHSSKMISKSTTNVYESSAVLNAEMYETLNGIEDI
                     KLLNGKNIQTNKIKSKLNNVIKSALKQSLHFIFFMQNLIVTNNFVTVIVLLVSGILILQ
                     NQLTIGVYTSFSIYMAKLLATTQALGSLDITLKPVCISIKRIKEFFNLDVENTLGTNIM
                     KEPINSIEFKDVCFKYNGNSDLIFDHLNVQIEKGDKLLIDGINGSGKSTFIKLLTGLYQ
                     PESGKILINNIDYNLIHKESVRDRIGIVSQNIFLFKGTILDNILYGQTNKTKEDVVKLM
                     KRYHLTSHLNRFENGLDTIIVQDGSSVSGGQAQFIAFLRAILTKRDIIILDEAASNLHI
                     DTRNLMYEILQNYNLCNILIMISHQQDGLYFLNKTLELTHGNKRIALNGSML"
     CDS             13289..13576
                     /locus_tag="ctg1_65"
                     /transl_table=11
                     /translation="MSKMKLINFDTYRNSIVLFENNGEIISVSAHFQFFEGSESYIQGF
                     IDNEEVIHFKSNNPGPNISIYRFAPKNITKLIISSENRTHGMVTLYTSEI"
     CDS             complement(13942..14727)
                     /NRPS_PKS="Domain: PKS_KR (8-120). E-value: 2e-10. Score:
                     32.7. Matches aSDomain: nrpspksdomains_ctg1_66_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     225; E-value: 1.7e-68)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_66"
                     /sec_met_domain="adh_short (E-value: 1.7e-35, bitscore:
                     117.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDLKGKVVVITGASTGLGRAMAIRFGEEQAKVVINYYSNESEA
                     NEVVQVVKQAGGEAIAVKGDVTVESDVINLVKSAVEEFGTLDVMINNAGIENSVPSHEM
                     PLSDWNKVIATNLTGAFLGSREAIKYFVEHDIKGSVINMSSVHEQIPWPLFVHYAASKG
                     GVKLMTETLALEYAPKGIRVNNIGPGAMNTPINAEKFADPEKRADVESMVPMGYIGEPK
                     EIAAVAAWLASSQASYVTGITLFADGGMSLYPSFQAGRG"
     aSDomain        complement(14368..14703)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_66_PKS_KR.1"
                     /evalue="2.00E-10"
                     /label="ctg1_66_PKS_KR.1"
                     /locus_tag="ctg1_66"
                     /protein_end="120"
                     /protein_start="8"
                     /score="32.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VVVITGASTGLGRAMAIRFGEEQAKVVINYYSNESEANEVVQVVK
                     QAGGEAIAVKGDVTVESDVINLVKSAVEEFGTLDVMINNAGIENSVPSHEMPLSDWNKV
                     IATNLTGA"
     CDS_motif       complement(14629..14700)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_66_0001"
                     /evalue="5.20E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1_66"
                     /protein_end="33"
                     /protein_start="9"
                     /score="9.5"
                     /tool="antismash"
                     /translation="VVITGASTGLGRAMAIRFGEEQAK"
     CDS             complement(14744..15601)
                     /locus_tag="ctg1_67"
                     /transl_table=11
                     /translation="MDILLAILPALFWGSIVLFNVKLGGGPYSQILGTTLGALVFSIGV
                     YIFIKPVLTPVVIIIGIISGLFWALGQANQLKSIDLIGVSKTMPISTGMQLVSTTLFGV
                     IVFHEWSTTTSVVLGVLALLCIIIGIVLTSLQSKEEKNDEQKGNFKKGIVMLLISTLGY
                     LVYVVIIRLFGIDGWSALLPQAIGMVLGGILLTFKHQPFNKYAIHNIIPGLIWAAGNMF
                     LFISQPRVGVATSFSLSQMGIVISTLGGIFILGEKKTKRQFIAIVIGIIFIIAAGIMLG
                     IAKG"
     CDS             15797..15913
                     /locus_tag="ctg1_68"
                     /transl_table=11
                     /translation="MTNTISSFENRNNGEKLDAKLRYVIQKQRIMFIHEKKK"
     CDS             16390..16986
                     /locus_tag="ctg1_69"
                     /transl_table=11
                     /translation="MTACSNSTQTKNDSRPAQAVQNGIQQHVKGKGIVDIPGNYKGKLK
                     DLETVKGKVLHIKDGDTIDVNVKGQKQMVRLLLLDTPESVSQKIPPQKMGKEPSSFLKK
                     QLEGKSVTFVYDRGPKEDKYGRKLAYVFCDGIHINELMVKSGYGIIAYISRPNTTILSE
                     MKEAENEAKESKVGVWSIKGFVDEKNQHYNRKDAA"
     CDS             17038..17241
                     /locus_tag="ctg1_70"
                     /transl_table=11
                     /translation="MNENKRNMLLSFIISILFIFASLLPFSNNEYVYVISKIGAAAGVI
                     NIVMMSVFLYFQSKKTGHLLNW"
     CDS             17314..17526
                     /locus_tag="ctg1_71"
                     /transl_table=11
                     /translation="MSQVPGFLKFVLAKERRYVYLVVGEKKNKKVLTHMVYRFGSLEKA
                     LETMYEMRGDFENLFPLELKERGYD"
     CDS             17796..18095
                     /locus_tag="ctg1_72"
                     /transl_table=11
                     /translation="MGVGIYRKDSHVSTYAFPFACIGLMLSVYQITIQAFPNSEMQICS
                     VGVSCTKDYLNLFGFISIPMLSFVGFLAIIILLYIKSERDKRINNTAIMNNMLE"
     CDS             18155..18448
                     /gene_functions="regulatory (smcogs) SMCOG1058:ArsR family
                     transcriptional regulator (Score: 77.5; E-value: 9.6e-24)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_73"
                     /transl_table=11
                     /translation="MTTMQVSNEMYKIPEADIELLKIMAHPVRLQIVKELEHHKICNVT
                     QLTELLDVPQSTVSQHLSKMRGKILRSERRGLEMYYHIVNSKACQIVGVLGI"
     CDS             18995..19408
                     /locus_tag="ctg1_74"
                     /transl_table=11
                     /translation="MREIAKKVKMIRLQEEHSGLKADAEQYSSKRCKIEREGINLEKNR
                     VKKRTQKFQTSEEKWDIKCKKAVQLFNQGEEYPTIAKNLRCNVSSLYRELKKRGTLQTP
                     KQVAVSKSLKSPITSTRTKKTNFERYKEYYMYK"
     CDS             20321..20719
                     /locus_tag="ctg1_75"
                     /transl_table=11
                     /translation="MKLDSNNHSVFLLYYHLVLVVKYRRNVFDDDMSDYAKDMFVRLSE
                     NYNITLVEWNHDVDHVHILFKAHPNTEMTKFINAYKSASSRLIKRDFPQVKKKLWKEMF
                     WSRSFCLLTTGGSPIDVVKTYIENQSEK"
ORIGIN
        1 aacttgaaca attgtgcttt ttgttaatag tgaaaatcag aagtagaaga ggcacaagcg
       61 ttaaagtgga ctgcaaaagt gacagaaaga gaacaaggat taacattatt tataaagata
      121 tctaataaga agtgctatcg gatttataca gaaggaggga taataccaga aaatatatga
      181 atgtatataa aatttgaggt gaatccacct attttctata cattagttga atcaaacaat
      241 agatgactag ggagtgtata acatccattt cccagttaaa ttttcttaga taaatagcat
      301 gaaatacagt atgttctcac tcatttgtat aaggataaaa tagcctttta tttttatgca
      361 aatgagtgaa acagaacgat tcaccatata agaatattcg actataatga aacactgtac
      421 gtcattgtaa tattaagatg ttttaagatt aaagtgatta ttagtcataa aatatgagtt
      481 tcgagacctc agcaaaatat tgcaatgctt tatatacatg agattgtaaa aattatttta
      541 ttaaaattac tggaggctga tgaaatatga taatagatca tataagcaac aatgtagtaa
      601 aaaaattgga acaaacggtg cgctatgaaa agaaacaggt acaggtatta cgtgtaagta
      661 aaagtagttc taatatgcac gcttacatga ttttcccaga attctcagag gttaaaattt
      721 caaatactga actggatgaa tatatagaaa atctatcaac aagtctgaaa tatgtcattg
      781 atcgcaagtt aagtctacaa gaaattgaaa aacaaaatca ttctttcatt atgacatgcg
      841 cagtcgagga agatggtgtt atagatgatg aaacgattca ttttaatacg acgtatgtta
      901 agccacctac acttgcgagt aaggtattta agctagtgtg tggtttagga aatcgtttga
      961 atagcttaaa agagttacat ataacagtat taaataataa tattaatcga attgaaatag
     1021 agttttataa tgaaaatgaa acatatgtag cagtagaaaa agaagaaatt gcaaatgcga
     1081 ttatgggggc atatacaaaa gccaatatct attattccgc agatctccgt tatgttgcag
     1141 aaggaaatga aatcaaatta aagagcatta agccaaaatt agcgggtgat gtgttgtgaa
     1201 gcgagaaaaa gggatgattg gagttttatg tacatatgtt tttatgatcc tagtactcat
     1261 acctttacat acagctcatg catctgtaaa aatggatttt aatgaattga aaggaaatga
     1321 tgtttcttca tcttttaacg aaggattaaa caatcgaaca aaaacgacag agaaagacga
     1381 ttcatttggg tcatcaatta tacaaaaagt tgagggtatg tatgcaccag cttttaaagt
     1441 aggggtaaat atcttttcta tctctttcat attaggtgtt attgtcatgg ttatggggtt
     1501 aattacaaag aatggtcaat ggatgaaatg ggcaacaggg agtatgattt tctcgttcgt
     1561 tagtatgatg gcaatgagat taagtgtata tttcttattt agttcggatg tattttcgtt
     1621 tatgaacatt tttacggatt ttttagacct gtttaaagca acagcactta tttttacacc
     1681 ctttatgtta attgcaggaa ttcgtttacg aagaattcat gagagtacaa aacaacctga
     1741 gtattatcgt tggtctaatc gcgttataac gggatcttgt ttactatgta tgttagccgt
     1801 actggctcca tggttatttg cgaatatgta aagaaatata tatagatgca aaaggtactg
     1861 aatgttcatt cagtaccttt tatctaccca tctgattttt cctttcatat tctgcaaata
     1921 tctcctctga tataggggat aatttgttcg atttttaatt gtttttcgtt gtaaattatt
     1981 tccatttgta gaatgaatac tcctcgtagt agagctggta tgcctacaaa acagacgagg
     2041 aagatagaaa ctaaaataat atttaaatta gaaattcata cctcgtattt aataataact
     2101 taatttattt tgataggagt gcttgttttg aaaagaaatc cagaatatac cgctttacgt
     2161 aattctatct tgataggttg gctgctcaca attattgtta tgggcttatc tatctatttt
     2221 tcttctatta tatatttact aattggatgt tttattttgt cattgaaata tggattaatg
     2281 ggcactataa agaatgtaga aaagcgtttg ccaacctggg ctaattttgg agtgattgaa
     2341 aaaacagtga atcggagggt gacaagaccg tttcaatttc ggggcggact cattgtttca
     2401 ttagcattag gattcataga gatggtgata aaaggtttat gtatctcata ttatatttta
     2461 ggattagaaa cccatgtata tcgtttaatg cgtagaaaca caagaatgtg aaaaggggac
     2521 ttaaattatg aaagtattaa tatttgaatt aattctaatt gtgcttctga taccgataaa
     2581 cattatggta aaaaaacatg ctccaaaatg gaaaggaaga gctggagaaa agatggtaaa
     2641 acgtatagta agaaaattag atcacgaaag gtattgggtg ttacatgatg tggcggttca
     2701 tacagagtat ggtgatacaa ctcaaattga ccatattgtt attgcagaaa caggtatatt
     2761 tgttatagag acgaagaact acgagggctg gatttatgga agtgagaagg cagcaagatg
     2821 gacacaaggt atttttagaa agaaacactc ttttcagaat ccatttagac aaaattataa
     2881 gcacatgaaa acaattgaat gggtgatgga acaacagctg ccgtgtattt ctattgcagc
     2941 gtttcatcca aaatgcagcc taaaaagagt aaatgttcat tctaaagata aacatgtcct
     3001 atattataac gatctaaaaa aatgtatcga atcctatatt gatgtgaaat taacaaaaga
     3061 cgaggtcgag catatttacc agactatttt gcaagcaaat attactgata aggatactga
     3121 aaataaacat gtgaagtatt tacagaataa gttcgctaaa caataagaaa cggagcaagg
     3181 aacaatgtta tatataatag gatttttggt aatcatcgta gtagttattc gtcttaacgt
     3241 gaagtattac cagttaaaag gtaatccaaa agattttgtg atgaaaaaga aggattaagg
     3301 atttatttta gaaatagagg taatagaata catatattat tttagccatc accaaaggtc
     3361 ataagaaccg ttttacgatc gataaataca tacattacta tattttatta atgaatttaa
     3421 gtgatataat aaataaaaat aaacaggagg tttagttgtg aaagaagtgt tagatgtaga
     3481 aacgtattta aagaaaatga agaatcagaa aataaattat gataaagtat taagaaaaat
     3541 gattaatgat tgggaagcaa ggaacgaaag accaaaagtg ttacttcatt catgctgtgc
     3601 tccttgtagt actgcttcat tggaatttct tgcagaacat gcagatatta cggttttttt
     3661 ctcgaattcg aatattcatc cgaaaagtga gtacatgcga cgctctaatg aacaaaagat
     3721 ctttgtagaa aagttcaatg atcgtactgg gcacacagta ggatttcttg aggatgacta
     3781 ccgttcaaat gtatttttta aaatggtaaa agaagaaggt ttggcagaag agccagaagg
     3841 cgggcttcgt tgttcagctt gttttgatat gagattggat cgttcagctg aggtagcaca
     3901 agaaaaaggt tttgattact ttgggagtgc cattactctt tctaaaaata aaaatagtca
     3961 attaataaat gaacttggaa tcggtgtaca aaaaaattat gattcgcgtt atttaccaag
     4021 tgatttcaaa aaaagtaatg gatatcaacg ttcaattgaa atgtgtaatg aatatgatgt
     4081 tttccgtcag tgttattgtg gatgttcatt tgcagcagag aaacaaggta tagatttaag
     4141 atcggtgaac aaagatgcaa tacattatct gaaagaaaat aatcttagtt taaaaaaata
     4201 gatttaatgg agagaaattc gatgtaagat taacctatga tttacaaacg aaacgcatta
     4261 tgtttctaaa ggaaaaacgt aaaaagctaa aatagttcgg gaataactcc ttactggtta
     4321 aagttctaga gaagaaaaaa ccaataagga gtgttttctt aatctcgcat tgcccctgcc
     4381 tctcgggaag tcattgctcc ttgtcctgct cttacatcat tttgaatttc ttgtttcact
     4441 ttttgtgcat ctgtttcagc aaaatctggt ttcataacag aaccaggact ttttatagat
     4501 tttttacgat cttgcataca acccctcctc gatttaacat ttaacaatct tattatttac
     4561 aaaaatacac tcggtatact ccgagtagta taatgtttat tgaagaaaaa attgattact
     4621 ataaggtgat agaggaacat agggaataac aatcttgcat taacatctct ctcaaaagtt
     4681 tagagaaata tctgccagaa aaacgccttt ctctctgtag aaatataaag gaagaatagt
     4741 gtttttttat tttggataca atagtctaat tatgcaaata accacttgtt aaggttatta
     4801 gtaaaagtgg gatccaagaa tgactaaata gggaatctaa tagatggata tggaaaaatt
     4861 taattcaata taataaaaaa cctttattta aggcgattag acttgcttta aataaaggtt
     4921 ccatcaaaaa atcactatca attgttagtt taaaaccaaa ttgaagtgta tatattttat
     4981 tgggaaatcg ctttatagac atcaagcaaa ccattaccaa aaaaactttt attagtaggg
     5041 gtatcattgc taactccatt tttataaaga tatctcacgg ccttatctgg atttttttta
     5101 aaattatttt tatcaataat taatgctaaa gcacctgaca cttttggagc ggcaagtgaa
     5161 acccctatag agagagcata gccaccacca ggggcggtag ttaatattag ttcttttaac
     5221 attaacttat tttttaccca ctgttctaaa ccatattgct gaaataatct attatctcct
     5281 ccaggtgcag caatatctat aaaactttca ccataatttg aaaataagga gagtaattta
     5341 gatggaccaa cagatgaaac tgttactata tttggcaact cagcaggaac atctaatact
     5401 tctccagtaa atgttatccc agtattttca tttttttttc taaaaaaatc attcatttcc
     5461 tgcttgttag taacatcaag agcatcatta ccagccgcag caactatgat acttcccttt
     5521 gatttagcat atttaatggc ttttctataa gctttaattt cggataattc ctcactagat
     5581 tcaccgtctg aagaagatac tataccattg atgaggtatt cgcctaaact taaattgata
     5641 acatcaacat tatctttcgc agcttcaact atggctttaa taacccaaat agcctcacct
     5701 gctccattac caaacactct atacatttta attccaatac caggagcaac ccctttcata
     5761 aaaccattag ctgcaacctg tccagcagta aaagttccat gtcctcttag atctattagg
     5821 cgatttaatt cacctgtttc ttgagattct tgctctctaa atccaccttt aggtactaaa
     5881 tttttagatc caggtgaaat gttatctttt aaatcaggat gatttatatc aatgcctgaa
     5941 tcaatgatac caacagttac atttttagtt cctggatata gtctatagct atcaccatta
     6001 tgggttactt gttgcatatc ccattgattc tcccatattt catttaaggg taggggggaa
     6061 gagacattgg ttgctacttc tcttgaatta aacgattgta atgacttatt atatgaatct
     6121 atattaggat ccgaatgaac aatattcatt gctttttcgg tagctttcac ttgtataaca
     6181 ccaatctctg ggacactata gactacttgc atatcatatt tttgaaactt actagctagt
     6241 ttttggttat tttcatagtt cttcaacatt atagtataat attgtgattt attttcagca
     6301 tgaactgtag taataggtat gaaagttccg gaaatcaagt taattaacaa aaggaattta
     6361 attatttttt tcataaaatc acctcttgat atattatgta taatccttag tttactaaat
     6421 cgttaatgaa aagagatgtt aagggaatta gtgatttgaa aaatttattc actttgatat
     6481 cgataaaatg tattttagga ataagttcat tagagaagag aattaaataa aagggaatga
     6541 gtaattaaat atataaagta tttaattact cattcctatg atttcaaatt taaattataa
     6601 atcttttttt gcatatactt tcagagatat tatcattgat ataaaaccaa taataattga
     6661 gatgaaacaa ggcatccatg ttaggacagt tggtgagaat ggaaaaatac ttttgaaatc
     6721 aatatcactt gattgtagtc cccttataag agtaggagca acaaaaggta ttaaaaaagc
     6781 agttaaaagt gatatgattt tggttttgtc ataaccaaat ttaaactgaa caggaagtag
     6841 tacaccaaat aaaatactta gagttaaaaa agttattcca agagcgctag cgctcaggct
     6901 ttctataccc gatggtgcga caactgaaat gattatacgg ataatagctg cacaaataaa
     6961 aattacaaaa agaaaaaggt acttcgcttt tacaaatgcg cttcgtgtgt atggggtagc
     7021 acaaagtaaa gccgctccct tgtactgatc ctcaaatttg gataccgttc cgaacaaaat
     7081 atattccatc aaaataacgg ttaaaagaaa gctaacaaga ccgccatcgt ttaattgtaa
     7141 ttgtgaagaa agataaatag gagctatagc agcaaaaacg agtaagatta gaaaatattt
     7201 tttgactaac aaaaagtctt tcatcactag gttaattaac atggatgttc cccccaatat
     7261 atgaaagcat aatctcctca atagttggtc tttctattaa tacatcaggc atgagtcgac
     7321 gtacatcatc ttttttatta gtaatccctt caaatccata gtgagtttga tgtaaattta
     7381 aaaaaagagg tcttgtttgt ttattaatta agcggttgtc gccctttacc aatgcatgtg
     7441 tatctattaa aacatctttt tcatcattta ctaaaacttt tccatcatca attaaaataa
     7501 tcatatcagc aattttatct aaatcagatg taatatgagt ggaaaaaaat acgcttttcc
     7561 ccggctcttt catgaaatca aggagaatat ccattaattc actccgtact aatggatcca
     7621 agccacttgt tggttcatcc attattaata gatctgcatg atgggatagg gctaatgcaa
     7681 ctgcaaattt cattcgcatt cctttggata gagtagagat tttttgttct agatttaagt
     7741 taaacttttt aatataattt tggaaaactg tttcatccca ttcagtgtag gatggagcaa
     7801 taacattttt catttccttt actgttaatt catcataaaa atagccctcg tctagcacaa
     7861 taccaatttt gtttttagac tttctttcat gcttatccat atcttttcct agaaaattaa
     7921 ttttcccaga atcttttaaa ataagaccca aaatcgcttt aattgtagtg gtctttccag
     7981 aaccatttgt accgataaat cctgttatac agtctgtatt aagtgaaaag gtaacatctt
     8041 ttaacgaaaa atttccgtaa gatttattta aattatttac ttctaacaca acattcattt
     8101 ttcattctcc tcctctaaaa ttaaatctaa aattgaatgg agatcatctg catgaatacc
     8161 tatactacga gccatttgac aaacttcagt aagtttaact tctaccatcc ggcgtttgga
     8221 ctccattaac aactctaaat ttgtaggagc tacataggtc ccttttccaa cctttgtaat
     8281 aataaagcct tctgtttcta attctgcata aactcttttt gtagtaagta cacttacatg
     8341 taagtcgtta gcaagtgagc ggattgatgg taattgttca ccctctttta attcattgtt
     8401 aaatatggat tccttaattt gctcctttat ctgttgatat aaaggcagac ttgatacatt
     8461 acttaagact attttcatta aacaacctct ctatcgataa gtgttatgtt atgtaatgca
     8521 caccatacac accatacaca gttaacatta taaattataa aaagcagttt aacaagatat
     8581 actgcgatta aataactttt cataaataaa atttttagta tcagttaata aagatatttg
     8641 ttattttaaa taaaccaaaa agaaagtttt gtaaatatat gtcacaaaat attaaagaaa
     8701 cacacacaaa atgtttaaaa ttttttgatt gtttttagaa aacataggga gttatacttt
     8761 agtcgcacca cacaatacag aaaagggggt aggtcaaatg gaaacaccag tagtacaacc
     8821 aagggactgg acttgttgga gtagtttagt atgtgcagca tgttctgtgg agttattaaa
     8881 tttagttact gcggcaacaa caggggctag tactgcaagc taatatcctt tcagaagttt
     8941 tttggttaaa agcactaaga gaatgagcac ttttggtcaa acgaattttc tagaagaaaa
     9001 ataaataagc aaaaaggaga tgttctaaat ggaaacacca gtagtacaac caagggatta
     9061 gacttgttgg agttgctgag tatgtgcagc atgttctgtg gaattattaa atttagttcc
     9121 tgcggcaaca ggggctagta ctgcaagata atatcctttt agaagttttt tggttaaagg
     9181 tactaagaga atgagcactt ttggtcaaat gaattttcta gaagaaaaat aaataaccaa
     9241 aaaggagatg ttctaaatgg aaacaccagt agtacaacca agggactgga cttgttggag
     9301 ttgtttagta tgtgcagcat gttctgtgga attattaaat ttagttactg cggcaacagg
     9361 ggctagtact gcaagctaat atcctttcag aagttttttg gttaaaagca ctaagagaat
     9421 gagcactttt ggtcaaatta gactttctag gagaaaaata aataatcaaa aaggagatgt
     9481 tctaaatgga aacaccagta gtacaaccaa gggactggac ttgttggagt tgtttagtat
     9541 gtgcagcatg ttctgtggaa ttattaaatt tagttactgc ggcaacaggg gctagtactg
     9601 caagctaata tccttttaga agttttttgg ttaaaggtac taagagaatg agcacttttg
     9661 gtcaaatgaa ttttctagaa gaaaaataaa taaccaaaaa ggagatgttc taaatggaaa
     9721 caccagtagt acaaccaagg gattggactt gttggagttg cttagtatgt gcagcatgtt
     9781 ctgtagagtt attaaatcta gttactgcgg caaccggagc tagtactgca agttaaaatt
     9841 ttaaaatgtg agagtgttta tggtgaaatt aaattaggac ttattctaat gacaaacagt
     9901 tatgttaaga ataagtccta tatatttatc gaaaacgagt atgggatttt tgtaatacat
     9961 aaactaaaaa caaatttaaa ttttatagga gatgattaaa gtgaatggct atttattttg
    10021 gaaagaaaag ctagaaataa gaaaattcac atcaaattat gaatctatgt tggtagttca
    10081 taaaaaccca aacgaaagcg ctcctacgct taaaaacgaa aatacattta cgataaataa
    10141 aaccgccact gaaattattg agttaattga tggtactaaa acatatggac aagttgtatc
    10201 tttcttgtct ttaaaataca gtgaagatcc aataagtatt gaaaagaaat taaatgcatt
    10261 tttaaataat gtatccaaag tttacaatat gaacattggt acgcaagaag aacctataaa
    10321 tgtaccagtt aatttaattg aagaacagac tatatatcca aaagtggctt caattgaaat
    10381 cacaaacaga tgtaatgtaa gatgtcgtca ttgctatgga gattttggag cagtaaagcc
    10441 aaaagtaatg agcttagatc aaataaaatc cttattagat gacttaaata atataggagt
    10501 gaaattaatt gaacttacgg gcggtgatat aacagtacat ccaaatctaa aagagatatt
    10561 gttatatgca cttaacttgg atttttctca aataacactg ttgaccaatg gtatagctct
    10621 ttctgagaaa gttatggaca taataataaa aaataagtcg aaaacatttg tgcaaattga
    10681 tatgcatagc ttagatgata attatttgac ttggttcttt aaagttccta atacacttca
    10741 taaaattaaa aataacataa tgaaattagc cgaaaatgat gttcgtttgc ggatcgccac
    10801 aatagttaca catttgaatg tgcacgaggt agaagatata gctgaatggg tacataattt
    10861 agggattgat agtattgggg tatctccagt aataccaatg ggaagagcct taggatgtag
    10921 tgatctttat ttaaatgaag aggatgttaa aacatatggt gaagcattgt tgaaaataaa
    10981 taaaaaatat cctaaatttg tttcattata tgaaggtgcg cgcgctgaga ttaggaattg
    11041 tggtgcaata acatcacata ttgtgattgc gcctgatggt gaaattaaaa tgtgtactat
    11101 gcatagttta gatgatttga aaaacagtat aggtaatgtt tttgaacaga atattaaaga
    11161 tatttatgac gaaaaattca aatacattaa tgcatttttt aacttgcaag cacctcaaat
    11221 ggactctgag gaatgtaaag agtgtgaaaa taaacgtttt tgtagtacat gcttcttaag
    11281 aagctttata aaagcacaag aaattggcga taaatgtaaa tggtttaaaa atcatgtccc
    11341 tgaaataatt aaggagccat taatggtagg gcaaaattag tatgattgga tgagatgaat
    11401 attgttaagt ttctgaggat aaaccaatat aattccatag acaatgcgtc gggataaggt
    11461 ctcaagatat ctatggaatt atataaacct cattatattg attcgtaaat taatataata
    11521 aatagacaaa ggaggagaaa gagggtgaat aagaagataa ataaacaaga tgaaattcaa
    11581 atttcttata aagagttatt atttttatat ccgtatttga aaaatacaaa aactttgtta
    11641 gctcttggtt taattgggat ggttatagct tctttgatta tcgcaccgat accatatatt
    11701 attggctaca ttattgataa agttatacta ttaaacaaaa gctacgatca attattaaaa
    11761 acaactctta tactcttatt aatttattgt attaactatt taatatcgat aggttatgag
    11821 tatttattta ctcgtgtaca acaaaatgta gttaatgaaa ttcgattatc tatgataagt
    11881 aatattatag atgcgcctct ttcttatatt aatcagaagg agaaaggtta cattcttagc
    11941 agaattgctg aatctggtaa tgtaagtgca ttattttctc caaatttatt aagggttttt
    12001 tcaggtatat tcgatttttt ctttgcttta tttataatgt ttaatttaag tgttaaactt
    12061 acaggtatca tagtaattat tatcccaata tattttataa tatccaaaca ttcttctaaa
    12121 atgatatcaa aaagtaccac aaacgtatac gagtcatcgg cagtattaaa cgcagaaatg
    12181 tatgaaacct taaatggaat agaggatata aaattattaa acggtaaaaa tatacaaacc
    12241 aataagatta agagtaaatt aaataatgta attaaaagtg cgctaaaaca aagtttacat
    12301 tttattttct ttatgcaaaa tttaatagta acaaataact ttgttacagt aatagtatta
    12361 ctggtatcag gtattttaat tttacaaaac cagcttacta taggggtgta tacttcattt
    12421 tcaatttata tggctaaact ccttgcgact acccaagctt taggcagctt agatataact
    12481 ctaaaacccg tgtgtattag tattaagaga attaaggagt tcttcaattt agatgttgaa
    12541 aatacactag gtacaaatat aatgaaagaa ccaattaatt caatagaatt taaagatgtt
    12601 tgttttaaat ataatggaaa tagtgatttg atatttgatc atttaaacgt gcaaattgaa
    12661 aagggtgaca agttattaat tgatggtata aatggatcag gaaaatctac ctttataaaa
    12721 ttattaacag gtttatatca acctgaaagt ggaaagatat tgataaataa tattgactat
    12781 aacttaatac ataaagaaag tgttagagat agaataggta tagtttcaca aaatatattt
    12841 ttgtttaaag gaactatatt agataacata ttatatggac aaacaaataa aacgaaagaa
    12901 gatgtagtta agttaatgaa aaggtatcat ttaacatcac atctcaacag atttgagaat
    12961 ggattagata ctataattgt acaagatggt tccagtgttt caggaggtca agcacaattt
    13021 atagcctttt taagggctat cctcacaaaa agggatataa taatattaga tgaagcagca
    13081 tctaatttac atattgatac aagaaatctt atgtatgaga tacttcaaaa ttacaatctt
    13141 tgtaatatat taattatgat ttcacatcag caagatggct tgtattttct caataaaaca
    13201 ttagaactta cacatggtaa taaaagaatt gctttaaatg gtagtatgct ttaatcatca
    13261 tgctttcata gaagggagca tcctaattat gtcaaaaatg aaacttatta attttgatac
    13321 atatagaaat tcaatagttt tatttgagaa caatggcgag attatatcag tgtcagctca
    13381 ttttcaattt tttgaaggaa gtgaaagcta tattcaaggt tttattgata atgaagaagt
    13441 tattcacttt aaatctaata atcctggtcc gaatatttct atatatcgat ttgcgcctaa
    13501 gaatattacc aaattaatta tatcaagtga aaatagaaca catggaatgg tcacattgta
    13561 tacttcagaa atatagctaa catctaaatt ttttaatagt taatacgatg aagtcttgga
    13621 ttaagatcgc ttgtataaca ttatttgttt ttaaatagca gctatataat caaaaaaaag
    13681 gaatccttta ttataaggta ttcttttttt tgattataat attaaattta ttatagggtt
    13741 tctttaccca tcggcattta actaaagcga aattgtaaac ctaaaataaa ataactttat
    13801 cctttcctat aattctacag aaagaaaagt gtattttttg caaaatgcat gtgatgtcac
    13861 gaataattaa aaggttattc aataaaaagc ttactgccgc atttaaactt attgaaagta
    13921 actaatttag ttatatatca atcaaccacg tccagcttgg aaagatggat atagcgacat
    13981 accaccatca gcaaacagtg taatacctgt tacatagctc gcttgtgaag aagcaagcca
    14041 tgctgctacc gctgcaattt ctttcggttc tccgatatat cccataggaa ccatactttc
    14101 aacatcggca cgtttttctg gatccgcaaa tttttcagca ttaatcggcg tattcatagc
    14161 accaggccca atattattta cacggattcc ttttggtgca tattctagtg ctaatgtttc
    14221 tgtcattagc ttaacgccac ctttacttgc tgcatagtgt acaaataatg gccatggaat
    14281 ttgctcgtga acgcttgaca tattaataac actaccttta atatcatgct caacaaaata
    14341 tttaattgct tcccggctcc ctaagaaagc ccctgttaaa ttcgtagcaa ttaccttatt
    14401 ccaatcactt aatggcattt catgtgaagg tactgaattt tcaatacccg cattattaat
    14461 catgacatcc agtgtaccaa attcttccac agcagattta acgagattga taacatctga
    14521 ttcaactgtt acatctcctt ttaccgcaat cgcttctcca cctgcttgtt taactacttg
    14581 tactacctca tttgcttctg attcgtttga ataataatta attacaactt tggcttgttc
    14641 ttctccaaaa cgaattgcca tcgctcttcc taatcctgtg gatgcacctg taataacaac
    14701 aactttccct tttaaatctg tatacataat tttttcctcc tttttatcct ttagcaattc
    14761 ctaacataat gccagctgca ataatgaaga taattccaat gacaatcgca ataaattgtc
    14821 gttttgtttt cttttcacct aatataaaaa ttccacctaa agttgagatc acgatcccca
    14881 tttgggaaag ggaaaaactt gttgccaccc ctacacgcgg ctgggaaata aataaaaaca
    14941 tatttcctgc tgcccaaatt aaaccaggaa taatattgtg aatcgcatat ttattaaatg
    15001 gttgatgctt aaaggttagt agaattccac ctaacaccat accaatggct tgtggtaata
    15061 acgctgacca tccgtctata ccgaaaaggc ggataattac cacatatact aagtaaccaa
    15121 gagttgaaat taataacatc acaatccctt ttttgaaatt tcctttttgt tcatcgtttt
    15181 tctcctcttt gctttggagg gatgtgagaa cgattccgat tatgatacaa agaagtgcca
    15241 gaacacctaa tacaacagat gttgttgttg accattcatg aaatacaatg accccaaata
    15301 aagtagtcga aactaattgc atccctgttg aaataggcat tgttttagaa accccaatta
    15361 aatcaatact tttcaattga ttggcttgtc ctaatgccca aaataggcca gatataatcc
    15421 cgataattat caccacgggc gtcaaaacgg gttttataaa aatataaaca ccgatagaaa
    15481 aaactagagc gccaagggta gttccaagta tttgactgta aggaccgcct cctagtttaa
    15541 cgttgaagag tacaatactt ccccaaaata aggctggtaa aatcgctaat aaaatatcca
    15601 tttttctaac cttcctaaaa catatttatt aagttgaatg cttgtacgag atagtatctt
    15661 tgtgtcgagg gaattatttt agaataagag aagtttttct acccgtaata tttgtttacc
    15721 caaaataaaa gataaataac atcatgttga aaaagaaaat aactagcacg aaataaaaaa
    15781 ggttattaga aagaatatga ccaatacaat ttcaagtttt gaaaatagga ataatggaga
    15841 aaaacttgat gcaaaattaa ggtatgttat acaaaaacaa cgcattatgt ttatacatga
    15901 gaaaaagaaa taatatcgta aaatctttaa tttcatatat aaatttaata agaagtatga
    15961 tatgatgaaa gtaacaaaat acatctaaaa ctatcttgca aaaggacaca cctacgcata
    16021 catatgcgat aggtgtgtcc ttttttattt gtttttaaga tttcaagact gaaaaggggg
    16081 atgtatattg tgtaccagta atatagcatc tactaatgtt tcttttgaaa aattgaaaag
    16141 tcaggaagag aatgaaaaaa acatagtgtc aatatgcccg aattgtaaga aacgctcatt
    16201 tagagtactt tataatgatt atccaaaatg gatacagtat tgcctatgtt gtaattatcg
    16261 agaagtaaat acaatagaga gtccgtttgt ttattagatg tagctattta cgtattttga
    16321 ttaggaggaa gaatttccga tatgaaaata tgaattaagg ctatttgtat aacatcattt
    16381 gtatttcaaa tgacagcatg tagcaattcg acgcaaacaa aaaatgattc gagacctgcc
    16441 caagcagtac aaaacggaat acaacagcac gtaaaaggga aaggtattgt tgatattcca
    16501 gggaattata aggggaaatt aaaagactta gagaccgtta aagggaaggt attacatata
    16561 aaagacggag atacaataga cgtaaacgta aaggggcaga aacagatggt aaggttactg
    16621 ttattagata cccctgagtc tgtatctcaa aaaattccac cacaaaagat gggaaaagaa
    16681 ccatcttcct ttttaaagaa acagctagaa gggaaaagtg taacatttgt ttatgatcgg
    16741 ggaccaaaag aagacaaata cggtagaaaa ttggcttatg tattttgcga tggaatacac
    16801 atcaacgaat taatggtcaa gtcgggttat gggattatag cctatatttc tagacctaat
    16861 actacaattc tatctgaaat gaaagaagca gaaaatgaag caaaagaatc aaaggttggc
    16921 gtatggagca ttaaaggctt tgtagatgaa aagaaccagc attataaccg taaagatgca
    16981 gcttaacacc ctaacccatt gcaatacaaa tatttgtgca aaatggaggt tttttgaatg
    17041 aatgaaaaca aaagaaatat gctcttatcc tttattattt caattttatt tattttcgcg
    17101 agtctattgc catttagtaa taatgaatat gtgtatgtta tctccaaaat tggtgctgca
    17161 gcaggtgtaa taaatattgt gatgatgagc gttttcttgt attttcaaag caaaaaaacg
    17221 ggacatttat taaattggta attaaagcta aatagttttc cttactcata tccttttaag
    17281 tttggtaagg aaagccgaaa aggagtgtga aaggtgagtc aagtacctgg atttttaaag
    17341 tttgttttag cgaaagaaag acggtatgta tatttagttg taggagaaaa gaaaaacaaa
    17401 aaagtactta cacacatggt atatagattt ggttcgctag aaaaagcatt agaaaccatg
    17461 tacgaaatgc gtggtgattt tgaaaatctt ttccctctag aattaaaaga gaggggatac
    17521 gactgagaag atatcaatga ttggatactt tctattgaaa cagggtactc gaaacacgga
    17581 aataaactag tcatatacta gcaaatgttt tgtattttaa aaaataggtg aggcgaaaat
    17641 aagatgttga tcattcaaaa gtatcacatt gtaattgctt ggacgatagc tactagtgca
    17701 atgttaatta gtttgttttt tagtgaatgg atgaagctgc cgccatgtga tttttgctgg
    17761 taccaaagaa tggccatgta tccattagta ttaatatggg ggtagggata tatagaaaag
    17821 attcgcacgt aagcacgtat gcatttccat ttgcgtgtat cggtttaatg ttatctgtat
    17881 atcaaattac aattcaagcg tttcctaata gtgagatgca gatttgttca gtaggagttt
    17941 cttgcacaaa agattactta aatttattcg gtttcatctc gatacctatg ctatcttttg
    18001 ttggattttt agctatcata atacttctat atattaaatc tgagagagac aaaagaataa
    18061 acaatacagc gattatgaac aatatgctcg aataaacaaa aaatacctat aaatagataa
    18121 aaatataaag aaattaaaaa aggagaaata aaaaatgaca acaatgcaag taagtaatga
    18181 aatgtacaaa attccagagg cagatataga actattaaaa atcatggccc atccagttag
    18241 attacaaatt gtgaaggagc tagaacacca caaaatttgt aatgtaacac agttaacaga
    18301 gctattagat gttcctcaat ctaccgtatc tcagcattta tctaaaatgc gtggaaaaat
    18361 tcttcgctca gaaagaagag gattagagat gtattatcat attgtgaatt ccaaggcatg
    18421 tcagattgtc ggagtattag gtatttaatt ctaaatcgaa ataggatgat agaaagagtg
    18481 ttgttaaata tagctgcaaa agatgatgta ctgcagaatg ataaattcac aagcttaaag
    18541 tttagtcctt ctaataatgg aggagctgac tgtggtgaaa aattgatata gaggttacta
    18601 aaaaagagtg cagtacatgt ctgcattctt tttctttgtg ccatagctat aatagataaa
    18661 gtattttgtt ttgtatgact ctgaataggg gatacagtgt tttgctatgc gaaaacgata
    18721 ttttcgactt tttaagcaaa ggggataatt agtttattga tgtgtatagt atgaattaag
    18781 gtttagaata ttctgtgtca atattatcaa tttactatag tttccaatta tgtaaaaata
    18841 gaattgatta taattttccg taaatattag attgaaaact attataaggg gaatgtgagt
    18901 atttatagct gtttataaac gatgattggg gatacagaca atagggtgat caagtactgg
    18961 tagaatttat caaacaaaat gaggtgactt taacttgaga gaaattgcaa aaaaagtaaa
    19021 aatgatacgt ttacaggagg agcattccgg gcttaaggca gacgcagaac agtattcttc
    19081 caagcgatgt aaaatagaaa gagagggtat taatttagaa aaaaatagag ttaaaaaacg
    19141 aactcaaaaa tttcaaacgt cagaagaaaa atgggacata aaatgtaaaa aagcagtaca
    19201 attatttaat caaggagagg aatatccaac tattgcaaaa aatctgaggt gcaatgtgag
    19261 tagtttgtat agagaactta agaaacgggg cacattacaa acaccaaagc aggtagcagt
    19321 atctaaatca ttaaaatcac ccataacatc aacacgaaca aaaaaaacaa actttgagag
    19381 atataaagaa tattatatgt acaaatagaa gaattcatgg ctataaatct atacttaatt
    19441 ctttagtgtt aaaaagctca gattataaaa ggtacaatga aaaaatgcat gtttagcagc
    19501 aaatcttctt acagtattga tagagcatct ttttattttt taggatattt ttaaatctaa
    19561 caaatattga aggctattac ctgttgctta gatcaaaaaa atattcttaa aactaaatcc
    19621 ttacttatat ttgttgagta gttggttaag aagaggtttt tttgcaaatg ctaaaataag
    19681 gatactttgt ccaaagcaaa agaatcccca tgtcataaag gattctttta ggagagttag
    19741 agagatgttg tcacttgact catattgatt ttacgataaa aagaaagaat attcaaattt
    19801 attatatatt tctcaatata tttcttttat ttttatatta taattaattc tttttattga
    19861 tgtatatctt tctgtggtga atccttttaa taaggattcc ttttttagtg gctcatatat
    19921 taataatgag ccactagagt ttaagatagt ttatacaaca actattgaaa ttgcttgatt
    19981 ataggggaat tgttgatttc tattgctggg gatcagccct gaaaatttat ctacagtaat
    20041 aatgattaca ggtattctaa cttcgttgat tagaaaattt gttattactc tttttaaata
    20101 ttttaatctt tttaagtttc tcttatagat gtaaaaggtt tggtgtaatt ataatgtttt
    20161 taacgaattt ccggaaagaa ttctccttcc tcaagcgtgt gaagggcgta gcccaacggt
    20221 aggtgggaga tgaatttcgg tttggcgtag ccaaaaggtt ttccttttta ttttgcctct
    20281 gatataatca gtcttataaa ttataagggc tggtatataa atgaaattag atagtaataa
    20341 ccattcagta ttcttgttat attatcacct tgtgttggtc gtgaaataca gaagaaatgt
    20401 gtttgatgat gatatgtcag actatgcaaa agatatgttt gttcgactat ctgaaaacta
    20461 taacatcacg ttagttgaat ggaatcatga tgtagaccac gttcatattt tgttcaaggc
    20521 acaccctaat acagaaatga caaaattcat caatgcttat aaaagtgcaa gttctcgact
    20581 tattaaaaga gactttccac aagtgaaaaa gaaactttgg aaagagatgt tttggtcaag
    20641 aagtttttgc ttgctaacta ctggtggttc gccaatagac gtagtaaaaa catatattga
    20701 aaatcaaagt gaaaagtgag gtgaaatgat atgacaaagc agaataaagc atataaattc
    20761 cgtttgtatc caacagaaga ccaagcacat cttatgcgta aaaccttcgg ttgtgtacgt
    20821 ttcgtgtata acagaatgtt agctgaacgg aaagaagcgt atgaaaaaca taaagatgat
    20881 aaggatcaac taaagaaaca aaagcttccc actcctgcaa aatacaaagc agaatttgag
    20941 tggttaaaag aagtagattc attagctttg gcaaatgctc aactaaactt gcaaactgcc
    21001 tataaaaatt tctttcgtgg tcaaaatgac ttcccaacat tcaaaagcaa aaaagacaga
    21061 aagtcttata caacgaatgt agtgaacgga aatattatgt tgcttaacgg tcatatcaaa
    21121 ttgccaaaac tgaaaatggt acgtatcaaa cagcatagag aaataccaca agaccatata
    21181 attaagtcat gtacgatttc tatgacacct actggtaaat actatgtgtc cattttgact
    21241 gaatacgaaa aagagatcgt acaaaaagaa gtagaaacag ttgttggatt agactttgcg
    21301 atggaacaat tatacgtcag ttctgaggat gagagagcca attatcctaa gttctatcgt
    21361 gaaatgttag accgattagc
//
