LOCUS       CP088669.1             11761 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  CP088669.1 Escherichia coli strain C16EC0292 plasmid pC16EC0292-1,
            complete sequence.
ACCESSION   CP088669
VERSION     CP088669.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 15:33:07
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 390397
            Orig. end    :: 402158
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11761
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6761]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6761
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..11761
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11761
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             864..1082
                     /locus_tag="ctg1_367"
                     /transl_table=11
                     /translation="MFHCPLCQHAAHARTSRYITDTTKERYHQCQNVNCSATFITYESV
                     QRYIVKPGEVHAVRPHPLPSGQQIMWM"
     CDS             complement(1401..3683)
                     /locus_tag="ctg1_368"
                     /transl_table=11
                     /translation="MSELNEKLATAWEGFTKGDWQNEVNVRDFIQKNYTPYEGDESFLA
                     GATEATTTLWDKVMEGVKLENRTHAPVDFDTAVASTITSHDAGYINKALEKVVGLQTEA
                     PLKRALIPFGGIKMIEGSCKAYNRELDPMIKKIFTEYRKTHNQGVFDVYTPDILRCRKS
                     GVLTGLPDAYGRGRIIGDYRRVALYGIDYLMKDKLAQFTSLQADLENGVNLEQTIRLRE
                     EIAEQHRALGQMKEMAAKYGYDISGPATNAQEAIQWTYFGYLAAVKSQNGAAMSFGRTS
                     TFLDVYIERDLKAGKITEQEAQEMVDHLVMKLRMVRFLRTPEYDELFSGDPIWATESIG
                     GMGLDGRTLVTKNSFRFLNTLYTMGPSPEPNMTILWSEKLPLNFKKFAAKVSIDTSSLQ
                     YENDDLMRPDFNNDDYAIACCVSPMIVGKQMQFFGARANLAKTMLYAINGGVDEKLKMQ
                     VGPKSEPIKGDLLNYDEVMERMDHFMDWLAKQYITALNIIHYMHDKYSYEASLMALHDR
                     DVIRTMACGIAGLSVAADSLSAIKYAKVKPIRDEDGLAIDFEIEGEYPQFGNNDPRVDD
                     LAVDLVERFMKKIQKLHTYRDAIPTQSVLTITSNVVYGKKTGNTPDGRRAGAPFGPGAN
                     PMHGRDQKGAVASLTSVAKLPFAYAKDGISYTFSIVPNALGKDDEVRKTNLAGLMDGYF
                     HHEASIEGGQHLNVNVMNREMLLDAMENPEKYPQLTIRVSGYAVRFNSLTKEQQQDVIT
                     RTFTQSM"
     CDS             complement(3738..4595)
                     /locus_tag="ctg1_369"
                     /transl_table=11
                     /translation="MKADNPFDLLLPAAMAKVAEEAGVYKATKHPLKTFYLAITAGVFI
                     SIAFVFYITATTGTGTMPFGMAKLVGGICFSLGLILCVVCGADLFTSTVLIVVAKASGR
                     ITWGQLAKNWLNVYFGNLVGALLFVLLMWLSGEYMTANGQWGLNVLQTADHKVHHTFIE
                     AVCLGILANLMVCLAVWMSYSGRSLMDKAFIMVLPVAMFVASGFEHSIANMFMIPMGIV
                     IRDFASPEFWTAVGSAPENFSHLTVMNFITDNLIPVTIGNIIGGGLLVGLTYWVIYLRE
                     NDHH"
     CDS             complement(5001..6761)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_370"
                     /sec_met_domain="YcaO (E-value: 3.8e-80, bitscore: 265.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQTFIPGKDAALEDSIARFQQKLSDLGFQIEEASWLNPVPNVWS
                     VHIRDKECALCFTNGKGATKKAALASALGEYFERLSTNYFFADFWLGETIANGPFVHYP
                     NEKWFPLSENDDVPEGLLDDRLRAFYDPENELAGSMLIDLQSGNEDRGICGLPFTRQSD
                     NQTVYIPMNIIGNLYVSNGMSAGNTRNEARVQGLSEVFERYVKNRIIAESISLPEIPAD
                     VLARYPAVVEAIETLEAEGFPIFAYDGSLGGQYPVICVVLFNPANGTCFASFGAHPDFG
                     VALERTVTELLQGRGLKDLDVFTPPTFDDEEVAEHTNLETHFIDSSGLISWDLFKQDAD
                     YPFVDWNFSGTTEEEFATLMAIFNKEDKEVYIADYEHLGVYACRIIVPGMSDIYPAEDL
                     WLANNSMGSHLRETILSLPGSEWEKEDYLNLIEQLDEEGFDDFTRVRELLGLATGSDNG
                     WYTLRIGELKAMLALAGGDLEQALVWTEWTMEFNSSVFSPERANYYRCLQTLLLLAQEE
                     DRQPLQYLNAFVRMYGADAVEAASAAMSGEAAFYGLQPVDSDLHAFAAHQSLLKAYEKL
                     QRAKAAFWAK"
     CDS             6891..7583
                     /locus_tag="ctg1_371"
                     /transl_table=11
                     /translation="MKAFDLHRMAFDKVPFDFLGEVALRSLYTFVLVFLFLKMTGRRGV
                     RQMSLFEVLIILTLGSAAGDVAFYDDVPMVPVLIVFITLALLYRLVMWLMAHSEKLEDL
                     LEGKPVVIIEDGELAWSKLNNSNMTEFEFFMELRLRGVEQLGQVRLAILETNGQISVYF
                     FEDDKVKPGLLILPSDCTQRYKVVPESADYACIRCSEIIHMNAGEKQLCPRCANPEWTK
                     ASRAKRVT"
     CDS             7782..8870
                     /NRPS_PKS="Domain: Aminotran_5 (3-350). E-value: 1.2e-73.
                     Score: 240.0. Matches aSDomain:
                     nrpspksdomains_ctg1_372_Aminotran_5.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_372"
                     /sec_met_domain="Aminotran_5 (E-value: 1.5e-77, bitscore:
                     256.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQIFNFSSGPAMLPAEVLKQAQQELRDWNGLGTSVMEVSHRGKE
                     FIQVAEEAEKDFRDLLNVPSNYKVLFCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAA
                     SAIKEAKKYCTPNVFDAKVTVDGLRAVKPMREWQLSDNAAYMHYCPNETIDGIAIDETP
                     DFGKDVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIGPAGLTIVIVREDLLGKANIAC
                     PSILDYSILNDNGSMFNTPPTFAWYLSGLVFKWLKANGGVAEMDKINQQKAELLYGVID
                     NSDFYRNDVAKANRSRMNVPFQLADSALDKLFLEESFAAGLHALKGHRVVGGMRASIYN
                     AMPLEGVKALTDFMIEFERRHG"
     aSDomain        7791..8831
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_372_Aminotran_5.1"
                     /evalue="1.20E-73"
                     /label="ctg1_372_Aminotran_5.1"
                     /locus_tag="ctg1_372"
                     /protein_end="350"
                     /protein_start="3"
                     /score="240.0"
                     /tool="antismash"
                     /translation="IFNFSSGPAMLPAEVLKQAQQELRDWNGLGTSVMEVSHRGKEFIQ
                     VAEEAEKDFRDLLNVPSNYKVLFCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAASAI
                     KEAKKYCTPNVFDAKVTVDGLRAVKPMREWQLSDNAAYMHYCPNETIDGIAIDETPDFG
                     KDVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIGPAGLTIVIVREDLLGKANIACPSI
                     LDYSILNDNGSMFNTPPTFAWYLSGLVFKWLKANGGVAEMDKINQQKAELLYGVIDNSD
                     FYRNDVAKANRSRMNVPFQLADSALDKLFLEESFAAGLHALKGHRVVGGMRASIYNAMP
                     LEGVKAL"
     CDS             8941..10224
                     /locus_tag="ctg1_373"
                     /transl_table=11
                     /translation="MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLL
                     DSDDVRHMLNALAALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAA
                     ALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVE
                     VDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQ
                     FVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLE
                     KMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVK
                     ETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDT
                     AVTILDPKCTAKTFPDYFEQLARISQPG"
     CDS             10394..11158
                     /locus_tag="ctg1_374"
                     /transl_table=11
                     /translation="MKNTKLLLAIATSAALLTGCQNTHGINTDLAISSGLNAYKAATLS
                     DADAKAIANQGCAEMDSGNQVASKSSKYGKRLAKIAKALGNNINGTPVNYKVYMTSDVN
                     AWAMANGCVRVYSGLMDMMNDNEIEGVLGHELGHVALGHSLAEMKASYAIVAARDAISA
                     TSGVASQLSRSQLGDIAEGAINAKYSRDKESEADDFSFDLLKKRGISTQGLVGSFEKLA
                     SLDGGRTQSMFDSHPPSTERAQHIRDRIASGK"
ORIGIN
        1 gtgcgattgt tgaggcgata gcctcccgta acaggctgga agccagtgtc gctccgtcac
       61 tggccggaat taaaatcccg cacatcgacc agtcgcagga gtctgatgcg aaattcctga
      121 cccgccttgc tgaacgcaac ggcggtgagg tgtcggtaaa aatgggaaaa ctgttgtttc
      181 tcaaagcggg gcagggggtg acggccagcg gtaaaaaaat cccgcaggtc accatcaccc
      241 gcagcgacgg cgaccgtcat cattttgcga ttgctgatcg tggagcctac accggcgtaa
      301 cggcaaagtg gttacacacc aaagacccga agccgcaaaa gcagaaggta aaactgaaac
      361 gcaaaaagaa agagaaacac ctgcgcgcac tggagcaccc gaaagcgaaa ccagtcacgc
      421 agaagaaagc gccaaaagta ccggaagcgc gtgaaggtga atacatggcc ggtgaggctg
      481 acaacgtttt tgccctgacc acggtatatg ccacgaaagc gcaggccatg cgcgccgctc
      541 aggcgaagtg ggataagctg caacggggcg ttgcggagtt ctccatcagt ctggctaccg
      601 gtcgtgctga tatttacacg gaaacaccgg ttaaagtgtc aggctttaag cgcgtcatag
      661 acgagcagga ctggacaatc actaaggtga cacattttct gaataatagc ggcttcacga
      721 cgtccttgga gcttgaggtc aggctttctg atgtggagta cgaaacagaa ggtgatgagt
      781 gatgttttta ttttatctgt ttgttttata aggataaatt aactaaaatg gcaccatcaa
      841 caaaaccgga agaggtgctc gcgatgtttc attgtccttt atgccagcat gccgcacatg
      901 cgcgtacaag ccgctatatc actgacacga caaaagagcg ttatcaccag tgtcagaacg
      961 tgaattgcag cgccacgttc ataacttatg agtcggtaca gcgatacatc gtgaagccgg
     1021 gagaagtcca cgccgtaagg ccgcacccgt tgccgtcagg gcagcaaatt atgtggatgt
     1081 aattacaaac aggaagcccc tcagtcgagg ggcttttttg tcgatgtggt caatgtgtgg
     1141 acgtgaccag aaataaatcc ttttatttca tgtgattaga tatcaaaaaa tgtcaccaat
     1201 aactgacatt gcggtgtttc tccagatgtg gcccatctga ggccgtgttg gtgcgcagct
     1261 cgaaggctac gtcgagtctg ttttggcagt caccttaaag tatagatagc tgacaaaaaa
     1321 ggctctcgtg ctaaaaaagg ccccactttc gtggagcctt tattgtacgc tttttactgt
     1381 acgatttcag tcaaatctaa ttacatagat tgagtgaagg tacgagtaat aacgtcctgc
     1441 tgctgttctt tagtcagcga gttgaaacgt actgcgtagc cagatacacg gatggtcagc
     1501 tgcggatatt tttccgggtt ttccatcgcg tcgagcagca tttcacggtt catcacgtta
     1561 acgttcaggt gctgaccacc ttcgatggat gcttcgtggt ggaagtaacc atccatcaga
     1621 ccagccaggt tggtcttacg aacttcgtcg tctttaccca gtgcgttcgg aacgatagag
     1681 aaggtgtagg agataccatc tttagcgtaa gcaaacggca gtttagcaac ggaagtcaga
     1741 gaggctactg cacctttctg gtcacgaccg tgcatcgggt tagcacccgg tccgaacggc
     1801 gcgccagcac gacgaccgtc tggggtgtta ccagttttct taccatacac aacgttagaa
     1861 gtgatggtca gaacagactg agtcgggata gcgtcacggt aggtgtgcag tttctgaatt
     1921 ttcttcatga aacgttctac caggtcaaca gccaggtcat ctacacgcgg atcgttgtta
     1981 ccaaactgcg ggtattcgcc ttcgatttcg aagtcgatag ccagaccgtc ttcgtcacga
     2041 atcggtttaa ctttcgcata tttgattgca gacagggagt cagcagcaac ggacagacca
     2101 gcgataccac acgccatggt gcggataacg tcacggtcgt gcagcgccat cagagaggct
     2161 tcgtagctgt acttgtcgtg catgtagtgg atgatgttca gtgcagtgat gtactgttta
     2221 gccagccagt ccatgaagtg atccatgcgc tccatcactt catcgtagtt caggagatcg
     2281 cctttgatcg gttcagactt cggaccaacc tgcattttca gtttttcgtc aacgccgccg
     2341 ttgattgcgt acagcatggt tttcgccagg tttgcacgcg caccgaagaa ctgcatttgt
     2401 ttaccaacga tcatcgggct tacgcagcaa gcgatagcgt agtcatcgtt gttgaagtcc
     2461 ggacgcatca ggtcatcgtt ctcatactgc agagaagagg tgtcgatgga cactttagca
     2521 gcgaatttct tgaagttcag cggcagtttt tcggaccaca gaatggtcat gttcggttcc
     2581 ggagacggac ccatggtgta cagggtgttc aggaaacgga agctgttttt ggtaaccagg
     2641 gtacgaccgt cgaggcccat accaccgata gattcggttg cccagatcgg gtcgccagag
     2701 aacagttcat cgtattccgg agtacgcagg aagcgaacca tacgcagttt catgaccagg
     2761 tggtcaacca tttcctgcgc ttcttgttcg gtgatcttgc cagctttcag gtcacgttcg
     2821 atgtacacat ccaggaaggt ggaggtacga ccgaaggaca ttgcagcacc gttctgagac
     2881 ttaacagcag ccaggtagcc gaagtaagtc cactggatag cttcctgagc gttggtagcc
     2941 ggaccagaga tgtcgtagcc gtatttcgca gccatttctt tcatctgacc cagagcgcgg
     3001 tgctgttcag cgatttcttc gcgcagacgg atagtctgtt ccaggtttac gccgttttcc
     3061 agatcagcct gcagagaggt gaactgtgca agtttgtctt tcatcaggta gtcgataccg
     3121 tacagcgcaa cgcgacggta gtcaccgatg atacgaccac ggccataagc atctggcaga
     3181 ccggtcagaa caccggattt acggcaacgc aggatgtccg gagtgtaaac gtcgaacacg
     3241 ccctggttgt gagttttacg gtattcagtg aagatttttt tgatcatcgg gtccagttcg
     3301 cggttgtacg ctttgcagga accttcgatc attttgatac caccgaacgg gataagagca
     3361 cgtttcagcg gagcttcagt ctgcagacca acaacttttt ccaacgcttt gttgatgtag
     3421 ccagcgtcgt gagaggtgat ggtggaagca acagcggtgt caaagtcaac tggcgcgtga
     3481 gtgcggtttt ccagtttaac gccttccatt actttgtccc acagggtggt ggtcgcttca
     3541 gtagcgccag ccaggaagga ctcgtcaccc tcgtacggag tgtagttttt ctgaatgaag
     3601 tcacggacgt ttacttcatt ctgccagtca cctttggtaa aaccttccca ggctgtggct
     3661 aacttttcat taagctcgga catgtaacac ctaccttctt aagtggattt tttatttact
     3721 gcgtacttcg acaaccatta atggtgatcg ttttcacgca ggtaaatgac ccagtatgtc
     3781 aacccaacca acaaaccacc gccgataata ttaccgatcg taaccggaat caggttatca
     3841 gtgatgaagt tcattacggt caggtgagaa aaattttccg gtgcagaacc gacagcggtc
     3901 cagaattccg gagatgcgaa gtcgcggatt acaataccca tcgggatcat aaacatgttt
     3961 gcgatactgt gctcaaaacc gctggcaaca aacatcgcga ccggcagcac cataatgaac
     4021 gctttgtcca tcaggctgcg gccagaataa ctcatccata ctgccagaca taccatcagg
     4081 tttgccagga taccaagaca gacggcctca ataaaagtat ggtgcacttt gtggtcggcg
     4141 gtttgtagga cgttgagtcc ccattgacca ttcgcggtca tatactcgcc ggaaagccac
     4201 attaaaagta caaacagcag tgcgccgacc aggttgccaa aatagacatt tagccagttt
     4261 ttcgccaact gaccccaggt gatgcgccca ctcgccttag caacaacaat caacactgtg
     4321 gaagtaaaga gatcggctcc gcagacaaca caaagaatca gccccagaga gaagcaaata
     4381 ccgccaacca gttttgccat gccgaagggc attgttcctg tgccagtggt tgctgtgata
     4441 tagaagacga atgcgattga gatgaaaaca ccggcggtaa tcgccagata gaaagtctta
     4501 agcggatgtt tcgttgcttt atagacacct gcctcttcgg ccactttggc cattgctgca
     4561 ggaagtaaaa gatcaaaagg gttgtcagct ttcacactaa ctctctcttt attaagtcgg
     4621 cgacgagata ctaacaaagc attatagatg agaaattgat atagatcata tctcgcctgg
     4681 cttataggcc cgtaactcgc atggttttta tgcaaatacg gagtaaatat ttgattatcc
     4741 aaataaaaat aaattttaaa aattaacaaa tgagttgaat tttttccgca tcctccgcta
     4801 aaacagttaa ttaaaaggga gcatcaggcg aataaagtaa caatatcgat cgtatttatt
     4861 aaatacaaat taccgatatt taactttata attacaatta ttttattaat gcaaatatat
     4921 gtaaagcggg gcattaaaaa aacgccccgt aatataactc agacgaatca ttaagcctac
     4981 attgcgtagg ctatttgatt ttattttgcc cagaatgctg ctttggcgcg ctgcagcttt
     5041 tcgtaggcct tcaacaacga ctgatgtgca gcaaacgcgt gcagatcgct atctactggt
     5101 tgcaaaccat aaaacgccgc ttcgccgctc attgccgcac tggcggcttc cacggcatct
     5161 gcgccgtaca tgcgaacaaa cgcattcaga tattgcagcg gctggcgatc ttcttcctgc
     5221 gccagtaata acaacgtttg caggcagcga taatagttgg cgcgttccgg gctgaatacc
     5281 gatgagttaa actccatcgt ccattcggtc cagaccagag cctgttccag atcgccacca
     5341 gccagcgcca gcatggcttt taattcaccg atacgcaggg tgtaccaacc gttatccgac
     5401 ccggtcgcca gacccaacag ctcacgcacg cgggtaaagt catcaaaacc ttcttcatcc
     5461 agttgctcga tgaggttcag gtaatcttct ttttcccact cgctgcctgg taacgaaaga
     5521 atcgtttcac gtaaatggct gcccatactg ttattcgcca gccacagatc ttcagccgga
     5581 taaatatcgg acatgccagg tacgataatt ctgcatgcat aaacgcccag atgctcgtaa
     5641 tcggcaatat aaacttcttt atcttctttg ttgaagatag ccatcagcgt agcaaactct
     5701 tcttccgtag tgccggagaa attccagtcc acaaacggat aatcggcatc ctgcttgaac
     5761 agatcccagg agattaaacc gctggaatcg ataaagtgcg tttcgaggtt ggtatgttca
     5821 gcaacttctt catcatcgaa ggttggcgga gtaaacacat ccaaatcttt caggccacga
     5881 ccttgcagca gctcggtcac ggtacgttcc agtgctacgc caaaatcagg atgtgcaccg
     5941 aaagaggcaa agcaggtgcc gttagcagga ttgaacagta ccacgcaaat caccggatac
     6001 tggccgccaa gcgaaccatc ataagcaaag attgggaaac cttctgcttc cagcgtttcg
     6061 atggcttcaa ccaccgctgg gtaacgcgcc agcacgtctg ccgggatttc cggcaagctg
     6121 atgctttcag caataatgcg gtttttcacg tagcgttcga aaacttcgga caacccctga
     6181 acgcgtgctt cgttgcgggt attgccagcg gacataccgt tagaaacgta caggttacca
     6241 atgatattca tcggaatata aacggtctga ttgtcggact ggcgcgtaaa cggcagaccg
     6301 caaataccac gatcttcgtt accggattgc aggtcaatca gcatactgcc ggccagttca
     6361 ttctccggat cgtaaaatgc gcgcagacgg tcatcgagca gcccttctgg cacatcgtca
     6421 ttttcgctca gtgggaacca tttttcgttg ggataatgca cgaacggacc gttggcgatg
     6481 gtttcgccca gccagaaatc agcaaaaaag tagttggttg agagacgctc gaaatattca
     6541 ccgagtgcag aagccagcgc cgcttttttg gttgcgcctt taccgttggt aaaacacagt
     6601 gcgcactctt tgtcgcgaat atgtacagac cagacgttag gcaccggatt cagccaggag
     6661 gcctcttcaa tctgaaagcc gaggtctgaa agtttttgct ggaagcgagc gatggaatct
     6721 tccagtgcgg catctttgcc ggggataaat gtttgcgtca tgaaaatcac tttagtcgta
     6781 cggaaagcgc gcaataatac gggttttatc tcaaaggcgc tatcaccgcc gccatgccga
     6841 tgaactgttg actatgcttt tagtggataa accacgataa gagcataaaa atgaaggcgt
     6901 ttgatctcca ccgtatggca tttgataaag tgccttttga tttccttggc gaagtggcac
     6961 tacgtagtct ttataccttt gtactggttt ttttgttcct caaaatgacc ggaagacgcg
     7021 gtgtgcggca gatgtcgctt tttgaagtgt taatcattct gacgctggga tcagcggcgg
     7081 gagatgtggc gttttatgat gatgtgccga tggtcccggt acttatcgtc tttattactc
     7141 tggcgttgtt ataccgcctg gtaatgtggt tgatggcaca cagtgaaaaa ctggaagatc
     7201 ttctggaagg taagccggtt gtcattattg aagatggcga gctggcctgg tcgaaactca
     7261 ataactccaa catgacggaa tttgagttct ttatggagct acgattgcgc ggtgtagagc
     7321 agttggggca agtacgtctg gcgattctcg aaaccaacgg gcaaatcagt gtctatttct
     7381 ttgaagatga caaggtgaaa ccgggcttac ttattttacc cagtgactgt actcagcgtt
     7441 acaaagtggt acccgagtcg gcggactatg cctgcattcg ttgcagtgaa atcattcata
     7501 tgaacgcggg ggaaaaacaa ttatgtccgc gctgtgcaaa tccagaatgg acgaaggcaa
     7561 gtcgggcaaa acgggtgacg tgacagtaaa aacatcggct ttttgctaat aatccgagag
     7621 attcttttgt gtgatgcaag ccacattttt gccctcaacg gttttactca ttgcgatgtg
     7681 tgtcactgaa tgataaaacc gatagccaca ggaataatgt attacctgtg gtcgcaatcg
     7741 attgaccgca ggttaatagc aacgcaacgt ggtgagggga aatggctcaa atcttcaatt
     7801 ttagttctgg tccggcaatg ctaccggcag aggtgcttaa acaggctcaa caggaactgc
     7861 gcgactggaa cggtcttggt acgtcggtga tggaagtgag tcaccgtggc aaagagttca
     7921 ttcaggttgc agaggaagcc gagaaggatt ttcgcgatct tcttaatgtc ccctccaact
     7981 acaaggtatt gttctgccat ggcggcggtc gcggtcagtt tgctgctgtt ccgctgaata
     8041 ttctcggtga taaaaccacc gcagattatg ttgatgccgg ttactgggcg gcaagtgcca
     8101 ttaaagaagc gaaaaaatat tgcacgccta atgtcttcga cgccaaagtg actgttgatg
     8161 gtctgcgcgc ggttaagcca atgcgcgaat ggcaactctc tgataatgct gcttatatgc
     8221 attactgccc gaatgaaacc atcgacggta tcgctatcga cgaaacgcca gacttcggca
     8281 aagatgtggt ggtcgccgcc gacttctctt caaccattct ttcccgtccg attgacgtca
     8341 gccgttatgg cgtgatttac gctggcgcgc agaaaaatat cggcccggca ggcctgacaa
     8401 tcgtcatcgt tcgtgaagat ttgctgggca aagcgaatat cgcgtgtccg tcgattctgg
     8461 attattccat cctcaacgat aacggctcca tgtttaacac gccgccgaca tttgcctggt
     8521 atctgtctgg tctggtcttt aaatggctga aagcgaacgg cggtgtagct gaaatggata
     8581 aaatcaatca gcaaaaagca gaactgctgt atggggtgat tgataacagc gatttctacc
     8641 gcaatgacgt ggcgaaagct aaccgttcgc ggatgaacgt gccgttccag ttggcggaca
     8701 gtgcgcttga caaattgttc cttgaagagt cttttgctgc tggccttcat gcgctgaaag
     8761 gtcaccgtgt ggtcggcgga atgcgcgcgt ctatttataa cgccatgccg ctggaaggcg
     8821 ttaaagcgct gacagacttc atgattgagt tcgaacgccg tcacggctaa tgccgaaatt
     8881 ttgcttaatc cccacagcca gcctgtgggg tttttatttc tgttgtagag agttgagttc
     8941 atggaatccc tgacgttaca acccatcgct cgtgtcgatg gcactattaa tctgcccggt
     9001 tccaagagcg tttctaaccg cgctttattg ctggcggcat tagcacacgg caaaacagta
     9061 ttaaccaatc tgctggatag cgatgacgtg cgccatatgc tgaatgcatt agcagcgtta
     9121 ggggtaagct atacgctttc agctgatcgt acgcgttgcg aaatcatcgg taacggcggt
     9181 ccattacacg cagaaggtgc cctggagttg ttcctcggta acgccggaac ggcaatgcgt
     9241 ccgctggcgg cagctctttg tctgggtagc aatgatattg tgctgaccgg tgaaccgcgt
     9301 atgaaagaac gccccattgg tcatctggtg gatgcgctgc gcctgggcgg ggcgaagatc
     9361 acttacctgg aacaagaaaa ttatccacca ttgcgtttac agggcggctt tactggcggc
     9421 aacgttgaag ttgatggctc cgtttccagc cagttcctca ccgcactgtt aatgactgcg
     9481 cctcttgcgc cggaagatac ggtgattcgt attaaaggcg atctggtttc taaaccttac
     9541 atcgacatca cactcaatct gatgaagacg tttggtgttg aaattgaaaa tcagcactat
     9601 caacaatttg tcgttaaagg cgggcagtct tatcagtctc cgggtactta tttggtcgaa
     9661 ggcgatgcat cttccgcttc ttacttcctg gcagcagcag caatcaaagg cggtactgta
     9721 aaagtgaccg gcattggacg caacagtatg cagggtgata ttcgctttgc tgatgtgctg
     9781 gaaaaaatgg gcgcgaccat ttgctggggc gatgattata tttcctgcac gcggggtgaa
     9841 ctgaacgcta ttgatatgga tatgaaccat attcctgatg cggcgatgac cattgccacg
     9901 gcggcgttat ttgcaaaagg caccaccacg ctgcgcaata tctataactg gcgtgttaaa
     9961 gagaccgatc gcctgtttgc gatggcaaca gaactgcgta aagttggtgc ggaagtagaa
    10021 gaggggcacg attacattcg tatcactcca ccggaaaaac tgaactttgc cgagatcgca
    10081 acatacaatg atcaccggat ggcgatgtgt ttctcgctgg tcgcattatc agatacggct
    10141 gtgacgattc ttgatccaaa atgtaccgct aaaacttttc cagactattt cgagcaattg
    10201 gcgcggataa gtcaacccgg ctgaatgaat aacgggcgat aacatagaca atcctttctt
    10261 ttcaaagacg tcggcacatt gccggcgttt tttttcggac cttgtggggt atttttatta
    10321 atggtagcgt taattatcaa tgtaacttgt tgatacataa tgtttatata taattaatca
    10381 acggatgatt cacatgaaga atactaaatt attgctggcg attgcgacct ctgcagcctt
    10441 actgacagga tgtcagaata cgcacggtat taataccgat ttggctatca gctcaggtct
    10501 gaatgcttat aaagccgcaa cattaagcga tgctgatgct aaagcaatcg ccaatcaggg
    10561 ctgtgccgaa atggacagcg gcaatcaagt cgcaagtaaa tccagcaagt acggtaaacg
    10621 tctggcaaaa atcgccaaag cattgggtaa caatattaat ggcacgccgg tcaactataa
    10681 ggtttatatg accagcgacg tcaacgcatg ggcgatggcg aacggctgtg ttcgtgtcta
    10741 cagtggcctg atggacatga tgaacgacaa cgaaattgaa ggcgttctgg gtcatgaact
    10801 gggccacgtc gcgttgggtc actcgctggc tgaaatgaaa gcttcttatg cgatcgttgc
    10861 cgcacgtgat gcgatttccg ctaccagcgg tgtggcttcc cagctttctc gctcacaatt
    10921 aggtgatatc gcagaaggcg cgatcaatgc taaatactcc cgcgataaag agtccgaagc
    10981 agatgatttc tcctttgatc tgttgaagaa acgtggcatc agcacccagg ggctggttgg
    11041 cagctttgaa aaattggcca gcctggatgg cggtcgtacc cagtccatgt ttgactctca
    11101 cccaccatca acagagcgtg cgcaacacat ccgtgatcgt atcgcctctg gtaagtaaat
    11161 cattgtcatc tttcgggctg gtcttctgcc agcccgctat aattgcgcaa taaatcccca
    11221 tctgaataca gacaaaactg gtttttgcac acaacgttaa cgatttgtgg cgtcggcgcg
    11281 tataatgcgc gcggttatgt taacggtacg cctgttttaa ggagataaag atgacggcaa
    11341 ttgccccggt tattaccatt gatggcccaa gcggtgcagg gaaaggcacc ttgtgtaagg
    11401 ctatggcgga agcgttgcaa tggcatctgc tggactcggg tgcaatttat cgcgtactgg
    11461 cactggcggc attacatcac catgttgatg ttgcatcgga agatgcgctg gtgccgctgg
    11521 catcccatct ggatgtacgt tttgtgtcga ccaatggcaa tctggaagtg atcctcgaag
    11581 gggaagatgt cagcggcgaa attcgtactc aggaagtggc gaatgctgct tcacaagtcg
    11641 cggcattccc acgcgttcgt gaagcattat tgcgtcgcca acgcgcgttt cgcgaattac
    11701 caggcttgat tgccgatggc cgcgatatgg gaacggtggt attccctgat gcgccagtga
    11761 a
//
