LOCUS       CP057670.1             17234 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  CP057670.1 Escherichia coli strain RHB18-C18 plasmid pRHB18-C18_2,
            complete sequence.
ACCESSION   CP057670
VERSION     CP057670.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 19:11:09
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17234
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..858
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MTDLQQTYYRQVKNPNPVFTPRKGAGTLKFCEKLMEKAVGFTSRF
                     DFAIHVAHARSRGLRRRMPPVLRRRAIDALLQGLCFHYDPLANRVQCSITTLAIECGLA
                     TESGAGKLSITRATRALTFLSELGLITYQTEYDPLIGCYIPTDITFTSALFAALDVSEE
                     AVAAARRSRVEWENRQRKKQGLDTLGMDELIAKAWRFVRERFRSYQTELKSRGIKRARA
                     RRDANRERQDIVTLVKRQLTREIAEGRFTASREAVKREVERRVKERMILSRNRNYSRLA
                     TASP"
     protocluster    1..17234
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5244:7234]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5245..7234
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     cand_cluster    1..17234
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="single"
                     /product="LAP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17234
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="LAP"
                     /region_number="1"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /tool="antismash"
     CDS             1790..2674
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MDLYHFTAIPMLHSILASEGLREGYLTLYDGTILYNKVWLTTSPL
                     PYGHGLCNGTEKLSESEKSFMRRVGNISESTSINGTHNKKLIRLKIDTEWIKKQPGFCS
                     YKKLMRDLGQPKAYVKYVGAMGVEGARGMTDEQISKIMRKGNTKEDTWYIFNGVIPPSK
                     IVSVEYMETKDKYIPYDFELHGRGYIENSGIYPISNLLLSDLNHTMRNITFLPGSVIAF
                     CHKANSEENILFRHVLFTCSISLRNFSVLIATGDETSFYIHLDVLKSWTQKNSKVLCQL
                     FEKARESYHRYYG"
     CDS             complement(3215..3778)
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MDIIEKRITKRHLSESELSGVNYYNCIFERIQLDNFNFRDCEFEK
                     CRFVNCSIKNLKLNFFKLIDCEFKDCLLQGVNAADIMFPCTFSLVNCDLRFVDFISLRL
                     QKSIFLSCRFRDCLFEETDLRKSDFTGSEFNNTEFRHSDLSHCDFSMTEGLDINPEINR
                     ILSIKIPQEAGLKILKRMGVVVGG"
     CDS             complement(3782..4513)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 95.1; E-value:
                     9.3e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MTIPLLEINSLSFSYKVNLPPVFNNLSLKIEQGELIGLLGENGAG
                     KTTLFNLIRGGVSNYEGTLKRNFSGGELVSLPQVINLSGTLRNEEVLDLICCFNKLTKK
                     QAWTELNHKWNDNFFIRYDKIRRKRTYTVSYGEKRWLIISLMLTLCKNARLFLLDEPTV
                     GIDIQYRMMLWELINKITADGKTVFFSTHIFDELTRDKIPFYMLSKNSINRYSDMSDFI
                     QSNNETTPEKAFIKEVMGTGD"
     CDS             complement(4510..5235)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MVTLKMAIIFLMEQIRTPFSLIWTIMSPTVLFFFLHFNEIELHYG
                     DTAWLGKQISWFVGYISFSVVLFNYCLYLVGRRESGFIATFVHNMDGRLLFIRSQLIAS
                     LIMSILYVFFFILVVLTGFQASPDYQIVMIILKSIYINAFMMVSLTFMASFRVTFQTAS
                     TIYSVLITVCMVSGIVSLKYNEGIVYWINQVNPIAIYSTILQSDQELSLMTIFFYSIML
                     IISIISALTFKTEPVWSSQ"
     CDS             complement(5245..6435)
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_6"
                     /sec_met_domain="YcaO (E-value: 1e-16, bitscore: 53.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVYSNLMSAWPATMAMSPKLNRNMPTFSQIWDYERITPASAAG
                     ETLKSIQGAIGEYFERRHFFNEIVTGGQKTLYEMMPPSAAKAFTEAFFQISSLTRDEII
                     THKFKTVRAFNLFSLEQQEIPAVIIALDNITAADDLKFYPDRDTCGCSFHGSLNDAIEG
                     SLCEFMERQSLLLYWLQGKANTEISSEIVTGINHIDEILLALRSEGDIRIFDITLPGAP
                     GHAVLTLYGTKNKISRIKYSTGLSYANSLKKALCKSVVELWQSYICLHNFLIGGYTDDD
                     IIDSYQRHFMSCNKYESFTDLCENTVLLSDDVKLTLEENITSDTNLLNYLQQISDNIFV
                     YYARERVSNSLVWYTKIVSPDFFLHMNNSGAININNKIYHTGDGIKVRESKMVPFP"
     CDS             complement(6416..7234)
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7"
                     /sec_met_domain="PF00881 (E-value: 8.4e-10, bitscore: 31.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKHELSLVEVTHYTDPEVLAIVKDFHVRGNFASLPEFAERTFVS
                     AVPLAHLEKFENKEVLFRPGFSSVINISSSHNFSRERLPSGINFCDKNKLSIRTIEKLL
                     VNAFSSPDPGSVRRPYPSGGALYPIEVFLCRLSENTENWQAGTNVYHYLPLSQALEPVA
                     TCNTQSLYRSLSGGDSERLGKPHFALVYCIIFEKALFKYRYRGYRMALMETGSMYQNAV
                     LVADQIGLKNRVWAGYTDSYVAKTMNLDQRTVAPLIVQFFGDVNDDKCLQ"
     CDS             complement(7236..8090)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04424"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_8"
                     /sec_met_domain="TIGR04424 (E-value: 2.1e-88, bitscore:
                     288.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINILPFEIISRNTKTLLITYISSVDITHEGMKKVLESLRSKQGI
                     ISEYLLDKLLDESLIDKDKGKEFLITTGVINKTKTSPLWVNSVIISDVPHLFSNAREQW
                     KSDGVFVSHIIDIKDNNINVSDSTLIWLHLENYHSDIVKRIYSKFESNPGVAFIQSYYL
                     KESFRIDGVYSPDLGTPCHFCHIERWLSREEKSFRRNEMSWANLLQLLKKYQMTLPALA
                     LGESERGFSYHLIKRRLQELTGTSLVKSHVDNFMSSVSADLITCILCKEPVIHWQACSC
                     LER"
     CDS             complement(8150..8356)
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MELKASEFGVVLSVDALKLSRQSPLGVGIGGGGGGGGGSCGGQGG
                     GCGGCSNGCSGGNGGSGGSGSHI"
     CDS             8812..9108
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MIQTRNQYLQFMLVMLAAWGISWGARFVMELAVLLYGPGKNYLFF
                     SHGAVLMYLLCVFLVYRRWIAPLPVVGQLRNVGVLWLVGAMAVVYIGVFLLDR"
     CDS             9123..9605
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MSSVFKGRVSMKFMECAVRNVIYGTNVRIVKPVNIYECELRDNVF
                     VGPFVEIQKGCVIGSGSRIQSHTFICENVTLGENCFIGHNVTFANDLFRSGAPDPSPDN
                     WISITLGDSVTVGSGAIILSPYICSGAVIGAGSVVVKPIENKGIYAGNPARLLRIL"
     CDS             complement(10009..10362)
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MMDKRRTIAFKLNPDVNQTDKIVCDTLDSIPQGERSRLNRAALTA
                     GLALYRQDPRAPFLLCELLTKETTFSDIVNILRSLFPKEMADLNSSTIIQSSSQSEQKS
                     DEETKKNAMKLIN"
     CDS             complement(10362..11324)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MLVFIDDGSTNIKLQWQENDGTIKQHISPNSFKREWAVSFGDKKV
                     FNYTLNGEQYSFDPISPDAVVTTNIAWQYSDVNVVAVHHALLTSGLPVSEVDIVCTLPL
                     TEYYDRNNQPNTENIERKKANFRKKITLNGGDAFTIKDVKVMPESIPAGYEVLQELDEL
                     DSLLIIDLGGTTLDISQVMGKLSGISKIYGDSSLGVSLVTSAVKDALSLARTKGSSYLA
                     DDIIIHRKDNNYLKQRINDENKISIVTEAMNEALRKLEQRVLNTLNEFSGYTHVMVIGG
                     GAELICDAVKKHTQIRDERFFKTNNSQYDLVNGMYLIGN"
     CDS             11841..12524
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MSRFILGDCVRVMATIPDNAIDFILTDPPYLVGFRDRSGRTIAGD
                     VNDDWLQPASNEMYRVLKKDALMVSFYGWNRIDRFMAAWKRAGFSVVGHLVFTKSYTSK
                     SAYVAYRHECAYILAKGRPALPPKPLPDVLGWKYSGNRHHPTEKPVTSLQPLIESFTHP
                     NAIVLDPFAGSGSTCVAALQSGRRYIGIELLEQYHRAGQQRLAAVQRAMQQGAANDDWF
                     MPEAA"
     CDS             12525..12746
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MNYAGHEKLRAEVAEVANAMYDLRTTMNEMERRYSFNADTLPERL
                     VRQTLFRANRLLMEAYTEILELDACFKD"
     CDS             12760..13194
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MYGTCETLCRALAAKYPGDTPLMLVIWSPEEIQALADGMDISLSD
                     HEIRTVLARLEDIPEDQRTESGISSGVAMEIINNVRENRQVTVPAELLASLIQTAEQAL
                     WKREWAARDYGLAVPECVTRRQAVVNQARSLLKNNTHEND"
     CDS             13239..14009
                     /locus_tag="ctg1_17"
                     /transl_table=11
                     /translation="MNKTLHALVCRHARNLLLAQGRPEETDIEQLNPHYPGWISIYVRL
                     DAPRLATLLINRHDGVLLPILASVVQKITGIGAEVILSGSQWQALPVLPADGTQVSFPY
                     AGEWLAEDEIRAVLAAVRDAIRSICYQVAEDTRRIRAALTTTGQTLLTRQTRRFRLVVK
                     ESDHPCWLDEDDENLPVVLDAILNRGARFSSVEMYLVSECVEHILASGLVCDVLRIPDE
                     PPRRWFDRGVLREVVREARVEIRSMADALAKIRK"
     CDS             14006..14203
                     /locus_tag="ctg1_18"
                     /transl_table=11
                     /translation="MMTIAGKIPAFFLPVPGQSTKEVAAGSALPGHAGHGLVGFQLCGR
                     RVVCGQCRASILAGLAGMQG"
     CDS             14422..14847
                     /locus_tag="ctg1_19"
                     /transl_table=11
                     /translation="MQYAKSVTLNVEECDRLSFLPYLFGQDFLYAEASVYALAKKMMPE
                     YEGGFWHFIRLPDGGGYMMPDGDRFHMVNGANWFDRTVSADAAGVILTSLVINRQLWLY
                     HDSGDAGLTQLYRMRDAQLWRHIEFHPECNAIYAVLD"
     CDS             14894..15316
                     /locus_tag="ctg1_20"
                     /transl_table=11
                     /translation="MYCTVKEIIRDVLDTDVPDSECVFAVVLTRGDVRHIAQDWSLTDD
                     EVETVRQRLDDAFEHGADVSVVHDVVRELMEEKRASRHVTVPAVMLEKVMALAGSEMKR
                     LYAVGSENGGDGDAFVREEREAMDVVLQALDGETMS"
     CDS             15313..15504
                     /locus_tag="ctg1_21"
                     /transl_table=11
                     /translation="MNISTETREILRNYRAVINARRREMGQKPLTTAQIVDEICDFVAN
                     QQAVFLGGHYILQGSRNR"
     CDS             complement(15474..16214)
                     /locus_tag="ctg1_22"
                     /transl_table=11
                     /translation="MTFRGNLLLYSLWYELHPFENLRRKGHHCHGLTHLSWAERKIFYR
                     VLGKKFCGLFIYPGQSVRQVVAVSAPGDRDSYGCVAPAGMSRDPPQRRRARARNGVAPY
                     IPAAFCRDAGSAGHGATRVARPFRSLQTRGFCVRDGSPPGRRQLRWLRSRQPAPPGDAR
                     ESHKQERNGKKKRKNSNRHGNHRKITSEKNMPDTSQTGRVTGDASAWPASLPAGVSLPG
                     GARGLTGGLHRLPLYHLFLLPCKM"
     CDS             16474..16704
                     /locus_tag="ctg1_23"
                     /transl_table=11
                     /translation="MTVSIVSPSSAAVKPRRHPRFRREDIPAPEIDPVLKAFGRHIARS
                     FHRGRGVHIPAMKNTAFGQVLRTLELKRAFN"
ORIGIN
        1 gtgactgatc ttcaacaaac gtattaccgc caggtaaaga acccgaatcc ggtgtttaca
       61 ccccgtaaag gtgccggaac gctgaagttt tgcgaaaaac tgatggaaaa ggcggtgggc
      121 ttcacctccc gttttgattt cgccattcat gtggcgcatg cccgttcgcg tggtctgcgt
      181 cgacgcatgc caccggtgct gcgtcgacgg gctattgatg cgctgctgca ggggctgtgt
      241 ttccactatg acccgctggc caaccgcgtc cagtgttcca tcaccacgct ggccattgag
      301 tgcggactgg cgacagagtc cggtgcagga aaactctcca tcacccgtgc cacccgggct
      361 ctgacgttcc tgtcagagct gggactgatt acctaccaga cggaatatga cccgcttatc
      421 gggtgctaca ttccgaccga tatcacgttc acatctgcac tgtttgctgc cctcgatgta
      481 tcagaggagg cagtggccgc cgcgcgccgc agccgtgtgg aatgggaaaa cagacagcgc
      541 aaaaagcagg ggctggatac cctgggtatg gatgagctga tagcgaaagc ctggcgtttt
      601 gtgcgtgagc gtttccgcag ttaccagaca gagcttaagt cccggggaat aaagcgtgcc
      661 cgtgcgcgtc gtgatgcgaa cagggaacgt caggatatcg tcaccctggt gaaacggcag
      721 ctgacgcgcg aaatcgcgga agggcgcttc actgccagtc gtgaggcggt aaaacgtgaa
      781 gtggagcgtc gtgtgaagga gcgcatgatt ctgtcacgta accgtaatta cagccggctg
      841 gccacagctt ccccctgaaa gtgacctcct cagaataatc cggcaagcgc cggaggcatt
      901 tgcacgcctg aagcccgcta gcgcacaaaa aatcagcgct acatacaaaa aacaacctca
      961 tcatccacct tctggtgcat ccggtccccc ctgtttttga tgaaaaactc gtctcacaga
     1021 cgggcaattt tgcttatcca cattaaactg caaggggctt ccctataagg ttacaaccgt
     1081 tcatgtcata aagcgccagc cgccagcgtt acagggtgca atgtatcttt taaacacctg
     1141 tttatatctc ctttaaacta cctaattaca ttcatttaaa aagaaaacct attcagtgtc
     1201 tgtcctgtgg acagacagat atgcacctcc caccgcaagc ggcgggcccc gaccggagcc
     1261 actttagtta caacacacga aaacagcctc cagaaaaacc ccggtccagc gcagaactga
     1321 aaccacaaag cccctccctc ataactgaaa agcggccccg ccccggccct tcgggccgga
     1381 acagagtcgc ttttaattat gaatgttgta actaaacatc attgctgtca gtcttctggt
     1441 tggacgtatc gagtacacgc tcgtaagcgg ccctcacggc ccgctaacgc ggagatacgc
     1501 cccgacttcg ggtaaaccct cgtcgggacc actccgaccg cgcacagaag ctctctcatg
     1561 gctgaaagcg ggtatggtct ggcagggctg gggatgggta aggtgaaatc tatcaatcag
     1621 taccggctta cgccgggctt cggcggtttt actccggtat cacatgtaac cacagcgtgc
     1681 cgccttacat gccgctgaag cggcattcag tagacaggct atgcacgact cgccagtctg
     1741 gcctgaacat gatataaaat gaatataaat agacagaata gggttattta tggatttata
     1801 tcactttaca gcaattccta tgttgcattc catacttgca tctgaaggcc tgagagaagg
     1861 atatctaacg ttgtatgatg gaacaatttt gtataataaa gtatggttaa cgacatctcc
     1921 attaccatat ggtcacggat tatgtaacgg tactgaaaaa ttaagtgaat cagaaaaatc
     1981 atttatgcga agagtcggta atatatctga gtctacgtct ataaatggaa cacataataa
     2041 aaagttaata aggttaaaaa tagatactga atggataaaa aagcagcctg gattttgctc
     2101 atataaaaag ctgatgcgtg accttggaca acctaaagct tatgttaagt acgtaggtgc
     2161 aatgggggtt gagggggcaa gggggatgac cgatgagcag ataagtaaaa ttatgcgaaa
     2221 aggtaacaca aaagaagata cctggtatat ctttaatggg gtcatcccac cttcaaaaat
     2281 agtctctgtt gaatatatgg aaactaaaga taaatatata ccatatgatt ttgaattgca
     2341 tggaagggga tatatagaaa actccggcat ttatccgatt tcgaatttat tattatctga
     2401 tctgaatcat acaatgcgaa atattacatt tttaccaggt tctgtcatag cgttttgtca
     2461 taaagcaaat tcagaagaaa atattttatt cagacatgta ttattcacat gttcaatctc
     2521 cttgagaaat ttttcagtac tgatagcaac aggtgatgag acatctttct atattcatct
     2581 ggatgtatta aaaagttgga ctcaaaaaaa cagtaaagta ctatgccaac tttttgaaaa
     2641 agcacgtgaa agttaccaca gatactatgg ttagaaacca ctgcggggag aacatcagtg
     2701 gcacaaaact agaccgcccg gaaccgggac gcttactgat ggacagtcat cgcaatgata
     2761 tcttgctggt tgagcagata ggggctccgt gggaatttct gcgataacac ccgctaagcg
     2821 atttctccct gacggaaatc acttgttttt cgttcagagg caggcaagag gaatattcat
     2881 ccccaaaaac ggcgttttca tatgcggaaa acgctgccgg atagtcgaat agtacgacaa
     2941 actgacttct gacgttttcc gtacatttca gattcagtaa ccccgaatat ttggggttgg
     3001 tatggctaac gccttgaatt tcaatgaaca atattttgtt accgtgtact gtcgcagaaa
     3061 tgcccacgga accccgagat ggagaactca gtcaatgttc cattctttct gaaatatgtg
     3121 tggggacact gatctgtcgg gagccggatg cggtagttcc gcaggtccgg ttctgaggag
     3181 gggcccgtcc gggcaaccgg cgggtctact cacctcatcc ccctacaacc actcccattc
     3241 gtttaagtat ttttaaacct gcttcctgtg gtatctttat agataagatc ctgtttatct
     3301 caggatttat atcgagacct tctgtcattg aaaaatcaca gtgagacaaa tcagaatgtc
     3361 tgaactctgt attattaaac tccgaaccag taaaatcaga tttacgaagg tctgtttcct
     3421 caaataaaca atcacggaag cgacaggata aaaaaataga tttctgtaac cgtaaactaa
     3481 taaaatcaac aaatctcaaa tcacaattta caagagaaaa agtacaggga aacataatgt
     3541 ctgctgcatt tactccttgt aataaacaat ctttgaattc acagtcaata agtttaaaaa
     3601 aattaagttt taaattcttt attgagcagt ttacgaagcg acatttttcg aactcacaat
     3661 cgcgaaagtt aaagttgtca agctgtattc gttcaaatat acaattgtaa taatttacac
     3721 ctgataattc actttcactg aggtgtcgtt ttgtgattct tttttctatt atatccatgt
     3781 gtcagtctcc tgttcccata acttctttaa taaatgcctt ttctggagtt gtttcattat
     3841 tggattgaat aaaatcactc atatcagaat aacgatttat actatttttt gaaagcatat
     3901 agaaggggat tttatctctt gttaattcat caaaaatatg agttgagaaa aataccgttt
     3961 tcccgtcagc ggtgatctta tttatcagtt cccataacat cattctgtac tgaatatcaa
     4021 tgcctacagt tggttcatcc agtaaaaata aacgggcatt tttgcaaagc gttagcatca
     4081 aagatatgat aagccaacgc ttctctccat aacttaccgt gtaagtcctt ttacgtctta
     4141 ttttatcata gcgaatgaaa aaattatcat tccatttatg attaagctct gtccatgcct
     4201 gttttttagt taacttattg aagcagcaaa tcaaatcaag aacctcctca ttccttagtg
     4261 tacctgaaag atttatgact tgaggtagac ttactaattc tccaccagag aaatttcgct
     4321 tgagggtccc ttcataatta ctgactccgc ccctgataag gttaaaaaga gtggtcttcc
     4381 cggctccatt ttctccaagc agacctatca actctccctg ctcaatctta agcgacagat
     4441 tattgaaaac agggggtaaa tttactttat atgaaaagct cagagagttg atttctaaaa
     4501 gaggtatggt cattgagaac tccagactgg ctcagttttg aaggttagtg ctgaaataat
     4561 acttatgatt aacattatac tatagaaaaa tatcgtcatc agagacaact cctggtctga
     4621 ctggagtatt gtagaataga tggcgatagg attaacctga tttatccagt aaacgatccc
     4681 ctcattatat tttaatgata caattcctga taccatacag acagttatta atacagaata
     4741 gatagtgctg gctgtttgga atgtgactct gaacgatgcc atgaaagtga gtgaaaccat
     4801 cataaatgca tttatgtata tcgattttaa aataatcatt actatttgat aatctggact
     4861 tgcctggaat cctgttagta cgactaaaat gaaaaaaaac acatacaaaa tagacatgat
     4921 aagtgaggct attaattgag aacgaataaa taatagtcga ccatccatat tatgcacgaa
     4981 ggtagcaata aaaccacttt ctcttcttcc gaccagatac agacagtaat taaacagaac
     5041 aacagaaaaa gaaatgtagc ctacaaacca tgatatttgt tttccgagcc atgctgtatc
     5101 accataatga agttcaattt cattgaaatg aaggaaaaag aacaacactg taggtgacat
     5161 aattgtccat attaagctga aaggggttct gatttgttcc atcagaaaaa ttatcgccat
     5221 ttttaatgta accatttgtt atccttatgg gaatggtacc atctttgatt ctctgacttt
     5281 aataccgtcc ccggtatggt aaattttatt attaatgttt attgcacctg agttattcat
     5341 atgaaggaaa aaatcagggc ttactatttt tgtgtaccag acaaggctgt tacttactct
     5401 ttccctggca tagtaaacaa aaatattatc agaaatttgt tgaagatagt ttaataaatt
     5461 tgtgtctgac gtaatatttt cctcaagcgt taacttgaca tcatcagaca gtagtaccgt
     5521 attttcacac aaatccgtaa acgactcgta cttgttgcat gacataaagt gacgctggta
     5581 actatcaata atgtcatcat cagtataacc gccaataaga aagttgtgca ggcatatata
     5641 cgattgccac aattccacta cggatttaca aagtgctttt ttcagactat tagcatagga
     5701 taatccggta ctgtatttta ttcgactgat tttgtttttt gtgccataca gggttagtac
     5761 tgcgtgtcca ggagctccgg gcagggtgat atcgaaaatc ctgatatctc cttctgacct
     5821 gagagccagt aaaatctcat ctatatgatt tatgcctgtt actatttcac tggatatttc
     5881 agtattggct tttccctgta accagtaaag aaggagggac tgtctctcca taaattcaca
     5941 caaggaacct tctatggcat cgttcaaact accatgaaag ctacatccgc atgtatctct
     6001 gtcaggataa aatttcagat catctgcagc ggttatattg tcgagtgcaa ttatgactgc
     6061 aggtatttct tgttgttcaa ggctaaacag attaaaggct ctgaccgttt taaatttatg
     6121 ggttatgatt tcatcgcggg tcagtgatga gatctgaaaa aatgcttcgg taaaagcctt
     6181 tgcagcagat ggaggcatca tctcatataa tgttttctga ccaccggtga ctatctcatt
     6241 aaaaaaatga cggcgttcaa aatattcacc tattgccccc tgaattgact tcagagtttc
     6301 accggccgcg ctggctggtg taatacgctc atagtcccat atctgagaaa acgttggcat
     6361 atttctgttc agttttggac tcatagccat tgtggccggc catgcggaca taaggttact
     6421 gtagacattt atcatcgttt acatctccaa aaaactgaac gatcagtggc gctacagtcc
     6481 tctgatccag attcattgtt tttgctacgt atgaatcggt atatcccgcc catacccggt
     6541 ttttcagtcc tatttgatct gcaaccaata ctgcgttctg atacatcgaa cctgtttcca
     6601 ttaaggccat ccggtatcct ctgtagcgat atttgaacaa agctttttca aaaataatgc
     6661 aatagacgag agcaaaatgg ggtttaccaa gacgttccga atccccaccg gacaggcttc
     6721 ggtagagtga ctgagtatta catgtagcaa caggttccag tgcctgactt agcggcaggt
     6781 agtgataaac attagttcct gcctgccagt tttctgtatt ttcagataat ctgcataaaa
     6841 aaacttcaat cgggtacaat gcccccccag aaggataagg tcttcttaca gagccaggat
     6901 caggtgagct gaatgcattg actaataact tttcaatagt acgaatggaa agtttatttt
     6961 tgtcgcaaaa gtttattcct gatgggagcc tttcacgact aaaattatgt gatgaggata
     7021 tgtttattac ggagctgaaa cctggcctga agagaacttc tttattttca aatttctcca
     7081 gatgggcaag aggtaccgcg gacacgaaag ttcgttcagc aaattcgggg agggaagcaa
     7141 agttacctct gacatgaaaa tctttaacaa tggccagaac ttcaggatct gtgtaatgcg
     7201 ttacttccac taaagagagt tcgtgttttg acatgttatc tctccagaca gctgcaagcc
     7261 tgccagtgaa ttaccggctc tttacataaa atacaggtga ttaaatcagc gctaacagat
     7321 gacataaagt tatcgacatg acttttaacc agtgaagtac ctgtcaactc ctgaagtcgc
     7381 cgttttatta aatgatagct gaatcctctt tctgattcgc ctaaagccaa tgctggtagt
     7441 gtcatttggt attttttcag taactgaagt aagtttgccc aggacatttc gttacgtctg
     7501 aagctttttt cttccctgct cagccatctc tctatatgac aaaaatggca gggagtacca
     7561 agatcaggtg aatatactcc atctatcctg aatgactcct ttaggtagta gctttggatg
     7621 aaggcaacac cagggttact ttcaaatttt gaatagattc tttttacaat gtctgaatga
     7681 tagttttcga gatgtaacca gattagtgtt gaatcgctca cattaatatt attatctttt
     7741 atatcaatga tatgagaaac aaaaacacca tcagatttcc attgttcccg ggcattactg
     7801 aaaagatgtg gaacatcgct tattatgact gagtttaccc agagaggtga tgttttcgtt
     7861 ttatttatca cgcctgtggt aataagaaac tctttgccct tgtctttatc aataagcgat
     7921 tcgtccagta gtttatcaag gaggtattca gaaataatac cctgtttgga tcgtaggctt
     7981 tcgagtactt ttttcattcc ctcatgtgta atgtctactg aagaaatgta ggtaataagc
     8041 agggtctttg tatttctgga aattatctca aatggcagaa tattgatcat atcttttcct
     8101 tttttaatat cagggagcac catgctccct gaacggttaa ttcaacgtat cagatatgtg
     8161 aaccacttcc gccgctgcca ccgtttccac cactacaacc gttgctgcaa ccaccacaac
     8221 cgccaccttg accaccgcag ctaccgccgc cgccgccgcc accaccacca atgccaacac
     8281 ctaatggaga ctggcgtgat aatttaagag catcaacgga caaaactaca ccaaattcac
     8341 tcgcttttaa ttccataagg actccttttt taagggaaat taatgcttat gacatctgaa
     8401 tagtatgttg gccaacacta gttacttgcc gtaattaact atattttgca atgataattt
     8461 gaactaaatt tgtacgcctg ttaaatattt aataataata tcagtcggtt atgtttgtgc
     8521 ggttattgtt ttttttacaa aaattaatat tgtgtttaca ttttgctttc agttgctgtc
     8581 aggatgtcac gctacccctt taagccccca ctggtctggc agggccgggg gtgggtaagg
     8641 tgaaacctgt caatcagtac cggcttacgc cagtatcata tgcaacaact gagtgccgcc
     8701 ttccatgccg ctggtgcggc atatcctggt gacgatatct gaattgttat agatatgtat
     8761 atacgtagta atgacaagaa taggataagt taaaaattta caggagatgc aatgattcag
     8821 acacgtaatc aatatctgca gtttatgctg gttatgctgg ctgcatgggg cattagctgg
     8881 ggagccagat ttgtcatgga gctggccgtt ctgctttatg ggccaggaaa aaactatttg
     8941 ttcttcagtc atggtgctgt tctgatgtac ctgctgtgtg ttttcttggt ataccgccgt
     9001 tggatagctc cgctaccggt cgttggtcag ctgcgcaacg ttggcgtact gtggctggtc
     9061 ggtgcgatgg ccgtggtgta tatcggtgta tttctgctcg atcgatagga atattccggc
     9121 aagtgtcatc tgtatttaaa ggtcgtgtga gtatgaaatt tatggaatgt gctgtccgga
     9181 atgtgattta tgggaccaat gtccgtattg tcaaaccggt caacatttat gaatgtgaac
     9241 tcagggacaa tgtgtttgtc ggccccttcg ttgagataca gaaaggctgt gtcattggta
     9301 gtggaagccg gatacagtcg cacacgttta tttgtgagaa cgtaacactg ggggagaact
     9361 gcttcattgg tcataacgtg acgttcgcca acgatctgtt tcgttcagga gcaccagatc
     9421 cgtcaccgga taactggatc agcattaccc tgggggattc ggttactgtt ggaagtggag
     9481 ccattattct gtctccgtat atatgcagcg gagctgttat tggtgcgggt tcagttgtgg
     9541 taaaaccgat tgagaacaaa ggcatttatg caggaaaccc ggcaagactg ctcagaatat
     9601 tatgaaaaag aaaagggccg ttactggccc tttttatcag aggtaggtct gtgaatacgg
     9661 taggtgtaca gaaatcgact gccggggatc gatttccagg gccgcccggt attctgcgtc
     9721 agtgatatca cctttttttc agtaaataac cgagagcatc gtttcccagc cctgacagta
     9781 tgcgtattct ggcgacccgg actggcaaat aacccatcaa aaacgttatt gccagacatt
     9841 gcgaactcac caattttgat tattggagcc actttttcat aagtttcgtg aaattatttc
     9901 ataataacga ccatgtttat tttatgtaat gactggcaat aaaataactt gattaagttc
     9961 cctttatcca gcctgatagt ggataaagga aactcaatca taatttaatt agtttattaa
    10021 cttcatcgca ttcttttttg tctcctcatc acttttttgc tccgattgtg aagaggactg
    10081 aatgattgtt gaagaattta aatcggccat ctcttttgga aatagcgatc tcaatatatt
    10141 cacgatatct gaaaatgtgg tttctttcgt cagcaattca cataaaagga aaggggccct
    10201 aggatcttgt ctgtataagg ccagacctgc cgtcagtgca gcccggttaa ggcggctgcg
    10261 ttccccttgc gggatactgt ccagtgtatc acaaacaatt ttatctgttt gatttacatc
    10321 tggatttagc ttaaaggcaa tggttctgcg cttgtccatc attaattacc tatgagatac
    10381 ataccgttaa ctaaatcata ttgagagtta ttggttttaa aaaaacgttc atcacgaatc
    10441 tgtgtgtgtt tttttactgc atcgcatatt aattctgcgc caccacctat aaccataaca
    10501 tgagtataac cagaaaattc attgagtgta tttaatacac gttgctcaag tttacgaagt
    10561 gcttcattca ttgcttcggt gactattgat attttgttct catcattaat tcgttgcttc
    10621 agatagttat tatcttttct gtgaataatt atatcgtcag caagatagct acttcctttt
    10681 gttctcgcaa gagaaagggc atcttttact gcagatgtga ccagagatac accaagagat
    10741 gagtctccgt atattttact gatccccgat aatttcccca ttacctgaga aatatctaat
    10801 gtggtgcccc cgagatctat aattaataaa gaatctaact catccagttc ttgtagaact
    10861 tcataacctg ccggtataga ttcaggcatg acttttacat cttttattgt gaatgcatcc
    10921 ccaccattta atgtaatttt tttccggaag tttgctttct tacgctcaat attttccgta
    10981 ttgggttggt tattcctgtc gtaatactct gtcagaggaa gtgtgcaaac aatatccact
    11041 tcgcttaccg gcagaccact ggtcagtaag gcgtggtgca ccgcaacgac attaacgtcg
    11101 ctgtattgcc atgcgatatt ggttgtgact acagcatccg ggctgattgg atcaaatgaa
    11161 tactgttcgc cgttcagtgt gtagttaaag acctttttat caccaaaaga aactgcccac
    11221 tcgcgtttga agctgttcgg gctaatgtgc tgtttaattg ttccgtcgtt ttcctgccac
    11281 tgtagtttga tgtttgttga accgtcatca atgaatacca acatttataa aactccttat
    11341 ggtgtttttg tggtgtgctt ttggggttgc tttgggtttt agatggggtc gtttgtcaag
    11401 tttaccccat tttgactatc agtcaatgat tgtttgtatt gtttttgggt ttgttatggt
    11461 gtgctttggg ttgtttttgg gttttatttg gcgggtaaca aaagatgtcg ctgtgcttct
    11521 ctttttactg cgccggctga cgcggcgcgg caggaacgct gcctgtggtc agtgtcccgc
    11581 gtccggccgg gcacgggacg ggcgctttta ccgctcctgg ctggcgtcgg tgacagtgta
    11641 cgccagcctg tcgccctttt ctgatgaatg cccttcaagc cgctttcgcg gcatatcctc
    11701 gccgttagaa agacgacggc tgcggtattc cacggtcggc ctgacccgtt accggacgcg
    11761 gtgaacagcc cacaggcagc ggagaacggg cgccacaggg gcgccctccc ggtgccctct
    11821 gtaagaggag gagtgctgtt atgtcccgtt ttatcctggg tgactgcgtg cgtgttatgg
    11881 ccacgattcc tgataacgcc attgatttca tcttaaccga cccaccatat ctcgttggtt
    11941 ttcgtgaccg ttccgggcgc accattgccg gtgacgttaa cgatgactgg ctgcaacctg
    12001 ccagtaatga gatgtaccgc gtactaaaaa aagatgcgct gatggtgagt ttctatggct
    12061 ggaaccgtat tgaccgcttt atggcagcct ggaaacgcgc cggattcagc gttgtagggc
    12121 accttgtgtt caccaaaagc tacacatcca aatctgcgta tgtcgcgtac cgtcacgaat
    12181 gcgcctatat cctggcaaaa ggccgtccgg cgctgcctcc gaagccatta cccgacgtgc
    12241 tgggctggaa atattcgggc aaccgccatc acccgacgga aaagcccgtt accagcctgc
    12301 aaccgctgat tgagagcttc acacacccga acgcaattgt gctggacccg tttgcaggca
    12361 gcggctcaac ctgcgtggcc gccctccagt ccggacgccg gtatatcggt atcgagctgc
    12421 ttgagcagta tcaccgtgcc gggcagcaac gccttgccgc cgtgcaacgg gccatgcagc
    12481 agggggccgc gaatgatgac tggtttatgc cggaggctgc gtaaatgaac tatgccggac
    12541 acgaaaaact tcgcgccgaa gtggcggagg tggccaatgc catgtacgac ctgcgtacaa
    12601 ccatgaatga gatggagcgg cggtacagct ttaatgctga caccctgccg gaacgtctgg
    12661 tgcgtcagac gttgttccgc gcaaaccgcc tcctgatgga ggcatatacc gaaattctgg
    12721 aactggatgc gtgctttaaa gattgagaag gagacgagaa tgtacggaac atgcgaaacg
    12781 ctatgccggg cgctggcagc aaagtatccg ggagacacgc cgttgatgct ggttatctgg
    12841 tccccggaag agattcaggc cctcgctgac ggaatggata tttccctgtc cgatcatgaa
    12901 atcaggaccg tcctggcgcg cctggaggat atcccggaag accagcggac tgaatccggt
    12961 atttcttccg gcgtggcgat ggagatcatc aataacgtga gagaaaaccg ccaggtgacc
    13021 gtcccggctg aactgctggc gtccctgatt cagaccgccg aacaggcact gtggaaacgt
    13081 gaatgggccg cccgtgatta cggcctcgcc gtcccggaat gcgttacccg ccgtcaggcg
    13141 gtggttaatc aggcccgcag cctgctgaaa aacaacacac acgaaaacga ctgatgttat
    13201 cgccgcctcc gggcggcgat tcagggagac catgaatcat gaataaaacg ctgcatgcac
    13261 tggtttgtcg tcacgcccgt aacctgctgc tggcgcaggg ccggccggaa gagacggata
    13321 ttgaacaact gaacccgcac tatccgggct ggatcagcat ttatgtgcgg ctggatgcgc
    13381 cccggctggc gacgttactt atcaaccgcc acgatggcgt gctgctgccg attctagcat
    13441 ctgtcgtgca aaaaataacc ggaatcgggg cggaagttat actgtccggt agccagtggc
    13501 aggcgctgcc ggtacttccg gcagacggaa cgcaggtgtc tttcccgtat gccggtgagt
    13561 ggctggcaga agacgaaatc agggctgtac ttgcggcggt gcgcgatgca atacgaagca
    13621 tctgttacca ggtagcagaa gatacgcggc gtatccgggc ggcgctgacc accaccggtc
    13681 agacgttgct gacccgccag acgcgccgct ttcgtctggt cgtgaaggaa agcgatcacc
    13741 cctgctggct tgatgaagat gacgaaaacc tgcccgtggt gctcgatgcc atcctgaacc
    13801 gtggcgcacg tttttcgtcg gtggaaatgt acctggtcag tgagtgtgtg gagcatatcc
    13861 tggccagtgg cctggtctgc gatgtgctgc gtataccgga tgaaccgccc cgccgctggt
    13921 ttgaccgtgg tgttctgcgg gaggtggtcc gggaagcccg ggtcgaaatc cgcagcatgg
    13981 cggatgccct ggcaaaaatc cggaaatgat gacgatagcg gggaaaatcc ccgccttttt
    14041 cctgccggtc cccggacaga gcacaaagga agtcgccgcc ggctccgctt tacccggcca
    14101 tgcggggcat ggccttgtgg ggtttcagtt atgtggccgt cgtgtcgtgt gcgggcagtg
    14161 ccgtgcctcc atcttagccg ggctggcggg gatgcaaggg taaaatgaac gcggcggtca
    14221 cccggtccct ccttcccgtc tgccgtgatt ttccggccgg ccgtccgcga aaacgcgtcc
    14281 gtccccttca actcccgcca gccgtgtgcg tcaggctgcg gcttcccttg cgcccctgca
    14341 tccccgcctt atcgcccggc ttttatggag gcacggcacc gcccggtgtc gcggaatatg
    14401 tgaacaacgg aggaaaacat catgcaatat gcgaaatctg tcaccctgaa cgttgaagag
    14461 tgcgaccgtc tgtcttttct gccttacctg tttggccagg attttctgta tgccgaagcg
    14521 tctgtatacg cgctggcgaa aaaaatgatg ccggaatatg aaggcggatt ctggcacttc
    14581 atccgcctgc cggacggtgg cggttacatg atgccggatg gcgaccgttt ccacatggtg
    14641 aacggtgcaa actggtttga ccgtaccgtg agtgctgatg ccgcaggtgt cattctgact
    14701 tcccttgtga ttaaccgtca gttgtggctg taccacgaca gcggtgatgc ggggctgact
    14761 cagctttacc ggatgcgtga tgcgcagttg tggcgtcaca tcgaatttca ccctgaatgc
    14821 aacgcgattt acgcggtact ggactgatta acggacgggg cggcaatgcc gcccctgtaa
    14881 aggagacgag aacatgtact gtactgttaa agaaatcatc cgcgatgtac tggatacaga
    14941 cgtgccggac agtgaatgcg tttttgctgt ggtgctgacc cgtggggatg tgcgtcacat
    15001 agcccaggac tggagtctga cagacgatga ggtggaaacc gtcaggcagc ggctggacga
    15061 tgcttttgag catggtgcgg atgtcagcgt tgttcacgac gttgttcgtg aactgatgga
    15121 agaaaagcgc gccagccgtc atgtgacagt cccggcggtg atgctggaaa aagtgatggc
    15181 gctggcaggc agtgaaatga agcgcctgta tgccgtcggg agtgagaacg ggggcgacgg
    15241 tgacgcattc gtcagggagg aacgcgaagc aatggacgtt gtgttacagg cgctggacgg
    15301 ggagacgatg tcatgaatat cagcacagaa actcgcgaaa ttctgcgtaa ttacagggcc
    15361 gtgattaatg cgcggcgtcg tgaaatgggg cagaaaccgc tcaccaccgc gcagattgtt
    15421 gatgaaatct gcgattttgt ggcgaatcag caggcggttt tcctgggcgg tcactacatc
    15481 ttacagggca gcagaaacag gtgatacagg ggcaggcggt ggaggccgcc tgtcagcccg
    15541 cgcgcccccc ctggcaggct gacgcctgcc ggaagggaag cgggccacgc tgacgcgtct
    15601 cccgttaccc ttcccgtttg tgatgtgtca ggcatgtttt tttctgatgt tatttttctg
    15661 tggttaccgt gcctgttact gttcttcctc ttcttctttc cgttcctctc ctgtttatgg
    15721 ctttcccggg cgtcccccgg cggggcgggc tgtcgtgaac ggagccagcg gagctgtctc
    15781 cgccctggcg ggcttccatc cctgacgcaa aaaccccggg tttgcagcga ccggaacggt
    15841 cgcgccaccc ttgtcgcgcc gtggcctgcg ctcccggcat cccggcaaaa ggccgccggg
    15901 atgtaagggg caacgccgtt tcgcgcacgc gctctccgtc gttgcggcgg gtccctgctc
    15961 atgcctgccg gtgccacaca cccgtatgag tccctgtcgc cgggggctga tacagccaca
    16021 acctgccgta ctgactgtcc agggtaaatg aacagcccac aaaatttttt acccaaaacc
    16081 cggtaaaaaa ttttgcgttc tgcccaggac aggtgcgtca ggccgtggca gtgatgcccc
    16141 ttgcggcgaa ggttctcaaa cgggtgaagt tcataccaca gggaatacag cagcaggttc
    16201 ccgcgaaacg tcaaaaccgc ggctcccgaa actcaacggg tgatgttctt taaaaatcag
    16261 gatttatttc aggctccggc aatacgcatt tatgtgttct gtcagtcatc cggctggcag
    16321 gtaatgagaa cgcaggaaca gaaggaggaa aacaccggaa agagtcagat gcagatatga
    16381 aaaaagcagg tcagggacct gcttaatcca catcgcaaaa actgttcgcg cagtttctgc
    16441 ggttccattc aacagtcata aggagattca tttatgacgg taagtattgt ttcaccttcc
    16501 tcagcggctg taaagccccg ccgtcatccc cgtttcagac gcgaagacat ccccgcgccg
    16561 gaaattgacc ccgtgctgaa agccttcggg cgacacattg cccggagttt tcaccggggg
    16621 cgtggtgtac acatccccgc catgaaaaac acggccttcg ggcaggtgct ccgcacactc
    16681 gaactgaaac gcgcttttaa ctgatgaggt gagccgcccc gtgaggggcg gcaacagacg
    16741 gaaggagaac attttatgac attagcagca atcaccatga ccgccccgga agccgccagc
    16801 cctgtgcaga tgtaccgcgc gacctactca ccggatgata acaaactgcg cctgtatgcc
    16861 gcgtcacgtc ttgaccagga aacgtataaa aaagtgcatg atgccggttt ccgctgggca
    16921 cccaaacagg cgctgtttgt ggcaccggcc tggacaccgg gccgggaaga cgtgctcctc
    16981 tcacttgcca gagagattga ggatgaagac agcacgctcg ctgaacgtca ggaagcacgg
    17041 gcggagcggt ttaccggata cagcggaaag cgggccagtg aatccgcaca ggcacttgat
    17101 gaagtggaaa gactggccgc gatgatcccg cccggtcagc ccattcttgt ggggcatcac
    17161 agcgaacgcc gcgcccgtcg tgatgcgcag cgtatcgaaa acggcatgaa acgagccgtg
    17221 atgctctttg aacg
//
