LOCUS       NZ_AP021947.1          22687 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AP021947.1 Escherichia coli strain WP2-S18-ESBL-08 plasmid
            pWP2-S18-ESBL-08_1, complete sequence.
ACCESSION   NZ_AP021947
VERSION     NZ_AP021947.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 19:04:13
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 143438
            Orig. end    :: 166125
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22687
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12687]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12687
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     cand_cluster    1..22687
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..22687
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="2"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     CDS             complement(174..599)
                     /locus_tag="ctg1_161"
                     /transl_table=11
                     /translation="MQYAKPVTLNVEECDRLSFLPYLFGNDFLYAEAYVYALAQKMMPE
                     YQGGFWHFIRLLDGGGYMMPDGDRFHLVNGENWFDRTVSADAAGIILTSLVINRQLWLY
                     HDSGNAGLTHLYRMRDAQLWSHIEFHPECNAIYAALD"
     CDS             1001..1972
                     /gene_functions="other (smcogs) SMCOG1242:transposase
                     (Score: 186; E-value: 1.7e-56)"
                     /gene_kind="other"
                     /locus_tag="ctg1_162"
                     /transl_table=11
                     /translation="MSQPNLQCMGIDVAKLSLDIATTDTIEPFTVGNDEDGFAVITDKL
                     KHTKINLILMEATGGLEAAIACKLQSEGYDVVVINPRQARDFARSMGYLAKTDKLDAAM
                     LAQLALVIDRHPDRSRYIRHLPDEARAVLATMVVRRRQLNHMLVAERNRLYPSHPQSRK
                     SIDNIIDALQNELDRINEQMKQHMTAFFQEQARLIGSVKGVGDITVASLIAELPEQGKL
                     NRREISALTGVAPLNRDSGKMRGKRTTFGGRAGVRATLNMAALVATQFNPAIKLFYQRL
                     LAAGKPKKLALVACMRKLITILNTMLRKGEEWNASFQSQVIS"
     CDS             complement(2233..2445)
                     /locus_tag="ctg1_163"
                     /transl_table=11
                     /translation="MSSAKILNAYFEASEEDRKEFLRVLSHFYKDNRRVPLQEGMESFA
                     VNESIRKSQSINFAPMQGGCPLCGK"
     CDS             complement(2458..3033)
                     /locus_tag="ctg1_164"
                     /transl_table=11
                     /translation="MDEEKTRAEVAHIEFISYGTSRIFDRRMRSLDWKRKVVTFLGVFV
                     PLMIGCAVLSFGLEAPFLPLCITIAGVASIMQLGFSLWSLVSGWDRSYSDCMASVKENT
                     AIYNLAGSVRKKIGKLDEAKLEILIDDLTEKFERREQEDLTLCVSDKELRYANRMSCFY
                     FKKKCHICNVVPLTLKPGKCVCDGCGKF"
     CDS             complement(3102..3440)
                     /locus_tag="ctg1_165"
                     /transl_table=11
                     /translation="MAGKIPAFFLPVPGQSTKEVAAGSALPGHAEHGLVGVQLCGRRVV
                     CGLCRASILAGLALMQATVLMGGGYLKKVRDNIMESPISSKKLTRFDTTLTGCFERDIS
                     RVGHRHFK"
     CDS             complement(4252..5223)
                     /locus_tag="ctg1_166"
                     /transl_table=11
                     /translation="MKRAPVIPKHTIKTQPLEDTPSSAPAAPMVDSLIARVGAMARGNA
                     ITLPVCGRDVKFTLEVLRGDSVEKTSRVWSGNERDQELLTEDALDDLIPSFLLTGQQTP
                     AFGRRVSGVIEIADGSRRRKAAALTESDYRVLVGELDDEQMAALSRLGNDYRPTSAYER
                     GQRYASRLQNEFAGNISALADAENISRKIITRCINTAKLPKSVVALFSHPGELSARSGD
                     ALQRAFTDKEELLKQQASNLHEQKKAGVIFEAEEVITLLTSVLKTSSASRTSLSSRHQF
                     APGATVLYKGDKMVLNLDRSRIPTECIERIEAILKELEKAAL"
     CDS             complement(5223..6389)
                     /gene_functions="other (smcogs) SMCOG1157:hypothetical
                     protein (Score: 130.3; E-value: 1.5e-39)"
                     /gene_kind="other"
                     /locus_tag="ctg1_167"
                     /transl_table=11
                     /translation="MRLMETLNQCINAGHEMTKAIAIAQFNDDSPEARKITRRWRIGEA
                     ADLVGVSSQAIRDAEKAGRLPHPDMEIRGRVEQRVGYTIEQINHMRDVFGTRLRRAEDV
                     FPPVIGVAAHKGGVYKTSVSVHLAQDLALKGLRVLLVEGNDPQGTASMYHGWVPDLHIH
                     AEDTLLPFYLGEKDDVTYAIKPTCWPGLDIIPSCLALHRIETELMGKFDEGKLPTDPHL
                     MLRLAIETVAHDYDVIVIDSAPNLGIGTINVVCAADVLIVPTPAELFDYTSALQFFDML
                     RDLLKNVDLKGFEPDVRILLTKYSNSNGSQSPWMEEQIRDAWGSMVLKNVVRETDEVGK
                     GQIRMRTVFEQAIDQRSSTGAWRNALSIWEPVCNEIFDRLIKPRWEIR"
     CDS             complement(6689..7201)
                     /locus_tag="ctg1_168"
                     /transl_table=11
                     /translation="MALDAGNCPHYGRWPQHDFTSLKKLRPQSVTSRIQPGSDVIVCAE
                     MDEQWGYVGAKSRQRWLFYAYDSLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTD
                     GWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHY
                     LNIKHYQ"
     CDS             7566..7931
                     /locus_tag="ctg1_169"
                     /transl_table=11
                     /translation="MIRQKDIRVMAVNVPTTWINSGMSEFDSRLFAAINDMLLDMLAAV
                     ARRDYEQRRERQKQGIEKARKDGKYKGRKPNQARYDAINRLIESGSSWSQVQKVPGCSR
                     GTISSAIKRKSGLKSSS"
     CDS             complement(8256..9998)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 187.1; E-value:
                     9.3e-57)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_170"
                     /transl_table=11
                     /translation="MERKQKNSLFNYIYSLMDARGKFLFFSMLFITSLSSIIISISPLI
                     LAKITDLLSGSLSNFSYEYLVLLACLYMFCVISNKASVFLFMILQSSLRINMQKKMSLK
                     YLRELYNENITNLSKNNAGYTTQSLNQASNDIYILVRNVSQNILSPVIQLISTIVVVLS
                     TKDWFSAGVFFLYILVFVIFNTRLTGSLASLRKHSMDITLNSYSLLSDTVDNMIAAKKN
                     NALRLISERYEDALTQENNAQKKYWLLSSKVLLLNSLLAVILFGSVFIYNILGVLNGVV
                     SIGHFIMITSYIILLSTPVENIGALLSEIRQSMSSLAGFIQRHAENKATSPSIPFLNME
                     RKLNLSIRELSFSYSDDKKILNSVSLDLFTGKMYSLTGPSGSGKSTLVKIISGYYKNYF
                     GDIYLNDISLRNISDEDLNDAIYYLTQDDYIFMDTLRFNLRLANYDASENEMFKVLKLA
                     NLSVVNNEPVSLDTHLINRGNNYSGGQKQRISLARLFLRKPAIIIIDEATSALDYINES
                     EILSSIRTHFPDALIINISHRINLLECSDCVYVLNEGNIVASGHFRDLMVSNEYISGLA
                     SVTE"
     CDS             complement(10001..11542)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: mcjC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_171"
                     /sec_met_domain="mcjC (E-value: 0.0, bitscore: 1219.4,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 2.7e-07, bitscore:
                     24.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIFNVKLNDTSIRIIFCKTLSAFRTENTIVMLKGKAVSNGKPVS
                     TEEIARVVEEKGVSEVIENLDGVFCILIYHFNDLLIGKSIQSGPALFYCKKNMDIFVSD
                     KISDIKFLNPDMTFSLNIKMAEHYLSGNRIATQESLITGIYKVNNGEFIKFNNQLKPVL
                     LRDEFSITKKNNSTIDSIIDNIEMMRDNRKIALLFSGGLDSALIFHTLKESGNKFCAYH
                     FFSDESDDSEKYFAKEYCSKYGVDFISVNKNINFNEKLYFNLNPNSPDEIPLIFEQTDE
                     EGEGQPPIDDDLLYLCGHGGDHIFGQNPSELFGIDAYRSHGLMFMHKKIVEFSNLKGKR
                     YKDIIFSNISAFINTSNGCSPAKQEHVSDMKLASAQFFATDYTGKINKLTPFLHKNIIQ
                     HYAGLPVFSLFNQHFDRYPVRYEAFQRFGSDIFWKKTKRSSSQLIFRILSGKKDELVNT
                     IKQSGLIEILGINHIELESILYENTTTRLTTELPYILNLYRLAKFIQLQSIDYKG"
     CDS             complement(11545..12171)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_172"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 7.1e-14,
                     bitscore: 45.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF13471 (E-value: 2e-23, bitscore: 76.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRYCLTSYREDLVILDIINDSFSIVPDAGSLLKERDKLLKEFPQ
                     LSYFFDSEYHIGSVSRNSDTSFLEERWFLPEPDKTLYKCSLFKRFILLLKVFYYSWNIE
                     KKGMAWIFISNKKENRLYSLNEEHLIRKEISNLSIIFHLNIFKSDCLTYSYALKRILNS
                     RNIDAHLVIGVRTQPFYSHSWVEVGGQVINDAPNMRDKLSVIAEI"
     CDS             12511..12687
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: micJ25"
                     /gene_functions="biosynthetic-additional (lassopeptides)
                     predicted lassopeptide"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_173"
                     /sec_met_domain="micJ25 (E-value: 6.1e-27, bitscore: 87.0,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKHFHFNKLSSGKKNNVPSPAKGVIQIKKSASQLTKGGAGHVPE
                     YFVGIGTPISFYG"
     CDS_motif       12511..12621
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MIKHFHFNKLSSGKKNNVPSPAKGVIQIKKSASQLTK"
                     /locus_tag="ctg1_173_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       12622..12687
                     /prepeptide="core"
                     /locus_tag="ctg1_173_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="5.40"
                     /molecular_weight="2107.3"
                     /monoisotopic_mass="2106.0"
                     /core_sequence="GGAGHVPEYFVGIGTPISFYG"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MIKHFHFNKLSSGKKNNVPSPAKGVIQIKKSASQLTK"
                     /leader_location="[12510:12621](+)"
     CDS             complement(13853..14065)
                     /locus_tag="ctg1_174"
                     /transl_table=11
                     /translation="MSNSHKVMKDGKLLHGNAATLHLAKKAGGMDQFLDQIVEISAVAA
                     ARDAVKSHIAQASRPALRVVNGGKK"
     CDS             complement(14472..15266)
                     /gene_functions="other (smcogs) SMCOG1151:transposase
                     (Score: 287.4; E-value: 1.1e-87)"
                     /gene_kind="other"
                     /locus_tag="ctg1_175"
                     /transl_table=11
                     /translation="MHELETLLSRLKMEHLGYHVESLLEQAAKKELNYREFLCMALQQE
                     WNGRHQRGMESRLKQARFPWVKTLEQFDFGFQPGIDRKVVRELAGLAFVERSENVILLG
                     PPGVGKTHLAVALGVKAADAGHRVLFMPLDKLIATLMKAKQENRLEKQLQQLGYARVLI
                     LDEIGYLPMTREEASLFFRLLNRRYEKASIVLTSNKGFADWGEMFGDNVLATAILDRLL
                     HHSTTLNIKGESYRLKEKRKAGVLAKNATPISDDEMAESGQH"
     CDS             complement(15266..16414)
                     /gene_functions="other (smcogs) SMCOG1213:transposase
                     (Score: 325; E-value: 8.8e-99)"
                     /gene_kind="other"
                     /locus_tag="ctg1_176"
                     /transl_table=11
                     /translation="MIKQMRQQGAYIVDIATQVGCSERTVRRYLKYPEPPARKTRHKMA
                     KLKPFMDYIDMRLAENVWNGEVILAEIKAMGYTGGRSMLRYYIQPKRKMRPSKKTVRFE
                     TQPGYQLQHDWGEVEAEVAGQRCRVNFAVNTLGFSRRFHVFAAPKQDAEHTYESLVRAF
                     RYFGGSVKTVLVDNQKAAVLKNNNGKVVFNSGFLLLADHYGFLPRACRPRRARTKGKVE
                     RMVKYLKENFFVRYRRFDSFAHVNQLLEQWMADVADRRELRQFRQTPEQRFTQEQEHLH
                     PLPGTDFDTSYFDIRHVSWDGYIEVGGNRYSVPESLCGQPVSIRISLDDELRIYSNEQQ
                     VASHRLCSAASSWQTVPEHHAPLWQQVSQVEHRPLSTYEELL"
     CDS             complement(16520..17026)
                     /locus_tag="ctg1_177"
                     /transl_table=11
                     /translation="MTEAGCWAHARRKIHDVYISTKSATAEEALKLIGELYAIEHEIRG
                     LPVSERLAVRQMQSKPLLTSLYKLMQEKEHTLSKKCRLRDAFRYIRKHWVALCNFCDDG
                     LAEADNNTAERALRAVCLGKKNYVFFGSDHGGERGALLYGLIGTCRLNGIDPEAYLRHM
                     SAPMI"
     CDS             17506..17694
                     /locus_tag="ctg1_178"
                     /transl_table=11
                     /translation="MNNDELVTRRAQEIAEDRCFSKGRLRDEFRMKPAPGAEPVKWYKN
                     TYGGRFAVYRIADCVHV"
     CDS             complement(17872..18117)
                     /locus_tag="ctg1_179"
                     /transl_table=11
                     /translation="MSHNLEHQKVHTRMVKEVLKAVARANNHPYQSVFTDFIAGHPSCT
                     VCFWETFNKMYPDSPYEYVTFCHTCRRLIYTKQKRR"
     CDS             18213..18446
                     /locus_tag="ctg1_180"
                     /transl_table=11
                     /translation="MEVGKDPELLKQFKNQNKVLVTKGKSSFVPESERVGERERFELHH
                     IKRVTDGGAVYDIDNLRVVTPKHHIEIHRGNK"
     CDS             18447..18704
                     /locus_tag="ctg1_181"
                     /transl_table=11
                     /translation="MEKKTISDYTEAEFLEFVRKICRAEGETEADDDKLVDEFRRLAEH
                     PDGSDLIYYPRDDREDSPEGIVKEVKEWRAKNGKPGFKQG"
     CDS             complement(18782..20014)
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 216.5; E-value: 7.2e-66)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_182"
                     /transl_table=11
                     /translation="MPLFSLRPAATLWPPVLLGSQFVFNIGFYAVVPFLALFLRDDMLL
                     SGGLIGLILGLRTFSQQGMFILGGTLADRYGAKAIILAGCVVRVAGFLLLACGASLWPI
                     ILGACLTGVGGALFSPSIEALLARAGTHSQANGKRSRAEWFALFAVCGELGAVIGPVAG
                     GVLSGIGFRHIALAGAGIFLLALAVLFFGLPADGHTTTTRRRVPWWTPLRQPRFVAFIL
                     AYSSWLLSYNQLYLALPVEIQRSGGREQDLAPLFMLASLLIITLQLPLARFARRMGAVR
                     ILPVGFLLLSASFASVALFAAAPPAESWLRLMPAAGFVTLLTLGQMLLVPAAKDLIPLF
                     AEESTLGAHYGALATAGGCAVLAGNLLLGHLLDQALIPSPQAVYPWLLLALFPLCSAVA
                     LRAICRPLAAT"
     CDS             complement(20026..20787)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 202.9; E-value:
                     9.9e-62)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_183"
                     /transl_table=11
                     /translation="MSICAENITWKAGKKVIVNNVSLRVPRGETVGLLGPNGCGKSSLL
                     RVLAGLRRPDAGRVTLDGQDIARMAKKQLARRVACVEQHGMTEANMRVRDVVRLGRIPH
                     HSPFSNWSAQDDEAIAAALQRVAMLEKSEQGWLSLSGGERQRVHIARALAQSPSEILLD
                     EPTNHLDIHHQMQLMQLISELPVTSIVAIHDLNHAAMFCDSLIVMQQGQILASGTPEEI
                     LSEALLWDVFRVKTKIEISPYHGKKHIHFIV"
     CDS             complement(20787..21824)
                     /gene_functions="transport (smcogs) SMCOG1011:transport
                     system permease protein (Score: 292.3; E-value: 6.6e-89)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_184"
                     /transl_table=11
                     /translation="MSVGAIETSRSILLTGWCVLAAIVLALVIAVGVSVGELAIPLQNV
                     FYAISNRTGLTAEPLNRIYESVIWDFRLSRALVAACCGAGLAICGVVLQSLLKNALAEP
                     YVLGVSAGASTGAVSIVVLGLGSGAISLSAGAFAGAFAAFAFVALLTNGARGGNERTIL
                     AGVAASQLFNAITAYTISTTASAQQARDVMFWLLGSFSGVRWPEFQLVIVVVLAGLAVC
                     LWYARALDAFTFGDDAAASLGIAVPRVRLILFTTAALITATIVSMAGSIGFVGLVVPHV
                     MRFFFGPLHRTLLIASALAGAILMVLADIASRLLIAPQSLPVGVVTALVGVPFFAVIIY
                     RSRNK"
ORIGIN
        1 gtctgacagg ttccagtcct gagccatatg gcgcacattc ccacgggtca gcaccacggc
       61 aaaaacgcat tcactgtccg gcacgtctgt atccagtaca tcgcggataa tttctttaac
      121 agtacatgtt ctcgtctcct ttacaggggc ggcattgccg ccccgtccgt taatcagtcc
      181 agcgccgcgt aaatcgcgtt acattcgggg tgaaattcga tgtggctcca caactgcgca
      241 tcacgcatcc ggtacaggtg tgtcagccct gcgttaccgc tgtcgtggta cagccacaac
      301 tggcggttaa tcacaaggga agtcagaatg atgcctgcgg catcggcact gaccgtgcgg
      361 tcaaaccagt tttcaccgtt aaccagatga aaacggtcgc catccggcat catgtaaccg
      421 ccaccgtcca gcaggcggat gaagtgccag aagcctccct gatattccgg catcattttt
      481 tgcgccagcg cgtacacata tgcttcggca tacagaaaat cgttgccaaa taggtaaggc
      541 agaaaagaca gacggtcgca ctcttcaaca ttcagagtga caggtttcgc atactgcatg
      601 ggatttcctc cgttgttcac atattccgcg acaccgggct gtgccgtgcc tccataaaag
      661 ccgggcgata aggcggggat gcatagggcg caagggaagc cgcagcctga cacacacggc
      721 tggcgggagt tggaggggga gaccgcgaaa tctgagcggg taaacgaccg gaaaatcacg
      781 gcagacggga aggagggacc gggtgaccgc agcggcgaag cgtatcctta tatcttgaag
      841 atggcataaa ctgaatctgt aggtctggca aagctcatgc agcacgtgcg aacccgaggg
      901 tattaagccc gcatgcaagc gtcccgcgca tgagctgagt cactcatcac aaatccgtac
      961 agttgattga aaccaaattc gtatcgtaag gaagggtcat atgagtcaac caaatctgca
     1021 atgcatgggt attgatgttg ccaaactatc gctggacatc gccaccaccg acacgattga
     1081 gccattcact gtgggtaacg atgaggatgg tttcgctgtt atcacagata aactgaagca
     1141 caccaaaatt aacctgattc tcatggaagc taccggtggc cttgaagcag ccattgcctg
     1201 taagcttcag tcagaaggat acgatgtggt tgtgatcaac ccacgacagg ctagggattt
     1261 tgcccgttca atgggatatc tggctaaaac agataaactt gacgccgcca tgctagcaca
     1321 actggccctg gtcattgatc gccatccgga ccgcagtcgt tatatacggc atctgccaga
     1381 tgaggcacga gcagtacttg ccacaatggt cgtccgtcgt cgtcagttga accatatgct
     1441 ggtcgctgag cgtaatcgtc tctatccttc tcatccccaa agcaggaaga gtatcgataa
     1501 cattattgat gcgcttcaaa acgagctcga ccggatcaat gagcaaatga aacaacacat
     1561 gacagcattc ttccaggagc aggccagact gataggcagc gtgaaaggcg tcggcgatat
     1621 caccgtcgcg tcgctgattg ccgaactacc ggaacagggg aaactcaatc gacgggagat
     1681 tagtgctcta actggcgtcg ctcctctaaa cagagactcc gggaaaatgc gagggaaacg
     1741 gaccacgttt ggtggcagag ccggagtgag agcaacgttg aacatggcag ctctggtggc
     1801 tacgcagttt aatcctgcca taaagctgtt ctaccagcgt ttgcttgccg ccggaaaacc
     1861 caaaaaactt gctctggtcg cctgcatgcg caaactcatc accattctga ataccatgct
     1921 cagaaaaggg gaagagtgga acgcctcatt tcaatcacag gtaatctcat gactgccggt
     1981 cattttacat aatgacagaa agaacaactt atcccgcagg cctgttgtga tccgccctcc
     2041 cacggacaaa gcatccgcga tgtcagtggg gccgctgctc atagctgctg atagtgcagc
     2101 tttcggctgt ttttgtacca aatacggaga attgcaagat agcgggcaat agccactttt
     2161 ttaacaggat gtaaagatgc tagttacaat ataaagaaat ctatcaagcc gctagtcaag
     2221 cggctttggt cgttacttgc cgcagagtgg acacccacct tgcatagggg caaagttaat
     2281 tgactgcgat ttacggatgc tttcattgac ggcaaagctc tccatgccct cttgcagagg
     2341 tactcttcgg ttatccttat aaaaatgact aagaacccgt aggaactcct ttcgatcttc
     2401 ttcagaagcc tcgaagtaag cgttaagaat ttttgcacta ctcatatgtt ctccttgtta
     2461 aaatttccca caaccatcac aaacacattt tcccggtttc aaagttaggg gaacgacatt
     2521 acaaatatgg catttttttt tgaagtagaa acaggacata cggtttgcat aacgaagttc
     2581 tttatcactc acacacaaag ttaagtcttc ctgctccctt cgctcaaatt tttccgtcaa
     2641 atcgtctatc aaaatttcca atttggcttc gtcaagctta cctattttct tgcgaacact
     2701 accagctagg ttataaatgg ctgtattttc cttaacggaa gccatgcaat cactatatga
     2761 gcgatcccat ccggaaacca aagaccacag cgagaacccc aattgcatga tacttgccac
     2821 accggcaatt gtgatgcaaa gcggcagaaa tggagcttca agtccgaatg ataaaactgc
     2881 acaacctatc atcagtggaa caaagacccc aaggaaggtg acaaccttac gcttccagtc
     2941 taaggatctc atacgcctat caaaaattcg agacgtacca tatgaaataa attctatgtg
     3001 tgccacttca gcacgagttt tctcttcatc cataatcaat aaaacttgtt atccggtgtt
     3061 ttaatcttta ataagactga ccctgctcat attatttaga atcatttaaa atgtcgatgc
     3121 ccgacacgag agatatctcg ctcaaaacag cctgtcagcg tagtatcgaa gcgagtcagt
     3181 tttttgcttg agatgggcga ttccataata ttatcccgta cttttttcag ataaccgcct
     3241 cccattaaga cagttgcttg catcaacgcc agcccggcta agatggaggc acggcacagc
     3301 ccgcacacga ctcgacgtcc acataactga acccccacaa ggccatgctc cgcatggccg
     3361 ggtaaagcgg agccggcggc gacttccttt gtgctctgtc cggggaccgg caggaaaaag
     3421 gcggggattt tccccgccat cgtcatcatt tccggatttt tgccagggca tccgccatgc
     3481 tgcggatttc atcccgtgcc tccaagaaaa ctcccgcaga atatagcggt caaacaagcg
     3541 gcggggcggt tcacccggta tacgcagcac atcacagacc aagccactgg ccaagatatg
     3601 ttccacacac tcactggcag gcattaatgg aatcgtagtc tcacgctgat aatcagatcg
     3661 acaatacaag tgagaccgtg gtcccagact gattagcaga ccaacaatac gagtgggacc
     3721 gcggtcccag actgattatc agactaacaa tatgagtggg accgtggtcc cagaccgata
     3781 atcagaccaa caatatgagt gggaccgtgg tcccagactg attagcagac cgacaatatg
     3841 agtgggaccg tggtcccaga ctgattagca gaccgacaat atgagtggga ccgtggtccc
     3901 agactgatta gcagaccgac aatatgagtg ggaccgtggt cccagactga ttagcagacc
     3961 aacaatacga gtgggaccgc ggtcccagac tgattagcag actaacaata tgagtgggcc
     4021 cgtggtccca gaccgataat cagaccgaca atatgagtgg gaccgtggtc ccagactgat
     4081 tatcagaccg acaatatgag tgggaccgtg gtcccagact gattatcaga ccgacaatac
     4141 aactgggacc gtggtcccag atataatatt caggccagtt agttatgctt tctagcctgt
     4201 gctaaaggaa attaagtaaa gacagataaa tgtagactaa aacgtgccgc atcaaagtgc
     4261 cgctttttca agttccttaa gaatggcttc aattctctct atacactcag ttggaatacg
     4321 agatctatct aggtttaaca ccattttatc gcccttgtac aacactgtcg ctccaggagc
     4381 aaactgatgt cgtgagctta agctagttct tgaggcagat gacgttttaa gcacagacgt
     4441 taaaagagtg atgacttctt cagcttcaaa tatcactcct gcttttttct gctcgtgaag
     4501 gttagatgcc tgctgcttaa gtaattcttc tttatctgta aaagctcttt gaagtgcatc
     4561 acctgaccgg gcagatagtt caccgggatg agaaaaaaga gcaacaactg atttaggcag
     4621 tttagctgtg ttgatacagc gggtaataat cttacgtgaa atattttctg catcagccag
     4681 cgcagaaata tttccagcaa attcattctg caatcggctt gcataacgct gaccacgttc
     4741 ataagcactt gttggcctat aatcgttacc caatctggac aatgcagcca tctgctcatc
     4801 atccagctca ccaaccagaa ctcgataatc actttctgta agtgcagcag ctttacgacg
     4861 gcggctccca tcggcaattt ctatgacccc agacactctt cgaccgaatg ctggtgtctg
     4921 ctgacctgtc agtagaaaag aagggataag atcatccagg gcgtcttcgg taagcagttc
     4981 ctggtcacgt tcattacctg accatacccg agaggtcttc tcaacactat ctccccggag
     5041 cacctcaagg gtaaatttca cgtccctacc acatacaggc aaagtaatag cattgccacg
     5101 agccatagct cctacgcgcg caattaacga atccaccatc ggtgcagctg gtgccgatga
     5161 cggagtatct tcaagcggtt gagtcttaat cgtatgtttt ggaatgacag gcgcacgctt
     5221 cattatctaa tctcccagcg tggtttaatc aaacgatcga aaatttcatt gcagacaggt
     5281 tcccaaatag aaagggcatt tctccaggca cctgttgaag agcgttgatc aatagcctgt
     5341 tcaaaaacag ttctcatccg gatctgacct ttaccaactt catccgtttc acgcacaaca
     5401 ttttttagga ccatgcttcc ccaggcgtcc cgaatttgct cctccatcca cggggactga
     5461 gaaccattac tattactgta tttggtaagc aaaatacgta catcaggctc gaatccttta
     5521 agatctacgt ttttgagcag atcacgaagc atatcgaaaa actgcagagc ggaagtgtag
     5581 tcgaacaact cagcaggcgt ggggacaatc aacacatcag cagcacatac aacattaatc
     5641 gtgccgatac ctaggttagg cgcgctgtca atgacaatga catcatagtc atgagcgacg
     5701 gtttcaatgg ccagtcggag catcaggtgt ggatcggtgg gcaatttacc ttcatcaaat
     5761 ttgcccatta gctcagtttc aatgcggtgc agagccaaac aggaaggaat aatgtcaagc
     5821 ccaggccagc aagtaggctt tattgcataa gtgacatcgt ccttttcccc aagatagaag
     5881 ggaaggagag tatcctctgc atgaatatga agatctggca cccagccgtg atacatcgat
     5941 gctgttccct gggggtcgtt accttccacg agcagaacac gtaatccctt cagagccaga
     6001 tcctgagcaa gatgaacaga aacagaggtt ttgtaaacgc cccctttatg agcagcaact
     6061 ccaatcaccg gcggaaatac gtcttcagca cgtcgtagtc tcgtaccaaa cacgtcacgc
     6121 atatgattaa tttgttcaat tgtataacca acacgttgct caacccgtcc tcgtatttcc
     6181 atatccgggt gcggtagccg gcctgctttc tcggcatccc tgatagcctg agaagatact
     6241 ccaactaaat ccgctgcttc acctattctc cagcgtcggg tgattttcct cgcttccggg
     6301 ctgtcatcat taaactgtgc aatggcgata gccttcgtca tttcatgacc agcgtttatg
     6361 cactggttaa gtgtttccat gagtctcatt ctgaacatcc tttaatcatt gctttgcata
     6421 ttttcattta atcttgcatt ttattgcaaa gcaacaacaa aattgcaaag tagtcaaaaa
     6481 accgcaaagt tgtttaaaat gagagcaaca catcaaaaaa ggaaacagga agagcacata
     6541 cctcagtcaa taattatcac tagtactcgt agccgtcgtg taaccgagcg tagcgagcta
     6601 actggcgagg acgcgcgcta actgttcaca ctcagtatcc ctagcaccaa aataactatc
     6661 tgatggtcaa ggcggtaatg actccaactt attgatagtg ttttatgttc agataatgcc
     6721 cgatgacttt gtcatgcagc tccaccgatt ttgagaacga cagcgacttc cgtcccagcc
     6781 gtgccaggtg ctgcctcaga ttcaggttat gccgctcaat tcgctgcgta tatcgcttgc
     6841 tgattacgtg cagctttccc ttcaggcggg attcatacag cggccagcca tccgtcatcc
     6901 atatcaccac gtcaaagggt gacagcaggc tcataagacg ccccagcgtc gccatagtgc
     6961 gttcaccgaa tacgtgcgca acaaccgtct tccggagact gtcatacgcg taaaacagcc
     7021 agcgctggcg cgatttagcc ccgacatagc cccactgttc gtccatttcc gcgcagacga
     7081 tgacgtcact gcccggctgt atgcgcgagg ttaccgactg cggcctgagt tttttaagtg
     7141 acgtaaaatc gtgttgaggc caacgcccat aatgcgggca gttacccgca tccaacgcca
     7201 ttcatggcca tatcaatgat tttctggtgc gtaccgggtt gagaagcggt gtaagtgaac
     7261 tgcagttgcc atgttttacg gcagtgagag cagagatagc gctgatgtcc ggcggtgctt
     7321 ttgccgttac gcaccacccc gtcagtagct gaacaggagg gacagctgat agaaacagaa
     7381 gccactggag cacctcaaaa acaccatcat acactaaatc agtaagttgg cagcatcacc
     7441 ctcgtctcga tcgtcctgaa ctcttccgtc ttctgagaga ttgccagcaa aatgacattt
     7501 tgctcattga ggacgttgac agactttccc gcctgtcagg ggaagactgg aataagctga
     7561 agaaaatgat ccgtcagaaa gatatccggg ttatggccgt gaacgttccg accacatgga
     7621 ttaattctgg catgagtgag tttgacagcc ggttgtttgc tgccattaac gatatgctgc
     7681 tggatatgct ggccgctgtt gccagaaggg actatgaaca acgacgggaa cgccagaaac
     7741 aagggataga gaaagcaagg aaagacggca aatataaagg tcgtaaacct aatcaagcca
     7801 gatatgacgc aattaacagg ttgattgaga gcggaagctc ctggagtcaa gttcagaaag
     7861 tgccagggtg cagccgtggc acaatcagta gcgcaataaa acgtaaatcc gggctgaaat
     7921 ccagtagtta gagaagggag gagatgtcgg aagttcggaa aacaaccccc gttaagatta
     7981 ttttttaatc aaattgtttt tggggcacct gaactgcggg gttacagcgg tttttgtgtc
     8041 tgaaaccgta caattctgta catttacgca aggggatgtg cggaagaagt aagctaaacg
     8101 attagcggac ggtcagagca tttcgaacaa cccttacatt ctggggctta gcttgccggg
     8161 atgtaaccac tcgtgcaacc caattctctt aacgtgggaa aaattccgtt ttccaagcga
     8221 ctccctttct gaatacagag caggagtcag atattttatt cagtaacaga agccagtccc
     8281 gatatgtatt cattgctgac catcaaatcc ctgaaatggc cagaagcaac aatatttcct
     8341 tcattcaata cataaacaca atcggaacac tccagaagat ttattcggtg actaatattt
     8401 ataattaacg catcaggaaa atgagttctt attgatgata aaatttctga ttcattaata
     8461 taatccagag ccgatgtggc ttcatcaata ataattattg caggttttct caaaaacagt
     8521 cgcgctaacg aaattcgttg tttttgccct cctgaatagt tattgcctct gtttataagg
     8581 tgtgtatcca gactcactgg ttcattgttg acgacagaaa gatttgccag tttaagaact
     8641 ttaaacattt cattttctga cgcgtcgtaa tttgcgagcc ggagattaaa tcgtagtgta
     8701 tccataaaaa tataatcatc ttgtgttagg tagtaaatag catcattcaa atcctcatca
     8761 ctgatattac gtaaggatat atcattcaga taaatgtctc caaagtaatt tttatagtaa
     8821 cctgatatta tttttacaag ggtggatttt cctgaaccac tgggtccggt taatgaatac
     8881 atttttccgg taaaaaggtc aagactgact gaattaagta tttttttatc atcactatag
     8941 ctaaatgaaa gctctcttat ggacaggttt aattttcgct ccatgttgag aaaaggtatt
     9001 gaaggagatg tggctttatt ctcggcatga cgttgaataa aacctgccag gctagacatt
     9061 gactgcctga tctcacttag caatgcccct atattttcca ctggcgttga aagaagaatg
     9121 atatatgatg taatcataat gaagtggccg atactaacta caccattcag cacacctaaa
     9181 atattatata tgaatacaga accaaataat attacagcaa gtaaagagtt caataaaaga
     9241 actttagaac tgagtaacca gtattttttc tgagcattgt tttcctgagt gagagcatct
     9301 tcataacgtt cagaaataag tcttaatgca ttattctttt tagctgctat catgttatca
     9361 acagtatcag ataacagact ataagagtta agagtgatat ccatgctgtg ttttctgagt
     9421 gacgctaaac tgccagtcag tctggtatta aaaattacaa ataccagaat atagagaaaa
     9481 aacacaccgg cagaaaacca gtccttcgta gataaaacaa caacaatagt agaaataagt
     9541 tgtataacag gtgacaggat attctgggaa acatttctca caagaatata aatgtcattt
     9601 gaagcctggt taagactttg cgttgtatat ccagcattat ttttactcaa gttagttata
     9661 ttttcgttat acaattctct caaatatttt agcgacattt ttttctgcat gttaatacgt
     9721 agactacttt gcagtatcat aaataaaaaa acacttgctt tattagatat aacgcaaaac
     9781 atgtataaac aggcaagtaa aaccagatat tcataactaa aatttgacaa tgagccagac
     9841 agtaaatctg taatctttgc aagaatcaat ggtgaaatag atatgattat cgatgataat
     9901 gatgtaatga ataacatgga aaagaataaa aatttacctc ttgcatccat taatgaataa
     9961 atataattaa ataatgagtt tttctgtttt ctttccataa ttaaccttta taatcaatgg
    10021 attgaagttg aatgaatttt gccagacggt ataagttaag tatatatggt agttccgttg
    10081 tcagacgtgt agtcgtattt tcatacaaaa tgctttctaa ttcaatatgg ttaatgccta
    10141 atatttcaat taatcctgac tgttttattg tattcactag ttcatccttt ttaccggata
    10201 gaattctgaa tattagctgt gaagatgacc gtttggtttt tttccagaaa atatctgaac
    10261 caaatcgttg aaacgcttca taacgaacgg gataacgatc aaagtgctgg ttaaatagac
    10321 taaaaactgg taagccagca taatgctgga taatattttt atgcaggaat ggagttagtt
    10381 tattaatttt tcctgtataa tcagttgcaa aaaactgagc agaggcaagt ttcatatctg
    10441 atacgtgctc ttgctttgct ggagaacatc cgttggatgt attaatgaat gcggaaatat
    10501 ttgaaaatat gatatcttta tatctctttc ccttgagatt ggaaaattct actatttttt
    10561 tatgcataaa catcaagcca tgacttcgat atgcatcaat gccaaaaagt tctgaaggat
    10621 tttgtccgaa aatatgatct ccaccgtgac cacatagata taataaatca tcgtctatgg
    10681 ggggctgacc ttcaccttct tcatctgtct gttcaaatat caaagggatt tcgtccggac
    10741 tattaggatt taaattgaaa taaagttttt cattaaagtt gatgttttta ttaacagata
    10801 taaaatcaac tccatatttt gaacagtatt ccttagcaaa atacttttca ctgtcatcag
    10861 attcatcaga aaaaaaatga taagcgcaga atttgttacc tgattcttta agtgtgtgaa
    10921 aaattaatgc agaatccaat cctccggaga ataatagggc tatttttcta ttatcccgca
    10981 tcatctcaat attatcaatg atactgtcga tagttgaatt gttctttttg gtaatactaa
    11041 actcatcacg aagtagcaca ggtttcaact gattattaaa ttttataaac tcaccattat
    11101 ttactttgta aatgccagtg attagtgatt cctgggttgc tattcgattt cctgacagat
    11161 aatgttctgc catttttata tttagactga atgtcatatc tggattcaaa aatttgatat
    11221 cagaaatttt atccgaaaca aaaatatcca tattcttttt acaataaaat agagcggggc
    11281 ctgattgaat gcttttccct ataaggagat cattaaaatg ataaattagg atacagaaaa
    11341 caccatctaa attttctatt acttctgaaa cacctttttc ttccactact ctggcaatct
    11401 cctctgtgga tacaggtttg ccatttgaaa ctgcttttcc tttgagcata acgatggtat
    11461 tttctgtccg gaaggcagaa agcgttttac agaaaataat tctaattgaa gtatcattta
    11521 acttgacatt aaatatttcc ataactatat ctctgcaata acagataatt tatcccgcat
    11581 attgggagca tcattgataa cttgtccccc aacctccacc caagagtggc tataaaaagg
    11641 ttgtgtcctt acaccaataa caagatgagc atcaatattt ctggaattaa gaattctttt
    11701 tagtgcgtat gaataggtaa gacagtcaga tttaaaaata ttaagatgaa agataatgga
    11761 aagattacta atttctttcc ggataagatg ctcttcattc aaggagtata gcctattctc
    11821 ttttttatta cttatgaaaa tccatgccat cccttttttt tcaatattcc agctatagta
    11881 aaagactttg agtaataata taaatcgttt aaatagagaa cacttatata atgttttgtc
    11941 aggttctggt agaaaccagc gttcttcaag aaaagaagtg tcactattac gagaaacact
    12001 tccaatatga tattcactgt caaaaaagta agatagttgt gggaattctt taagcaattt
    12061 atctctttct tttagcaagc tacctgcgtc aggcactatg ctgaaactat cattaattat
    12121 atccaggata acaagatcct ctctataact ggttaagcag taacggatca ttttgcacac
    12181 tccctcctgt agttatgcct ttacactcaa ttggaataat aaaacttctg aatttatcta
    12241 caagctaaat ttttttctta attgatggct aaatattctg aaataattag aaaaatgtat
    12301 aaaaatccaa aatattgtac taaatttgac cacttttgca gattgattag tttatggatg
    12361 tttgtatcta aataatttta ttgataaatt actaaagcgt aatgattatt gatctcaatt
    12421 ttattttgtg ctaataaaat tctaacagaa ggacgtgagg ttcctctgta aaaatcatca
    12481 tactattttc atcaaataag gaacgtaaaa atgattaagc attttcattt taataaactg
    12541 tcttctggta aaaaaaataa tgttccatct cctgcaaagg gggttataca aataaaaaaa
    12601 tcagcatcgc aactcacaaa aggtggtgca ggacatgtgc ctgagtattt tgtggggatt
    12661 ggtacaccta tatctttcta tggctgatat tctgaaagaa gaactctgtc attttgtcta
    12721 tcaacaataa atcacatatc agaagctttt tgaaaattaa ctcaagaaat actatggagg
    12781 atcatggagg gggcaggaat actttacatg gcgttattac agagttaaca actgcccctt
    12841 tgaaaattac atatgctggc tgggagctat ttggaacttc ctgtcctgag ttacgtttcc
    12901 gctgtcatca aacgatgaac tggcgaatca gttccagaac tgcaatccgc gcgtttgcaa
    12961 cggcgaccac atccctgaga atgatgatta acaggttaat cattcgtttc tcttagccca
    13021 acctcactga actgaccccc ataaagttgg gcttttctgt gcctgttgtt caccagtttc
    13081 ccagacacgt cgcctggtga cgtgagaacc tggttcaaat ttactgttct ggccatatgc
    13141 attcaggaaa ctggctatca gctccgatgc tgtcgccgat attgtcattc actgatattt
    13201 ttcagtaggt tacaggaaat gacacattca aaaaatagtc atttgttgat ggatacagta
    13261 tcgacggtac gctacgtgaa atctggaaaa ttttggcggg taagtgactc aatttttaaa
    13321 tctccgctcc tgttttttgg gatgtgtcag caattatgac ctgaagaaga ggtgcgtccg
    13381 acaacaaaaa ttccgatcac caaaaaaatt ttggacattt tttccgataa tgcatttttg
    13441 tccaggggga tatgaacgac aggacagggc gaaaaggaag cggttatcct gaataaccca
    13501 ggatatgggc acatatactg ggttattcag gataacccag gatatgggca catatactgg
    13561 aacagggcac cggataaagg aacagaacgc gtgaatgttg taactaatga ggtatggaca
    13621 gaacgacggt tgtgtccaat gtgagggagg aattaacgag ggaggtatcc gggtggctgc
    13681 tgagcagtac ccggacggag tgattgagtc atgtaaactc tcgtggtgcg gatttagaag
    13741 atgtgacgta aatcgatgta tccggtaact ttgtgcagcg gattacattt caggcagacc
    13801 aactgcatac ctaccggtgt cagcggaatg ttatgtacag gacacgtatt cattattttt
    13861 taccaccgtt gactacacgc aatgccggac gtgatgcctg cgcaatgtgg gatttaactg
    13921 catcccgtgc ggcagccaca gctgaaatct ccacgatctg gtcaaggaac tgatccatcc
    13981 cacccgcttt ttttgccagg tgaagcgttg ccgcgttgcc gtgcaataac ttcccgtctt
    14041 tcatgacctt atgtgaatta ctcatgtgtt ctacctcatt cagtgagagt taaatccctg
    14101 tcagcacctg ccgaccgggt tctcatttac catacatcag ttcatgcaca tgtaaagtgt
    14161 tattcgttta aataattcac aggagctatt ttaatggctt ttcccctcac ccctttcatt
    14221 tggtctcatt gtgctctgaa cgcctctctg ggttgctctg agtgcgtgta gtggaatgct
    14281 tctttgttta ccaactctgc aaaaaaaatg gctgaaattg tacttggctg gtttcaagcg
    14341 taaggtgcgc tacgtgaaat ctgaaaattt ttgaggggga taaccagcca gaattcacgt
    14401 aggaacgtca aaactgtcaa cgccaagatt attggccgtt tttcgccatt tttaatgtcc
    14461 gctattggtc attaatgttg tccgctttcc gccatttcat catcactgat tggcgtggcg
    14521 ttttttgcca gcactcccgc tttgcgtttt tcctttaacc ggtagctttc tcctttgatg
    14581 ttcagtgtgg ttgagtggtg gagcagtcga tccaggattg ccgttgccag cacgttatcg
    14641 ccgaacatct ctccccagtc ggcgaaccct ttatttgatg tcagcacgat gctcgctttt
    14701 tcatatcgac ggttcagcaa ccggaagaac agactggctt cctcgcgggt catcggcaga
    14761 tagcctatct catccagtat cagtacccgg gcataaccaa gctgctgtag ctgtttttcc
    14821 agccggtttt cctgttttgc cttcatgagt gtggcgatca gcttatccag tggcatgaac
    14881 agtacccgat gaccagcgtc cgccgctttt accccgagag cgactgccag gtgcgtttta
    14941 cccacaccgg gcggacccag caggatcacg ttctcgctac gctccacgaa cgccagcccg
    15001 gccagctcac ggacgacctt acgatcgata cctggctgga agccgaagtc gaactgctcc
    15061 agcgttttga cccacgggaa gcgggcctgt ttcagccggg actccatacc gcgctgatgc
    15121 ctcccgttcc attcctgctg caacgccatg cacaggaact cgcggtagtt cagttctttt
    15181 ttggccgcct gctccagcag gctttcaacg tggtagccca gatgttccat tttaagacga
    15241 ctcagcagtg tctccagttc atgcatcaca acagctcctc atacgtactc aacggtctgt
    15301 gttccacctg actgacctgc tgccagagtg gggcgtgatg ctccggcacg gtttgccagc
    15361 tggatgcagc cgaacagaga cggtgcgatg ctacctgttg ctcattactg tagatccgta
    15421 gttcatcatc cagcgagatc cgtattgata ccggctggcc acacaggctt tccggtacgc
    15481 tgtaacggtt cccgccaacc tcgatatagc catcccagga gacatgacgg atatcgaaat
    15541 agctggtatc gaagtccgta cccggcagcg gatgcagatg ctcctgttcc tgcgtgaagc
    15601 gctgttccgg tgtctgcctg aactggcgaa gttctcgcct gtcagcaacg tcagccatcc
    15661 actgctccag tagctggtta acatgggcga agctgtcgaa ccggcggtac cggacgaaga
    15721 agttttcctt gaggtatttc accatccgtt caaccttacc tttggttctg gcccttcgtg
    15781 gacggcaggc ccgtggcagg aagccatagt gatcggccag cagcaggaac ccggagttga
    15841 acaccacctt cccattgtta tttttcagaa ctgcggcttt ctggttatcg accagcacgg
    15901 ttttcacgct accgccgaag tagcgaaagg cgcggaccag tgactcatag gtatgttcag
    15961 catcctgctt tggtgccgcg aagacatgga agcgacgtga gaaccccagc gtattaaccg
    16021 cgaagttaac cctgcatcgt tgcccggcaa cctcagcctc aacttctccc cagtcatgct
    16081 gtagctggta accgggctga gtttcgaagc gaaccgtttt cttcgatggc cgcatcttac
    16141 gtttgggctg gatgtagtag cgcaacatgg aacggccacc ggtataaccc atcgctttga
    16201 tttccgccag gatgacctcg ccgttccaga cgttctcagc cagacgcata tctatatagt
    16261 ccatgaacgg cttgagtttg gccattttgt ggcgtgtttt tctggccgga ggttccgggt
    16321 atttcaggta ccgtctgacg gtccgctcag agcaaccaac ctgagtggca atatcaacaa
    16381 tatacgcacc ttgctggcgc atttgcttta tcatgtaaaa atcctctctg ctcagcatga
    16441 gtgttccctt tgtggtgtag gaaccttaag gaaacaacat gttgggtgga gcggacaatc
    16501 caaatggtga attactgtct tatatcattg gcgctgacat atggcgcaga tacgcttccg
    16561 gatcgatacc gttcagacgg caggtgccga tcagcccgta cagcagtgca ccacgctcgc
    16621 cgccgtgatc gctaccgaag aacacgtaat ttttctttcc gagacagact gcacgaagcg
    16681 ctctttccgc tgtgttattg tccgcctccg ccagaccgtc atcacagaag ttgcacaacg
    16741 caacccagtg cttcctgata taccggaacg catctctcag acggcatttt ttcgataacg
    16801 tgtgttcttt ctcctgcatc agcttataca aggaagtcag tagcggttta ctctgcattt
    16861 gcctgaccgc caggcgttca gacaccggca acccgcgtat ttcgtgctca atggcgtaca
    16921 gttcgccgat tagtttcagt gcttcttccg ccgtcgcgct tttggtactg atatatacat
    16981 cgtggatttt gcgccgcgca tgagcccagc atcctgcttc cgtcaacgcg ccgccttcac
    17041 gttcggcact gaacagccga tcgtaacctg cgaacgcatc tgcctgcagg ataccccgga
    17101 agggacgaag gtgttgctcc ggatgtttac cctgatggtc cggtgagtag gcgaaccaga
    17161 ccgccggagg ttctggcgaa ccggcattcc ggtcatcccg gacatacgtc cagatatatc
    17221 ctgttttcgc cttcttcctg cccggtgcca gtacttttac tggtgtgtca tcagtgtgaa
    17281 ccttgcgggt gttcagccag cagcctagcc gggcagccgt ataaaggccg caatggtcgt
    17341 gtggaaggta cccgggaact ggttattcac ccgcattttg ttctggttta tgaggtcgac
    17401 agccagtggg gaaaagtgta tatcctgcgt gtattgcata ctgcacagaa gtggccatag
    17461 aggggctgtc cggatataaa aacgtctgac ggagatgcaa gaaccatgaa taatgatgag
    17521 ctggtcacca gacgtgcgca ggagattgcc gaagacaggt gtttctcgaa aggacgtctg
    17581 cgcgatgaat tcagaatgaa gcctgccccc ggtgctgagc cagttaagtg gtataaaaac
    17641 acttatggtg gcaggttcgc tgtataccga attgcagatt gtgttcacgt ataggaaatt
    17701 gaaaaaccag acgataccgc tgtccacgcc ttatgccacg tgagcctttc tgcttttccc
    17761 accactccgg tggtttctct ctctgcatgg tcgattttta taccgcgaca ttgtgaacag
    17821 gcgtttcagc ggtcggggct gaaaatcacc accacttcgg gtcatccgcc ttcatctccg
    17881 cttctgtttc gtataaatca aacgacggca ggtatggcag aacgtgacgt attcgtacgg
    17941 tgaatccggg tacattttgt tgaaggtttc ccagaaacag accgtgcagg agggatgacc
    18001 ggcgataaag tctgtaaata cggactgata agggtgatta ttggctctgg cgacggcttt
    18061 cagaacctct ttcaccattc tggtgtggac tttctggtgc tctaggttgt gtgacatggg
    18121 aactcattct ggatggttac tctgaaagct catattctgc cacaccccga tttgcagcct
    18181 ccaggctgcc gtggttccgt aaggcgttgt ggatggaagt ggggaaagat ccggagttac
    18241 tgaagcagtt caaaaatcag aataaggttc tggttacaaa aggtaaatct tcgtttgttc
    18301 ctgaatcaga gcgtgtaggt gaacgagaac gtttcgaact gcaccatatc aagcgcgtta
    18361 cggatggtgg cgctgtttat gatatcgata atctcagggt agtgacaccc aagcatcata
    18421 ttgaaattca cagaggaaat aagtaaatgg aaaagaaaac gatttctgac tataccgagg
    18481 cggagtttct ggagttcgtc agaaaaatct gccgggctga aggtgaaact gaggctgatg
    18541 atgataaatt agtggatgaa tttcgtcgat tagctgaaca ccctgatggt tctgatctta
    18601 tttattatcc aagggatgac cgtgaggaca gtcctgaagg tatcgtaaaa gaagtgaagg
    18661 aatggcgagc caaaaacggc aagccgggct ttaaacaggg ctgaggatct ttgttaaagg
    18721 attagctgaa aatatggata ccagctgttc acttccagag cgggctgtta cccgctctgc
    18781 gtcatgttgc cgccagcggg cgacagatcg cccgcagggc gacggcgctg cacagcggaa
    18841 acagcgccag cagaagccag ggataaaccg cctgcggcga cggaatgagc gcctggtcaa
    18901 gtaaatgacc gagcagtaaa ttcccggcta acaccgcgca ccctcctgcg gtggcgagcg
    18961 ctccgtagtg ggcgcccagc gtcgactcct cggcgaacag cgggatcaga tccttggctg
    19021 cgggcactaa cagcatctgg ccgagggtga gcagcgtgac aaaaccagcc gccggcatta
    19081 accgcagcca actttcggcg ggtggggcgg cggcgaataa cgccacgctg gcaaaggaag
    19141 ccgacagcag cagaaagccc accggcagga tgcgcacggc gcccattcgc cgggcgaagc
    19201 gggcgagagg gagctggagg gtgataatca acagcgaggc cagcataaag agcggcgcca
    19261 gatcctgctc gcggccgccg gaacgttgga tctccaccgg cagagcgagg tagagttggt
    19321 tgtagctcaa cagccatgag ctgtaggcga gaataaacgc gacaaagcgc ggctggcgca
    19381 aaggcgtcca ccatgggact cgtctgcgcg ttgttgtcgt gtgcccgtcg gcgggcagac
    19441 cgaaaaagag caccgccagc gccagaagaa atattcccgc gccggcgagg gcgatatgtc
    19501 gaaagccgat cccgctcagc acgcctccgg ccaccgggcc gatcaccgct cccagttcac
    19561 cgcataccgc aaacagcgca aaccactcgg cgcggctgcg tttcccgttg gcctggctgt
    19621 gggtaccggc ccgcgccagc agggcctcta tcgacgggga gaacagggcg ccgccgacgc
    19681 cggtcaggca ggcgccaagg ataatgggcc acagcgacgc cccgcacgcc agcaggagaa
    19741 aaccggcgac gcgaacgacg cagccggcga gaatgatcgc cttagcgcca tagcggtcgg
    19801 ccagcgtccc gccgaggata aacatcccct gttgggagaa ggtacgcagc ccgaggatca
    19861 ggccgataag tccgcctgag agcagcatgt cgtcgcgcag gaagagggcg aggaaaggta
    19921 cgaccgcgta aaagccaata ttaaaaacga actggcttcc cagtaacacc ggaggccaga
    19981 gggttgccgc agggcgcagg gagaaaagag gcatatccgc ccaacctaaa cgatgaaatg
    20041 aatgtgcttt ttgccgtggt aaggggagat ctcgattttg gttttcaccc ggaaaacgtc
    20101 ccacagcagc gcttcggaca aaatctcctc cggcgtcccg ctggcgagga tctgcccctg
    20161 ctgcatcacg atcagcgaat cgcagaacat cgcggcatgg ttaagatcgt gaatggccac
    20221 aatgctggtt accggcagct cgctgatcaa ctgcattaac tgcatctgat ggtgtatatc
    20281 cagatggttg gtcggctcat ccagcaggat ttcgctcggg ctctgcgcca gcgcgcgggc
    20341 gatatgcacc cgctgccgct cgccgccgga gaggcttaac catccctgtt cgcttttctc
    20401 cagcatcgct acccgctgca gcgcggcggc aatcgcttcg tcatcctgag cgctccagtt
    20461 tgagaacgga gagtggtggg gaatgcgtcc caggcgcacg acgtcgcgca cccgcatatt
    20521 ggcctcggtc atgccgtgtt gctcgacgca agccacgcgg cgggcgagct gctttttcgc
    20581 catccgggcg atatcctggc cgtcgagggt gacgcgacct gcatccgggc ggcgcaggcc
    20641 cgccagaacg cgcagcagcg aggatttgcc gcagccgttg ggccccagca gtccgaccgt
    20701 ttctccgcgc ggcacccgca gcgagacatt attgacgatg acctttttgc ctgccttcca
    20761 ggtgatattt tcagcgcaaa tactcatcac ttattccttg agcggtagat aatcacggca
    20821 aagaaaggca ccccaaccag ggcggttact accccaacgg gcagactttg cggggcaatc
    20881 agcaggcgcg acgcaatgtc cgccagtacc atcaatatcg cccctgccag cgcgctggcg
    20941 atcagcaacg ttcggtgcag cgggccaaag aagaaacgca tcacgtgcgg caccaccagg
    21001 ccaacaaagc cgattgagcc ggccatgctg acgatggtgg cggtgatcag cgccgcagtg
    21061 gtgaagagga tcaggcgcac gcgcggcaca gcaatcccca gcgaggcggc ggcatcgtcg
    21121 ccgaaggtga acgcgtccag cgcccgggca taccacaggc agaccgccag acccgcgagc
    21181 accaccacga tgaccaactg gaattcgggc cagcggacgc cgctgaagct gcccagcagc
    21241 cagaacatca catcgcgcgc ctgctgcgcg ctggcggtgg tgctgatggt ataggccgtg
    21301 atggcgttaa ataactgcga ggcggcgacg cccgcaagaa tcgtacgctc attgccgccg
    21361 cgcgcgccgt tagtcagcaa ggcgacaaag gcgaaggcgg cgaaggcccc ggcaaaggcg
    21421 cctgccgaga gggaaattgc gccagagcca aggcccagca ccacgatcga caccgcgccg
    21481 gtggaggccc cggcggagac gccgaggacg tagggttcgg cgagggcatt cttcagcaag
    21541 ctttgcagca cgacaccgca gatagcgagg ccggcgccgc agcaggcggc gaccagcgcg
    21601 cggctgaggc ggaaatccca gataacgctc tcatagatac ggttgagcgg ctcagcggtt
    21661 aagccggttc tgttgctgat agcataaaag acattctgca gcgggatggc cagctcgcca
    21721 acgctgacgc ccacagcgat caccagcgcc agcacgatcg ctgccagtac acaccagccg
    21781 gtgagcagta tgctgcggct cgtctcaatc gcgccgacgc tcatcagttc agccccattt
    21841 ttctcagctg ctcgcccacc tgctccgcgc cgtaaagcgt gcgaatggtc ggattcatcg
    21901 cctgaccgtc catgaccacg atatggcctt ttttcaccgc ctccagctgg ctgacggcgg
    21961 gatcgctttt gaggaatttg atcttctcct cggctttatc cagcgcccag cggttacgat
    22021 ctaggctggc gaccacgatc acatccgggt tggcggcaat aatgctctcc cagctcaccg
    22081 tgggccactc ggtttcggag gtaatcgcat tatgtccgcc cagcacgctg gcgataaatc
    22141 cggaggcgct gtttttgccg ccgacatagg catcggccga aggtgaggcg ctggagaacc
    22201 agaagacgaa ggagagatcc tttttgcttt taccaaactc ctggcgcagg tcggcttcac
    22261 gttttttgaa atcggcaatc agcgcctgac cacgatcttc gacgttgaaa atgcgggaaa
    22321 aatcgctaat ttcctgatac agccaggtca tatcccacag cttttgccgg ctgccgtaca
    22381 tatcgccggt ggcctttttg gtggcgcaca cccccggtga gacgtagctg ttcacgccga
    22441 cggtggcgag atcttcacgc ctagcgactt tgctttccgg ccccagcagc agcggcaact
    22501 gggcgggaac gaaatcagga ttttgcgcca gcaccgattc caggctcgga atttccaccg
    22561 tcaaggtttt aatcttcgcg ttttgctcag ccagctgcgg taaaacgctg gtcggccaga
    22621 aggcgctggc gaccacctgc ttttgcagcc cgagcagcag cagaatttcg accgtatttt
    22681 gccccag
//
