NC_020394.1 - 2 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NC_020394.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii,NRPS,T1PKS	8,397	106,257
Region 2	lanthipeptide-class-i	116,536	140,929

NC_020394.1 - Region 1 - NRPS,T1PKS,lanthipeptide-class-ii

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Location: 8,397 - 106,257 nt. (total: 97,861 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

NRPS/PKS domains

Lanthipeptides

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_19

ctg1_12

Leader:

MEKTRSKLNNATIEGS

Core:

IETLKDENECLRMEINYLKKLKALLQKEKKLQNKTK

Core with dehydrations:

IEDhbLKDENECysLRMEINYLKKLKALLQKEKKLQNKDhbK

antiSMASH-DB 4.0 matches for ctg1_12

100.0% NZ_CM000748.1and 1 other:

NZ_KB976165.1 Lanthipeptides: ICC_RS35950_lanthipeptide

Lanthipeptides: BTHUR0003_RS35340_lanthipeptide

IETLKDENECLRMEINYLKKLKALLQKEKKLQNKTK

89.7% NZ_CM000758.1: Lanthipeptides: BTHUR0013_RS36715_lanthipeptide

IETLKDENECLRMEINYLKKLKALLQKEKKLQNKTK

IETLKDENECLRMEI+YLKKLKALLQKEKKLQNKTK

IETLKDENECLRMEIDYLKKLKALLQKEKKLQNKTK

69.2% NZ_MOOT01000057.1: Lanthipeptides: BK765_RS32535_lanthipeptide

LKDENECLRMEINYLKKLKALLQKEKKLQN

LKDENECLRMEI+YLKKLKAL+QKEKKLQ+

LKDENECLRMEIDYLKKLKALVQKEKKLQS

ctg1_20

Leader:

MKVGIKMDNEKYLQVVEDEELEQLVGG

Core:

IGPGWVETLTKDCPWNMPVACVTIMGQRICKKCR

Core with dehydrations:

IGPGWVEDhbLDhbKDCysPWNMPVACysVDhbIMGQRICysKKCysR

antiSMASH-DB 4.0 matches for ctg1_20

100.0% NZ_CM000748.1and 1 other:

NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS26815_lanthipeptide

Lanthipeptides: BTHUR0003_RS30910_lanthipeptide

IGPGWVETLTKDCPWNMPVACVTIMGQRICKKCR

91.2% NZ_JH792312.1and 1 other:

NZ_QNRN01000010.1 Lanthipeptides: DET63_RS17570_lanthipeptide

Lanthipeptides: IIG_RS24665_lanthipeptide

GPGWVETLTKDCPWNMPVACVTIMGQRICKKC

GPGWVETLTKDCPWN+PVACVTIMGQRICKKC

GPGWVETLTKDCPWNVPVACVTIMGQRICKKC

88.2% NZ_CP036100.1and 1 other:

NZ_CP072062.1 Lanthipeptides: J5V93_RS29280_lanthipeptide

Lanthipeptides: EXW47_RS29185_lanthipeptide

GPGWVETLTKDCPWNMPVACVTIMGQRICKKC

GPGWVET+TKDCPWN+PVACVTIMGQRICKKC

GPGWVETVTKDCPWNVPVACVTIMGQRICKKC

with 41 more sequence matches

82.4% NZ_KB976276.1: Lanthipeptides: IIC_RS09105_lanthipeptide

GPGWVETLTKDCPWNMPVACVTIMGQRICKKC

GPGWVETLTKDCPW PVACV IMGQ+ICKKC

GPGWVETLTKDCPWKQPVACVIIMGQKICKKC

79.4% NZ_CM000731.1and 2 others:

NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptideNZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide

Lanthipeptides: BCERE0020_RS28875_lanthipeptide

GPGWVETLTKDCPWNMPVACVTIMGQRICKKC

GPGWVETLTKDCPW P ACV IMGQ+ICKKC

GPGWVETLTKDCPWKQPAACVIIMGQKICKKC

79.4% NZ_CP036053.1and 7 others:

NZ_JAOPRA010000024.1 Lanthipeptides: OCE16_RS27090_lanthipeptideNZ_KB976667.1 Lanthipeptides: IG5_RS06165_lanthipeptideNZ_LDKD02000003.1 Lanthipeptides: ABH17_RS27060_lanthipeptideNZ_NUAO01000019.1 Lanthipeptides: CN544_RS19345_lanthipeptideNZ_NVFH01000027.1 Lanthipeptides: COL40_RS24675_lanthipeptideNZ_NVHY01000021.1 Lanthipeptides: COM05_RS26660_lanthipeptideNZ_NVOV01000033.1 Lanthipeptides: CON78_RS26470_lanthipeptide

Lanthipeptides: EXW64_RS27135_lanthipeptide

GPGWVETLTKDCPWNMPVACVTIMGQRICKKC

GPGWVETLTKDCPW P ACV IMGQ+ICKKC

GPGWVETLTKDCPWKQPGACVIIMGQKICKKC

79.4% NZ_KB976165.1: Lanthipeptides: ICC_RS24850_lanthipeptide

IGPGWVETLTKDCPWNMPVACVTIMGQRICKKCR

IGPGWVETLTKDCP P AC+TI GQ ICKKCR

IGPGWVETLTKDCPGYKPYACITIAGQTICKKCR

73.5% NZ_CM000758.1and 1 other:

NZ_MOOT01000057.1 Lanthipeptides: BK765_RS20265_lanthipeptide

Lanthipeptides: BTHUR0013_RS15850_lanthipeptide

IGPGWVETLTKDCPWNMPVACVTIMGQRICKKCR

+GPGW+ TLTKDCP N P AC+TI GQ ICKKCR

VGPGWIATLTKDCPANKPYACITIAGQTICKKCR

58.8% NZ_FNYB01000007.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS28100_lanthipeptide

Lanthipeptides: BMZ34_RS15340_lanthipeptide

IGPGWVETLTKDCPWNMPVACVTIMGQRICKKC

IGPG++ETLTKDCP P CV I G CK+C

IGPGYIETLTKDCPRVTPQICVPINGIWTCKRC

50.0% NZ_CP040409.1and 3 others:

NZ_CP040415.1 Lanthipeptides: FE330_RS03440_lanthipeptideNZ_CP040417.1 Lanthipeptides: FE328_RS00755_lanthipeptideNZ_CP040424.1 Lanthipeptides: FE321_RS03455_lanthipeptide

Lanthipeptides: FE336_RS03460_lanthipeptide

IGPGWVETLTKDCPWNMPVACVTIMGQRICKKCR

+GPG V TLTKDCP +P C CK CR

VGPGLVRTLTKDCPNVVPKVCF----DGNCKYCR

50.0% NZ_CP040414.1: Lanthipeptides: FE331_RS04030_lanthipeptide

IGPGWVETLTKDCPWNMPVACVTIMGQRICKKCR

+GPG V TLTKDCP +P C CK CR

VGPGLVRTLTKDCPNVVPKVCF----DGKCKYCR

47.1% NC_017621.1and 16 others:

NZ_CP039462.1 Lanthipeptides: E8M06_RS05390_lanthipeptideNZ_JABTZM010000032.1 Lanthipeptides: HRQ47_RS09675_lanthipeptideNZ_JAEVFQ010000010.1 Lanthipeptides: JNO64_RS06375_lanthipeptideNZ_JAFFHD010000003.1 Lanthipeptides: JN532_RS02075_lanthipeptideNZ_JAGFVG010000007.1 Lanthipeptides: J5581_RS04225_lanthipeptideNZ_JAIJZO010000001.1 Lanthipeptides: K5Q34_RS00965_lanthipeptideNZ_JAIMDS010000024.1 Lanthipeptides: K6V32_RS10650_lanthipeptideNZ_JAJUWV010000001.1 Lanthipeptides: LZF89_RS05505_lanthipeptideNZ_JAMDIS010000017.1 Lanthipeptides: M5P45_RS08180_lanthipeptideNZ_JAMYIU010000001.1 Lanthipeptides: NKE44_RS01780_lanthipeptideNZ_JAMYIX010000001.1 Lanthipeptides: NKE54_RS02675_lanthipeptideNZ_JAMYIY010000001.1 Lanthipeptides: NKE64_RS02785_lanthipeptideNZ_JAMYJP010000014.1 Lanthipeptides: NKE68_RS07350_lanthipeptideNZ_LR738722.1 Lanthipeptides: STREPSUIS_RS03955_lanthipeptideNZ_VZMP01000023.1 Lanthipeptides: F6P50_RS09295_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05700_lanthipeptide

Lanthipeptides: SSUD12_RS06540_lanthipeptide

GPGWVETLTKDCPWNMPVACVTIMGQRICKKC

G G+V+TLTKDCP + CV I CK C

GSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

47.1% NZ_AQQB01000068.1and 6 others:

NZ_BCEY01000024.1 Lanthipeptides: GOZ53_RS05100_lanthipeptideNZ_BCEZ01000067.1 Lanthipeptides: GOZ55_RS11230_lanthipeptideNZ_BCFC01000053.1 Lanthipeptides: GOZ35_RS07920_lanthipeptideNZ_BCFG01000017.1 Lanthipeptides: GOZ50_RS03220_lanthipeptideNZ_BCFI01000009.1 Lanthipeptides: GOZ54_RS02495_lanthipeptideNZ_CP019557.1 Lanthipeptides: BZG42_RS05725_lanthipeptide

Lanthipeptides: K738_RS01000000110290_lanthipeptide

GPGWVETLTKDCPWNMPVACVTIMGQRICKKC

G G V+TLTKDCP + CV I CK C

GSGLVKTLTKDCPGFLSNICVNIGFISGCKNC

47.1% NZ_CP040409.1and 4 others:

NZ_CP040414.1 Lanthipeptides: FE331_RS04020_lanthipeptideNZ_CP040415.1 Lanthipeptides: allorf_0721024_0721203_lanthipeptideNZ_CP040417.1 Lanthipeptides: FE328_RS00745_lanthipeptideNZ_CP040424.1 Lanthipeptides: FE321_RS03445_lanthipeptide

Lanthipeptides: FE336_RS03450_lanthipeptide

GPGWVETLTKDCPWNMPVACVTIMGQRICKKCR

GPG ++TLTKDCP + CV + CKKC

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

38.2% NZ_CP058255.1: Lanthipeptides: HW369_RS18920_lanthipeptide

VETLTKDCPWNMPVACVTIMGQRICKKC

V T+TKDCP + CVT CK C

VPTITKDCPNTVSSVCVTFPFISACKNC

32.4% NZ_BMMB01000007.1and 1 other:

NZ_BMMB01000007.1 Lanthipeptides: IEX62_RS15675_lanthipeptide

Lanthipeptides: IEX62_RS15680_lanthipeptide

GPGWVETLTKDCPWNMPVAC

G GW+ TLT DCP ++ V C

GDGWITTLTDDCPNSIIVCC

32.4% NZ_CP018188.1and 5 others:

NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09335_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09335_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06620_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06620_lanthipeptideNZ_VDNV01000006.1 Lanthipeptides: FSV44_RS08680_lanthipeptide

Lanthipeptides: BSR19_RS10820_lanthipeptide

GPGWVETLTKDCPWNMPVAC

GPGW+ T+T DCP ++ V C

GPGWIATITDDCPNSIFVCC

32.4% NZ_PKIA01000004.1: Lanthipeptides: CYK22_RS03780_lanthipeptide

GPGWVETLTKDCPWNMPVAC

GPGW+ T+T DCP ++ V C

GPGWIATITDDCPNSVFVCC

30.6% NZ_CP059734.1: Lanthipeptides: SG34_RS31140_lanthipeptide

PGWVETLTKDCPWNMPVACVTIMGQRICKKC

P L K+ P A T MG IC C

PAATNELDKEVMDGNPQA-FTAMGSAICSPC

29.4% NC_004070.1and 26 others:

NC_008024.1 Lanthipeptides: MGAS10750_RS08460_lanthipeptideNZ_CAAHHZ010000002.1 Lanthipeptides: E9518_RS02835_lanthipeptideNZ_CAAHIH010000002.1 Lanthipeptides: E9602_RS03585_lanthipeptideNZ_CAAHIO010000002.1 Lanthipeptides: E9584_RS04360_lanthipeptideNZ_CAAHJE010000002.1 Lanthipeptides: E9605_RS03435_lanthipeptideNZ_CAAHJS010000002.1 Lanthipeptides: E9628_RS02300_lanthipeptideNZ_CAAHKC010000012.1 Lanthipeptides: E9636_RS08085_lanthipeptideNZ_CAAHMR010000003.1 Lanthipeptides: E9727_RS05510_lanthipeptideNZ_CAAHQE010000003.1 Lanthipeptides: E9931_RS04945_lanthipeptideNZ_CAAHQG010000004.1 Lanthipeptides: E9903_RS05690_lanthipeptideNZ_CAAIFD010000008.1 Lanthipeptides: FAG63_RS07845_lanthipeptideNZ_CAAJDK010000010.1 Lanthipeptides: FAO79_RS08000_lanthipeptideNZ_CAAJFI010000003.1 Lanthipeptides: FAP60_RS03740_lanthipeptideNZ_CP008926.1 Lanthipeptides: DP15_RS03855_lanthipeptideNZ_CP035434.1 Lanthipeptides: ETT65_RS08240_lanthipeptideNZ_CP035435.1 Lanthipeptides: ETT64_RS07905_lanthipeptideNZ_CP035447.1 Lanthipeptides: ETT52_RS07920_lanthipeptideNZ_CP035449.1 Lanthipeptides: ETT50_RS08255_lanthipeptideNZ_CP035453.1 Lanthipeptides: ETT46_RS08220_lanthipeptideNZ_CP060646.1 Lanthipeptides: H7789_RS07920_lanthipeptideNZ_CP065054.1 Lanthipeptides: I2432_RS09105_lanthipeptideNZ_LRGW01000003.1 Lanthipeptides: AWU01_RS03260_lanthipeptideNZ_LS483298.1 Lanthipeptides: DQM39_RS08650_lanthipeptideNZ_LS483407.1 Lanthipeptides: DQM86_RS08100_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS07865_lanthipeptideNZ_LS483430.1 Lanthipeptides: DQN28_RS07600_lanthipeptide

Lanthipeptides: SPYM3_RS08605_lanthipeptide

GPGWVETLTKDCPWNMPVAC

G GW T+T DCP ++ V C

GSGWFATITDDCPNSVFVCC

29.4% NZ_CAJHJN010000010.1and 4 others:

NZ_CP066093.1 Lanthipeptides: I6I02_RS06995_lanthipeptideNZ_JACLQK010000029.1 Lanthipeptides: H7U04_RS10750_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02855_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05170_lanthipeptide

Lanthipeptides: JMZ68_RS08975_lanthipeptide

GPGWVETLTKDCPWNMPVAC

G GW T+T DCP ++ V C

GTGWFATITDDCPNSVFVCC

29.4% NZ_CP036073.1and 11 others:

NZ_CP036073.1 Lanthipeptides: EXW45_RS04930_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04925_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04920_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04915_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04910_lanthipeptideNZ_NUEG01000031.1 Lanthipeptides: CN905_RS18915_lanthipeptideNZ_NUEG01000031.1 Lanthipeptides: CN905_RS18910_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05275_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05270_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05265_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05260_lanthipeptide

Lanthipeptides: EXW45_RS04935_lanthipeptide

GPGWVETLTKDCPWNMPVAC

G GW+ T+T DCP ++ V C

GCGWLCTVTDDCPNSVFVCC

29.4% NZ_CP048273.1and 3 others:

NZ_CP048273.1 Lanthipeptides: M654_RS18555_lanthipeptideNZ_LT745776.1 Lanthipeptides: B2C81_RS11280_lanthipeptideNZ_LT745776.1 Lanthipeptides: B2C81_RS11275_lanthipeptide

Lanthipeptides: M654_RS18560_lanthipeptide

GPGWVETLTKDCPWNMPVAC

G GW T+T DCP ++ V C

GCGWACTITDDCPNSVFVCC

29.4% NZ_CP048890.1and 3 others:

NZ_CP071478.1 Lanthipeptides: J0P05_RS32905_lanthipeptideNZ_LUCO01000008.1 Lanthipeptides: BMBG_RS24280_lanthipeptideNZ_NVLN01000014.1 Lanthipeptides: CON11_RS24965_lanthipeptide

Lanthipeptides: BMG_RS30865_lanthipeptide

GPGWVETLTKDCPWNMPVAC

G GW T+T DCP ++ V C

GCGWSCTITDDCPNSVFVCC

29.4% NZ_JANHJQ010000013.1: Lanthipeptides: NON16_RS14160_lanthipeptide

GPGWVETLTKDCPWNMPVAC

G GW T+T DCP ++ V C

GCGWSCTVTDDCPNSVFVCC

29.4% NZ_MJEH01000022.1and 2 others:

NZ_MJEH01000022.1 Lanthipeptides: BFG57_RS18360_lanthipeptideNZ_MJEH01000022.1 Lanthipeptides: BFG57_RS09480_lanthipeptide

Lanthipeptides: BFG57_RS18365_lanthipeptide

GPGWVETLTKDCPWNMPVAC

G GW+ T+T DCP ++ V C

GDGWISTITDDCPNSIIVCC

29.4% NZ_NIHT01000008.1and 1 other:

NZ_NIHT01000008.1 Lanthipeptides: CDL23_RS06740_lanthipeptide

Lanthipeptides: CDL23_RS06745_lanthipeptide

GPGWVETLTKDCPWNMPVAC

G GW+ T+T DCP ++ V C

GSGWLPTITDDCPNSIFVCC

26.5% NZ_AULU01000012.1: Lanthipeptides: H580_RS25790_lanthipeptide

GPGWVETLTKDCP

G GWV T T DCP

GCGWVCTYTLDCP

26.5% NZ_BMSZ01000006.1: Lanthipeptides: allorf_250966_251172_lanthipeptide

GPGWVETLTKDCPWNMPVACVTI

G G V T PW+ P +C T+

GSGKVWNSTFRFPWSAPRSCRTL

26.5% NZ_CAAIJM010000014.1: Lanthipeptides: FAI23_RS09465_lanthipeptide

GWVETLTKDCPWNMPVAC

GW T+T DCP ++ V C

GWFATITDDCPNSVFVCC

26.5% NZ_CP037940.1: Lanthipeptides: EQG49_RS07315_lanthipeptide

GPGWVETLTKDCPWNMPVACVT

G G ++TLT +C N A +T

GSGVIKTLTHECKMNTYQAILT

23.5% NZ_MOWR01000001.1: Lanthipeptides: BMI76_RS01705_lanthipeptide

GWVETLTKDCPWNMPVAC

GW T+T +CP ++ V C

GWSFTITDECPNSVFVCC

23.5% NZ_VATK01000028.1: Lanthipeptides: FDO66_RS19480_lanthipeptide

GWVETLTKDCPWNMPVACVTI

GW+ + T DC W +P C +

GWICSYTLDCAW-LPFGCSCL

21.4% NZ_FMXP01000004.1: Lanthipeptides: BLQ04_RS01515_lanthipeptide

GWVETLTKDCP

GW++TLTKDCP

GWIKTLTKDCP

20.6% NZ_CP036455.1and 4 others:

NZ_JAGPXN010000019.1 Lanthipeptides: KBX06_RS22045_lanthipeptideNZ_JAODUN010000003.1 Lanthipeptides: BXY51_RS10560_lanthipeptideNZ_KB895893.1 Lanthipeptides: C569_RS0129325_lanthipeptideNZ_KB900614.1 Lanthipeptides: SALPAC6_RS0114155_lanthipeptide

Lanthipeptides: EKD16_RS25235_lanthipeptide

PGWVETLTKDC

GWV TLT +C

SGWVCTLTIEC

20.6% NZ_CP046629.1and 3 others:

NZ_FNJX01000002.1 Lanthipeptides: BLR40_RS05025_lanthipeptideNZ_FNZS01000001.1 Lanthipeptides: BMX70_RS03125_lanthipeptideNZ_FOLK01000002.1 Lanthipeptides: BM262_RS05670_lanthipeptide

Lanthipeptides: GPA00_RS05740_lanthipeptide

GPGWVETLTKDCPWN

G G V T++ DC N

GSGVVPTVSHDCHMN

20.6% NZ_CP083176.1and 4 others:

NZ_JABUHD010000002.1 Lanthipeptides: HRR08_RS05415_lanthipeptideNZ_LSLF01000001.1 Lanthipeptides: AXE72_RS04025_lanthipeptideNZ_PNHB01000001.1 Lanthipeptides: CJ210_RS02800_lanthipeptideNZ_QJVA01000001.1 Lanthipeptides: D0T19_RS02755_lanthipeptide

Lanthipeptides: K9E37_RS06280_lanthipeptide

GPGWVETLTKDCPWN

G G + TLT +C N

GDGVMHTLTHECHMN

20.6% NZ_JAGFVL010000062.1: Lanthipeptides: J5J03_RS19425_lanthipeptide

GPGWVETLTKDC

GPGW+ + T DC

GPGWIPSFTGDC

20.6% NZ_QSNA01000006.1and 1 other:

NZ_VEAP01000011.1 Lanthipeptides: allorf_058964_059119_lanthipeptide

Lanthipeptides: allorf_108759_108914_lanthipeptide

CPWNMPVACVTIMG

CP N + V+IMG

CPNNTVASTVSIMG

20.0% NC_015957.1: Lanthipeptides: STRVI_RS53125_lanthipeptide

IGPGWVETLTKDC

+ GWV TLT +C

LSSGWVCTLTTEC

20.0% NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17980_lanthipeptide

Lanthipeptides: C794_RS17980_lanthipeptide

GWVETLTKDCPWNMPVA

GW T+TK+C N V

GWFCTITKECQVNCNVG

17.6% NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01890_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01095_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01750_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07560_lanthipeptide

Lanthipeptides: SMUNN2025_RS09965_lanthipeptide

ETLTKDCPWNMPVA

T++ DC WN A

NTISSDCRWNSLQA

17.6% NZ_BNBJ01000003.1and 1 other:

NZ_JAMFLF010000021.1 Lanthipeptides: allorf_030895_031062_lanthipeptide

Lanthipeptides: allorf_023401_023568_lanthipeptide

PWNMPVACVTI

PWN P +C T+

PWNPPRSCRTL

13.6% NZ_CP078093.1: Lanthipeptides: KVH43_RS13025_lanthipeptide

WNMPVACVTIMGQRICKK

W V C T + +R C +

WTANVFCYTYISERHCSE

MIBiG 3.1 matches for ctg1_20

20.6% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

GWVETLTKDC

GW TLTK+C

GWC-TLTKEC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Module view

Legend

Lanthipeptides

NRPS/PKS products

NRPS/PKS substrates

Core peptide predictions

ctg1_12 - Class II

Cleavage pHMM score: -3.00

RODEO score: 0

Monoisotopic mass: 4337.5 Da

Molecular weight: 4340.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4358.2 Da N = 1

ctg1_20 - Class II

Cleavage pHMM score: 2.90

RODEO score: 0

Monoisotopic mass: 3778.9 Da

Molecular weight: 3781.6 Da

Number of bridges: 3

Predicted core structure(s)

For candidate cluster 1, location 8396 - 106257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal) + (bOH-Tyr - Pro) + (X - ohmal) + (D-Asn) + (X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 14824 - 106257:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal) + (bOH-Tyr - Pro) + (X - ohmal) + (D-Asn) + (X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_35

AMP-binding (280..682): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFYFGLVCK
Nearest Stachelhaus code(s):: Met DVFYLGGVFK (59% 8Å match); Ala DVFFVGLVAK (50% 8Å match); Pro DLFYLALVCK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1323..1725): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFYLGGVCK
Nearest Stachelhaus code(s):: Met DVFYLGGVFK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

ctg1_37

Search NORINE for peptide: strict or relaxed

AMP-binding (461..855): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_41

AMP-binding (448..845): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DMWNTGMVHK
Nearest Stachelhaus code(s):: Ser DMWNTGLVHK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

PKS_AT (1551..1847): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 139.4
inactive: 97.6
Methoxymalonyl-CoA: 46.0
Methylmalonyl-CoA: 26.8
Propionyl-CoA: 17.9
Isobutyryl-CoA: 8.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg1_42

Search NORINE for peptide: strict or relaxed

AMP-binding (8..410): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLIDK
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_46

PKS_AT (5..291): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 54.8
Methoxymalonyl-CoA: 32.2
inactive: 24.9
Methylmalonyl-CoA: 14.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg1_51

Search NORINE for peptide: strict or relaxed

AMP-binding (274..685): bOH-Tyr

nrpys: bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAQDIAAVDK
Nearest Stachelhaus code(s):: bOH-Tyr DASTIAAVDK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1329..1728): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVLNLAMVIK
Nearest Stachelhaus code(s):: Ala DVHNLAIVYK (76% 8Å match); Ser DVWNVAMVHK (62% 8Å match)
Stachelhaus code match:: 70% (weak)

ctg1_52

PKS_AT (1897..2192): mal

ATSignature: 2-Rhyd-Malonyl-CoA

Top 3 matches:: 2-Rhyd-Malonyl-CoA: 95.8%; Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 110.6
inactive: 75.1
Methoxymalonyl-CoA: 52.2
Methylmalonyl-CoA: 43.7
Propionyl-CoA: 33.3
CHC-CoA: 15.8
Ethylmalonyl-CoA: 15.0
2-Methylbutyryl-CoA: 13.6
Isobutyryl-CoA: 12.6
3-Methylbutyryl-CoA: 10.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0

NC_020394.1 - Region 2 - lanthipeptide-class-i

Download region GenBank file

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Location: 116,536 - 140,929 nt. (total: 24,394 nt) Show pHMM detection rules used

lanthipeptide-class-i: ((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene overview

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_94

ctg1_96

Leader:

MNKELFDLDINKKMETPTEMTAQ

ctg1_97

Leader:

MNKELFDLDINKKMETPTEMTAQ

Shared core:

TWTTIVKVSKAVCKTGTCICTTSCSNCK

Core with dehydrations:

DhbWDhbDhbIVKVDhaKAVCysKDhbGDhbCysICysDhbDhbDhaCysDhaNCysK

antiSMASH-DB 4.0 matches for ctg1_96

100.0% NZ_MOOT01000054.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17680_lanthipeptide

Lanthipeptides: BK765_RS17685_lanthipeptide

TWTTIVKVSKAVCKTGTCICTTSCSNCK

89.3% NZ_QNRN01000010.1: Lanthipeptides: DET63_RS17955_lanthipeptide

TWTTIVKVSKAVCKTGTCICTTSCSNCK

TW T+VKVSKA+CKTGTCICTTSCSNCK

TWGTVVKVSKAICKTGTCICTTSCSNCK

85.7% NZ_CP036100.1and 1 other:

NZ_CP072062.1 Lanthipeptides: J5V93_RS29680_lanthipeptide

Lanthipeptides: EXW47_RS29590_lanthipeptide

TWTTIVKVSKAVCKTGTCICTTSCSNCK

TW +I+KVS+AVCKTGTCICTTSCSNCK

TWGSILKVSRAVCKTGTCICTTSCSNCK

with 20 more sequence matches

78.6% NZ_CP036100.1and 5 others:

NZ_CP036100.1 Lanthipeptides: EXW47_RS29575_lanthipeptideNZ_CP036100.1 Lanthipeptides: EXW47_RS29570_lanthipeptideNZ_CP072062.1 Lanthipeptides: J5V93_RS29670_lanthipeptideNZ_CP072062.1 Lanthipeptides: J5V93_RS29665_lanthipeptideNZ_CP072062.1 Lanthipeptides: J5V93_RS29660_lanthipeptide

Lanthipeptides: EXW47_RS29580_lanthipeptide

TTIVKVSKAVCKTGTCICTTSCSNCK

TT++K SKA CKTGTCICTTSCSNCK

TTVIKFSKAFCKTGTCICTTSCSNCK

78.6% NZ_KB976165.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17675_lanthipeptide

Lanthipeptides: ICC_RS37095_lanthipeptide

TWTTIVKVSKAVCKTGTCICTTSCSNCK

TWT+I+KVS+A CK+GTC+CTTSCSNCK

TWTSILKVSRAPCKSGTCLCTTSCSNCK

71.4% NZ_KB976165.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17670_lanthipeptide

Lanthipeptides: ICC_RS25585_lanthipeptide

TIVKVSKAVCKTGTCICTTSCSNCK

T+VKVSKA+CKTGTCI T SC+NCK

TVVKVSKAICKTGTCIGTISCTNCK

70.0% NZ_CP023711.1and 11 others:

NZ_CP034141.1 Lanthipeptides: EGM68_RS25880_lanthipeptideNZ_CP040829.1 Lanthipeptides: FGY93_RS26165_lanthipeptideNZ_CP049598.1 Lanthipeptides: G7L40_RS03920_lanthipeptideNZ_CP071875.1 Lanthipeptides: J4I02_RS05145_lanthipeptideNZ_CP086373.1 Lanthipeptides: LMH85_RS04795_lanthipeptideNZ_CP092831.1 Lanthipeptides: MLD56_RS04795_lanthipeptideNZ_CP102865.1 Lanthipeptides: NWS42_RS17805_lanthipeptideNZ_JAFJXZ010000012.1 Lanthipeptides: JYU28_RS03620_lanthipeptideNZ_JAKVDC010000009.1 Lanthipeptides: MKN04_RS18550_lanthipeptideNZ_JWJJ01000002.1 Lanthipeptides: U707_RS25810_lanthipeptideNZ_POVT01000017.1 Lanthipeptides: C1T20_RS25545_lanthipeptide

Lanthipeptides: CPY53_RS19275_lanthipeptide

TIVKVSKAVCKTGTCICTTSCSNCK

T +KVSKAVCKT TCICT SCSNCK

TTIKVSKAVCKTLTCICTGSCSNCK

64.3% NZ_KB976165.1: Lanthipeptides: ICC_RS25590_lanthipeptide

TIVKVSKAVCKTGTCICTTSCSNCK

T + VS++VCKT TCICT SCSNCK

TTILVSRSVCKTLTCICTISCSNCK

64.3% NZ_MOOT01000054.1: Lanthipeptides: BK765_RS17665_lanthipeptide

TIVKVSKAVCKTGTCICTTSCSNCK

T + VS++VCKT TCICT SCSNCK

TTIFVSRSVCKTLTCICTISCSNCK

53.6% NZ_QNRN01000010.1: Lanthipeptides: DET63_RS17960_lanthipeptide

VKVSKAVCKTGTCICTTSCSNCK

+ +S+ +CKT TC+CTTSCSNCK

ILISRTICKTLTCVCTTSCSNCK

53.1% NZ_BDDH01000005.1and 2 others:

NZ_CP073265.1 Lanthipeptides: KCX77_RS01160_lanthipeptideNZ_JALAUD010000002.1 Lanthipeptides: MOE28_RS05435_lanthipeptide

Lanthipeptides: A7P71_RS15855_lanthipeptide

TWTTIVKV---SKAVCKTGTCICTT-SCSNCK

TW TI K S C+T TC C+ SCSNCK

TWATIGKTIVQSVKKCRTFTCGCSLGSCSNCK

50.0% NC_014976.1and 6 others:

NZ_CP029461.1 Lanthipeptides: DJ572_RS00745_lanthipeptideNZ_CP031675.1 Lanthipeptides: DYS67_RS00910_lanthipeptideNZ_CP045824.1 Lanthipeptides: GII78_RS01205_lanthipeptideNZ_CP046591.1 Lanthipeptides: GO004_RS12840_lanthipeptideNZ_CP049924.1 Lanthipeptides: G4G26_RS01205_lanthipeptideNZ_CP095736.1 Lanthipeptides: MX663_RS01330_lanthipeptide

Lanthipeptides: BSN5_RS12800_lanthipeptide

TWTTIVKV---SKAVCKTGTCICTT-SCSNCK

TW TI K S C+T TC C+ SCSNC

TWATIGKTIVQSVKKCRTFTCGCSLGSCSNCN

38.7% NZ_MLKL01000042.1: Lanthipeptides: BKK45_RS27405_lanthipeptide

TIVKVSKAVCKTGTCICTTSC

TIV VS +C TG +CT SC

TIVAVSVKLCPTG--VCTKSC

32.4% NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

TTIVKVSKAVCKTGTC

TTI+ VS AVC T TC

TTIIPVSLAVCPTTTC

28.6% NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

WTTIVKVSKAVCKTGTC

WT V +S A+C T C

WTVTVPLSIALCPTAKC

27.3% NZ_BOSN01000007.1and 5 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptideNZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

TWTTIVKVSKAVCKTGTC

T TI+ VS A+C T C

TPATIIPVSLAICPTTKC

26.7% NZ_BQME02000001.1and 5 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

WTTIVKVSKAVCKTGTC

WT I+ +S A C T C

WTIIIPISLAACPTTRC

26.5% NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

TWTTIVKVSKAVCKTGTC

T TI+ VS A+C T C

TPATIIPVSLAICPTTRC

25.0% NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide

Lanthipeptides: FE328_RS09035_lanthipeptide

WTTIVKVSKAVCKTGTC

WT++V +S A+C + C

WTSLVPISLAICPSTKC

23.5% NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide

Lanthipeptides: BK581_RS20095_lanthipeptide

TWTTIVKVSKAVCKTGTC

TWT + +S A C T C

TWTITIPISAAACPTTQC

21.9% NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

WTTIVKVSKAVCKTGTC

WT + +S A C T C

WTVTIPISLAACPTTQC

18.0% NZ_CP019286.1: Lanthipeptides: allorf_097046_097228_lanthipeptide

TWTTIVKVSKAVCKTGTCICTTSCS

WT ++ C TG+C+C+ SC

NWTKKAGIASLDC-TGSCLCSLSCD

17.6% NZ_CP019286.1: Lanthipeptides: allorf_097362_097547_lanthipeptide

TWTTIVKVSKAVCKTGTCICTTSCS

WT ++ C TG+C+C+ SC

NWTKKAGIATLDC-TGSCLCSLSCD

MIBiG 3.1 matches for ctg1_96

14.3% BGC0001155 (AGY49587.1): Thiopeptide: GE2270

TCICTTSCS

C+C CS

NCVCGFCCS

11.8% BGC0000535 (ADJ56352.1): Lanthipeptide: nisin A

AVCKTG

CKTG

PGCKTG

ctg1_98

Leader:

MDKELFDLDINKKMETPTEMTAQ

Core:

TWTSILKVSRAPCKSGTCLCTTSCSNCK

Core with dehydrations:

DhbWDhbDhaILKVDhaRAPCysKDhaGDhbCysLCysDhbDhbDhaCysDhaNCysK

antiSMASH-DB 4.0 matches for ctg1_98

100.0% NZ_KB976165.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17675_lanthipeptide

Lanthipeptides: ICC_RS37095_lanthipeptide

TWTSILKVSRAPCKSGTCLCTTSCSNCK

85.7% NZ_CP036100.1and 1 other:

NZ_CP072062.1 Lanthipeptides: J5V93_RS29680_lanthipeptide

Lanthipeptides: EXW47_RS29590_lanthipeptide

TWTSILKVSRAPCKSGTCLCTTSCSNCK

TW SILKVSRA CK+GTC+CTTSCSNCK

TWGSILKVSRAVCKTGTCICTTSCSNCK

78.6% NZ_MOOT01000054.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17680_lanthipeptide

Lanthipeptides: BK765_RS17685_lanthipeptide

TWTSILKVSRAPCKSGTCLCTTSCSNCK

TWT+I+KVS+A CK+GTC+CTTSCSNCK

TWTTIVKVSKAVCKTGTCICTTSCSNCK

with 20 more sequence matches

71.4% NZ_QNRN01000010.1: Lanthipeptides: DET63_RS17955_lanthipeptide

TWTSILKVSRAPCKSGTCLCTTSCSNCK

TW +++KVS+A CK+GTC+CTTSCSNCK

TWGTVVKVSKAICKTGTCICTTSCSNCK

64.3% NZ_CP036100.1and 5 others:

Lanthipeptides: EXW47_RS29580_lanthipeptide

TSILKVSRAPCKSGTCLCTTSCSNCK

T+++K S+A CK+GTC+CTTSCSNCK

TTVIKFSKAFCKTGTCICTTSCSNCK

64.3% NZ_KB976165.1: Lanthipeptides: ICC_RS25590_lanthipeptide

TSILKVSRAPCKSGTCLCTTSCSNCK

T+IL VSR+ CK+ TC+CT SCSNCK

TTIL-VSRSVCKTLTCICTISCSNCK

53.6% NZ_KB976165.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17670_lanthipeptide

Lanthipeptides: ICC_RS25585_lanthipeptide

SILKVSRAPCKSGTCLCTTSCSNCK

+++KVS+A CK+GTC+ T SC+NCK

TVVKVSKAICKTGTCIGTISCTNCK

53.6% NZ_MOOT01000054.1: Lanthipeptides: BK765_RS17665_lanthipeptide

LKVSRAPCKSGTCLCTTSCSNCK

+ VSR+ CK+ TC+CT SCSNCK

IFVSRSVCKTLTCICTISCSNCK

53.6% NZ_QNRN01000010.1: Lanthipeptides: DET63_RS17960_lanthipeptide

LKVSRAPCKSGTCLCTTSCSNCK

+ +SR CK+ TC+CTTSCSNCK

ILISRTICKTLTCVCTTSCSNCK

53.3% NZ_CP023711.1and 11 others:

Lanthipeptides: CPY53_RS19275_lanthipeptide

LKVSRAPCKSGTCLCTTSCSNCK

+KVS+A CK+ TC+CT SCSNCK

IKVSKAVCKTLTCICTGSCSNCK

46.9% NZ_BDDH01000005.1and 2 others:

NZ_CP073265.1 Lanthipeptides: KCX77_RS01160_lanthipeptideNZ_JALAUD010000002.1 Lanthipeptides: MOE28_RS05435_lanthipeptide

Lanthipeptides: A7P71_RS15855_lanthipeptide

TWTSILKV---SRAPCKSGTCLCTT-SCSNCK

TW +I K S C++ TC C+ SCSNCK

TWATIGKTIVQSVKKCRTFTCGCSLGSCSNCK

43.8% NC_014976.1and 6 others:

Lanthipeptides: BSN5_RS12800_lanthipeptide

TWTSILKV---SRAPCKSGTCLCTT-SCSNC

TW +I K S C++ TC C+ SCSNC

TWATIGKTIVQSVKKCRTFTCGCSLGSCSNC

32.3% NC_010816.1and 5 others:

NZ_CP069278.1 Lanthipeptides: JQN89_RS04800_lanthipeptideNZ_JADNCJ010000029.1 Lanthipeptides: I2B64_RS09750_lanthipeptideNZ_JADNLW010000041.1 Lanthipeptides: I2F45_RS10575_lanthipeptideNZ_JADPBO010000046.1 Lanthipeptides: I4V38_RS08850_lanthipeptideNZ_JADPES010000050.1 Lanthipeptides: I4U88_RS09655_lanthipeptide

Lanthipeptides: BLD_RS08345_lanthipeptide

TSILKVSRAPCKSGTCLCTTSCSNCK

S+L VS + C SC NCK

VSVLSVSFSACSVTVVTRLASCGNCK

32.3% NZ_CP046514.1and 12 others:

NZ_CP083257.1 Lanthipeptides: BCBL_RS08920_lanthipeptideNZ_CP084012.1 Lanthipeptides: LCQ81_RS01125_lanthipeptideNZ_CP084020.1 Lanthipeptides: LCQ52_RS09765_lanthipeptideNZ_GL622638.1 Lanthipeptides: HMPREF0177_RS02885_lanthipeptideNZ_JADMSA010000006.1 Lanthipeptides: I2H42_RS05020_lanthipeptideNZ_JADMUN010000007.1 Lanthipeptides: I1M16_RS07360_lanthipeptideNZ_JADNBL010000011.1 Lanthipeptides: I2A13_RS07655_lanthipeptideNZ_JADPBZ010000019.1 Lanthipeptides: I4V99_RS08285_lanthipeptideNZ_JADPCP010000015.1 Lanthipeptides: I4W34_RS09795_lanthipeptideNZ_JADPFY010000033.1 Lanthipeptides: I4V11_RS10065_lanthipeptideNZ_JAHTKJ010000004.1 Lanthipeptides: KUF58_RS04255_lanthipeptideNZ_SPGO01000021.1 Lanthipeptides: FGQ71_RS09210_lanthipeptide

Lanthipeptides: GN236_RS08545_lanthipeptide

TSILKVSRAPCKSGTCLCTTSCSNCK

S+L VS + C + SC NCK

VSVLSVSFSACSATVVTRLASCGNCK

30.6% NZ_LDCN01000003.1: Lanthipeptides: allorf_808935_809114_lanthipeptide

TSILKVSRAPCKSG-TCLCTTSCS

T++ V+R CKS TC+CT C+

TALCWVTRVTCKSTCTCVCTAMCT

30.0% NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

WTSILKVSRAPCKSGTCLCTTSCSN

WT I+ +S A C + C S N

WTIIIPISLAACPTTRCASIVSSCN

28.6% NZ_CP040417.1and 7 others:

Lanthipeptides: FE328_RS09035_lanthipeptide

WTSILKVSRAPCKSGTC

WTS++ +S A C S C

WTSLVPISLAICPSTKC

25.0% NZ_JAEQNB010000006.1: Lanthipeptides: JJB07_RS18720_lanthipeptide

SGTCLCTTS

SGTC CT S

SGTCFCTIS

23.3% NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

WTSILKVSRAPCKSGTC

WT I+ +S A C + C

WTIIIPISLAACPTTRC

18.4% NZ_AP018365.1and 3 others:

NZ_AP018365.1 Lanthipeptides: allorf_8002653_8002877_lanthipeptideNZ_AP018365.1 Lanthipeptides: allorf_8002653_8002877_lanthipeptideNZ_AP018365.1 Lanthipeptides: allorf_8002653_8002877_lanthipeptide

Lanthipeptides: allorf_8002653_8002877_lanthipeptide

TSILKVSRAPCKSGT

T + +RAPC +GT

TGATRATRAPCATGT

18.0% NZ_CP019286.1: Lanthipeptides: allorf_097046_097228_lanthipeptide

TWTSILKVSRAPCKSGTCLCTTSCS

WT ++ C +G+CLC+ SC

NWTKKAGIASLDC-TGSCLCSLSCD

17.6% NZ_CP019286.1: Lanthipeptides: allorf_097362_097547_lanthipeptide

TWTSILKVSRAPCKSGTCLCTTSCS

WT ++ C +G+CLC+ SC

NWTKKAGIATLDC-TGSCLCSLSCD

13.5% NZ_CP013219.1: Lanthipeptides: allorf_0179059_0179217_lanthipeptide

TWTSILKVSRAPCK

W ++ +SR PC

AWGTVPHISRRPCP

ctg1_99

Leader:

MNKELFDLDINKKMEAPTEMTVQTW

Core:

GTVVKVSKAICKTGTCIGTISCTNCK

Core with dehydrations:

GDhbVVKVDhaKAICysKDhbGDhbCysIGDhbIDhaCysDhbNCysK

antiSMASH-DB 4.0 matches for ctg1_99

100.0% NZ_KB976165.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17670_lanthipeptide

Lanthipeptides: ICC_RS25585_lanthipeptide

GTVVKVSKAICKTGTCIGTISCTNCK

82.1% NZ_QNRN01000010.1: Lanthipeptides: DET63_RS17955_lanthipeptide

GTVVKVSKAICKTGTCIGTISCTNCK

GTVVKVSKAICKTGTCI T SC+NCK

GTVVKVSKAICKTGTCICTTSCSNCK

73.1% NZ_CP036100.1and 5 others:

Lanthipeptides: EXW47_RS29580_lanthipeptide

TVVKVSKAICKTGTCIGTISCTNCK

TV+K SKA CKTGTCI T SC+NCK

TVIKFSKAFCKTGTCICTTSCSNCK

with 16 more sequence matches

71.4% NZ_MOOT01000054.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17680_lanthipeptide

Lanthipeptides: BK765_RS17685_lanthipeptide

TVVKVSKAICKTGTCIGTISCTNCK

T+VKVSKA+CKTGTCI T SC+NCK

TIVKVSKAVCKTGTCICTTSCSNCK

64.3% NZ_CP036100.1and 1 other:

NZ_CP072062.1 Lanthipeptides: J5V93_RS29680_lanthipeptide

Lanthipeptides: EXW47_RS29590_lanthipeptide

GTVVKVSKAICKTGTCIGTISCTNCK

G+++KVS+A+CKTGTCI T SC+NCK

GSILKVSRAVCKTGTCICTTSCSNCK

61.5% NZ_KB976165.1: Lanthipeptides: ICC_RS25590_lanthipeptide

GTVVKVSKAICKTGTCIGTISCTNCK

T + VS+++CKT TCI TISC+NCK

PTTILVSRSVCKTLTCICTISCSNCK

61.5% NZ_MOOT01000054.1: Lanthipeptides: BK765_RS17665_lanthipeptide

GTVVKVSKAICKTGTCIGTISCTNCK

T + VS+++CKT TCI TISC+NCK

PTTIFVSRSVCKTLTCICTISCSNCK

60.0% NZ_CP023711.1and 11 others:

Lanthipeptides: CPY53_RS19275_lanthipeptide

TVVKVSKAICKTGTCIGTISCTNCK

T +KVSKA+CKT TCI T SC+NCK

TTIKVSKAVCKTLTCICTGSCSNCK

53.6% NZ_KB976165.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17675_lanthipeptide

Lanthipeptides: ICC_RS37095_lanthipeptide

TVVKVSKAICKTGTCIGTISCTNCK

+++KVS+A CK+GTC+ T SC+NCK

SILKVSRAPCKSGTCLCTTSCSNCK

50.0% NZ_QNRN01000010.1: Lanthipeptides: DET63_RS17960_lanthipeptide

VKVSKAICKTGTCIGTISCTNCK

+ +S+ ICKT TC+ T SC+NCK

ILISRTICKTLTCVCTTSCSNCK

30.8% NZ_MWLM01000062.1: Lassopeptides: MNBBLIKP_RS18070_lassopeptide

TGTCIGTISCTNCK

TGTC GT NC

TGTCQGTNGGGNCP

30.0% NZ_CKMQ01000043.1and 10 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide

Lanthipeptides: AE832_RS11585_lanthipeptide

VSKAICKTGT-CIGTISCTN

+S+A+ G C GTI C N

ISEALGNKGAVCTGTIECQN

30.0% NZ_JAELVP010000007.1and 1 other:

NZ_LT963438.1 Lanthipeptides: DG016_RS11145_lanthipeptide

Lanthipeptides: JF558_RS03770_lanthipeptide

GTVVKVSKAICKTGTCIGTISC

GT +K +K C T + T+SC

GTAIKATKNACPKVTRLVTVSC

27.3% NZ_JAENHN010000066.1and 1 other:

NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24400_lanthipeptide

Lanthipeptides: JHL18_RS24400_lanthipeptide

GTVVKVSKAI-CKTGTCIG

G +KV+ A+ C+TG C G

GLTIKVATAVVCETGACTG

25.8% NZ_MLKL01000042.1: Lanthipeptides: BKK45_RS27405_lanthipeptide

TVVKVSKAICKTGTC

T+V VS +C TG C

TIVAVSVKLCPTGVC

24.2% NZ_BOSN01000007.1and 5 others:

Lanthipeptides: KJS43_RS18000_lanthipeptide

GTVVKVSKAICKTGTCIGTI

T++ VS AIC T C +

ATIIPVSLAICPTTKCASVV

23.5% NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

GTVVKVSKAICKTGTC

T++ VS AIC T C

ATIIPVSLAICPTTRC

23.5% NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

TVVKVSKAICKTGTC

T++ VS A+C T TC

TIIPVSLAVCPTTTC

17.5% NC_016791.1: Lanthipeptides: CLO1100_RS15705_lanthipeptide

TGTCIGTISCTNCK

TGTC+ +I+ T C+

TGTCLPSITVTICQ

MIBiG 3.1 matches for ctg1_99

23.1% BGC0002111 (EVG22_32245): Lanthipeptide: andalusicin A or andalusicin B

GTCIGTISCTNC

G TIS NC

GAWASTIS-NNC

ctg1_100

Leader:

MNKELFDLDINKKMETPTEMTAQTV

Core:

PTTIFVSRSVCKTLTCICTISCSNCK

Core with dehydrations:

PDhbDhbIFVDhaRDhaVCysKDhbLDhbCysICysDhbIDhaCysDhaNCysK

antiSMASH-DB 4.0 matches for ctg1_100

100.0% NZ_MOOT01000054.1: Lanthipeptides: BK765_RS17665_lanthipeptide

PTTIFVSRSVCKTLTCICTISCSNCK

96.2% NZ_KB976165.1: Lanthipeptides: ICC_RS25590_lanthipeptide

PTTIFVSRSVCKTLTCICTISCSNCK

PTTI VSRSVCKTLTCICTISCSNCK

PTTILVSRSVCKTLTCICTISCSNCK

70.0% NZ_CP023711.1and 11 others:

Lanthipeptides: CPY53_RS19275_lanthipeptide

PTTIFVSRSVCKTLTCICTISCSNCK

TTI VS++VCKTLTCICT SCSNCK

KTTIKVSKAVCKTLTCICTGSCSNCK

with 13 more sequence matches

69.2% NZ_QNRN01000010.1: Lanthipeptides: DET63_RS17960_lanthipeptide

TIFVSRSVCKTLTCICTISCSNCK

TI +SR++CKTLTC+CT SCSNCK

TILISRTICKTLTCVCTTSCSNCK

65.4% NZ_CP036100.1and 5 others:

Lanthipeptides: EXW47_RS29580_lanthipeptide

TTIFVSRSVCKTLTCICTISCSNCK

T I S++ CKT TCICT SCSNCK

TVIKFSKAFCKTGTCICTTSCSNCK

64.3% NZ_CP036100.1and 1 other:

NZ_CP072062.1 Lanthipeptides: J5V93_RS29680_lanthipeptide

Lanthipeptides: EXW47_RS29590_lanthipeptide

VSRSVCKTLTCICTISCSNCK

VSR+VCKT TCICT SCSNCK

VSRAVCKTGTCICTTSCSNCK

64.3% NZ_MOOT01000054.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17680_lanthipeptide

Lanthipeptides: BK765_RS17685_lanthipeptide

TTIFVSRSVCKTLTCICTISCSNCK

T + VS++VCKT TCICT SCSNCK

TIVKVSKAVCKTGTCICTTSCSNCK

61.5% NZ_KB976165.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17670_lanthipeptide

Lanthipeptides: ICC_RS25585_lanthipeptide

PTTIFVSRSVCKTLTCICTISCSNCK

T + VS+++CKT TCI TISC+NCK

GTVVKVSKAICKTGTCIGTISCTNCK

60.7% NZ_QNRN01000010.1: Lanthipeptides: DET63_RS17955_lanthipeptide

PTTIFVSRSVCKTLTCICTISCSNCK

T + VS+++CKT TCICT SCSNCK

GTVVKVSKAICKTGTCICTTSCSNCK

53.6% NZ_KB976165.1and 1 other:

NZ_MOOT01000054.1 Lanthipeptides: BK765_RS17675_lanthipeptide

Lanthipeptides: ICC_RS37095_lanthipeptide

IFVSRSVCKTLTCICTISCSNCK

+ VSR+ CK+ TC+CT SCSNCK

LKVSRAPCKSGTCLCTTSCSNCK

43.8% NZ_BDDH01000005.1and 2 others:

NZ_CP073265.1 Lanthipeptides: KCX77_RS01160_lanthipeptideNZ_JALAUD010000002.1 Lanthipeptides: MOE28_RS05435_lanthipeptide

Lanthipeptides: A7P71_RS15855_lanthipeptide

TIFVSRSVCKTLTCICTI-SCSNCK

TI S C+T TC C++ SCSNCK

TIVQSVKKCRTFTCGCSLGSCSNCK

40.6% NC_014976.1and 6 others:

Lanthipeptides: BSN5_RS12800_lanthipeptide

TIFVSRSVCKTLTCICTI-SCSNC

TI S C+T TC C++ SCSNC

TIVQSVKKCRTFTCGCSLGSCSNC

32.4% NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

PTTIF-VSRSVCKTLTC

PTTI VS +VC T TC

PTTIIPVSLAVCPTTTC

31.0% NZ_CP040417.1and 2 others:

NZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptideNZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptide

Lanthipeptides: FE328_RS05340_lanthipeptide

PTTIFVSRSVCKTLTC

P T+ VS +VC TL C

PCTVMVSAAVCPTLVC

30.8% NZ_CP115484.1: Lanthipeptides: PDL12_RS07010_lanthipeptide

LTCICTISCSNC

+T I TIS SNC

ITLISTISNSNC

27.8% NZ_LDCN01000003.1: Lanthipeptides: allorf_808935_809114_lanthipeptide

FVSRSVCK-TLTCICTISCS

+V+R CK T TC+CT C+

WVTRVTCKSTCTCVCTAMCT

MIBiG 3.1 matches for ctg1_100

21.4% BGC0000517 (BAB04173.1): Lanthipeptide: haloduracin β or haloduracin α

TLTCICTISCS

TLT C SC+

TLTVECMPSCN

20.6% BGC0000535 (ADJ56352.1): Lanthipeptide: nisin A

KTLTCICTISCS

KT TC C+I S

KTATCHCSIHVS

16.7% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

TLTCICTISCS

TLT C +C+

TLTKECQPNCN

with 1 more sequence matches

15.4% BGC0001155 (AGY49587.1): Thiopeptide: GE2270

TCICTISCS

C+C CS

NCVCGFCCS

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg1_96 - Class I

Cleavage pHMM score: 10.10

RODEO score: 26

Monoisotopic mass: 2785.4 Da

Molecular weight: 2787.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 2805.3 Da N = 1; 2823.4 Da N = 2; 2841.4 Da N = 3; 2859.4 Da N = 4; 2877.4 Da N = 5

ctg1_97 - Class I

Cleavage pHMM score: 10.10

RODEO score: 26

Monoisotopic mass: 2785.4 Da

Molecular weight: 2787.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 2805.3 Da N = 1; 2823.4 Da N = 2; 2841.4 Da N = 3; 2859.4 Da N = 4; 2877.4 Da N = 5

ctg1_98 - Class I

Cleavage pHMM score: 10.10

RODEO score: 26

Monoisotopic mass: 2797.4 Da

Molecular weight: 2799.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 2817.3 Da N = 1; 2835.3 Da N = 2; 2853.4 Da N = 3; 2871.4 Da N = 4; 2889.4 Da N = 5

ctg1_99 - Class I

Cleavage pHMM score: 7.60

RODEO score: 24

Monoisotopic mass: 2488.3 Da

Molecular weight: 2490.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2508.0 Da N = 1; 2526.1 Da N = 2; 2544.1 Da N = 3

ctg1_100 - Class I

Cleavage pHMM score: 10.10

RODEO score: 26

Monoisotopic mass: 2645.4 Da

Molecular weight: 2647.2 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 2665.2 Da N = 1; 2683.2 Da N = 2; 2701.3 Da N = 3; 2719.3 Da N = 4