LOCUS       NZ_AP021965.1          21053 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AP021965.1 Escherichia coli strain WP3-W18-CRE-03 plasmid
            pWP3-W18-CRE-03_2, complete sequence.
ACCESSION   NZ_AP021965
VERSION     NZ_AP021965.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 14:13:34
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 18003
            Orig. end    :: 39056
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21053
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11053]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11053
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..21053
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21053
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             672..1085
                     /locus_tag="ctg1_26"
                     /transl_table=11
                     /translation="MKKILMISILLLTACSSPPEPPQVEWEKTPEVMNTQIMNWKPTSG
                     VIKSDNINSLWSKVLPDFKPENRLYDDSVFYAVAHSEKIVVRTSSFDNYWSAKDWLRKN
                     GATGVIEYQPLKRWLNNDYVEIYLSRINIQRLL"
     CDS             1082..1384
                     /locus_tag="ctg1_27"
                     /transl_table=11
                     /translation="MKRICKGLIVIFTVSLFTAPTYAADPCKSVFCLYGKAVGSSGGSE
                     CSSAEKDFFKNVEKKKGKIRWGKTFDLRKNFLNQCSTADPAAISLIMSKFGRVRG"
     CDS             1485..2669
                     /locus_tag="ctg1_28"
                     /transl_table=11
                     /translation="MKVTKSIIVILLGSLGLFSGSSYASCTYHLTGNSETIDLSGCVAT
                     AENTANTASSTASNALTIAQKAQTTADTANTTAQSAQTTANEASSAAKNALNTANTAQT
                     TADAANTAAQSAQTTANEANSAAQNALNAANTAQTTADAANTAAQSAQTTANQAIQDAA
                     EKAEAAEENANNYTDNKITDAKNELNTNIDSAKNDAINSSNSYTDSKIGDTKTELNASI
                     DKAKNDAISSSNSYTDNKISDTKTELNTSIDNAKNEAISTSNNYTDKKYQQGIQYAQNA
                     ADKAEQNANNYTDNRFSQLSNQSNQRFEQLNSKIERAEKRLNAGIAGVTAISSIPYVAE
                     NSFSYGIGVGNYQNGNAIAAGIQYKTSLNTNVRLNVSWDSSHNTVLGAGFAGGW"
     CDS             2703..2930
                     /locus_tag="ctg1_29"
                     /transl_table=11
                     /translation="MKPLVYAVILSLTTFSAFAKQNSANSQKTGASNIERQSYENTDAG
                     KKQAEWMKGKLVKSDCSPAMNRIGWSEGCK"
     CDS             3010..3531
                     /locus_tag="ctg1_30"
                     /transl_table=11
                     /translation="MKIILITFIFLFTVFQSANAGGIPGVFTLNLEIQGKVIRVLDGDT
                     IEVKTLPAKIVVYEVPIRVRLINIDAPEKKQPFGRWSRNQLKALLAGQSVTVSYTQTDR
                     YGRIVGRVFTTNGTEASRFMVQSGAAWVYERYNTDKSLPALQREAQEQKRGLWADSNPV
                     PPWEWRHKQN"
     CDS             3613..4875
                     /locus_tag="ctg1_31"
                     /transl_table=11
                     /translation="MGKLTLVEQALRLHKEYYGEDNFGTVVKDCDYYPKVAEIFINRKN
                     RKIYSNLDIEPVASTVVHTGSSPVMAKAGRIKKLMFKDGSGAYRIHLGQNEVVHIIRFI
                     LNSKVRMEYAVGTTKSMSMLHNLCEAGRAKLNRSLPRKGIWKLGYYDGVYYHGKARKEE
                     IENAMRFSVHPKFDELENDFNQFFSDIDFYTRYGQSGMRKVLFTGPPGTGKTTIAKALG
                     AKYQDKYVFVYADDYFKDVCYAAAQKKIPVIIIAEEVDELYRADAGTLSFLDGADTPRN
                     VAGTYVIFSTNYPKRIDPRIRKRPGRIDRIISVGAFRTKAAAACAKMYLPEDVEIDLKE
                     LGAVLDRTTPAEIKEIINIAIGMIRGTKNELSVDVIKNARAFLKGTLDLSVQEADEDIE
                     EREELYKKNGAQPDYLSYLED"
     CDS             4879..5454
                     /locus_tag="ctg1_32"
                     /transl_table=11
                     /translation="MQYALFDGFERKFLLDALEFGVLKDWKENPVKELPDIDESAHPFH
                     VCYGGYLLNPGVSDSDISRKIKDQTGFWLAAIDDTRMDCHSIAYYDIHTLPLISCGHQK
                     IVPFTALIKADECIISKIASYSGFAVTAFLRIKDQDIATNILNREGIFAFNGCERRFRH
                     PVSEDNWQQVISEERAIRCAKRLIQCKG"
     CDS             5459..7612
                     /locus_tag="ctg1_33"
                     /transl_table=11
                     /translation="MRLFIAEKPAVANDIVKALGGNFTRHDGWFESDNAIVTNCFGHII
                     ESQPPENYNPEYKAWKVETLPLRLYPVKYQPVESAAKQVKTILELIRRGDVTEIVHAGD
                     PDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALANLKDNRDFKGLYLKALARS
                     VADAVYGFSMTRAYTIPAKARGYQGVLSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMT
                     GVFQRGADVLRANWKPGEFAPLTDRKLLDKAWADGTAASLAGKPATVEAAATDDKKTAA
                     PLPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKYKAITYNRSDCSYLSDEQFSEAPQV
                     IDALKSVFPQSLDIDSSRKSKAFNSAKVTAHTAIIPTSSVPDVNALSTDERNVYLAIAQ
                     HYLVQFMPEKAYQEVSVAIQCGDESFYARARKTTDSGFEAFLGAEITDEGESEDNDDSA
                     FELLCKIRTGETLTTKEVVVNEKKTTPLPLFTEASLLAALVRVADFVTDPTIKKLLKDK
                     DKDKKDEHGGIGTPATRAAILETLKKRNYITLEKGKLIPTDTGYALIDALPGIAVNPDM
                     TALWSEKQSAIENGDLTVEQFINELYGELTGMISDVDLGKMKIEPVAPAGQFQHLDSPC
                     PSCGKHIVIRPKGYFCTGCEFKIWSEFSGKKITQAQAEKLVKSGKTDLIKGFKKKSGGT
                     YDTVLVLEDKKTGKLGFPARAKK"
     CDS             7609..7815
                     /locus_tag="ctg1_34"
                     /transl_table=11
                     /translation="MKTKQEWLFQLRKCTSRDTLEKVIEINRYKLPLSESEAFYSAADH
                     RRAELVMNKLYDKVPSGVWKYVH"
     CDS             7831..8295
                     /locus_tag="ctg1_35"
                     /transl_table=11
                     /translation="MSELTKEDEYGIISRTMMNIRSLRVFAREIDFEQLLEMQEKLNVV
                     IEERREDAEREAAERAERERKRQELLQLIAGEGFSPEELLGLSEEAPKLRKKTLPKAPP
                     KYQFEENGETKYWSGRGRAPKPIAEALAGGRSLDEFIIKKDASSSAGDEQ"
     CDS             8350..8757
                     /locus_tag="ctg1_36"
                     /transl_table=11
                     /translation="MSLTLPLMYFQTGADLSKITHHEVHYQDGFVQQAWLQPEIQLFVV
                     CIARKKGSRREIKGGMAVLTSIPASNGAELAKALDNVMRQSDELRPLAGKDENVFIPAR
                     IGISGEEPPTEQELLSVFYQQCLKHGSWGSA"
     CDS             8965..9300
                     /locus_tag="ctg1_37"
                     /transl_table=11
                     /translation="MIAVDTEENVFIAESGNEYDGAKCWVVDDDDSHRTRYSELQQAFD
                     FYNQRLFDGELPECLITFQRVTLELFQGKFALSWFDRFPVQVEQQKEMAAVIDQWRETT
                     CSSTSKC"
     CDS             10001..11053
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_38"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 2.2e-20,
                     bitscore: 64.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 9.3e-48, bitscore: 154.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYILGRYVKIARYGSGGLVGGGGKEQYVEDLALWENIIKTAYCF
                     ITPSSYTAALETVNIPEKDFSNCFRFLKENFFIIPGEYNNSTENNRYSRNFLHYQSYGA
                     NPVLVQDKLKDAKVVILGCGGIGNHVSVILATSGIGEIILIDNDQIENTNLTRQVLFSE
                     NDVGKNKTEVIKRELLKRNSEISVSEIALNINDYTDLHKVPEADIWVVSADHPFNLINW
                     VNKYCVRANQPYINAGYVNDIAVFGPLYVPGKTGCYECQKVVADLYGSEKENIDHKIKL
                     INSRFKPATFAPVNNVAAALCAADVIKFIGKYSEPLSLNKRIGIWSDEIKIHSQNMGRS
                     PVCSVCGNRM"
     CDS             11050..12264
                     /locus_tag="ctg1_39"
                     /transl_table=11
                     /translation="MNTANILSVNYGAYNAIRMLIGVYHAAFLISTGVTISQLAVLQIV
                     FSVTVLILDFPLSVIADRFYRKQVVVSGVFFTILFYPLCIQSPDMLALVFSEIFYAIGI
                     CCISGAIEGWVLSALDGRNEKFTLCAHLCERVSSFGSVITGAVGILVVYFYDSYKSGYI
                     VSFFLMFVVFIVFLCVKTNGSGGEKEARDSIIKQAKESIGLITGSYNGTYFLSITCMFT
                     LGIQVIYHFWQPIMLSGESIGSLSKRELITLLMCHIGAFSMQYIANYLMPKIDVRCKLY
                     ILVCTLCSFLSSIACILLFMLITDNNVVLGVAIFSIIHGMISTIPVGAQNIFISRLNGN
                     YKNIISGALGLVSLSCRVASISVLGVISVLPGNMPVTTYIFISAIACVLCGCLFLMWSF
                     KKEMV"
     CDS             12261..13064
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 60.1; E-value:
                     3.7e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_40"
                     /transl_table=11
                     /translation="MTIKHVEELTEEVILNMNYPDFVALMQQDNTPPGAEYTIDYWIKH
                     GCINKKSHLLDLACSTGFSSRECFKKEGASAEGIDISESAVMVANEKAKKLKANNLLKY
                     YVADACDLPFEDNSFTHVLGGCNFAFIQNRLIALNETHRCLNHMGSMCISNFYYRRKIS
                     DKLINDVYNAINFRPNPLWTLEYWYQFFSERFTLVSEENHEMESQSEDELKADIYDYIF
                     NRNEFTKGLNGSLQNVFFERFLKIRRPLNIQRDYQGVTLQIWRKK"
     CDS             13049..14818
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264:diaminopimelate decarboxylase (Score: 134.7;
                     E-value: 4.9e-41)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_41"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 3.4e-21, bitscore:
                     67.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQKITPSKIVKHARELIIKGIESGDNSFVIFDVDGALERLEHYR
                     CQLKSFFPNSSIAYSYKSNNLAQWCQIISGKGLYAEVCSVDEMNLAKRDGFNRIVFDGP
                     LKKTSELLKAIEIGALIEVDNIDECKRLNELCKLHKLTCRIHLRLSHYYDDNLSRFGLS
                     ESEAINLLEMLISKSEYLILDGFHLHVGSNLPNAEKICKAIIQYHELILRYMPDDGTLN
                     LGSGIPADSFSASSDNPTPCPEVFFSSIYDTIKNCFGTVCDKWNYIFEPGRHLVEDFGY
                     FIGKVISTKNRYGVKVAQTNIGINWIPSIRNWDHSFTLFHNHNHISDDKSDEYIIAGFN
                     CFECDCLFPSVILPSNLSDYLFSVRGCGAYDMQTGNQWTRNLYAVYTITNDVVNISRIH
                     RRELDFRKYDVSLTPSGIKVNDEITLLYPALKYAEELYLLINQNKINFIKSMAWPAFVN
                     NISDSVSFIEQSMIDNQNEKALILFIKYKTKIAGVVSFNIIDHANKTAYIGYWLGANFQ
                     GKGIVTNAINKLIQEYGDSGIIKRFVIKCIVDNKKSNATALRCGFTLEGVLQKAEILNG
                     VSYDQNIYSKVIG"
     CDS             complement(14875..15909)
                     /locus_tag="ctg1_42"
                     /transl_table=11
                     /translation="MMIQSHPLLAAPLAVGDTIGFFSSSAPATVTAKNRFFRGVEFLQR
                     KGFKLVSGKLTGKTDFYRSGTIKERAQEFNELVYNPDITCIMSTIGGDNSNSLLPFLDY
                     DAIIANPKIIIGYSDTTALLAGIYAKTGLITFYGPALIPSFGEHPPLVDITYESFIKIL
                     TRKQSGIYTYTLPEKWSDESINWNENNILRPKKLYKNNCAFYGSGKVEGRVIGGNLNTL
                     TGIWGSEWMPEIRNGDILFIEDSRKSIATVERLFSMLKLNRVFDKVSAIILGKHELFDC
                     AGSKRRPYEVLTEVLDGKQIPVLDGFDCSHTHPMLTLPLGVKLAIDFDNKNISITEQYL
                     STEK"
     CDS             16835..17014
                     /locus_tag="ctg1_43"
                     /transl_table=11
                     /translation="MDFMSILGRCLLLPFPVAMFVGCLFLGIDDRFTGMFMSFIVGCLS
                     WYITKPKPQKAEVA"
     CDS             complement(17419..19320)
                     /locus_tag="ctg1_44"
                     /transl_table=11
                     /translation="MEIVSFKVSQYRSISGEISSDNFNGLTIVGQNNSGKTNLLKAMRV
                     FFEGKFNPDLYDYEKDKPHGVKQGQTSFAVRFTFSESELDDVSEDLSQDDDDDDDDSII
                     ELGVLGEQEEPSNSISFDDGSSKQQESKPTQSRGRKLSLRDRYLQLFNMIDDSRLSSPQ
                     NEVTVHLTISNKNNYFYTVFKGYKRKPEVTSSMYTSVERRFIEKILSSFECVYIPSSKS
                     IDDIYHNLLVPYVRSEVASAMKTSVQVIHDKLLEVSEKITNEMILSGIDDCSFMIKAPP
                     SLDELFGRFEVSIKDTIENVISSKGMGLQCLSLFSSFKSISERKLTLGKKTIWMVEEPE
                     SFLHPSLGRSCNHIFKSLMDVAYVLITTHSLSFVSDEPSKIIELYKDDAGVTKDKKHEK
                     RFNAVASIRENLGVRFSDFFNISSSAVFVEGITDKQYIESILKLTSEHDEFKNRWPFLR
                     SAKVDEFGGVSQLGGFLKGCYEFISKDVPVISVFDGDEAGVKERTRLQSYFGKKQIRFE
                     SNKDYISVRSGFAIEGLFPDDFISDAMETHPSWFIGGKSVDADDVIEPFKVQDNKKTNL
                     LNFFLERCRVQPICGWISRWEKVFNVIDSALRDKSESITNKKRTEDTSGNTSDHQAA"
     CDS             complement(19426..19935)
                     /locus_tag="ctg1_45"
                     /transl_table=11
                     /translation="MATEWVDVADNAVKIGLGALITIVGGWITLKLTHCHEIRKDAIAQ
                     RLRDIDKKTDRYIDFLSSSQTLMQKYLYESCNPGSEDYTNYMRLHNIVSLTSSPELRIY
                     AFDTQSKVSQFILLRKPNEPEVIDSCRNAARNAVSVLQGAVSAELLQDKAALQDKQHAW
                     WAFWRK"
     CDS             complement(20027..20638)
                     /locus_tag="ctg1_46"
                     /transl_table=11
                     /translation="MSGRITTLCTAFGVVIAAVGLYLPYKNELNAALYQREFLTGKWST
                     EAEYIINSGDLGLDKPQSIMTIQLFVDKDGSIDGEFISEGLCDAMPLTWNITFNSDSPS
                     LINFIFARKFQIRQLVNGAMDKSPVVATLKLVDEDHKHNSIVFDVVNDSTGTLPKQITL
                     AKNLPKFEENYKYLQSYCANSTEKMYEKMMPEIRNLNKGL"
ORIGIN
        1 gattttctga acctgttttt caacttcgtt gttgaagtga cattgcgtga aaatcctgat
       61 tttgatccca ccctgaaaca tgactgcctg atgtttcttg atgagttccc ttcgattggt
      121 tatatgccaa ttattaaaaa ggggtcaggg tatattgcag gttttaaact taaactgctg
      181 acgatttatc agaatatcag tcagctaaat gaaatctatg gtattgaggg agccaaaacg
      241 ctgatgagtg ctcatccatg ccgtattatc tatgctgtca gcgaagagga tgatgccgcg
      301 aagatatcag aaaaacttgg gtatattaca accacatcaa agagcacaag caagagccgg
      361 ggacgatcag cttcacaggg cgaatcagaa agtgaagccc gaagagcact ggtgcttcca
      421 caggagctgg gaacgctgga ctttaaagaa gaatttatca tcctgaaggg ggagaaccct
      481 gttaaagcag aaaaggcact ttattacctt gatccgtatt ttatggacag gttaatgaag
      541 gtcagtccta aactggcatc attgacgatg gaactaaata agacgaaaaa aatatttggt
      601 gtgaaagggc ttaaatatcc gtcaaaagaa aaaatgctct ccgtagggga gctggagtct
      661 gaggttttgc tatgaaaaaa atacttatga tcagtattct tctcctcaca gcctgttcct
      721 ctccacctga accgccacag gttgaatggg aaaaaacgcc tgaagttatg aatacacaaa
      781 taatgaactg gaaaccaaca tccggtgtta ttaaatcaga taatataaat tccttatgga
      841 gtaaggtgtt gcctgatttt aaaccagaaa accgtcttta cgatgattct gttttttatg
      901 ccgttgccca ttctgaaaaa atagttgtaa ggacatcttc ttttgataat tactggtcag
      961 cgaaagactg gctaagaaaa aatggtgcaa caggtgttat tgaatatcag ccactaaaaa
     1021 gatggttgaa taatgactat gttgaaattt atctgtcaag aataaatatt cagaggttac
     1081 tatgaaaagg atatgcaaag gtctaatcgt aatttttact gtgtccttgt ttacagcgcc
     1141 aacgtatgcc gctgatccct gtaaatccgt tttttgtctt tatggtaaag ctgtcggtag
     1201 tagtggaggg agtgagtgca gtagtgcaga aaaggatttt tttaaaaatg ttgaaaagaa
     1261 aaaggggaaa atccgctggg gtaaaacatt tgatctccgt aagaattttt taaatcagtg
     1321 ttcaactgca gacccggctg caatctcact gatcatgagt aagtttggtc gcgtcagagg
     1381 ctgattaaaa cctgataccc gcgccaacgg gtatcaggtg actgcaagta tcacatgccg
     1441 cgtcaacgga atgtgattat tagttacaat caaaggtgtc aaaaatgaaa gtaaccaagt
     1501 ctattatagt tattttattg ggttcactgg gactgttttc tggtagctca tatgcatcat
     1561 gcacctatca tctgactggt aattctgaaa ccattgacct ttcaggatgt gttgcgactg
     1621 ccgaaaatac cgcaaataca gccagctcaa ctgcatcgaa cgcattaaca atcgcgcaaa
     1681 aggcacaaac tacagcggat actgcaaaca ccactgcaca atccgcacag acgaccgcaa
     1741 atgaggccag ttcagcggca aagaacgccc tgaacacagc taatacggca caaactacag
     1801 cggatgctgc aaacactgct gcacagtcgg cgcagacaac agcaaatgag gctaattcag
     1861 cggcacagaa cgccctgaat gcagctaata cggcacaaac tacagcggat gctgcaaata
     1921 ctgccgcaca gtcagcgcag acaaccgcca accaggcaat ccaggatgcg gcagaaaaag
     1981 ctgaagcggc agaagagaac gcaaacaact atacagacaa taaaattacg gatgctaaaa
     2041 atgaactgaa tacgaatatt gatagtgcga aaaatgacgc gatcaattca tcgaacagtt
     2101 acactgacag caaaataggt gacacgaaga cagaactgaa cgccagtatc gataaggcaa
     2161 agaacgacgc gatcagctca tcaaatagct acaccgacaa taaaatcagt gatacgaaaa
     2221 cagaactgaa taccagtatc gacaatgcaa aaaatgaggc aatcagcaca tcaaacaact
     2281 atacggataa gaaatatcaa caaggtatac agtatgctca gaatgcagcc gataaagctg
     2341 aacaaaatgc gaataactac acagataacc ggttcagtca gttaagcaat caatcaaatc
     2401 agcggttcga acaattaaac agtaaaattg aacgtgcgga aaaacgtctt aatgccggta
     2461 ttgcaggtgt aacagcaata tcatcaatcc cgtatgttgc tgaaaatagt ttctcatatg
     2521 gtattggtgt tggtaattat cagaatggaa atgcgattgc agcaggcatt caatataaaa
     2581 cgtcattaaa cacaaacgtg cgtcttaacg tttcatggga ttcatctcat aacactgttc
     2641 ttggcgcagg ttttgcgggt ggctggtaat aaacatatct acatatgtga aaggagataa
     2701 aaatgaaacc attagtttat gcagtaattc tgtcactgac gaccttttct gcttttgcaa
     2761 aacagaactc ggctaacagt cagaaaactg gtgcaagtaa tattgaaaga caaagctatg
     2821 agaataccga tgcggggaaa aaacaagctg aatggatgaa aggtaaatta gttaaatctg
     2881 attgttctcc agccatgaac cgtattggct ggtcagaagg ttgtaagtaa tcatcaatga
     2941 taacctcgca gattccagat tttaatctgg attttgcggg gttgaacaac cgaagggcgt
     3001 tagtatttta tgaaaattat attaataaca tttatttttc tgtttactgt ttttcagtct
     3061 gcaaatgcag gtggaatacc tggtgttttc acattaaacc tggaaattca ggggaaagtt
     3121 attcgcgttc tcgatggcga caccatagaa gttaaaacac tacccgcaaa aattgttgtg
     3181 tatgaagttc cgattcgggt ccgattgata aacatcgatg cccctgaaaa gaaacaacct
     3241 tttggacgct ggtcaagaaa tcaacttaaa gccttgctcg ccggacaatc cgttactgtc
     3301 tcttatacgc aaacagatcg ctacggccgc attgtcggtc gcgtgttcac gacgaacggc
     3361 acggaggcca gccgcttcat ggttcagtct ggcgctgcgt gggtatatga acgttacaac
     3421 acagataaat cattaccagc tctgcaacgg gaagcgcagg aacaaaaacg aggtttatgg
     3481 gctgacagta atccggttcc accgtgggaa tggcgacata aacagaactg acgcgcgttg
     3541 cttgtccaac ccctccacta ccttaaataa atttcaggca gtgtcacggt tttaaatata
     3601 catggtgcgc ttatgggtaa attaactctg gtagagcagg ctttacggct tcacaaagaa
     3661 tattacggtg aagataattt tggaactgtc gtaaaggatt gtgattacta tcctaaagtg
     3721 gcagagattt ttataaacag aaagaaccgt aaaatttatt cgaatctgga tatcgaacct
     3781 gttgcttcaa ccgttgttca tacgggaagt agccctgtta tggctaaagc cgggagaatt
     3841 aaaaaactta tgttcaaaga tggttctggt gcatacagga ttcatcttgg tcaaaatgaa
     3901 gttgttcata ttattcgctt cattcttaac tctaaagtca ggatggagta cgccgttggg
     3961 actactaaaa gtatgtcaat gctccacaat ctttgcgagg caggtcgcgc taaattaaac
     4021 cgctcattac cacgtaaagg tatctggaaa cttgggtact atgatggtgt ttattatcac
     4081 ggtaaggcaa gaaaggagga aattgaaaat gctatgcgtt tctcagttca tccaaaattt
     4141 gacgagctgg aaaacgactt taatcagttc ttttctgata ttgatttcta tacccggtat
     4201 ggtcagtcag gtatgcgtaa agtgctcttt actggccccc caggaacagg caagacaact
     4261 atcgcaaaag ctttgggggc aaagtatcag gataagtatg tttttgttta tgccgacgat
     4321 tactttaaag atgtttgcta cgctgctgct cagaagaaaa tacccgtcat tattatagct
     4381 gaagaggttg atgaacttta tcgggctgat gccggaacgt taagttttct tgatggagct
     4441 gatacaccgc gaaatgtcgc aggaacatat gtgatctttt ctacaaacta tccaaaacgt
     4501 atcgacccac gtattagaaa acgtccaggt cgaattgaca ggataatctc tgtaggtgct
     4561 ttcagaacca aagccgctgc cgcttgcgcc aaaatgtact taccagaaga tgtagaaatt
     4621 gaccttaaag agcttggcgc agtgctggac agaacgactc cggctgaaat caaggaaatt
     4681 attaatatcg caatcggaat gattcgcgga accaaaaatg aattatcagt ggatgtaata
     4741 aaaaatgctc gtgccttttt gaaaggaacc cttgatctga gcgtgcagga agcagatgaa
     4801 gatatagagg aaagggaaga gctttataaa aagaacgggg cgcaacctga ctatttaagt
     4861 tacctggagg attaacacat gcaatatgca ttgtttgatg gatttgaacg aaagtttttg
     4921 ctggatgctc ttgaatttgg tgttctgaaa gactggaaag aaaatccggt aaaagaactt
     4981 cctgatattg atgaatctgc tcaccccttc catgtctgtt atggtggata tttattaaac
     5041 cctggtgtgt cagattctga tattagcaga aaaataaaag accagacagg attctggctg
     5101 gcagctattg atgatacccg tatggattgt cattcaatag cttattatga tattcacacc
     5161 ctccctttaa tttcgtgtgg tcatcagaag atagttcctt ttacagcgtt aataaaagct
     5221 gatgaatgca tcatttcaaa aattgcttcg tattctggtt ttgccgtaac agcctttttg
     5281 agaattaaag accaggatat cgcaacgaat atacttaacc gtgaggggat ttttgctttt
     5341 aatggctgtg aacgcagatt cagacatcca gtaagtgaag ataactggca acaggtaata
     5401 tcagaagaac gtgctatccg ttgtgcaaaa agattaattc aatgtaaagg ataacaaaat
     5461 gagacttttt atcgcagaaa aacccgcagt agcaaatgat attgttaagg cacttggtgg
     5521 caattttacc cgccatgatg gctggtttga aagtgataac gccattgtga cgaactgttt
     5581 tggtcatatt atcgaatcac aaccgccgga aaactataat cctgaataca aagcctggaa
     5641 ggttgaaacg cttcctttac gtctttatcc cgtgaagtat cagcctgttg aaagtgcagc
     5701 aaaacaggtt aaaacgattc tcgaacttat cagacgtgga gacgtgactg aaattgttca
     5761 cgctggcgat cctgatgatg agggacagct acttgttgat gaagtcctgg aatatgcagg
     5821 aaacacaaaa cccgtgaagc gcgttctgat aaacgacaac acgcttccgg cagtgaaaaa
     5881 ggcactggca aatcttaaag ataatcgtga tttcaaaggg ctttacctta aggcgctggc
     5941 gcgttcagtt gccgatgccg tctatggatt ctccatgacg cgtgcttaca ccattcctgc
     6001 aaaagccaga ggatatcagg gcgttctgtc tgtcgggcgc gtccagacac ccgttcttgg
     6061 cctgattgtg aatcgtaccc gtgctaacca gaaccataaa tccagttttt actacaccat
     6121 gaccggagtt tttcagcgtg gtgctgatgt tctcagggcg aactggaaac caggtgaatt
     6181 tgctccgctg accgaccgta aattacttga taaggcgtgg gcagacggaa cggcagcatc
     6241 ccttgcagga aaaccggcta cagttgaagc agcagcaact gatgataaaa aaacggctgc
     6301 gccgttgccg tttaacctgg tcagactcca gcaatacatg aacaagaagt ttaaaatgac
     6361 ggcacaaaaa acgctggata ttacgcaaca actacgtgaa aaatataaag caattactta
     6421 taaccgctca gattgctcat atctttctga tgaacaattc agtgaagcgc cgcaggttat
     6481 cgatgccctg aaatcagtct ttcctcagtc gctggatatt gattcttcac gtaaaagcaa
     6541 agcgtttaac agtgcaaagg tgactgcgca tactgcgata atcccgacct ccagtgtgcc
     6601 tgatgttaac gcactcagca ccgacgagcg caatgtttac ctggcgatcg cacaacacta
     6661 tcttgttcag ttcatgcctg aaaaagcata ccaggaagta tcggttgcca ttcagtgtgg
     6721 tgatgagtcg ttctatgccc gtgccagaaa aacaactgac agcggatttg aggcgtttct
     6781 tggcgcggaa atcacagacg aaggtgaatc agaagataat gatgattccg cttttgaact
     6841 gctctgtaaa attcgcacag gagaaacact gacgacaaaa gaagttgttg ttaatgagaa
     6901 gaaaacaaca ccgctgccgt tattcaccga agcctccttg cttgctgcgc ttgttcgtgt
     6961 cgcggatttt gtcactgatc caacgattaa aaaattactg aaagataagg ataaagacaa
     7021 aaaagatgaa catggcggta ttggtacgcc agctacccgt gcagccattc tggaaacgct
     7081 gaagaagaga aactatatca cgctggaaaa agggaaactt attccgactg ataccggata
     7141 tgcgcttatt gatgccctgc caggtatagc ggttaatcct gatatgacag cattatggtc
     7201 tgaaaaacag tctgccattg aaaatggcga cctgacggtt gaacagttta ttaatgagct
     7261 gtacggtgaa ctgacaggca tgatttctga tgttgacctg ggcaagatga agattgaacc
     7321 cgttgcgcca gcagggcagt ttcaacacct ggactctccc tgcccttcct gtggtaaaca
     7381 tattgttatc aggccgaaag gttatttctg taccggatgt gaatttaaaa tctggagtga
     7441 gttttctggt aagaaaatca cccaggcaca ggccgaaaaa ctggttaaat cagggaaaac
     7501 cgatttgatt aagggattta aaaagaaaag tggtggaacg tatgatacag ttcttgtcct
     7561 tgaggataag aaaacaggga agctgggttt tccggcaagg gctaagaagt gaaaacaaag
     7621 caggaatggc tttttcagtt aagaaaatgt acatcaagag atactcttga aaaagttatt
     7681 gagattaacc gttacaagct gcctttatca gaatcagagg cattttattc tgccgcagat
     7741 caccgccgtg cagaactggt gatgaataaa ctttatgata aggttccttc cggcgtatgg
     7801 aagtacgtcc attaaacaag aggattaatt atgagcgaac tgactaaaga agatgaatac
     7861 ggcattatca gccggactat gatgaatatt cgttcattgc gtgtgtttgc ccgtgagatt
     7921 gattttgagc agttgctcga aatgcaggaa aagctcaacg ttgttattga agaacgtcgt
     7981 gaagatgctg aacgtgaagc ggctgaacga gcagagcgtg aacggaaacg tcaggaactg
     8041 cttcagttaa tcgccggaga gggtttctca ccggaagaac tgcttggtct gtccgaagaa
     8101 gcaccaaaat tacgtaaaaa aacgttacca aaagcgccac ccaagtatca atttgaagaa
     8161 aatggtgaaa cgaaatactg gtctggtcgt ggacgtgcgc caaaaccgat agctgaagca
     8221 ctggcaggcg gtcgctctct tgatgagttt atcatcaaaa aagatgcttc cagctctgct
     8281 ggcgacgaac agtaatataa taagcttctg gtttacgcag gagacttttt tgataaacag
     8341 gaggatgttt tgagtctgac attaccatta atgtatttcc agacaggtgc agatctcagc
     8401 aaaatcacac atcatgaagt gcactatcag gacggctttg ttcagcaggc atggttgcaa
     8461 cctgaaatac agctatttgt tgtgtgtatc gccaggaaaa aaggctcccg tcgcgagatt
     8521 aaaggtggaa tggccgttct taccagtatt ccggccagca atggagcgga gttggcaaaa
     8581 gcgttggata acgttatgcg ccagtctgat gagttgcggc cactggcagg gaaagacgaa
     8641 aacgtattta tcccagccag aattggaatt tctggcgaag aaccgccaac agagcaagag
     8701 cttctaagtg tcttttacca gcaatgcctg aaacatggct catggggcag tgcctgattt
     8761 ctggtacata aagcagggat accccctgct tacctttctt gccagcaata ttacgcgctc
     8821 gatgctcttc ctaggcttga tattgccagg gtatggcgtc agcacaaccc ggagcacgca
     8881 gattcgggtg tgattctgat ttgggacggg aaggtgtatt gctggaaaaa tattctccgc
     8941 gcccctcagc atgagcgccc cagagtgata gcggtagata ctgaagagaa cgtgtttatt
     9001 gcagaaagtg gcaatgaata tgacggcgcg aaatgctggg ttgtcgatga tgacgatagc
     9061 cacagaacgc gctacagcga gctacaacag gcatttgatt tctataacca gcgccttttt
     9121 gacggtgaac tccccgagtg tctgattacg ttccagcgcg tcacactgga actgtttcag
     9181 ggtaaatttg ctttgagctg gtttgatcgc ttccctgtcc aggttgaaca acaaaaagag
     9241 atggccgccg tcatcgatca atggcgggaa actacttgct caagcacatc aaaatgctga
     9301 accgggattg atatcgaagc cggtgctgtc agtgtcaccg tagaacggga gcaatgataa
     9361 cgatctgttt gttgcggctt ttgaggacaa gctaaaaagg aacaaagtca aatatcagtg
     9421 tcggggtgtg gtgctgctgt ctgggggaag tccggagtga atattgaatg cggtgattgc
     9481 gagctgcctt tcatcgaaaa ttaatctcca ttttcgtggc atttcctgat tctttctcat
     9541 aaattctcgt gtccaatccg acccgaaaaa cctcagattt cacgtagcgc accaccgctc
     9601 attgagtggc ttctcaacgt gactggtaat caggattatt ggtttctaat gtaatgaacg
     9661 atggatgtat caaattttat tacaaaatgg tttaaacgta gatgattata ttctgtatgg
     9721 ttatttatgt ctaaatatat aaattaataa attttagaat aaaaatgtat aaccgcaaat
     9781 aatatgattg tgctgttctt tttttgtgaa atgaatctat gtttgtatat tttcatgagg
     9841 aatattgttt tttatagtga taaaaacact tgtgaattaa tcacagtaat aggaggcgta
     9901 gaatgcgtac tggtaatgca aactaatggc aaaatataaa tgtccattaa atgccaccct
     9961 gtacagggtg gcatacaaaa tttatctgcg aggtttattt atggattata tattgggtcg
    10021 ctatgtcaaa attgctcgat acgggagcgg tggattagtt ggtggaggcg gaaaggagca
    10081 atatgttgag gatttagcgc tttgggaaaa tattataaaa accgcatatt gtttcataac
    10141 cccatcgagt tatactgcag cgttggaaac tgtcaatata cctgaaaaag atttctctaa
    10201 ttgctttagg ttccttaagg aaaatttctt tattatacct ggtgagtata ataactctac
    10261 tgagaataat cgttactctc gtaacttttt acattatcaa agttatggtg ctaaccctgt
    10321 tcttgtgcaa gataaactaa aagatgctaa ggtagtaatt cttggttgtg ggggtatagg
    10381 aaatcatgta tctgttatac tcgcaacgtc tggtattggc gaaattatac taattgataa
    10441 tgatcaaata gaaaatacaa atttgacaag gcaggtttta ttttcagaga atgatgtcgg
    10501 taaaaataaa acagaagtta taaaacgcga gttattaaaa agaaactctg aaatttcggt
    10561 gtctgagatc gctttgaata taaacgatta cactgatctt cataaggtac cagaagctga
    10621 tatatgggtt gtttctgcag atcatccatt taatctgatc aactgggtta ataaatattg
    10681 cgttagagca aatcagccct atataaatgc tgggtatgtt aatgatattg cagtctttgg
    10741 tccattatat gttcctggta aaacaggatg ttatgagtgc caaaaagtcg tggcagatct
    10801 atatggttca gaaaaggaaa acattgatca taagattaag ctaatcaata gcagatttaa
    10861 accagcaaca tttgcacctg tgaataatgt tgccgctgca ttatgtgcgg cagacgtaat
    10921 taagttcatt ggaaaatact ccgagccatt atcacttaat aaaagaatag gcatctggtc
    10981 agatgaaata aaaatacatt cccaaaatat gggccgttcg cctgtttgct ctgtgtgtgg
    11041 aaatagaatg tgaatactgc aaatatttta tctgtgaact atggagctta taatgctata
    11101 cgtatgttaa ttggtgtcta ccatgcagca tttcttatat ctacaggtgt cactatatct
    11161 caacttgctg ttttacagat cgttttttct gtgacagtgc tgattcttga ttttccttta
    11221 tctgtcattg cagacagatt ttacaggaaa caggttgtag ttagtggcgt attttttact
    11281 attttatttt accctctttg tattcagtct cctgatatgc tggcattggt tttttctgaa
    11341 atattttatg ccattggtat ttgttgtata tctggggcta tagagggatg ggtgttaagt
    11401 gctctggatg gtagaaatga aaaatttacc ttatgtgctc atttatgcga aagggtatct
    11461 tcctttggga gtgtgataac tggtgctgtt ggaatattag ttgtctactt ctatgattct
    11521 tataaatctg gctatatagt atcgttcttc ttgatgtttg ttgtctttat cgttttttta
    11581 tgtgtaaaaa ctaacggcag tgggggtgaa aaagaagcac gagatagtat tattaaacaa
    11641 gcaaaagaga gtattggatt gataacagga agttataatg ggacatattt tttatctata
    11701 acatgtatgt ttacacttgg tatacaggta atttatcatt tttggcagcc aattatgtta
    11761 tctggggaaa gtattggctc attatcaaaa agagagctta taactttact gatgtgtcat
    11821 attggtgcat tttcaatgca atatatagca aactatctta tgccaaagat agatgtaagg
    11881 tgtaaacttt atatacttgt ttgtacatta tgttcatttc ttagttcaat cgcctgtatt
    11941 ttactattta tgttaataac agataataat gttgttctcg gtgtagctat tttctctata
    12001 atccatggga tgatttcaac aatacctgtt ggagcacaga atatattcat aagcagactt
    12061 aatggcaatt ataagaatat tatttcggga gctcttggtc ttgtttctct ttcatgtcgt
    12121 gttgcttcca tttctgtgtt gggagttata tctgtattac caggtaatat gcctgtcacc
    12181 acttatatat ttatctctgc aattgcatgt gtactgtgtg gttgtttgtt cttaatgtgg
    12241 tcctttaaaa aggagatggt atgacgatta aacatgttga agaattgacg gaagaagtca
    12301 ttttaaatat gaattaccct gattttgttg ctctgatgca acaggataac actcctcctg
    12361 gagcagagta caccatagac tactggatta agcatggatg tattaacaaa aagtctcacc
    12421 tattagattt agcatgttcc acgggtttta gttcacgtga atgcttcaaa aaagaaggtg
    12481 catctgcaga gggtattgat atatctgaat cagctgtaat ggtcgcaaat gaaaaggcaa
    12541 aaaagcttaa ggctaataat ttattgaaat attatgtagc tgatgcttgt gatttaccat
    12601 ttgaagataa ctcttttaca catgttctcg gtggatgtaa ttttgcattt atacaaaatc
    12661 ggttaatagc tttgaatgaa actcatcgat gtttaaacca catgggaagc atgtgcattt
    12721 caaattttta ttacaggcgt aaaatatcag ataaacttat caatgatgta tataatgcaa
    12781 taaatttcag acccaatcct ttgtggactt tggaatactg gtatcagttt ttttctgaaa
    12841 gatttactct ggtttcagaa gaaaatcatg agatggaatc tcaaagtgaa gatgagttaa
    12901 aagccgatat ttatgattac attttcaata gaaatgagtt tacaaaaggt ttgaatggtt
    12961 cacttcagaa tgtatttttt gaaagatttt taaaaatacg cagaccatta aatatccaaa
    13021 gagattatca gggagttaca ttgcaaatat ggcgcaaaaa ataacaccat ctaaaattgt
    13081 taaacatgcc cgggagttaa ttattaaggg gattgaatcg ggtgataact catttgtcat
    13141 ttttgatgta gatggagctc tggagcgtct ggaacattac aggtgtcaac ttaagagttt
    13201 tttccccaac agcagtatcg catattcata taagtcaaat aatctggcac aatggtgcca
    13261 gattatctca ggtaaaggtt tgtatgcaga ggtgtgctct gttgatgaaa tgaacctcgc
    13321 taaaagagac ggttttaacc ggattgtttt tgatggccct ttaaaaaaaa cgagtgaact
    13381 attaaaggca atagagattg gggcattaat tgaagttgac aatattgatg aatgtaaaag
    13441 acttaatgaa ctatgtaaat tgcataagtt gacatgtaga attcatttga gattatcgca
    13501 ttactatgat gataatttat caagatttgg cttatctgaa agtgaggcta ttaatttact
    13561 ggagatgttg atcagtaagt cagagtatct cattttagac gggttccatt tacatgttgg
    13621 ctctaatcta cccaatgcgg aaaaaatatg taaagctatt atacagtatc atgagttgat
    13681 tcttaggtat atgccagatg atggcactct taatcttggt agtgggatac ctgcagattc
    13741 tttctcagca tccagtgata acccaactcc atgtccggag gtatttttct catcgatata
    13801 tgatacaata aaaaattgct tcggtactgt atgtgataaa tggaactata tttttgaacc
    13861 agggagacat ctggtcgaag actttggcta ctttataggg aaagttatta gtactaaaaa
    13921 caggtatggt gttaaagttg ctcaaactaa cattggtata aactggatac cttcgatcag
    13981 aaattgggac cattcattta cattgtttca taatcataac catatttcag atgataaatc
    14041 tgatgagtat attattgctg gattcaattg ctttgaatgt gattgcttgt ttccttcagt
    14101 tattcttccc agtaacttat ctgattattt attttctgtt cgagggtgtg gtgcttatga
    14161 tatgcaaaca ggaaaccagt ggacgcgtaa tctttatgct gtatatacca taacaaatga
    14221 tgttgttaat atatcaagga ttcacagaag agaacttgat ttccggaagt atgatgtatc
    14281 tcttacgcca tcaggaataa aagtaaatga tgagattaca ttattgtatc cagcgttaaa
    14341 atacgctgaa gagttatatt tgctcattaa tcaaaacaaa ataaatttca ttaaaagcat
    14401 ggcatggcca gcgtttgtta ataacatttc tgattctgtt tctttcattg agcaatcaat
    14461 gattgataac cagaatgaaa aagcattaat cctctttatt aaatacaaaa ctaagatagc
    14521 tggcgttgta tcgtttaata ttattgacca tgccaataaa acagcatata ttggctattg
    14581 gttaggcgct aactttcagg gaaaggggat tgtaaccaat gctataaata aactgataca
    14641 ggagtatggg gattcgggca ttataaaaag atttgttata aaatgtattg ttgataataa
    14701 aaaaagtaat gccacggcat tgaggtgtgg cttcacctta gaaggtgttc tgcaaaaagc
    14761 agaaatactc aacggtgtat catacgatca aaatatttat tcaaaagtaa ttggttaata
    14821 ctgtatggcg tagtattcta cgccattttg tttatgtctg tgagatgata atatttattt
    14881 ctcggtagat agatattgtt ctgttataga tatatttttg ttgtcaaagt caatagctaa
    14941 ttttacacca agtggaagag ttagcattgg atgtgtatgt gaacaatcaa atccatccag
    15001 tacaggaatc tgtttcccat ctaatacctc tgttaatact tcatatggtc tgcgtttact
    15061 tcctgcacaa tcaaaaagct catgtttccc gagtattatt gcactaactt tatcaaacac
    15121 gcgattaagc tttagcatag agaataatcg ttcaactgtt gcaatgcttt tccgactgtc
    15181 ctcaataaac aatatatctc cattccgaat ttcaggcatc cattcactcc cccatatacc
    15241 tgtcaaagta tttagatttc ctccaattac acgcccctca acttttccgg aaccataaaa
    15301 ggcacagttg tttttatata gtttcttagg ccttaatata ttgttttcat tccagtttat
    15361 gctctcatca ctccactttt caggtaatgt gtaggtatat attcctgatt gttttcttgt
    15421 tagtatttta ataaatgatt catatgttat atccacaaga ggtggatgtt caccaaacga
    15481 aggaataaga gctggtccat agaatgttat taaccctgtt tttgcatata ttcctgctaa
    15541 taaagcagtt gtatctgagt aacctatgat aattttgggg tttgcaatga tagcatcata
    15601 gtccagaaac ggtagtagtg aattactgtt atctccaccg atcgttgaca ttatacaggt
    15661 aatatcagga ttgtagacta actcattaaa ttcttgagct ctttctttaa tagtacctga
    15721 acgataaaaa tctgttttac cggtaagctt ccctgatacc agcttaaatc cctttctctg
    15781 aagaaactca actccccgaa aaaaacgatt ttttgcagta actgttgccg gagcagatga
    15841 tgaaaagaaa ccaattgtat ctcctactgc caggggagcg gccagtagtg gatgagattg
    15901 tatcatcatg aggatttttc ctttccattt agtgtcaaaa tgaacccgtt ttgagatatg
    15961 tcagtagcac tttcagttta tgggcttttt ttgaaaatcg cagtgttctc tcgtaaattt
    16021 tctcgtccaa tcccccccga aaagcctcag atttcacgta gcgcaccgcc actactgtat
    16081 ccatcaaaaa aactgatagc ttttttaatc atctgttgtg ctgcaactta ctgaaaaaat
    16141 ggattcatga aaacgccgat aacggcattg atctgttggc caacgcgatc agcagtattg
    16201 gccgcaacaa aaaatgaaag aaaaatccct caaatgaagg ggaaaaaacg gaagtacagc
    16261 cggacgacag gcacaaaaaa acccgactgg taatcgggct tttttgtgtt ttccagccct
    16321 gagttggtgg ctctgactgg agaaggttac tctacaccta acgtttacat tttattcact
    16381 atggtgctgt aaagcaacta aatgtggtta aggaaccaca tttagtggtg taacgggtgt
    16441 tttgtgtagc gtataatcag tcagttagtc atgtagttga cttgcaatcc tgctcttccc
    16501 gtatctgcgg gtatgaacga ttttaaagtc ctggctggat aaacaggtgg tgctgtattc
    16561 ggtgctctgg caggaggagg tcactctaca cctaacaatg cgagagagcc gttgtgacag
    16621 gcagtgtatg agtaagcaac ggtgatttcc tccagtttta ctggagaaac ggatgattaa
    16681 tttgttaatc atcgttctca gggctgtggt cgccgttgca aacgcgctga ttgcaattct
    16741 ggaactgatt cgccagttca tcgactgatg acagcggaaa cgtaactaag ggcaggaagt
    16801 gaaccgcttc ctgcccttta acaaaggagg atttatggat tttatgagca ttttggggcg
    16861 ctgtttactt cttcctttcc ctgttgcgat gtttgtcggt tgcctgtttc taggcattga
    16921 tgatcgtttt actggaatgt tcatgagttt tattgtcggt tgtctatcgt ggtatatcac
    16981 caagccaaaa ccgcaaaagg ctgaggtcgc gtaagcggcc ttttttacgc ccctcgttta
    17041 attcctcgcc cgacttggat atacactcat tctgtccaga aatagtattg cggctaatca
    17101 agccaattcc tacgtctttt cgctgttgca cgatctaaaa gaaaatatgg gaaaatttca
    17161 tgaaagtatg gtactaaagg gtctttaatt cctttatctt gttccttcaa ctgcacagta
    17221 tctcgtaaaa accaacaagc cggttgttta aaaaacgctc ttagcgtagg atgttttcca
    17281 ttttccaagt gaaacccaag tacgatgccc gcgaaaaaga cagccctctt atgaagaggg
    17341 ctgttatctg atataggctt gttatggtct cactcttgat taatcaggtg tatgtgcaac
    17401 cttggtgtac acaatcgatt atgcagcttg atgatctgaa gtgttaccgg aagtatcttc
    17461 ggttcgtttt ttgtttgtga tggattcact tttatctcgc aaggctgagt ctatgacgtt
    17521 aaacaccttt tcccaccgag aaatccaacc gcatataggt tgaacacgac atctttccag
    17581 gaagaaattt aataagttag tttttttatt atcttgcact ttgaatggtt caattacatc
    17641 atcggcatca acagattttc ctccgatgaa ccacgacgga tgggtttcca ttgcgtcaga
    17701 aatgaaatcg tcagggaaga ggccttcaat agcaaaacca cttcttacag aaatatagtc
    17761 tttatttgac tcaaatctaa tttgtttttt accaaagtag ctttgtaatc tggttctttc
    17821 tttgacccca gcttcatcac cgtcaaaaac agatattacg gggacatctt tagaaataaa
    17881 ctcgtagcac cctttcaaga atcctccaag ttgactgact ccaccaaact catcaacttt
    17941 agcactcctc agaaaaggcc atctgttctt aaactcatca tgttcagatg tcaatttcaa
    18001 tattgattct atatattgtt tgtcggtgat accttcaacg aaaactgcac tacttgatat
    18061 gttaaagaaa tcagaaaatc tgaccccaag attttctctt atgcttgcaa ctgcattaaa
    18121 tcttttttca tgctttttgt cttttgtaac accggcgtca tctttatata actcaatgat
    18181 cttacttggc tcatcactga caaatgataa ggaatgagtt gtaataagaa cataagcaac
    18241 atccatcagt gatttgaaaa tgtgattaca tgaccggcct aatgagggat gcaagaaaga
    18301 ctcaggctcc tcaaccatcc aaatcgtttt cttacctaga gtaagttttc tctctgaaat
    18361 agatttaaat gaagaaaata aagataagca ttgtagcccc atacctttac tcgatatcac
    18421 attctcaata gtatctttta ttgaaacctc aaagcgacca aataactcat caagagatgg
    18481 cggagcttta atcataaagc tacagtcatc tataccgctt agaatcattt catttgttat
    18541 cttttcagaa acttccaaca gtttatcatg aatcacttga accgatgttt tcatggctga
    18601 agctacttca ctcctaacat atggaactaa tagattatga tatatatcat caatactttt
    18661 tgacgatggt atatacacac actcaaaact agaaagtatt ttttctatga accttctttc
    18721 aacagatgta tacatggagg aagttacttc aggtttcctc ttgtaacctt taaagacagt
    18781 gtagaagtaa ttgtttttat tagatattgt cagatgtacg gtcacttcgt tttgaggtga
    18841 acttaacctg gagtcatcaa tcatgttaaa tagctgcaaa tatctatctc tcaaacttag
    18901 ctttctgcct cttgattgag ttggttttga ttcttgttgt ttagagctgc catcatcaaa
    18961 tgaaatagaa ttactaggtt cttcttgctc ccctaaaaca ccaagttcaa taatcgagtc
    19021 atcatcgtca tcatcatcgt cttggctcaa atcctcagag acatcatcta gctcactttc
    19081 agaaaaagta aatcttacag caaaactagt ttgtccttgc ttaacaccat gtggcttatc
    19141 tttttcatag tcatataagt caggattaaa ttttccttca aaaaaaaccc tcatagcttt
    19201 taataggttt gttttaccac tgttgttttg cccaacaatg gttaatccat taaagttatc
    19261 agaggatatc tcccctgaaa tagacctata ctgagaaact ttaaatgata ctatttccat
    19321 ttttcttcct acgatagaat gttgctcgga ttatcgacat tttttcccaa ggctttaact
    19381 gtccttcgct acttggagaa atggctcttc ctccactgtt ctgctttatt ttcgccagaa
    19441 agcccaccat gcatgttgtt tgtcctgaag tgctgcttta tcctgaagca attcagcact
    19501 cactgccccc tgaagcacag aaacggcgtt tctcgcggca ttgcgacagg aatcaataac
    19561 ctctggttcg ttgggctttc tgagcaggat aaattgcgat actttggact gagtatcaaa
    19621 agcatagatt cgcaattcag gggaggatgt caggcttaca atattatgca accgcatata
    19681 attggtgtag tcctcgctac ctggattaca tgattcataa agatatttct gcattagcgt
    19741 ttgcgatgaa gaaagaaaat ctatatagcg gtcagttttt ttatctatat cccgcagtcg
    19801 ctgagctatt gcatcttttc ttatttcgtg gcagtgtgtt aatttcagtg taatccagcc
    19861 accaacaatg gtgattaatg cacccagccc aattttaacg gcattatcag ccacatctac
    19921 ccactcagtt gccatctgtt acgcgttctt cctgtgatga tcatggtcgc tagtataatt
    19981 ctccggctga ctggacatac agcattttct gtctagcacc gaaacgttat aaacctttgt
    20041 tcaaattcct gatctctggc atcatctttt cgtacatctt ttcagttgag ttagcgcaat
    20101 aactctgtag gtatttatag ttttcttcga atttcggaag gtttttagct aaagtgatct
    20161 gtttaggtaa ggttccggta gaatcgttga ccacatcaaa cactatcgaa ttatgtttat
    20221 gatcttcatc aactaatttt aatgtagcta caacagggct tttatccatt gccccgttaa
    20281 ctagttgtct aatttggaat tttctcgcaa aaataaaatt aattagagat ggactgtcac
    20341 tattaaaagt tatattccac gtcaaaggca ttgcatcaca taatccttct gagataaatt
    20401 caccatcaat agaaccatct ttatcaacaa ataattgtat agtcataatt gattgcggtt
    20461 tatctagtcc aagatcccca ctattaataa tatattcagc ttctgttgac cattttccgg
    20521 taaggaattc tctttgataa agagcagcat tcaattcatt tttatatggt aggtaaagtc
    20581 ccactgctgc gataaccacc ccaaatgcag tgcataaggt tgtgattcgt ccactcattt
    20641 ttttccctta tcttcatatg taaaatttat aaccaattgt acattaatag cctcctttag
    20701 taatcccccg cccatattgg acattttgtt tttttgttta gactcaatta gttacaacat
    20761 tcatatattt agttccttta tcctgtgccc tgttccggca tatgtgccca tatcctaggt
    20821 tattcaggat aatcgcttcc ttttcgccct gcccggcgtt cactggtgtt tacggcaggg
    20881 aacttaacca ccggacgggt ggaaacatgt ggatttgtgt gtggctggaa tgctaatgta
    20941 cgcgtacact agcattaatg gggagggagt taactctctt ttattctgga tgccttgatt
    21001 ccctcctgat acagacgctt tacccgttca atttcgtcca gcgttgccgc cca
//
