LOCUS       CP067860.1             16959 bp    DNA              UNK 01-JAN-1980
DEFINITION  CP067860.1 Klebsiella pneumoniae strain ARLG-3213 plasmid pC268_2,
            complete sequence.
ACCESSION   CP067860
VERSION     CP067860.1
KEYWORDS    .
SOURCE      .
  ORGANISM  .
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 20:30:47
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..180
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
     CDS             complement(208..738)
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
     protocluster    422..12107
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5421:7107]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5422..7107
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    422..12107
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          422..12107
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(745..1476)
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
     CDS             complement(1476..3440)
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
     CDS             complement(4152..4280)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MEKRHLRGLAVLPHMLVPCLFTESVGNFACVRSARRSLTAGA"
     CDS             complement(5155..5412)
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
     CDS             complement(5422..7107)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Cloacin"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7"
                     /sec_met_domain="Cloacin (E-value: 2.3e-113, bitscore:
                     367.1, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
     CDS             complement(7843..8547)
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
     CDS             complement(8559..8816)
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDID
                     LLVTVTVRLDETTRRALINDLLETALLQIVGGDKLIIPFC"
     CDS             complement(8898..9395)
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYI
                     AMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVE
                     LLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRS
                     VA"
     CDS             9578..9766
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) darobactin_precursor"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_11"
                     /sec_met_domain="darobactin_precursor (E-value: 1.0,
                     bitscore: 7.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTRKSIDTVLLSVGAEKLSQREWDWMKMLKPMDPPPAMVTTSIL
                     KRRGDTAALTLLQDTGV"
     CDS             9776..10975
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MLSGFTPRPLKRLFTANQCWTSFLDAGGLRDIEVEAVTKMLACGT
                     RILGVKEFGCDNPDCQHVKYLTNSCGSRACPSCGKKATDLWTATQLNRLPDCDWVHLVF
                     TLPDTLWPVFESNRWLLNDVCRLAVENLLYAARKRGLEPGIFCAIHTYGRRLNWHPHVH
                     VSVTCGGLNKHGQWKKLSFLKDAMRSRWMWNMRQLLLKAWSEGMAMPESLSHITTESQW
                     RSLVLKSGGKYWHVYMSKKTAGGRNTARYLGRYLKKPPIAASRLAHYNGGASLSFRYLD
                     HKTGETATETLTQRELVARLKQHIPEKFFKMVRYFGFLANRVCGEKLPQVYRALGMDKP
                     EPVAKVCYAQMVKQFLSRDPFECVLCGCRMVYRRAIAGLNVSGLKKNARDISLLRYMPA
                     "
     CDS             complement(11374..11931)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MRIFGYARVSTSQQSLDIQIRALKDAGVKANRIFTDKASGSSTDR
                     EGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGDMG
                     QMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTGATE
                     IAHQLSIARSTVYKILEDERAS"
     CDS             12093..15098
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MPVDFLTTEQVESYGRFTGEPDELQLARYFHLDEADKEFIGKSRG
                     DHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTRRE
                     HAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILPGAT
                     TLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGPVTIS
                     GPAFNEAIERWKTLNDFGLHAENLSTLPAVRLKNLARYAGMTSVFNIARMSPQKRMAVL
                     VAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALASACSYL
                     LKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHDEMVEQYGRVRRFLPHL
                     LNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISQSWKRLVINKEKHITRR
                     GYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRSLGHPTDPQE
                     AIKSLGHQLDSRYRQVAARLGENEAVELDVSGPKPRLTISPLASLDEPDSLKRLSKMIS
                     DLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMAEACNIGLEPLI
                     RSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGGGEVASADGMRFV
                     TPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDSIFVLEGLLEQETG
                     LNPTEIMTDTAGASDLVFGLFWLLGYQFSPRLADAGASVFWRMDHDADYGVLNDIARGQ
                     SDPRKIVLQWDEMIRTAGSLKLGKVQASVLVRSLLKSERPSGLTQAIIEVGRINKTLYL
                     LNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYTDGQEDQLGALGLVTNA
                     VVLWNTIYMQAALDHLRAQGETLNDEDIARLSPLCHGHINMLGHYSFTLAELVTKGHLR
                     PLKEASEAENVA"
     CDS             15175..15594
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
     CDS             15900..16163
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
     CDS             16153..16452
                     /locus_tag="ctg1_17"
                     /transl_table=11
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
     CDS             complement(16514..16891)
                     /locus_tag="ctg1_18"
                     /transl_table=11
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
ORIGIN
        1 atgacaaaac aggaaaaaac agccctcaat atggctaaat ttattaagga gcagtcgctg
       61 ctattgctcg ataaactgaa tgagctggat atggataccc cggccgacat gtgcgagcgg
      121 ctacacgagg atgcggaaac actctggcag gtgatgcggg ataagctcgg ggaggaataa
      181 cagcaccggc atggccggtg ctggcattta ttttttgccg aacggccacc accggcgggc
      241 aggtttgtcc tccggcagtt caggtaccgg cacgttaaaa tagcggctgt tatattcccg
      301 catcagctcc gctttcagct tctcgttcac cgcgctttcc ccgtgccgct cactcaccac
      361 gtcaatcatc gcgttaatct gctccggtga gcacttcccg gcatcaacca cctgcacacc
      421 gttctcgatg gcgaaccgct ccaccttgcg atagaggtaa tcacacagct tcattcctgt
      481 gggtttgttc cgttcccatt gcggattttt accagtgaaa aagtacgtgg ctttttcgtc
      541 gctgttgagc cgctcgtcat acatcccgat ggatttcatc atcgccagat gctgggcccg
      601 gtcgacaaaa cagaaaacat acgccccggt ctgccaggcg agcaccacca tatcttccag
      661 atgctcgctg gtcggcatga tgcagcgctc gccgttccgg tcctccgcgt cttcaataaa
      721 taccatgtac agcgccataa tccctcactc cgttgtcata aatttaaagc acgcaaacaa
      781 ccgttcacga tccagctctg ccgttttgcg ggcctcgccg gtctgtgggt tcacgatttc
      841 atccaccgac aggattgccc gctgcaccct gacctgcgtc gcccggtccg ggcagatgta
      901 ccagatttca tcgatgccgt tagctttgcg gttgaacaga tacccggaca ccacttcctg
      961 ataccggcga cggctcttga cggtgcgctc cacctcaaac gccaccgttt taccgtccag
     1021 ctccgccagg gcgtccggca ctttcatgcc tttaagactc agacggtgca gaatgcgcca
     1081 gccggtggcc cctctggctt ccatatcaag gcgcagggat tgcacggcca gccggtgcgg
     1141 cagatgtgct gccgacaccc ttgacggctg aaacggaata acatccgcca gcggttcgtc
     1201 ctcgtcgaac gagaacgcca cgccatgcgg cgtcagcccc cacacgctga cctgacggcc
     1261 gtccaccgga tatttggtcc ggaccagcag ccctttcgcc accaggctgt cgaggaagcg
     1321 gtagaccggc tgcaccgccg caatccccag ccgccgcgca accagctccg ccgtggaaca
     1381 cagctcttcc cgcaaccagc gcagggtcag ccgggttttc tccgcgttcc gcgcctgtcg
     1441 tttcgcgtgg ctgacgttgt acagctccag cgccatcagt aaatccccgc aaaatcatca
     1501 tccgctttcg gcccgccgcc gtcggccggg ggccggaact ccgccagggg atcggttttc
     1561 gccagcaccg ggaaacgctg caacgggatt tcccggcgct caacccgcag cggactgctg
     1621 aacgccatcc gggccacacc cagcccggtc atgaccgcga acccgtccgg caggtgttgc
     1681 agggtgttca cgtcaaacag cggccgcgcc tccttctgga tgaagctgtc cccgctgata
     1741 tgctccacgt tccccgcctc ccggctggca cggcggcgct ccacgtccac cctgatttcc
     1801 ccggtctgcc ccgccgccca ctgcgcggac tccaggctgg ccgcccggta aaaccagcgg
     1861 atcggcgtgt tatccagtac cgtggttttc acaaattcag cgggcagatc ctgcccgcac
     1921 tgcccgaaat cgcccagcga ctggtgcgcg agcaacagat tgcagtcccg gctgcgcagc
     1981 gtccccagtg cgttcagtac atacttcgac agcagatatt taatttcatc gagcatcacg
     2041 ctgacgtgtg gccactcccg gaactcgtcc cgcgcaatga tgatttgcgc gcagcgggca
     2101 aacagcattt tttgcacacg gatcaccgcc tcgtcgtcca tcgagccgat aacgtacagg
     2161 cagccgccgc cgttgataat ccccgccaca tcgatgccac tgtccgtctg caggacgctc
     2221 aggtcagcga cgttttccag cctagtgatc aaccccttca cgtccttttt cagggcctcc
     2281 ggcagcgcgt acgccgccgc cagcacctgc tgaatgtttg ccccctgcgg aaactgctcc
     2341 gcaatcagct tcgccgcttt ctgctcgctg atgcggtagt ggtccgccac gtcgccggtc
     2401 tcgcccaggt taagcccggc aatcagcagg tttttcagcg cgtactggtc gagatcgcgg
     2461 aacagattca gctgcgccgg tttccccggc cgcagatcca gcagggtgaa gtccggacag
     2521 tgcgcccgga agacgtgcgg cgcccatgcg tcccctttgg ggtcgaagta caccaccgcg
     2581 tccccgaaat cgcgtacgca gcgaatgagc gcgttggtgg ccatcacgct cttgccgctc
     2641 ccgggcaggc cgaggatctg aatgttggtc ttgcgccagg tatcacgcgg aaccagcacc
     2701 ggcttgccct gctcatcctt acccagaaac accgcctgct cctgccgggc ctgctccgag
     2761 gaaaaatcgg ccagcgcatt aaccggtacc ggctccccga aatgcaggtg gcgcacgtcg
     2821 gtcatctctc ctgtccgctg gctgctgcgc cggctctcct gattcagttt cgcgttcacc
     2881 gcctcgtcag cagccgcaaa atgaccgtca agcagcagga acgccagcag ccgcgccaac
     2941 acaatcccga cagccagccc gcccgcgcac caggcaatcc cgaacaggtt agccggctgc
     3001 agcaggtaat aatctgcgtt tgcgtagagg tccggacgca ggacggtttc tccccagctc
     3061 tcgataaaca cggcgacaac cagccccccc agaagggcca gaccggccgc gccggtcagc
     3121 cagtacgcgt agttccagac atgtcgacgt gccctgacca tccgcccggg cgaatccagc
     3181 gaggccagca ccgaaaatgg cgctggccgt ttattatcgc gcttatagcg atcggcatac
     3241 tcccgtcgct ccttatgact cagccccaca aaacgcatcc gtccggccca aagttcagcc
     3301 agaccgaaaa acaggccgat aactaggaaa gccccggcca gaccgtaata ctcctggtac
     3361 agccagctga cccacggata aatctgccgg gccagctccg gaatgtgcca cttccaggca
     3421 agcgaatccg tattaaacat gttctctctc cttcagacga tggtttgccg gcgtgatgtg
     3481 cagcccccgc tgcacaagcc gcggacatgc cccaaggcat ggcggcggcg gtcacgtccg
     3541 tggtgattgc gttcagcttt caccacggag gccagcctct ttccgcccca tgcggaaaag
     3601 gcgcagcccc ggaggaacaa cgagcacgcc ccagcgtgtg agaggaaaag gcggcacccc
     3661 agtgcggtct tttccggtgt tccggccccc gtcagagttc gccatagcga gcggctgacc
     3721 acccgcaaaa tcaggagcag ctttgctgct tcgccaggtg cgtccagcac cgtggatttt
     3781 tgtgggtggt caggcgtgag cctgacgggg gccgggtgaa tttctggcgt ggccggcgtc
     3841 cagccggacg gagccagaaa gagggggaga gaccgtgcgt cggtggcgtc cagccagcgt
     3901 aagcagggga tatccccctg aggtcagcca cgccctcgcg gggatgacct gtatttctcc
     3961 gtaaggagaa aaaagcaaca gagataggtt aacgtaaaat gttcagcgaa aaaccgatat
     4021 gattcaccta tcctggtaat ttattatcag ggaatataaa gacttaatca ggggacaata
     4081 tgccacatca gcgcgtccgg tgtccgtctt gtaggtgccg gggaaattgc gcctcctcgc
     4141 tcactcggtc gctacgctcc ggccgtgaga ctgcggcggg cgctgcggac acatgcaaag
     4201 ttacccacag attccgtgaa taagcagggg actaacatgt gaggcaaaac ggcaaggcca
     4261 cgcaggtggc gtttttccat aggctccgcc ctcctgactg agttcacata aacagacgct
     4321 ttttcggtgc atctgtggga gccggtggct caaccatgaa tcagtcagga gtggcgaaac
     4381 ccgacaggac ttaaagatca tcaccgtttc cgatgaatcg ctccctcttg cgctctcctg
     4441 ttccaaccct gccgtttccc ggatacctgt tccgcctttc tcccttgcgg gaagtgtggc
     4501 gctttctcat agctcacact ctggtatctc ggctcggtgt aggtcgttcg ctccaagctg
     4561 ggctgtaagc aagaaccccc cgttcagccc gactgctgcg ccttatccgg taactgttca
     4621 cttgagtcca acccggaaaa gcacgcaaaa cgccactggc agcagccatt ggtaactggg
     4681 agttcgcaga ggatttgttt agctaaacac gcggttgctc ttgaagtgtg cgccaaagtc
     4741 cggctacact ggaaggacag atttggttgc tgtgctctgc gaaagccagt taccacggtt
     4801 aagcagttcc ccaactgact taaccttcga tcaaaccacc tccccaggtg gttttttcgt
     4861 ttacagggca aaagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt
     4921 ctactgaacc gcgatccccg tcagttcaga ggaggacgat ggtgccaccg ttccaccctg
     4981 aacatcccgg atatagtttg cctgacatgc gaccagaaga aagcctgaaa aaatcaatat
     5041 aaaaagaaaa acaaccttta cctttttcat ataccttccc tgtatttaaa aaccccggta
     5101 ttcatccctg aacaccggaa gtctgtattt caaatcatcc ttgataactt ttgcttacca
     5161 gttaccatcc cggtaaacaa aggatacaaa gtaatcaaat ttactaatat cgattacatt
     5221 tttaaagtgt ggctgtaata tcgaaaccca tgatttttca acatcaaacc aaccattatt
     5281 aatattatcc tttaaaggca tccccagact ttcaatgaca gaaccatcat caccgaagtc
     5341 ttttgagtat tcaccacctt taaactcttc ggttttctta tcaaaccaat gaatatgtaa
     5401 tttaagcccc atatttacct cttaaagata ttttttaatg tttcgttttg gatccggccc
     5461 tttaacctgc ttacccgttt ttggatcgaa tgccccgagg tgttcgccat cactggcgcg
     5521 gtacccttca agctcaccgt gctgggaatc ccattcataa attttacgct ttttatcacc
     5581 ataccatcgg gcccgcttac caccaccacc ttgtttaggg gttttaggtt taccctcttt
     5641 caactctccc aaccccttaa tatcttcagt cttgggatca ggaaaataat catggccgta
     5701 atctttagtt cccttacgag gttttttctt ttcctcattt aatttatttt ctgcatcctt
     5761 cgcttttttc tccttttgtt tccggctctc catcgccccg gaaagcgcag ccttatccct
     5821 ggataaggat tcattcattt cgtttaaaga tgtctgggca gcttttaatt tctcattctg
     5881 attctgaata tccttatcaa gatagcgaac ctgatcctgc cacccggagc catattcatg
     5941 aggcgggtta taagtcacaa aatcatcttt atttgcctct gcctctttta cctttttatc
     6001 ggcttcctga acagcagccc ttgcaccggg gatcgccttc tctgtcgatg caatgcgact
     6061 gtttaaggtc gcaatatttt tatcttcagc atccagctca gctttcgctt tatcatactc
     6121 tcttttcagc ccctcttccg ggtgagcagc gtcccatgcc tgctggcgac gcttttcttc
     6181 ctccagacgc tgttttacct gtgccggagt aagaacatcc gtcaccgaca catagaccgg
     6241 tttctgtccg ctctctttcg ggaaacgaat aacggcttca cgggagttac caccggccgt
     6301 aaaaccagcc ggacgtgaat cacctttttc agcaataatg ccttttggcg gggctttcgc
     6361 ggccggaaca cctttaggta cgctcacctg cagagacggg agacccggaa tcgacacact
     6421 gaataccccc ggacgttttg tcggtttcgc atccaccaca ggaacactca ttggccggcc
     6481 ggtgacaacc gcaatatgct gccgctcgtc cttcacaata tccgccacac gtttagtgac
     6541 gctgaccgtc gcctggtcca gcggcaggga gctgaccggc gtctccgtta ccgtgtctgc
     6601 cggcaatgac gtcacgattt ttgacatcat tttcggatca tcttttgcta tctcagaagg
     6661 cagcactccg taaatcgcaa tcccccacag accaaactta aacggacctt tcagggcagc
     6721 cagcacatca gcaacagcgg ccgacaacgc atcgccggaa acggataaag ccagtccttc
     6781 agcccccgga gtggccaagg caggcagacc gaaggccatc gcggtggccg aagactgtcc
     6841 gccaccagag ctcccgctat gattgccgct gttaccgcca ttaccaccgg gtttactccc
     6901 gccgttacca aactcccccg ggttatagtt atgaatatcc ccgttaggtg tatgcgtcgt
     6961 accccagccc ggcccgctgt ttggatccgt accaccacct gatgaagggc cacctttacc
     7021 tgatgtaccg ttcacattcc cactggcctg accaccattg tgtcccagac ctgaattacc
     7081 cggacctcgt ccgtctccgc cactcatata cttttcctct ttgactttta aaacaataaa
     7141 ctaaaataaa atactgtaca tataaccact ggttttatat acagtataaa aattacgctg
     7201 ccttgttttt catgtcaagt ctgtaaattt gcgtttttgt gaaaatgatc aaaaaaacag
     7261 ccactcacac catgcgcaat cccctccaga tgcaacaaaa accagcacaa acggcgccgt
     7321 tctccggcct cagtatgttt tactgaaatc attatatgag ataccagaaa gccccctccg
     7381 ggacaggaaa agaaacgggg gtctggttcg ggttgttcgg tcactgaaca cggtcagaaa
     7441 ctgatgataa gatagcctgc ggatatataa ggggtctgac gctcagtgga acgaaaactc
     7501 acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa
     7561 ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta
     7621 ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt
     7681 tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag
     7741 tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag ggcactgttg
     7801 caaagttagc gatgaggcag ccttttgtct tattcaaagg ccttacattt caaaaactct
     7861 gcttaccagg cgcatttcgc ccaggggatc accataataa aatgctgagg cctggccttt
     7921 gcgtagtgca cgcatcacct caataccttt gatggtggcg taagccgtct tcatggattt
     7981 aaatcccagc gtggcgccga ttatccgttt cagtttgcca tgatcgcatt caatcacgtt
     8041 gttccggtac ttaatctgtc ggtgttcaac gtcagacggg caccggcctt cgcgtttgag
     8101 cagagcaagc gcgcgaccat aggcgggcgc tttatccgtg ttgatgaatc gcgggatctg
     8161 ccacttcttc acgttgttga ggattttacc cagaaaccgg tatgcagctt tgctgttacg
     8221 acgggaggag agataaaaat cgacagtgcg gccccggctg tcgacggccc ggtacagata
     8281 cgcccagcgg ccattgacct tcacgtaggt ttcatccatg tgccacgggc aaagatcgga
     8341 agggttacgc cagtaccagc gcagccgttt ttccatttca ggcgcataac gctgaaccca
     8401 gcggtaaatc gtggagtgat cgacattcac tccgcgttca gccagcatct cctgcagctc
     8461 acggtaactg atgccgtatt tgcagtacca gcgtacggcc cacagaatga tgtcacgctg
     8521 aaaatgccgg cctttgaatg ggttcatgtg cagctccatc agcaaaaggg gatgataagt
     8581 ttatcaccac cgactatttg caacagtgcc gtttccaaaa ggtcgttgat caaagctcgc
     8641 cgcgttgttt catcaagcct tacggtcacc gtaaccagca aatcaatatc actgtgtggc
     8701 ttcaggccgc catccactgc ggagccgtac aaatgtacgg ccagcaacgt cggttcgaga
     8761 tggcgctcga tgacgccaac tacctctgat agttgagtcg atacttcggc gatcaccgct
     8821 tccctcatga tgtttaacgt ttgacatgag gggcggccaa gggcgccagc ccttggacgt
     8881 ccccctcgat ggaagggtta ggcaacactg cgtgttcgct cgaatgcctg gcgtgtttga
     8941 accatgtaca cggctggacc atctggggtg gttacggtac cttgcctctc aaaccccgct
     9001 ttctcgtagc atcggatcgc tcgcaagttg ctcggcgacg ggtccgtttg gatcttggtg
     9061 acctcgggat cattgaacag caactcaacc agagctcgaa ccagcttggt tcccaagcct
     9121 ttgcccagtt gtgatgcatt cgccagtaac tggtctattc cgcgtactcc tggatcggtt
     9181 tcttcttccc accatccgtc cccgcttcca agagcaacgt acgactgggc atacccaatc
     9241 ggctctccat tcagcattgc aatgtatgga gtgacggact cttgcgctaa aacgcttggc
     9301 aagtactgtt cctgtacgtc agcaagtgtc gggcgtgctt cttctccgcc ccaccactcg
     9361 acgatatgag atcgatttag ccactcatag agcatcgcaa ggtcatgctc agtcatgagg
     9421 cgcagtgtga cggaatcgtt gctgttggtc acgatgctga accacggcag cctggcggct
     9481 gcaaattgaa aaccgccccg gttcgtcctg ttgttgccgc acgccccgca gaatatgtat
     9541 gctctgagga cctgttttat taaggactca tccccttatg ttgacccgca aaagtatcga
     9601 tacagttctg ctctctgttg gtgctgagaa gctctcacaa cgagaatggg actggatgaa
     9661 aatgctcaaa cccatggacc caccacctgc gatggtgacg acctccatcc tgaagcgccg
     9721 tggcgataca gcagccctta ccctgctaca ggataccggg gtttaatcca tcctcatgtt
     9781 gtccggtttt actccccgcc ctctgaaacg tctgttcaca gccaaccagt gctggacgtc
     9841 cttcctggat gcgggcggtc tgcgcgatat cgaggttgaa gccgtcacca aaatgctggc
     9901 ctgcggcaca cggatactgg gtgtaaaaga gttcgggtgt gataacccgg actgtcagca
     9961 cgtaaagtac ctgaccaact catgcggcag ccgtgcctgc ccgtcctgcg gaaagaaggc
    10021 cacagacctg tggacagcaa cacagctgaa tcgtcttcct gactgcgact gggtacatct
    10081 ggtcttcacc ctgccggaca cgctgtggcc ggtgttcgaa agcaaccgct ggctgctgaa
    10141 tgacgtgtgc cgtctggcgg tggagaatct gctgtatgcc gcccgaaaac gggggctgga
    10201 acccggtatc ttctgcgcca tccacacgta tggccgtcgt ctcaactggc atccgcatgt
    10261 acatgtgtct gtaacctgtg gaggtctgaa taagcatggt cagtggaaaa agctgagctt
    10321 cctgaaagac gcgatgcgtt cacggtggat gtggaatatg cggcagctgc ttctgaaagc
    10381 gtggtcagag gggatggcaa tgccggagtc gttgtcacat atcacgacgg aatcacagtg
    10441 gagaagcctg gtgctgaaat ccggcggaaa atactggcat gtgtacatgt cgaagaagac
    10501 agccggaggg cggaatacgg cacgctacct aggtcgttat ctgaagaagc caccaatagc
    10561 ggcttcccga ctggctcatt acaacggagg ggcaagcctg agcttccgtt acctggacca
    10621 caaaacggga gaaacggcga cggaaacgct gacacagcgt gagctggtcg cgaggctgaa
    10681 acagcacatc ccggagaagt tttttaagat ggtgaggtac ttcgggttcc ttgccaaccg
    10741 tgtgtgtgga gagaagctgc cgcaggtgta ccgtgcactg gggatggata aaccggaacc
    10801 agtggcgaaa gtgtgctatg cacaaatggt gaaacagttc ctgagtcgtg acccgttcga
    10861 atgcgtgctg tgtggctgcc ggatggtata ccgccgggcc attgcggggc tgaatgtatc
    10921 agggctgaag aaaaacgcgc gggatatcag tctactgagg tatatgccgg cctgacacag
    10981 gctaagtgtg cccgggaatc ggtgaaagta taaaaaacag cctgttacgg tataaaaatc
    11041 gaccatacag agagggaaac caccggagtg gtgggaaaag cagaaaggct cacgtggcat
    11101 aaggcgtgga caatggtatc gactggtttt tcaatttcct atacgtgtac tttgtgatgc
    11161 ctaactttgt ttggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca
    11221 tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac
    11281 aaataggggt tccgcgcact tttccccgaa aagtgccacc tgacgtctaa gaaaccatta
    11341 ttatcatgac attaacctat aaaaataggc gtatcacgag gccctttcgt cttcaagaat
    11401 tttataaacc gtggagcggg caatactgag ctgatgagca atttccgttg caccagtgcc
    11461 cttctgatga agcgtcagca cgacgttcct gtccacggta cgcctgcggc caaatttgat
    11521 tcctttcagc tttgcttcct gtcggccctc attcgtgcgc tctaggatcc tccggcgttc
    11581 agcctgtgcc acagccgaca ggatggtgac caccatttgc cccatatcac cgtcggtact
    11641 gatcccgtcg tcaataaacc gaaccgctac accctgagca tcaaactctt ttatcagttg
    11701 gatcatgtcg gcggtgtcgc ggccaagacg gtcgagcttc ttcaccagaa tgacatcacc
    11761 ttcctccacc ttcatcctca gcaaatccag cccttcccga tctgttgaac tgccggatgc
    11821 cttgtcggta aagatgcggt tagcttttac ccctgcatct ttgagcgctc tgatctgaat
    11881 atcgagggac tgctggctgg ttgagacccg cgcataacca aaaattcgca taaaaatgta
    11941 ccttaaatcg aatatcagac acgatgtgtc tattatgcca aaatgacgat ttaatggaca
    12001 ctcaaacgaa gccgttttac tatgtctgat aatttataat atttcgaacg gttgcagttg
    12061 tgttaaaaaa gccgtcaggc agggaggccg atatgcccgt tgattttttg accactgagc
    12121 aggttgagag ttatggcagg ttcactggcg aacccgatga acttcagctg gcgcgttatt
    12181 ttcatcttga tgaagcggat aaagaattta tcgggaaaag ccggggtgat cacaatcgac
    12241 ttggtattgc cctgcaaatc gggtgtgtgc gttttctggg cacttttctt actgacatga
    12301 atcatattcc ttccggcgtc cggcatttta ccgccagaca gctcgggatt cgtgatatca
    12361 ccgttcttgc agaatacggt cagagggaaa atacccgccg tgagcatgca gcgctgatac
    12421 gtcagcacta tcagtatcgt gaatttgcct ggccctggac atttcgcctt acccgtcttt
    12481 tatatacccg gagctggata agcaacgaac gtcctggcct gcttttcgac ctggcgacag
    12541 ggtggcttat gcaacatcgt attattctcc ccggagccac cacgctgacc cggttgattt
    12601 cagaggtaag ggaaaaggcg acgttgcgcc tgtggaacaa actggcactg ataccgtcag
    12661 ccgaacagcg ttcacagctg gagatgctgc tggggccaac tgattgcagc cgcctgtctt
    12721 tactggaatc actgaaaaaa ggccctgtga ccatcagtgg tccggcgttt aatgaagcaa
    12781 ttgaacgctg gaaaactctg aacgattttg gcctgcatgc tgaaaacctg agtacactcc
    12841 cggctgtgcg cctgaaaaat ctcgcacgtt atgctggtat gacttcggtg ttcaatattg
    12901 ccaggatgtc accgcagaaa aggatggcgg ttctggttgc ctttgtcctt gcatgggaaa
    12961 cgctggcgct ggatgatgca ctggacgttc tggacgccat gctggccgtt atcatccgtg
    13021 acgccagaaa gattgggcag aaaaaacggc tccgctcgct gaaggatctg gataaatctg
    13081 cattggcgct cgccagcgca tgttcgtact tgctgaaaga agaaacaccg gacgaatcga
    13141 ttcgtgctga ggtgttcagc tacatcccta ggcaaaagct ggctgaaatc atcacgcttg
    13201 tccgtgaaat tgcccggccc tcagacgata attttcatga cgaaatggtg gagcagtacg
    13261 ggcgcgttcg tcgtttcctg ccccatctgc tgaataccgt taaattttca tccgcacctg
    13321 ccggggttac cactctgaat gcctgtgact acctcagccg ggagttcagc tcacggcggc
    13381 agttttttga cgacgcacca acggaaatca tcagtcagtc atggaaacgg ctggtgatta
    13441 acaaggaaaa acatatcacc cgaaggggat acacgctctg ctttctcagt aaactgcagg
    13501 atagtctgag acggagggat gtctacgtta ccggcagtaa ccggtgggga gatcctcgtg
    13561 caagattact acagggtgct gactggcagg caaatcggat taaggtttat cgttctttgg
    13621 ggcacccgac agacccgcag gaagcaataa aatctctggg ccatcagctt gatagtcgtt
    13681 acagacaggt tgctgcacgt cttggcgaaa atgaggctgt cgaactcgat gtttctggcc
    13741 cgaagccccg gttgacaatt tctcccctcg ccagtcttga tgagccggac agtctgaaac
    13801 gactgagcaa aatgatcagt gatctgctcc ctccggtgga tttaacggag ttgctgctcg
    13861 aaattaacgc ccataccgga tttgctgatg agtttttcca tgccagtgaa gccagtgcca
    13921 gagttgatga tctgcccgtc agcatcagcg ccgtgctgat ggctgaagcc tgcaatatcg
    13981 gtctggaacc actgatcaga tcaaatgttc ctgcactgac ccgacaccgg ctgaactgga
    14041 caaaagcgaa ctatctgcgg gctgaaacta tcaccagcgc taatgccaga ctggttgatt
    14101 ttcaggcaac gctgccactg gcacagatat ggggtggagg agaagtggca tctgcagatg
    14161 gaatgcgctt tgttacgcca gtcagaacaa tcaatgccgg accgaaccgc aaatactttg
    14221 gtaataacag agggatcacc tggtacaact ttgtgtccga tcagtattcc ggctttcatg
    14281 gcatcgttat accggggacg ctgagggact ctatctttgt gctggaaggc cttctggaac
    14341 aggagaccgg gctgaatcca accgaaatta tgaccgatac ggcaggtgcc agcgatcttg
    14401 tctttggcct tttctggctg ctgggatacc agttttctcc acgcctggct gatgccggtg
    14461 cttcggtttt ctggcgaatg gaccatgatg ccgactatgg cgtgctgaat gatattgcca
    14521 gagggcaatc agatccccga aaaatagtcc ttcagtggga cgaaatgatc cggaccgcag
    14581 gctccctgaa gctgggcaaa gtacaggcct cagtgctggt ccgttcattg ctgaaaagtg
    14641 aacgtccctc cggactgact caggcaatca ttgaagtggg gcgcatcaac aaaacgctgt
    14701 atctgcttaa ttatattgat gatgaagatt accgccggcg cattctgacc cagcttaatc
    14761 ggggagaaag ccgtcatgca gttgccagag ccatctgtca cggtcaaaaa ggtgagataa
    14821 gaaaacgata taccgacggt caggaagatc agttgggagc tctggggctg gtcactaacg
    14881 ccgtcgtgtt atggaacact atttatatgc aggcagctct ggatcatctc cgggcgcagg
    14941 gtgaaacact gaatgatgaa gatatcgcac gcctctcccc gctttgccac ggacatatca
    15001 atatgctcgg ccattattcc ttcacgctgg cagaactggt gaccaaaggt catctgagac
    15061 cattaaaaga ggcgtcagag gcagaaaacg ttgcttaacg tgagttttcg ttccactgag
    15121 cgtcagaccc ctataactca atgagaaaaa agaattaaag gtaaggagac gctcatgaga
    15181 cgttccggca gcaaactgtg tcttatcgcc atgataacag cgacagcaac tctcactgcc
    15241 tgtgctccaa agggcagcgt ggaacagcat acccggcatt acgtatatgc ttcagatgac
    15301 ggttttgatc ccaatttttc cacccagaaa gctgacacaa cacgaatgat ggtgcctttt
    15361 ttccggcagt tctgggatat gggcgcaaag gataaagcga ccggaaaatc acggagtgat
    15421 gtgcagcaac gcattcagca gtttcacagt caggaatttt taaactcact ccaaggcaca
    15481 acacaatttg cgggtaccga ttaccgcagc aaagacctca caccgaaaaa atcaaggcta
    15541 ctggctgaca ccatttcagc tgtttatctc gatggctatg aaggcagaca gtaagtggat
    15601 ttaccataac gcgtcattac gcgcaccgct cagacgggct cagggcgttt ccggcggcta
    15661 cgggataaaa caggcaacaa cccccccgga aaactgccgg aaacgcgccc gataaatttt
    15721 atcctaatgc atgcctatgc acgcaactgc atggcatatg ttttgacgta aaatggatgc
    15781 cgtaagccct tttttaccga ctttctgctt catcagcctg actgacacga ccatattctt
    15841 tcagaccgcc ccctgctaaa cttccttcat attgccgcat taacccggga ggctccgcaa
    15901 tgagcaacac tacacactac gaaaacgcca actttcttcg ggaactggct gaaagcctgc
    15961 cccgcatact gccggaaggt ggcccggaca aagctgcgct gttgcagcga ctggctaacg
    16021 aagaactggc ccaggcagag tatgaagatc aggttcgcgc caaagtgacc gccgcccgtg
    16081 ctgacacgcg tccgggtatg accacggaac aactccgcca gcgcctgcat ggccgttatc
    16141 aggaactgcg cgatgccgta tgacgtggaa tggaagcagg gagccatcga ggatgtaacg
    16201 acgctgtttg actatatcgc ggaaaattca tccctgtggg atgcgcagaa cgttaccgac
    16261 cgggttctcg ctgcggcgga caaactggcc gacttcccgc gactctatga agtggactca
    16321 cgctatggcg aggacgttcg ccggatcagt ctgatgggac agcatgtcct ctatgatgtt
    16381 gatgaccaga ccagaaaagt ccgggttctg gccgtggtcg gccagcgcca gaatccccat
    16441 attgttctct aataaccggt gacggggacg caattcattg cgtggccgtc gccggttgga
    16501 caagcacagc gcgtcagcgt tttccccacg gccaccaccg gcgcggtgtt ccggccgggg
    16561 tctctgctgt ctccggtttg tgttccagca gtctcatgga ctgcatttcc tgccgtagcc
    16621 cggccacctc ctccctgagt gcttttatct ccgcgatcaa cgcgtcggag gccatttttt
    16681 cagtctcacc cgacagtctc aactcgtccc gctcgtgagt ctcatcctgt cttaactcac
    16741 cgtacacccg gataagctcg ctggtatcca ccacccggcc gccatcagct tccgtacggt
    16801 atgatacgcg gcctttcgcc atatcccgat acagggaact tcgggcttta cccgtcagtt
    16861 ccgtcgcctg tctcaccgtc acccacgcca ttgtctcacc ccgctatttt tgagacagta
    16921 tacctgacag gcgcacacca tgcccggaag gaaagaatc
//
