LOCUS       CP057775.1             17234 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  CP057775.1 Escherichia coli strain RHB15-C22 plasmid pRHB15-C22_3,
            complete sequence.
ACCESSION   CP057775
VERSION     CP057775.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 17:32:44
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17234
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..858
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MTDLQQTYYRQVKNPNPVFTPRKGAGTLKFCEKLMEKAVGFTSRF
                     DFAIHVAHARSRGLRRRMPPVLRRRAIDALLQGLCFHYDPLANRVQCSITTLAIECGLA
                     TESGAGKLSITRATRALTFLSELGLITYQTEYDPLIGCYIPTDITFTSALFAALDVSEE
                     AVAAARRSRVEWENRQRKKQGLDTLGMDELIAKAWRFVRERFRSYQTELKSRGIKRARA
                     RRDANRERQDIVTLVKRQLTREIAEGRFTASREAVKREVERRVKERMILSRNRNYSRLA
                     TASP"
     protocluster    1..17234
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5244:7234]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5245..7234
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     cand_cluster    1..17234
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="single"
                     /product="LAP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17234
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="LAP"
                     /region_number="1"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /tool="antismash"
     CDS             1790..2674
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MDLYHFTAIPMLHSILASEGLREGYLTLYDGTILYNKVWLTTSPL
                     PYGHGLCNGTEKLSESEKSFMRRVGNISESTSINGTHNKKLIRLKIDTEWIKKQPGFCS
                     YKKLMRDLGQPKAYVKYVGAMGVEGARGMTDEQISKIMRKGNTKEDTWYIFNGVIPPSK
                     IVSVEYMETKDKYIPYDFELHGRGYIENSGIYPISNLLLSDLNHTMRNITFLPGSVIAF
                     CHKANSEENILFRHVLFTCSISLRNFSVLIATGDETSFYIHLDVLKSWTQKNSKVLCQL
                     FEKARESYHRYYG"
     CDS             complement(3215..3778)
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MDIIEKRITKRHLSESELSGVNYYNCIFERIQLDNFNFRDCEFEK
                     CRFVNCSIKNLKLNFFKLIDCEFKDCLLQGVNAADIMFPCTFSLVNCDLRFVDFISLRL
                     QKSIFLSCRFRDCLFEETDLRKSDFTGSEFNNTEFRHSDLSHCDFSMTEGLDINPEINR
                     ILSIKIPQEAGLKILKRMGVVVGG"
     CDS             complement(3782..4513)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 95.1; E-value:
                     9.3e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MTIPLLEINSLSFSYKVNLPPVFNNLSLKIEQGELIGLLGENGAG
                     KTTLFNLIRGGVSNYEGTLKRNFSGGELVSLPQVINLSGTLRNEEVLDLICCFNKLTKK
                     QAWTELNHKWNDNFFIRYDKIRRKRTYTVSYGEKRWLIISLMLTLCKNARLFLLDEPTV
                     GIDIQYRMMLWELINKITADGKTVFFSTHIFDELTRDKIPFYMLSKNSINRYSDMSDFI
                     QSNNETTPEKAFIKEVMGTGD"
     CDS             complement(4510..5235)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MVTLKMAIIFLMEQIRTPFSLIWTIMSPTVLFFFLHFNEIELHYG
                     DTAWLGKQISWFVGYISFSVVLFNYCLYLVGRRESGFIATFVHNMDGRLLFIRSQLIAS
                     LIMSILYVFFFILVVLTGFQASPDYQIVMIILKSIYINAFMMVSLTFMASFRVTFQTAS
                     TIYSVLITVCMVSGIVSLKYNEGIVYWINQVNPIAIYSTILQSDQELSLMTIFFYSIML
                     IISIISALTFKTEPVWSSQ"
     CDS             complement(5245..6435)
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_6"
                     /sec_met_domain="YcaO (E-value: 1e-16, bitscore: 53.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVYSNLMSAWPATMAMSPKLNRNMPTFSQIWDYERITPASAAG
                     ETLKSIQGAIGEYFERRHFFNEIVTGGQKTLYEMMPPSAAKAFTEAFFQISSLTRDEII
                     THKFKTVRAFNLFSLEQQEIPAVIIALDNITAADDLKFYPDRDTCGCSFHGSLNDAIEG
                     SLCEFMERQSLLLYWLQGKANTEISSEIVTGINHIDEILLALRSEGDIRIFDITLPGAP
                     GHAVLTLYGTKNKISRIKYSTGLSYANSLKKALCKSVVELWQSYICLHNFLIGGYTDDD
                     IIDSYQRHFMSCNKYESFTDLCENTVLLSDDVKLTLEENITSDTNLLNYLQQISDNIFV
                     YYARERVSNSLVWYTKIVSPDFFLHMNNSGAININNKIYHTGDGIKVRESKMVPFP"
     CDS             complement(6416..7234)
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7"
                     /sec_met_domain="PF00881 (E-value: 8.3e-10, bitscore: 31.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKHELSLVEVTHYTDPEVLAIVKDFHVRGNFASLPEFAERTFVS
                     AVPLAHLEKFENKEVLFRPGFSSVINISSSHNFSRERLPSGINFCDKNKLSIRTIEKLL
                     VNAFSSPDPGSVRRPYPSGGALYPIEVFLCRLSENTENWQAGTNVYHYLPLSQALEPVA
                     TCNTQSLYRSLSGGDSERLGKPHFALVYCIIFEKALFKYRYRGYRMALMETGSMYQNAV
                     LVADQIGLKNRVWAGYTDSYVAKTMNLDQRTVAPLIVQFFGDVNDDKCLQ"
     CDS             complement(7236..8090)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04424"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_8"
                     /sec_met_domain="TIGR04424 (E-value: 2.1e-88, bitscore:
                     288.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINILPFEIISRNTKTLLITYISSVDITHEGMKKVLESLRSKQGI
                     ISEYLLDKLLDESLIDKDKGKEFLITTGVINKTKTSPLWVNSVIISDVPHLFSNAREQW
                     KSDGVFVSHIIDIKDNNINVSDSTLIWLHLENYHSDIVKRIYSKFESNPGVAFIQSYYL
                     KESFRIDGVYSPDLGTPCHFCHIERWLSREEKSFRRNEMSWANLLQLLKKYQMTLPALA
                     LGESERGFSYHLIKRRLQELTGTSLVKSHVDNFMSSVSADLITCILCKEPVIHWQACSC
                     LER"
     CDS             complement(8150..8356)
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MELKASEFGVVLSVDALKLSRQSPLGVGIGGGGGGGGGSCGGQGG
                     GCGGCSNGCSGGNGGSGGSGSHI"
     CDS             8812..9117
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MIQTRNQYLQFMLVMLVMLAAWGISWGARFVMELAVLLYGPGKNY
                     LFFSHGAVLMYLLCVFLVYRRWIAPLPVVGQLRNVGVLWLVGAMAVVYIGVFLLDR"
     CDS             9132..9614
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MSSVFKGRVSMKFMECAVRNVIYGTNVRIVKPVNIYECELRDNVF
                     VGPFVEIQKGCVIGSGSRIQSHTFICENVTLGENCFIGHNVTFANDLFRSGAPDPSPDN
                     WISITLGDSVTVGSGAIILSPYICSGAVIGAGSVVVKPIENKGIYAGNPARLLRIL"
     CDS             complement(10018..10371)
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MMDKRRTIAFKLNPDVNQTDKIVCDTLDSIPQGERSRLNRAALTA
                     GLALYRQDPRAPFLLCELLTKETTFSDIVNILRSLFPKEMADLNSSTIIQSSSQSEQKS
                     DEETKKNAMKLIN"
     CDS             complement(10371..11333)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MLVFIDDGSTNIKLQWQENDGTIKQHISPNSFKREWAVSFGDKKV
                     FNYTLNGEQYSFDPISPDAVVTTNIAWQYSDVNVVAVHHALLTSGLPVSEVDIVCTLPL
                     TEYYDRNNQPNTENIERKKANFRKKITLNGGDAFTIKDVKVMPESIPAGYEVLQELDEL
                     DSLLIIDLGGTTLDISQVMGKLSGISKIYGDSSLGVSLVTSAVKDALSLARTKGSSYLA
                     DDIIIHRKDNNYLKQRINDENKISIVTEAMNEALRKLEQRVLNTLNEFSGYTHVMVIGG
                     GAELICDAVKKHTQIRDERFFKTNNSQYDLVNGMYLIGN"
     CDS             11850..12533
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MSRFILGDCVRVMATIPDNAIDFILTDPPYLVGFRDRSGRTIAGD
                     VNDDWLQPASNEMYRVLKKDALMVSFYGWNRIDRFMAAWKRAGFSVVGHLVFTKSYTSK
                     SAYVAYRHECAYILAKGRPALPPKPLPDVLGWKYSGNRHHPTEKPVTSLQPLIESFTHP
                     NAIVLDPFAGSGSTCVAALQSGRRYIGIELLEQYHRAGQQRLATVQRAMQQGAANDNWF
                     EPEAA"
     CDS             12534..12743
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MNYAGHENLAEVANAMCDLRARLNDMEHRCRFDSDVLVERLARQT
                     LYRANRLFMEAYTEILELDACFKD"
     CDS             12756..13190
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MYGTCETLCRELEAKYPGDTPLMLVIWSPEEIQALADGMEISLTD
                     HEIRAVLARMEDIPEDQRTESGISSAAVMEIISNVSENRQVTVPAELLASLIQTAEQAL
                     WKREWAARDNGLVVPECVTRRQAVVNQARALLKNNTREND"
     CDS             13235..14005
                     /locus_tag="ctg1_17"
                     /transl_table=11
                     /translation="MNETLNALICRHARNLLLAQGWPEETDVDQRNPNHPGWISIYVRL
                     DAPRLATLLINRHGGVLPPHLASAIQKLTGTGAELVLSGSQWQSLPVLPADGTQVSFPY
                     AGEWLAEDEIRAVLAAVRDAIRSICYQVADDARRIRAALTTTGQTLLTRQTRRFRLVVK
                     ESDHPCWLDEDDENLPVVLDAIVNRGARFSSVEMYLVSDCIEHILSSGLACDVLRIPDE
                     PPRRWFDRGVLREVVREARVEIRSMADALAKIRD"
     CDS             14364..14789
                     /locus_tag="ctg1_18"
                     /transl_table=11
                     /translation="MQYAKPVTLNVEECDRLSFLPYLFGNDFLYAEAYVYALAQKMMPE
                     YQGGFWHFIRLPDGGGYMMPDGDRFHMVNGANWFDRTVSADAAGVILTSLVINRQLWLY
                     HDSGDAGLTQLYRMRDAQLWRHIEFHPECNAIYAALD"
     CDS             14836..15258
                     /locus_tag="ctg1_19"
                     /transl_table=11
                     /translation="MYCTVKEIIREVLDTDVPDSECVFAVVLTRGDVRHMAQDWSLSDD
                     ELETVMQRLDDAFEYGADVSVVHGVVRELMEEKRASRQVTVPAVMLEKVMALAGSEMKR
                     LYAVGSENGGDGDAFVREEREAMDVVLQALDGETMS"
     CDS             15255..15446
                     /locus_tag="ctg1_20"
                     /transl_table=11
                     /translation="MNISTESREILRNYRAVINARRREMGQKPLTTAQIVDEICDFVAN
                     QQAVFLGGHYILQGSRNR"
     CDS             complement(15759..17033)
                     /locus_tag="ctg1_21"
                     /transl_table=11
                     /translation="MQALWLLALEPVSETTADHNSYGFRPMRSTHDAIESIFLRMSQKV
                     SPKWILEGDIKGCFDNISHDWLLSHIPLDRKLLKKWLKAGYMERGVFNHTNSGTPQGGI
                     ISPVLANMALDGLEKELMQTFRKSGYHSAKHQVNYVRYADDFICSGSSRELLENEVRPL
                     IAAFMRERGLELSEEKTAITHIDKGFDFLGQNVRKYNGKMLIKPSKKNLKNFLCKVREI
                     IKRNPTLPAWKLIGQLNPVIRGWATYHRHVVAKETFNYVDTQIWRAIWRWCVRRHPRKG
                     LRWIAGRYFSFEGRRWIFKAITPEGKILTLFRAMETPIKRHIKIKGEATPYTPGMEIYF
                     ERRLDLIWKGKSKKMKTVVQLWKRQGKHCPQCGQPITNQTGWNIHHRIRKVMGGSDELT
                     NLELLHPNCHRQLHSREAGAHRKHL"
ORIGIN
        1 gtgactgatc ttcaacaaac gtattaccgc caggtaaaga acccgaatcc ggtgtttaca
       61 ccccgtaaag gtgccggaac gctgaagttt tgcgaaaaac tgatggaaaa ggcggtgggc
      121 ttcacctccc gttttgattt cgccattcat gtggcgcatg cccgttcgcg tggtctgcgt
      181 cgacgcatgc caccggtgct gcgtcgacgg gctattgatg cgctgctgca ggggctgtgt
      241 ttccactatg acccgctggc caaccgcgtc cagtgttcca tcaccacgct ggccattgag
      301 tgcggactgg cgacagagtc cggtgcagga aaactctcca tcacccgtgc cacccgggct
      361 ctgacgttcc tgtcagagct gggactgatt acctaccaga cggaatatga cccgcttatc
      421 gggtgctaca ttccgaccga tatcacgttc acatctgcac tgtttgctgc cctcgatgta
      481 tcagaggagg cagtggccgc cgcgcgccgc agccgtgtgg aatgggaaaa cagacagcgc
      541 aaaaagcagg ggctggatac cctgggtatg gatgagctga tagcgaaagc ctggcgtttt
      601 gtgcgtgagc gtttccgcag ttaccagaca gagcttaagt cccggggaat aaagcgtgcc
      661 cgtgcgcgtc gtgatgcgaa cagggaacgt caggatatcg tcaccctggt gaaacggcag
      721 ctgacgcgcg aaatcgcgga agggcgcttc actgccagtc gtgaggcggt aaaacgtgaa
      781 gtggagcgtc gtgtgaagga gcgcatgatt ctgtcacgta accgtaatta cagccggctg
      841 gccacagctt ccccctgaaa gtgacctcct cagaataatc cggcaagcgc cggaggcatt
      901 tgcacgcctg aagcccgcta gcgcacaaaa aatcagcgct acatacaaaa aacaacctca
      961 tcatccacct tctggtgcat ccggtccccc ctgtttttga tgaaaaactc gtctcacaga
     1021 cgggcaattt tgcttatcca cattaaactg caaggggctt ccctataagg ttacaaccgt
     1081 tcatgtcata aagcgccagc cgccagcgtt acagggtgca atgtatcttt taaacacctg
     1141 tttatatctc ctttaaacta cctaattaca ttcatttaaa aagaaaacca attcagtgtc
     1201 tgtcctgtgg acagacagat atgcacctcc caccgcaagc ggcgggcccc gaccggagcc
     1261 actttagtta caacacacga aaacagcctc cagaaaaacc ccggtccagc gcagaactga
     1321 aaccacaaag cccctccctc ataactgaaa agcggccccg ccccggccct tcgggccgga
     1381 acagagtcgc tttaaattat gaatgttgta actaaacatc attgctgtca gtcttctggt
     1441 tggacgtatc gagtacacgc tcgtaagcgg ccctcacggc ccgctaacgc ggagatacgc
     1501 cccgacttcg ggtaaaccct cgtcgggacc actccgaccg cgcacagaag ctctctcatg
     1561 gctgaaagcg ggtatggtct ggcagggctg gggatgggta aggtgaaatc tatcaatcag
     1621 taccggctta cgccgggctt cggcggtttt actccggtat cacatgtaac cacagcgtgc
     1681 cgccttacat gccgctgaag cggcattcag tagacaggct atgcacgact cgccagtctg
     1741 gcctgaacat gatataaaat gaatataaat agacagaata gggttattta tggatttata
     1801 tcactttaca gcaattccta tgttgcattc catacttgca tctgaaggcc tgagagaagg
     1861 atatctaacg ttgtatgatg gaacaatttt gtataataaa gtatggttaa cgacatctcc
     1921 attaccatat ggtcacggat tatgtaacgg tactgaaaaa ttaagtgaat cagaaaaatc
     1981 atttatgcga agagtcggta atatatctga gtctacgtct ataaatggaa cacataataa
     2041 aaagttaata aggttaaaaa tagatactga atggataaaa aagcagcctg gattttgctc
     2101 atataaaaag ctgatgcgtg accttggaca acctaaagct tatgttaagt acgtaggtgc
     2161 aatgggggtt gagggggcaa gggggatgac cgatgagcag ataagtaaaa ttatgcgaaa
     2221 aggtaacaca aaagaagata cctggtatat ctttaatggg gtcatcccac cttcaaaaat
     2281 agtctctgtt gaatatatgg aaactaaaga taaatatata ccatatgatt ttgaattgca
     2341 tggaagggga tatatagaaa actccggcat ttatccgatt tcgaatttat tattatctga
     2401 tctgaatcat acaatgcgaa atattacatt tttaccaggt tctgtcatag cgttttgtca
     2461 taaagcaaat tcagaagaaa atattttatt cagacatgta ttattcacat gttcaatctc
     2521 cttgagaaat ttttcagtac tgatagcaac aggtgatgag acatctttct atattcatct
     2581 ggatgtatta aaaagttgga ctcaaaaaaa cagtaaagta ctatgccaac tttttgaaaa
     2641 agcacgtgaa agttaccaca gatactatgg ttagaaacca ctgcggggag aacatcagtg
     2701 gcacaaaact agaccgcccg gaaccgggac gcttactgat ggacagtcat cgcaatgata
     2761 tcttgctggt tgagcagata ggggctccgt gggaatttct gcgataacac ccgctaagcg
     2821 atttctccct gacggaaatc acttgttttt cgttcagagg caggcaagag gaatattcat
     2881 ccccaaaaac ggcgttttca tatgcggaaa acgctgccgg atagtcgaat agtacgacaa
     2941 actgacttct gacgttttcc gtacatttca gattcagtaa ccccgaatat ttggggttgg
     3001 tatggctaac gccttgaatt tcaatgaaca atattttgtt accgtgtact gtcgcagaaa
     3061 tgcccacgga accccgagat ggagaactca gtcaatgttc cattctttct gaaatatgtg
     3121 tggggacact gatctgtcgg gagccggatg cggtagttcc gcaggtccgg ttctgaggag
     3181 gggcccgtcc gggcaaccgg cgggtctact cacctcatcc ccctacaacc actcccattc
     3241 gtttaagtat ttttaaacct gcttcctgtg gtatctttat agataagatc ctgtttatct
     3301 caggatttat atcgagacct tctgtcattg aaaaatcaca gtgagacaaa tcagaatgtc
     3361 tgaactctgt attattaaac tccgaaccag taaaatcaga tttacgaagg tctgtttcct
     3421 caaataaaca atcacggaag cgacaggata aaaaaataga tttctgtaac cgtaaactaa
     3481 taaaatcaac aaatcttaaa tcacaattta caagagaaaa agtacaggga aacataatgt
     3541 ctgctgcatt tactccttgt aataaacaat ctttgaattc acagtcaata agtttaaaaa
     3601 aattaagttt taaattcttt attgagcagt ttacgaagcg acatttttcg aactcacaat
     3661 cgcgaaagtt aaagttgtca agctgtattc gttcaaatat acaattgtaa taatttacac
     3721 ctgataattc actttcactg aggtgtcgtt ttgtgattct tttttctatt atatccatgt
     3781 gtcagtctcc tgttcccata acttctttaa taaatgcctt ttctggagtt gtttcattat
     3841 tggattgaat aaaatcactc atatcagaat aacgatttat actatttttt gaaagcatat
     3901 agaaggggat tttatctctt gttaattcat caaaaatatg agttgagaaa aataccgttt
     3961 tcccgtcagc ggtgatctta tttatcagtt cccataacat cattctgtac tgaatatcaa
     4021 tgcctacagt tggttcatcc agtaaaaata aacgggcatt tttgcaaagc gttagcatca
     4081 aagatatgat aagccaacgc ttctctccat aacttaccgt gtaagtcctt ttacgtctta
     4141 ttttatcata gcgaatgaaa aaattatcat tccatttatg attaagctct gtccatgcct
     4201 gttttttagt taacttattg aagcagcaaa tcaaatcaag aacctcctca ttccttagtg
     4261 tacctgaaag atttatgact tgaggtagac ttactaattc tccaccagag aaatttcgct
     4321 tgagggtccc ttcataatta ctgactccgc ccctgataag gttaaaaaga gtggtcttcc
     4381 cggctccatt ttctccaagc agacctatca actctccctg ctcaatctta agcgacagat
     4441 tattgaaaac agggggtaaa tttactttat atgaaaagct cagagagttg atttctaaaa
     4501 gaggtatggt cattgagaac tccagactgg ctcagttttg aaggttagtg ctgaaataat
     4561 acttatgatt aacattatac tatagaaaaa tatcgtcatc agagacaact cctggtctga
     4621 ctggagtatt gtagaataga tggcgatagg attaacctga tttatccagt aaacgatccc
     4681 ctcattatat tttaatgata caattcctga taccatacag acagttatta atacagaata
     4741 gatagtgctg gctgtttgga atgtgactct gaacgatgcc atgaaagtga gtgaaaccat
     4801 cataaatgca tttatgtata tcgattttaa aataatcatt actatttgat aatctggact
     4861 tgcctggaat cctgttagta cgactaaaat gaaaaaaaac acatacaaaa tagacatgat
     4921 aagtgaggct attaattgag aacgaataaa taatagtcga ccatccatat tatgcacgaa
     4981 ggtagcaata aaaccacttt ctcttcttcc gaccagatac agacagtaat taaacagaac
     5041 aacagaaaaa gaaatgtagc ctacaaacca tgatatttgt tttccgagcc atgctgtatc
     5101 accataatga agttcaattt cattgaaatg aaggaaaaag aacaacactg taggtgacat
     5161 aattgtccat attaagctga aaggggttct gatttgttcc atcagaaaaa ttatcgccat
     5221 ttttaatgta accatttgtt atccttatgg gaatggtacc atctttgatt ctctgacttt
     5281 aataccgtcc ccggtatggt aaattttatt attaatgttt attgcacctg agttattcat
     5341 atgaaggaaa aaatcagggc ttactatttt tgtgtaccag acaaggctgt tacttactct
     5401 ttccctggca tagtaaacaa aaatattatc agaaatttgt tgaagatagt ttaataaatt
     5461 tgtgtctgac gtaatatttt cctcaagcgt taacttgaca tcatcagaca gtagtaccgt
     5521 attttcacac aaatccgtaa acgactcgta cttgttgcat gacataaagt gacgctggta
     5581 actatcaata atgtcatcat cagtataacc gccaataaga aagttgtgca ggcatatata
     5641 cgattgccac aattccacta cggatttaca aagtgctttt ttcagactat tagcatagga
     5701 taatccggta ctgtatttta ttcgactgat tttgtttttt gtgccataca gggttagtac
     5761 tgcgtgtcca ggagctccgg gcagggtgat atcgaaaatc ctgatatctc cttctgacct
     5821 gagagccagt aaaatctcat ctatatgatt tatgcctgtt actatttcac tggatatttc
     5881 agtattggct tttccctgta accagtaaag aaggagggac tgtctctcca taaattcaca
     5941 caaggaacct tctatggcat cgttcaaact accatgaaag ctacatccgc atgtatctct
     6001 gtcaggataa aatttcagat catctgcagc ggttatattg tctagtgcaa ttatgactgc
     6061 aggtatttct tgttgttcaa ggctaaacag attaaaggct ctgaccgttt taaatttatg
     6121 ggttatgatt tcatcgcggg tcagtgatga gatctgaaaa aatgcttcgg taaaagcctt
     6181 tgcagcagat ggaggcatca tctcatataa tgttttctga ccaccggtga ctatctcatt
     6241 aaaaaaatga cggcgttcaa aatattcacc tattgccccc tgaattgact tcagagtttc
     6301 accggccgcg ctggctggtg taatacgctc atagtcccat atctgagaaa acgttggcat
     6361 atttctgttc agttttggac tcatagccat tgtggccggc catgcggaca taaggttact
     6421 gtagacattt atcatcgttt acatctccaa aaaactgaac gatcagtggc gctacagtcc
     6481 tctgatccag attcattgtt tttgctacgt atgaatcggt atatcccgcc catacccggt
     6541 ttttcagtcc tatttgatct gcaaccaata ctgcgttctg atacatcgaa cctgtttcca
     6601 ttaaggccat ccggtatcct ctgtagcgat atttgaacaa agctttttca aaaataatgc
     6661 aatagacgag agcaaaatgg ggtttaccaa gacgttccga atccccaccg gacaggcttc
     6721 ggtagagtga ctgagtatta catgtagcaa caggttccag tgcctgactt agcggcaggt
     6781 agtgataaac attagttcct gcctgccagt tttctgtatt ttcagataat ctgcataaaa
     6841 aaacttcaat cgggtacaat gcccccccag aaggataagg tcttcttaca gagccaggat
     6901 caggtgagct gaatgcattg actaataact tttcaatagt acgaatggaa agtttatttt
     6961 tgtcgcaaaa gtttattcct gatgggagcc tttcacgact aaaattatgt gatgaggata
     7021 tgtttattac ggagctgaaa cctggcctga agagaacttc tttattttca aatttctcca
     7081 gatgggcaag aggtaccgcg gacacgaaag ttcgttcagc aaattcgggg agggaagcaa
     7141 agttacctct gacatgaaaa tctttaacaa tggccagaac ttcaggatct gtgtaatgcg
     7201 ttacttccac taaagagagt tcgtgttttg acatgttatc tctccagaca gctgcaagcc
     7261 tgccagtgaa ttaccggctc tttacataaa atacaggtga ttaaatcagc gctaacagat
     7321 gacataaagt tatcgacatg acttttaacc agtgaagtac ctgtcaactc ctgaagtcgc
     7381 cgttttatta aatgatagct gaatcctctt tctgattcgc ctaaagccaa tgctggtagt
     7441 gtcatttggt attttttcag taactgaagt aagtttgccc aggacatttc gttacgtctg
     7501 aagctttttt cttccctgct cagccatctc tctatatgac aaaaatggca gggagtacca
     7561 agatcaggtg aatatactcc atctatcctg aatgactcct ttaggtagta gctttggatg
     7621 aaggcaacac cagggttact ttcaaatttt gaatagattc tttttacaat gtctgaatga
     7681 tagttttcga gatgtaacca gattagtgtt gaatcgctca cattaatatt attatctttt
     7741 atatcaatga tatgagaaac aaaaacacca tcagatttcc attgttcccg ggcattactg
     7801 aaaagatgtg gaacatcgct tattatgact gagtttaccc agagaggtga tgttttcgtt
     7861 ttatttatca cgcctgtggt aataagaaac tctttgccct tgtctttatc aataagcgat
     7921 tcgtccagta gtttatcaag gaggtattca gaaataatac cctgtttgga tcgtaggctt
     7981 tcgagtactt ttttcattcc ctcatgtgta atgtctactg aagaaatgta ggtaataagc
     8041 agggtctttg tatttctgga aattatctca aatggcagaa tattgatcat atcttttcct
     8101 tttttaatat cagggagcac catgctccct gaacggttaa ttcaacgtat cagatatgtg
     8161 aaccacttcc gccgctgcca ccgtttccac cactacaacc gttgctgcaa ccaccacaac
     8221 cgccaccttg accaccgcag ctaccgccgc cgccgccgcc accaccacca atgccaacac
     8281 ctaatggaga ctggcgtgat aatttaagag catcaacgga caaaactaca ccaaattcac
     8341 tcgcttttaa ttccataagg actccttttt taagggaaat taatgcttat gacatctgaa
     8401 tagtatgttg gccaacacta gttacttgcc gtaattaact atattttgca atgataattt
     8461 gaactaaatt tgtacgcctg ttaaatattt aataataata tcagtcggtt atgtttgtgc
     8521 ggttattgtt ttttttacaa aaattaatat tgtgtttaca ttttgctttc agttgctgtc
     8581 aggatgtcac gctacccctt taagccccca ctggtctggc agggccgggg gtgggtaagg
     8641 tgaaacctgt caatcagtac cggcttacgc cagtatcata tgcaacaact gagtgccgcc
     8701 ttccatgccg ctggtgcggc atatcctggt gacgatatct gaattgttat agatatgtat
     8761 atacgtagta atgacaagaa taggataagt taaaaattta caggagatgc aatgattcag
     8821 acacgtaatc aatatctgca gtttatgctg gttatgctgg ttatgctggc tgcatggggc
     8881 attagctggg gagccagatt tgtcatggag ctggccgttc tgctttatgg gccaggaaaa
     8941 aactatttgt tcttcagtca tggtgctgtt ctgatgtacc tgctgtgtgt tttcttggta
     9001 taccgccgtt ggatagctcc gctaccggtc gttggtcagc tgcgcaacgt tggcgtactg
     9061 tggctggtcg gtgcgatggc cgtggtgtat atcggtgtat ttctgctcga tcgataggaa
     9121 tattccggca agtgtcatct gtatttaaag gtcgtgtgag tatgaaattt atggaatgtg
     9181 ctgtccggaa tgtgatttat gggaccaatg tccgtattgt caaaccggtc aacatttatg
     9241 aatgtgaact cagggacaat gtgtttgtcg gccccttcgt tgagatacag aaaggctgtg
     9301 tcattggtag tggaagccgg atacagtcgc acacgtttat ttgtgagaac gtaacactgg
     9361 gggagaactg cttcattggt cataacgtga cgttcgccaa cgatctgttt cgttcaggag
     9421 caccagatcc gtcaccggat aactggatca gcattaccct gggggattcg gttactgttg
     9481 gcagtggagc cattattctg tctccgtata tatgcagcgg agctgttatt ggtgcgggtt
     9541 cagttgtggt aaaaccgatt gagaacaaag gcatttatgc aggaaacccg gcaagactgc
     9601 tcagaatatt atgaaaaaga aaagggccgt tactggccct ttttatcaga ggtaggtctg
     9661 tgaatacggt aggtgtacag aaatcgactg ccggggatcg atttccaggg ccgcccggta
     9721 ttctgcgtca gtgatatcac ctttttttca gtaaataacc gagagcatcg tttcccagcc
     9781 ctgacagtat gcgtattctg gcgacccgga ctggcaaata acccatcaaa aacgttattg
     9841 ccagacattg cgaactcacc aattttgatt attggagcca ctttttcata agtttcgtga
     9901 aattatttca taataacgac catgtttatt ttatgtaatg actggcaata aaataacttg
     9961 attaagttcc ctttatccag cctgatagtg gataaaggga actcaatcat aatttaatta
    10021 gtttattaac ttcatcgcat tcttttttgt ctcctcatca cttttttgct ccgattgtga
    10081 agaggactga atgattgttg aagaatttaa atcggccatc tcttttggaa atagcgatct
    10141 caatatattc acgatatctg aaaatgtggt ttctttcgtc agcaattcac ataaaaggaa
    10201 aggggcccta ggatcttgtc tgtataaggc cagacctgcc gtcagtgcag cccggttaag
    10261 gcggctgcgt tccccttgcg ggatactgtc cagtgtatca caaacaattt tatctgtttg
    10321 atttacatct ggatttagct taaaggcaat ggttctgcgc ttgtccatca ttaattacct
    10381 atgagataca taccgttaac taaatcatat tgagagttat tggttttaaa aaaacgttca
    10441 tcacgaatct gtgtgtgttt ttttactgca tcgcatatta attctgcgcc accacctata
    10501 accataacat gagtataacc agaaaattca ttgagtgtat ttaatacacg ttgctcaagt
    10561 ttacgaagtg cttcattcat tgcttcggtg actattgata ttttgttctc atcattaatt
    10621 cgttgcttca gatagttatt atcttttctg tgaataatta tatcgtcagc aagatagcta
    10681 cttccttttg ttctcgcaag agaaagggca tcttttactg cagatgtgac cagagataca
    10741 ccaagagatg agtctccgta tattttactg atccccgata atttccccat tacctgagaa
    10801 atatctaatg tggtgccccc gagatctata attaataaag aatctaactc atccagttct
    10861 tgtagaactt cataacctgc cggtatagat tcaggcatga cttttacatc ttttattgtg
    10921 aatgcatccc caccatttaa tgtaattttt ttccggaagt ttgctttctt acgctcaata
    10981 ttttccgtat tgggttggtt attcctgtcg taatactctg tcagaggaag tgtgcaaaca
    11041 atatccactt cgcttaccgg cagaccactg gtcagtaagg cgtggtgcac cgcaacgaca
    11101 ttaacgtcgc tgtattgcca tgcgatattg gttgtgacta cagcatccgg gctgattgga
    11161 tcaaatgaat actgttcgcc gttcagtgtg tagttaaaga cctttttatc accaaaagaa
    11221 actgcccact cgcgtttgaa gctgttcggg ctaatgtgct gtttaattgt tccgtcgttt
    11281 tcctgccact gtagtttgat gtttgttgaa ccgtcatcaa tgaataccaa catttataaa
    11341 actccttatg gtgtttttgt ggtgtgcttt tggggttgct ttgggtttta gatggggtcg
    11401 tttgtcaagt ttaccccatt ttgactatca gtcaatgatt gtttgtattg tttttgggtt
    11461 tattatggtg tgttttgggt tgtttttggg ttttatttgg cgggtaacaa aagatgtcgc
    11521 tgtgcttctc tttttactgc gccggctgac gcggcgcggc aggaacgctg cctgtggtca
    11581 gtgtcccgcg tccggccggg cacgggacgg gcgcttttac cgctcctggc tggcgtcggt
    11641 gacagtgtac gccagcctgt cgcccttttc tgatgaatgc ccttcaagcc gctttcgcgg
    11701 catatcctcg ccgttagaaa gacgacggct gcggtattcc acggtcggcc tgacccgtta
    11761 ccggacgcgg tgagcagccc acaggcagcg gagaacgggc gccacagggg cgccctcccg
    11821 gtgccctctg taagaggagg agtgctgtta tgtcccgttt tatcctgggt gactgcgtgc
    11881 gtgttatggc cacgattcct gataacgcca ttgatttcat cttaaccgac ccaccatatc
    11941 tcgttggttt tcgtgaccgt tccgggcgca ccattgccgg tgacgttaac gatgactggc
    12001 tgcaacctgc cagtaatgag atgtaccgcg tactaaaaaa agatgcgctg atggtgagtt
    12061 tctatggctg gaaccgtatt gaccgcttta tggcagcctg gaaacgcgcc ggattcagcg
    12121 ttgtagggca ccttgtgttc accaaaagct acacatccaa atctgcgtat gtcgcgtacc
    12181 gtcacgaatg cgcctatatc ctggcaaaag gccgtccggc gctgcctccg aagccattac
    12241 ccgacgtgct gggctggaaa tattcgggca accgccatca cccgacggaa aagcctgtta
    12301 ccagcctgca accgctgatt gagagcttca cacacccgaa cgcaattgtg ctggacccgt
    12361 ttgctggcag cggctcaacc tgtgtggctg cccttcagtc cggacgccgg tatatcggta
    12421 tcgagctgct tgaacagtat caccgtgccg gacagcaacg actggccacc gtgcaacggg
    12481 ccatgcagca gggggccgcg aatgataact ggtttgaacc ggaggctgcg taaatgaact
    12541 atgccggaca cgaaaacctg gcggaggtgg ccaatgccat gtgtgacctt cgggccaggc
    12601 tgaacgatat ggagcatcgc tgtcgctttg attccgatgt gctcgtcgaa cgcctggcac
    12661 gccagacgct gtatcgcgcc aatcgcctgt tcatggaggc atataccgaa attcttgaac
    12721 tggatgcgtg cttcaaagat taagggggag acgaaatgta cggaacatgc gaaacgctct
    12781 gccgggagct ggaagcaaag tatccgggag acacgccgct gatgctggtt atctggtctc
    12841 cggaagagat tcaggcactg gctgacggta tggaaatttc tctgaccgat catgaaatca
    12901 gggccgtcct ggcgcgcatg gaggacatcc cggaagacca gaggactgaa tccggtattt
    12961 cttccgccgc ggtgatggag attatcagca acgtgagcga aaaccgccag gtgaccgtcc
    13021 ctgctgaact gctggcgtcc ctgattcaga ccgctgaaca ggcactgtgg aaacgtgagt
    13081 gggccgcccg tgataacggc ctcgtcgtcc cggaatgcgt cacccgccga caggcggtgg
    13141 ttaatcaggc ccgcgccctg ctgaaaaaca acacacgcga aaacgactga tgttatcgcc
    13201 gcctgcgggc ggcgattcag ggagaccatg aatcatgaac gaaacgctga atgcactgat
    13261 ttgtcgccac gcccgtaacc tgctgctggc gcagggctgg ccggaagaga cggatgttga
    13321 ccagcgaaat ccgaaccatc cgggctggat cagcatttac gtgcggctgg atgcgccccg
    13381 gctggcgacg ttacttatca accgtcacgg cggcgtactg ccgccgcacc tggcctctgc
    13441 cattcagaaa ctgaccggaa ccggggcgga acttgttctg tccggcagtc agtggcagtc
    13501 gctgccggta cttccggcag acggaacgca ggtgtctttc ccgtatgccg gtgagtggct
    13561 ggcagaagac gaaatcaggg ctgtacttgc ggcggtgcgc gatgcaatac gaagcatctg
    13621 ttaccaggtg gcagacgatg cgcggcgtat ccgggcggcg ctgaccacca ccggtcagac
    13681 gttgctgacc cgccagacgc gccgctttcg tctggttgtg aaggaaagcg atcacccctg
    13741 ctggctcgat gaagatgacg aaaacctgcc cgtggtgctc gatgccatcg tgaaccgggg
    13801 agcacgtttt tcgtcggtgg aaatgtacct ggtcagcgat tgtattgagc atatcctgtc
    13861 cagtgggctg gcctgcgatg tgctgcgtat accggatgaa ccgccccgcc gctggtttga
    13921 ccgtggtgtt ctgcgggagg tggtccggga agcccgggta gaaatccgca gcatggcgga
    13981 tgccctggca aaaatcaggg actaaggaag tcgccgccgg ctccgcttta cccggccatg
    14041 cggggcatgg ccttgtgggt tttcagttat gtggccgctg tgtcgtgtgc gggctgtgcc
    14101 gtgcctccat cttagccggg ctggcaggga tgcaagggta cgcttcgccg ctgcggtcac
    14161 ccggtccctc cttcccgtct gccgtgattt tccggtcgtt cgcccgctca ggtttcgcgg
    14221 cctcaccctg caactcccgc cagccgtgtg cgtcaggctg cggcttccct tgcgcccctg
    14281 catccccgcc ttatcgcccg gcttttatgg aggcacggca ccgcccggtg tcgcggaata
    14341 tgtgaacaac ggaggaaaac atcatgcaat atgcgaaacc tgtcactctg aacgttgaag
    14401 agtgcgaccg tctctccttt ctgccttacc tgtttggcaa cgattttctg tatgccgagg
    14461 cgtatgtgta cgcgctggcg caaaaaatga tgccggaata tcagggcggc ttctggcact
    14521 tcatccgcct gccggacggt ggcggttaca tgatgccgga tggcgaccgt ttccacatgg
    14581 tgaacggtgc aaactggttt gaccgtaccg tgagtgctga tgccgcaggt gtcattctga
    14641 cttctcttgt gattaaccgc cagttgtggc tgtaccacga cagcggggat gcaggactga
    14701 cccagcttta ccggatgcgc gatgcgcagt tgtggcgtca catcgaattt caccccgaat
    14761 gcaacgcgat ttacgcggct ctggactgat taacggacgg ggcggcaatg ccgcccctgt
    14821 aaaggagacg agaacatgta ctgtactgtt aaagaaatta tccgcgaagt gctggataca
    14881 gacgtgccgg acagtgaatg cgtttttgcc gtggtgctga cccgtgggga tgtgcgccat
    14941 atggctcagg actggagcct gtcagacgat gagctggaaa ccgtcatgca gcggctggac
    15001 gatgcctttg aatatggtgc ggatgtcagc gttgttcacg gcgttgttcg tgaactgatg
    15061 gaagaaaagc gcgccagccg tcaggtgaca gtcccggcgg tgatgctgga aaaagtgatg
    15121 gcgctggcag gcagtgaaat gaagcgcctg tatgccgtcg ggagtgagaa tgggggcgac
    15181 ggtgacgcat tcgtcaggga ggaacgcgaa gcaatggacg ttgtgttaca ggcgctggac
    15241 ggggagacga tgtcatgaat atcagcacag aaagtcgcga aattctgcgt aattacaggg
    15301 ccgtgattaa tgcgcggcgt cgtgaaatgg ggcagaaacc gctcaccact gcgcagattg
    15361 ttgatgaaat ctgcgatttt gtggcgaatc agcaggcggt tttcctcggt ggtcactata
    15421 tccttcaggg cagcagaaac aggtgataca gggcaggcgg tggaggccgc ctgtcagccc
    15481 gcgcgaaaac ccctggcagg ctgacgcctg ccggaaggga agcgggccac gctggcgcgt
    15541 cgcccgttac ccttcccgtc tgtgatgtgt ctgactcagg agtgtttctt tcttatgtta
    15601 tggaactgtt cctgatgttg ttgttccttt atctgctgct ctgattctga ctactgcagt
    15661 gttgttctgt ctgccgggtc gggtagcagc ggcacattgc tgcgccgccg ccccctaaga
    15721 acggagcgtg cgagtttccc cgcactccgc tcaagccttt ataagtgctt tcggtgagca
    15781 ccggcttccc tgctgtgtaa ctgtcggtgg cagttcggat gtaacaactc gagattggtc
    15841 agttcgtcac tgccgcccat aactttcctg atccggtgat gtatattcca tccggtctgg
    15901 ttggttatgg gttgtccgca ctgcggacag tgtttcccct gcctcttcca gagttgaact
    15961 actgtcttca tcttctttga tttgcctttc cagattagat ccagacgacg ttcaaagtag
    16021 atttccattc cgggggtgta tggtgttgct tcgcctttga tttttatatg gcgctttatc
    16081 ggtgtttcca ttgcccggaa gagagtcaga attttccctt ccggggttat ggctttaaag
    16141 atccagcgcc tgccttcaaa ggagaagtat cgtccggcga tccaccgcaa tccttttcgg
    16201 gggtgccttc ttacacacca tcgccatata gctcgccaga tttgggtgtc gacataatta
    16261 aatgtttctt tcgccacgac gtgtcggtga taggtagccc atccccggat caccgggttt
    16321 agctggccta tcagtttcca tgccgggagc gtcggattgc gtttaattat ttctctgact
    16381 ttacagagga agttcttcag gtttttcttc gacggtttaa tcagcatttt accgttgtac
    16441 ttcctgacgt tctgccctaa aaagtcgaag cctttatcta tatgtgtgat cgcggttttt
    16501 tcttccgaca gttccagccc tcgttcgcgc atgaaagctg caatcagtgg tctgacctca
    16561 ttttccagca attcacggga gctgcctgaa cagatgaaat catcagcata tctcacataa
    16621 ttcacctggt gctttgcact gtgataacca cttttcctga acgtttgcat cagttccttc
    16681 tccagtccgt ccagagccat gttggcgaga acaggggata tgatgcctcc ctgcggtgtc
    16741 ccgctgttcg tatggttaaa cacgcctctt tccatgtaac ctgctttcaa ccatttttta
    16801 agaagtttcc tgtccagcgg aatatgggaa agcagccagt catggctgat gttatcgaaa
    16861 caccctttaa tatcgccctc cagtatccat ttgggcgata ctttctggct catccgcaga
    16921 aaaatggact caatggcgtc atgcgtgctg cgcattggtc tgaaaccata gctgttgtgg
    16981 tcagcagtgg tctcggatac gggttccaga gccagcagcc acagtgcctg catggcccgg
    17041 tccctcattg tgggtatgcc cagcggtcgc gttttgccgt ttgattttgg gatatatatt
    17101 cgccgtagtg gctgtggcct gtaaccacac agattcaggc tgcatatccc ttcccatttc
    17161 tccttcggtg tgtgccatat ttttccgtca ataccgggtg tccttttacc ggtattttca
    17221 gttacacgcc tgac
//
